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1دورية أكاديمية
المؤلفون: Bédère, Nicolas, Dupont, Joëlle, Baumard, Yannick, Staub, Christophe, Gourichon, David, Frédéric, Elleboudt, Le Roy, Pascale, Zerjal, Tatiana
المساهمون: Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage Rennes (PEGASE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Physiologie de la reproduction et des comportements Nouzilly (PRC), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité Expérimentale Avicole de Tours (UE PEAT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Plate-forme Phénotypage par imagerie in/ex vivo de l'Animal à la Molécule (Plate-forme PIXANIM), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
المصدر: ISSN: 2804-3871.
مصطلحات موضوعية: [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics
الوصف: International audience ; In this study, we pursued three primary objectives: firstly to test and validate the phenotyping of backfat thickness as an indicator of the overall fatness of laying hens; secondly, to estimate genetic parameters for this trait; thirdly, to study the phenotypic and genetic relationships between this trait and other traits related to production and body composition. To address these questions, hens from two lines under divergent selection for residual feed intake, were phenotyped for body weight, body composition traits (backfat, total fat volume, and blood adipokines levels), and egg number. Linear mixed models enabled to estimate variance components and calculate genetic parameters. The two lines largely differed in body fatness: the efficient line had larger backfat and lower chemerin levels compared to the inefficient line. However, there were no significantly differences between the two lines concerning body weight, total fat volume, other blood adipokines levels (adiponectin, ghrelin, and visfatin), and egg production. The genetic parameter estimation revealed moderate heritability (0.38 and 0.42) for backfat and body weight, high heritability (higher than 0.80) for blood adipokines levels and low heritability (0.24 and 0.27) for egg production and total fat volume. The backfat and total fat volume were genetically highly and positively correlated (0.91). The body weight and total fat volume were also highly positively correlated (0.67). However, backfat and body weight were moderately positively correlated (0.39). The genetic correlation between backfat and egg number was moderate and negative. In conclusion, backfat could provide additional genetic information to that of the body weight as a selection criterion for body reserves. However, its correlation with laying performance should be taken into account to avoid undesired responses to selection
العلاقة: hal-04533050; https://hal.inrae.fr/hal-04533050Test; https://hal.inrae.fr/hal-04533050/documentTest; https://hal.inrae.fr/hal-04533050/file/Bedere%202024%20-%20backfat%20thickness%20R%2BR-.pdfTest
الإتاحة: https://doi.org/10.24072/pcjournal.412Test
https://hal.inrae.fr/hal-04533050Test
https://hal.inrae.fr/hal-04533050/documentTest
https://hal.inrae.fr/hal-04533050/file/Bedere%202024%20-%20backfat%20thickness%20R%2BR-.pdfTest -
2دورية أكاديمية
المؤلفون: Lecoeur, Alexandre, Blanc, Fany, Gourichon, David, Bruneau, Nicolas, Burlot, Thierry, Pinard-van der Laan, Marie-Hélène, Calenge, Fanny
المصدر: Poultry Science ; volume 103, issue 5, page 103609 ; ISSN 0032-5791
مصطلحات موضوعية: Animal Science and Zoology, General Medicine
الإتاحة: https://doi.org/10.1016/j.psj.2024.103609Test
https://api.elsevier.com/content/article/PII:S0032579124001883?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0032579124001883?httpAccept=text/plainTest -
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المؤلفون: Bi, Huijuan, Tranell, Jonas, Harper, Dawn C., Lin, Weifeng, Li, Jingyi, Hellström, Anders R., Larsson, Mårten, Rubin, Carl-Johan, Wang, Chao, Sayyab, Shumaila, Kerje, Susanne, Bed'hom, Bertrand, Gourichon, David, Ito, Shosuke, Wakamatsu, Kazumasa, Tixier-Boichard, Michele, Marks, Michael S., Globisch, Daniel, Andersson, Leif
المصدر: PLOS Genetics. 19(4)
الوصف: The biochemical pathway regulating the synthesis of yellow/red pheomelanin is less well characterized than the synthesis of black/brown eumelanin. Inhibitor of gold (IG phenotype) is a plumage colour variant in chicken that provides an opportunity to further explore this pathway since the recessive allele (IG) at this locus is associated with a defect in the production of pheomelanin. IG/IG homozygotes display a marked dilution of red pheomelanin pigmentation, whilst black pigmentation (eumelanin) is only slightly affected. Here we show that a 2-base pair insertion (frame-shift mutation) in the 5th exon of the Catechol-O-methyltransferase containing domain 1 gene (COMTD1), expected to cause a complete or partial loss-of-function of the COMTD1 enzyme, shows complete concordance with the IG phenotype within and across breeds. We show that the COMTD1 protein is localized to mitochondria in pigment cells. Knockout of Comtd1 in a mouse melanocytic cell line results in a reduction in pheomelanin metabolites and significant alterations in metabolites of glutamate/glutathione, riboflavin, and the tricarboxylic acid cycle. Furthermore, COMTD1 overexpression enhanced cellular proliferation following chemical-induced transfection, a potential inducer of oxidative stress. These observations suggest that COMTD1 plays a protective role for melanocytes against oxidative stress and that this supports their ability to produce pheomelanin.
وصف الملف: electronic
الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-501324Test
https://doi.org/10.1371/journal.pgen.1010724Test
https://uu.diva-portal.org/smash/get/diva2:1754964/FULLTEXT01.pdfTest -
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المؤلفون: Schwochow, Doreen, Bornelöv, Susanne, 1984, Jiang, Tingxing, Li, Jingyi, Gourichon, David, Bed'Hom, Bertrand, Dorshorst, Ben J., Chuong, Cheng-Ming, Tixier-Boichard, Michele, Andersson, Leif
المصدر: Pigment Cell & Melanoma Research. 34(6):1015-1028
مصطلحات موضوعية: chicken, feather patterning, genetics, MC1R, pigmentation, SOX10
الوصف: Color patterns within individual feathers are common in birds but little is known about the genetic mechanisms causing such patterns. Here, we investigate the genetic basis for autosomal barring in chicken, a horizontal striping pattern on individual feathers. Using an informative backcross, we demonstrate that the MC1R locus is strongly associated with this phenotype. A deletion at SOX10, underlying the dark brown phenotype on its own, affects the manifestation of the barring pattern. The coding variant L133Q in MC1R is the most likely causal mutation for autosomal barring in this pedigree. Furthermore, a genetic screen across six different breeds showing different patterning phenotypes revealed that the most striking shared characteristics among these breeds were that they all carried the MC1R alleles Birchen or brown. Our data suggest that the presence of activating MC1R mutations enhancing pigment synthesis is an important mechanism underlying pigmentation patterns on individual feathers in chicken. We propose that MC1R and its antagonist ASIP play a critical role for determining within-feather pigmentation patterns in birds by acting as activator and inhibitor possibly in a Turing reaction-diffusion model.
وصف الملف: electronic
الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-468865Test
https://doi.org/10.1111/pcmr.12975Test
https://uu.diva-portal.org/smash/get/diva2:1642236/FULLTEXT01.pdfTest -
5مؤتمر
المؤلفون: Cerutti, Chloé, Leroux, Sophie, Terzian, Paul, Lledo, Joanna, Gourichon, David, Hubert, Jean-Noël, Labrune, Yann, Serre, Rémy-Félix, Vandecasteele, Céline, Klopp, Christophe, C., Iampietro, Carole, Gaspin, Christine, Milan, Denis, Donnadieu, Cécile, Coustham, Vincent, Pitel, Frédérique, Devailly, Guillaume
المساهمون: Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de Mathématiques et Informatique Appliquées de Toulouse (MIAT INRAE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génome et Transcriptome - Plateforme Génomique ( GeT-PlaGe), Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité Expérimentale Avicole de Tours (UE PEAT), Nutrition, Métabolisme, Aquaculture (NuMéA), Université de Pau et des Pays de l'Adour (UPPA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biologie des Oiseaux et Aviculture (BOA), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), FEDER-FSE MIDI-PYRENEES ET GARONNE 2014-2020 (SeqOccIn “Sequençage Occitanie Innovation”), Région Occitanie, INRAE Animal Genetics Division, ETH Zurich, Switzerland
المصدر: Epigenetic Inheritance: Impact for Biology and Society ; https://hal.inrae.fr/hal-04212971Test ; Epigenetic Inheritance: Impact for Biology and Society, Aug 2023, Zurich, Switzerland
مصطلحات موضوعية: Transgenerational epigenetics, quail, DNA methylation, [SDV]Life Sciences [q-bio]
جغرافية الموضوع: Zurich, Switzerland
الوصف: International audience ; Prenatal environment influence on adult phenotype development is partially mediated by epigenetics phenomena. Our previous study highlighted significant effects of the in-ovo injection of endocrine disruptors or a DNA methyltransferase inhibitor on quail development, significantly reducing their weight [1]. An increasing number of studies highlighted the transmission of epigenetics marks between generations following environmental exposure. However, there is much debate about their acquired transmission beyond the exposed generation. Recent studies revealed that non-genetics inheritance was probably present in avian species. In one of them [2], fertilized eggs were divided into two groups: one group injected with an endocrine disruptor, Genistein, and a non-injected control group. After three generations without any other injection, several traits were impacted by the ancestor treatment such as reproduction and behavioral traits. This pilot study highlighted the potential existence of transgenerational transmission of environmental effects in quails. To better understand the transgenerational transmission of these environmental effects, DNA methylation data were generated from blood samples of the third generation (WGBS and ONT). To analyse the DNA methylation state, we developed a bioinformatics pipeline in order to detect differential methylated cytosines (DMCs) affected by these transgenerational phenomena. We detected thousands of DMCs between both groups. A preliminary genetic analysis of the data suggests that most of these differentially methylated positions are related to genetic variability between both epilines, even if a mirror crossing was set up to reduce the genetic differences between both lines. In addition to these analyses, these data allowed us to perform a comparative analysis between the WGBS and ONT sequencing technologies for DNA methylation analysis. References[1] C. Cerutti, S. Leroux, D. Gourichon, Y. Labrune, I. David, T. Zerjal, V. Coustham, G. Devailly, F. ...
العلاقة: hal-04212971; https://hal.inrae.fr/hal-04212971Test; https://hal.inrae.fr/hal-04212971/documentTest; https://hal.inrae.fr/hal-04212971/file/Cerutti2023.pdfTest
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6كتاب
المؤلفون: Arnould, Cécile, Cognie, Juliette, Sabrina, Dehay, Gourichon, David, Govoroun, Marina, Alassane, Keita, Leterrier, Christine, Jean-Philippe, Moysan, Tixier-Boichard, Michèle
المساهمون: Physiologie de la reproduction et des comportements Nouzilly (PRC), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité Expérimentale Avicole de Tours (UE PEAT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Presses universitaires François-Rabelais, Michèle de Monte, Philippe Chambrier, Juliette Cognié
المصدر: Manuel d’Expérimentation Animale. La Pratique ; https://hal.inrae.fr/hal-04278101Test ; Presses universitaires François-Rabelais. Manuel d’Expérimentation Animale. La Pratique, Tome 1, , pp.527-639, 2024, 978-2-86906-918-3 ; pufr-editions.fr
مصطلحات موضوعية: [SDV]Life Sciences [q-bio]
الوصف: National audience
العلاقة: hal-04278101; https://hal.inrae.fr/hal-04278101Test
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7مؤتمر
المؤلفون: Rousse, Stacy, Leroux, Sophie, Gourichon, David, Calandreau, Ludovic, Cerutti, Chloé, Devailly, Guillaume, Zerjal, Tatiana, Lagarrigue, Sandrine, Pitel, Frédérique, Eynard, Sonia, E
المساهمون: Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité Expérimentale Avicole de Tours (UE PEAT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Physiologie de la reproduction et des comportements Nouzilly (PRC), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage Rennes (PEGASE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)
المصدر: Environmental and Agronomical Genomics Symposium ; https://hal.inrae.fr/hal-04474289Test ; Environmental and Agronomical Genomics Symposium, Feb 2024, Toulouse, France. , pp.128, 2024, Book of abstracts ; https://eags2024.sciencesconf.org/resource/page/id/4Test
مصطلحات موضوعية: Transgenerational inheritance, Epigenetics, DNA methylation, Coturnix japonica, [SDV]Life Sciences [q-bio]
الوصف: International audience ; While the typical evaluation of an offspring’s phenotypic traits usually focuses on the inheritance of parental alleles, variations across generations can also result from the transmission of non-genetic factors. Epigenetic marks like DNA methylation offer a dynamic molecular signature of an individual’s history, as they can carry a memory of the individual’s environmental past, and also of its parents. A recent study in quail (Coturnix japonica) found that alterations in the embryonic environment can have an impact on subsequent generations, resulting in significant reduction of the offspring’s body weight. To better disentangle the complex interplay between genetic and epigenetic effects, a specific quail breeding plan was designed. Twenty initial founder families were crossed to generate two epilines with similar genetic backgrounds. In the first generation, one epiline received a genistein supplementation whereas the other was only provided with regular feed. After this initial diet disruption, the groups were maintained under standard breeding conditions, and animals from the next two generations were mated following a mirrored design to ensure a balanced genetic structure in both groups. By recording multiple phenotypes (production, breeding, behaviour), genotypes and epigenotypes of both epilines, this approach aims to investigate the transgenerational inheritance of an environmental effectthrough changes in DNA methylation profiles.
العلاقة: hal-04474289; https://hal.inrae.fr/hal-04474289Test
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8مؤتمر
المؤلفون: Cerutti, Chloé, Leroux, Sophie, Terzian, Paul, Lledo, Joanna, Gourichon, David, Serre, Rémy-Félix, Vandecasteele, Céline, Klopp, Christophe, C., Iampietro, Carole, Gaspin, Christine, Milan, Denis, Donnadieu, Cécile, Pitel, Frederique, Devailly, Guillaume
المساهمون: Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de Mathématiques et Informatique Appliquées de Toulouse (MIAT INRAE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génome et Transcriptome - Plateforme Génomique ( GeT-PlaGe), Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité Expérimentale Avicole de Tours (UE PEAT), Région Occitanie - FEDER, SeqOccIn
المصدر: ECCB2022 - 21st European Conference on Computational Biology ; https://hal.inrae.fr/hal-03935584Test ; ECCB2022 - 21st European Conference on Computational Biology, Sep 2022, Sitges, Spain
مصطلحات موضوعية: [SDV]Life Sciences [q-bio]
الوصف: International audience ; The influence of the prenatal environment on the adult phenotype development is partially mediated by epigenetics phenomena. One study highlighted significant effects of the in-ovo injection of endocrine disruptors or DNA methyltransferase inhibitor on quail development, significantly reducing their weight [1]. Recently, an increasing number of studies highlighted the transmission of epigenetics marks between generations following an environmental exposure. However, there is much debate about their acquired transmission beyond the exposed individuals. Recent studies revealed that non-genetics inheritance was probably present in avian species. In one of them [2], fertilized eggs were divided into two groups: one group injected with an endocrine disruptor, Genistein, and a non-injected control group. After three generations without any other injection, several traits were impacted by the ancestor treatment such as the reproduction and the behavior. This pilot study highlighted the potential existence of transgenerational transmission of environmental effects in quails. To better understand the transgenerational transmission of these environmental effects, DNA methylation data are available from blood samples from the third generation (WGBS and ONT). To analyse the DNA methylation state, we developed a bioinformatics pipeline in order to detect differential methylated cytosines (DMCs) affected by these transgenerational phenomena. We detected thousands of DMCs between both groups. In addition to these analyses, these data allowed us to perform a comparative analysis between the WGBS and ONT sequencing technologies.
العلاقة: hal-03935584; https://hal.inrae.fr/hal-03935584Test; https://hal.inrae.fr/hal-03935584/documentTest; https://hal.inrae.fr/hal-03935584/file/poster_ECCB_2022_CERUTTI_Chloe_final.pdfTest
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9مؤتمر
المؤلفون: Jehl, Frédéric, Degalez, Fabien, Bernard, Maria, Lecerf, Frédéric, Lagoutte, Laetitia, Desert, Colette, Coulée, Manon, Bouchez, Olivier, Leroux, Sophie, Abasht, Behnam, Tixier-Boichard, Michèle, Bed’hom, Bertrand, Burlot, Thierry, Gourichon, David, Acloque, Hervé, Foissac, Sylvain, Djebali, Sarah, Giuffra, Elisabetta, Zerjal, Tatiana, Pitel, Frédérique, Klopp, Christophe, C., Lagarrigue, Sandrine
المساهمون: Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage Rennes (PEGASE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Toulouse Réseau Imagerie-Genotoul ( TRI-Genotoul), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Animal and Food Sciences, University of Delaware Newark, NOVOGEN, Groupe Grimaud, Unité Expérimentale Avicole de Tours (UE PEAT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Système d'Information des GENomes des Animaux d'Elevage (SIGENAE)
المصدر: World Poultry Congress (WPC) 2022 ; https://institut-agro-rennes-angers.hal.science/hal-04258396Test ; World Poultry Congress (WPC) 2022, Aug 2022, Paris, France
مصطلحات موضوعية: [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics
الوصف: International audience ; Context 2 • For detecting polymorphisms in the whole genome of a population, DNA-seq data analyzed by the bioinformatics GATK tool is the standard approach. • DNA-seq data are expensive to generate and to store, because these data are large
العلاقة: hal-04258396; https://institut-agro-rennes-angers.hal.science/hal-04258396Test; https://institut-agro-rennes-angers.hal.science/hal-04258396/documentTest
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10تقرير
المؤلفون: Bédère, Nicolas, Dupont, Joëlle, Baumard, Yannick, Staub, Christophe, Gourichon, David, Frédéric, Elleboudt, Le Roy, Pascale, Zerjal, Tatiana
المساهمون: Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage Rennes (PEGASE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Physiologie de la reproduction et des comportements Nouzilly (PRC), Institut Français du Cheval et de l'Equitation Saumur (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité Expérimentale Avicole de Tours (UE PEAT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Plate-forme Phénotypage par imagerie in/ex vivo de l'Animal à la Molécule (Plate-forme PIXANIM), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), département Génétique Animale d'INRAE
المصدر: https://hal.inrae.fr/hal-04172576Test ; 2023.
مصطلحات موضوعية: body composition, body reserves, backfat thickness, ultrasonography, CT-scan, adipokines, genetic correlations, heritability, laying hens, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV.BA]Life Sciences [q-bio]/Animal biology
الوصف: pré-publication recommandée par PCI Animal Science : Rafat, S. (2023) Towards a better optimization of the genetic improvement of chicken breeds: Introduction of simple phenotypic traits related to body composition for easy measurement in the selection programs of laying hens. . Peer Community in Animal Science, 100233. 10.24072/pci.animsci.100233 ; In this study, we pursued three primary objectives: firstly to test and validate the phenotyping of backfat thickness as an indicator of the overall fatness of laying hens; secondly, to estimate genetic parameters for this trait; thirdly, to study the phenotypic and genetic relationships between this trait and other traits related to production and body composition. To address these questions, hens from two lines under divergent selection for residual feed intake, were phenotyped for body weight, body composition traits (backfat, total fat volume, and blood adipokines levels), and egg number. Linear mixed models enabled to estimate variance components and calculate genetic parameters. The two lines largely differed in body fatness: the efficient line had larger backfat and lower chemerin levels compared to the inefficient line. However, there were no significantly differences between the two lines concerning body weight, total fat volume, other blood adipokines levels (adiponectin, ghrelin, and visfatin), and egg production. The genetic parameter estimation revealed moderate heritability (0.38 and 0.42) for backfat and body weight, high heritability (higher than 0.80) for blood adipokines levels and low heritability (0.24 and 0.27) for egg production and total fat volume. The backfat and total fat volume were genetically highly and positively correlated (0.91). The body weight and total fat volume were also highly positively correlated (0.67). However, backfat and body weight were moderately positively correlated (0.39). The genetic correlation between backfat and egg number was moderate and negative. In conclusion, backfat could provide additional genetic ...
العلاقة: hal-04172576; https://hal.inrae.fr/hal-04172576Test; https://hal.inrae.fr/hal-04172576v3/documentTest; https://hal.inrae.fr/hal-04172576v3/file/Phenotyping%20backfat%20thickness_vf.pdfTest
