المؤلفون: Borghaei, Hossein, Ciuleanu, Tudor-Eliade, Lee, Jong-Seok, Pluzanski, Adam, Bernabé Caro, Reyes, Gutierrez, Martin E., Ohe, Yuichiro, Nishio, Makoto, Goldman, Jacki P., Ready, Neal, Spigel, David R., Ramalingam, Suresh S., Paz-Ares, Luis, Gainor, Justin F., Ahmed, Samreen, Reck, Martin, Maio, Michele, O'Byrne, Kenneth J., Memaj, Arteid, Nathan, Faith Ellen, Tran, Phuong, Hellmann, Matthew D., Brahmer, Julie R.

المساهمون: Bristol Myers Squibb Foundation, Ono Pharmaceutical

مصطلحات موضوعية: NSCLC, Dual immunotherapy, Nivolumab, Ipilimumab

الوصف: © 2023 The Authors. Published by Elsevier Ltd on behalf of European Society for Medical Oncology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0Test/). ; [Background] First-line nivolumab plus ipilimumab prolongs survival versus chemotherapy in advanced non-small-cell lung cancer (NSCLC). We further characterized clinical benefit with this regimen in a large pooled patient population and assessed the effect of response on survival. ; [Patients and methods] Data were pooled from four studies of first-line nivolumab plus ipilimumab in advanced NSCLC (CheckMate 227 Part 1, 817 cohort A, 568 Part 1, and 012). Overall survival (OS), progression-free survival (PFS), objective response rate, duration of response, and safety were assessed. Landmark analyses of OS by response status at 6 months and by tumor burden reduction in responders to nivolumab plus ipilimumab were also assessed. ; [Results] In the pooled population (N = 1332) with a minimum follow-up of 29.1-58.9 months, median OS was 18.6 months, with a 3-year OS rate of 35%; median PFS was 5.4 months (3-year PFS rate, 17%). Objective response rate was 36%; median duration of response was 23.7 months, with 38% of responders having an ongoing response at 3 years. In patients with tumor programmed death-ligand 1 (PD-L1) <1%, ≥1%, 1%-49%, or ≥50%, 3-year OS rates were 30%, 38%, 30%, and 48%. Three-year OS rates were 30% and 38% in patients with squamous or non-squamous histology. Efficacy outcomes in patients aged ≥75 years were similar to the overall pooled population (median OS, 20.1 months; 3-year OS rate, 34%). In the pooled population, responders to nivolumab plus ipilimumab at 6 months had longer post-landmark OS than those with stable or progressive disease; 3-year OS rates were 66%, 22%, and 14%, respectively. Greater depth of response was associated with prolonged survival; in patients with tumor burden reduction ≥80%, 50% to <80%, or 30% to <50%, 3-year OS rates were 85%, 72%, and 44%, ...

وصف الملف: application/pdf

العلاقة: Publisher's version; The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1016/j.annonc.2022.11.006Test; https://doi.org/10.1016/j.annonc.2022.11.006Test; Sí; Annals of Oncology 34(2): 173-185 (2023); http://hdl.handle.net/10261/351369Test

الإتاحة: https://doi.org/10.1016/j.annonc.2022.11.006Test
http://hdl.handle.net/10261/351369Test

المؤلفون: Bailey, Chris, Sanderson, Theo, Townsley, Hermaleigh, Goldman, Jacki, Black, James R M, Young, George, Goldstone, Robert, Fowler, Ashley S, Ward, Sophia, Jackson, Deborah J, Cubitt, Laura, Dearing, Vicky, O'Neil, Olga, Crawford, Marg, Snell, Daniel, Finadis, Makis, Edwards, Amelia, Perez-Lloret, Jimena, Gahir, Joshua, Carr, Edward J, Riddell, Andy, Aitken, Jim, Ambrose, Karen, Sawyer, Chelsea, O'Reilly, Nicola, Caidan, Simon, Wu, Mary Y, Walker, Philip A, Hindmarsh, Steve, Howell, Michael, Jordan, Andrew, Fleming, James, Houlihan, Catherine, Nastouli, Eleni, Moores, Rachel, Hsu, Desmond, Papineni, Padmasayee, Corrah, Tumena, Gilson, Richard, MacRae, James, Hubank, Michael, Van As, Nicholas, Turajlic, Samra, Beale, Rupert, Levi, Marcel, Barrell, Sam, Williams, Bryan, Gamblin, Steve, Nicod, Jerome, Gandhi, Sonia, Bauer, David L V, Wall, Emma C, Swanton, Charles

المصدر: The Lancet; July 2023, Vol. 402 Issue: 10395 p21-24, 4p

المؤلفون: Spencer, David M., Hsiang, Yun-Hui, Goldman, Jacki P., Raulet, David H.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 1991 Feb 01. 88(3), 800-804.

الوصول الحر: https://www.jstor.org/stable/2356073Test

المؤلفون: Johnson, Colin G, Goldman, Jacki P, Gullick, William J

المصدر: Progress in Biophysics and Molecular Biology ; volume 86, issue 3, page 379-406 ; ISSN 0079-6107

مصطلحات موضوعية: Molecular Biology, Biophysics

الإتاحة: https://doi.org/10.1016/j.pbiomolbio.2003.11.001Test
https://api.elsevier.com/content/article/PII:S0079610703000944?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0079610703000944?httpAccept=text/plainTest

المؤلفون: Aitken, Jim, Ambrose, Karen, Barrell, Sam, Beale, Rupert, Bineva-Todd, Ganka, Biswas, Dhruva, Byrne, Richard, Caidan, Simon, Cherepanov, Peter, Churchward, Laura, Clark, Graham, Crawford, Margaret, Cubitt, Laura, Dearing, Vicky, Earl, Christopher, Edwards, Amelia, Ekin, Chris, Fidanis, Efthymios, Gaiba, Alessandra, Gamblin, Steve, Gandhi, Sonia, Goldman, Jacki, Goldstone, Robert, Grant, Paul R., Greco, Maria, Heaney, Judith, Hindmarsh, Steve, Houlihan, Catherine F., Howell, Michael, Hubank, Michael, Hughes, Deborah, Instrell, Rachael, Jackson, Deborah, Jamal-Hanjani, Mariam, Jiang, Ming, Johnson, Mark, Jones, Leigh, Kanu, Nnennaya, Kassiotis, George, Kirk, Stuart, Kjaer, Svend, Levett, Andrew, Levett, Lisa, Levi, Marcel, Lu, Wei-Ting, MacRae, James I., Matthews, John, McCoy, Laura E., Moore, Catherine, Moore, David, Nastouli, Eleni, Nicod, Jerome, Nightingale, Luke, Olsen, Jessica, O’Reilly, Nicola, Pabari, Amar, Papayannopoulos, Venizelos, Patel, Namita, Peat, Nigel, Pollitt, Marc, Ratcliffe, Peter, Reis e Sousa, Caetano, Rosa, Annachiara, Rosenthal, Rachel, Roustan, Chloe, Rowan, Andrew, Shin, Gee Yen, Snell, Daniel M., Song, Ok-Ryul, Spyer, Moira J., Strange, Amy, Swanton, Charles, Turner, James M. A., Turner, Melanie, Wack, Andreas, Walker, Philip A., Ward, Sophia, Wong, Wai Keong, Wright, Joshua, Wu, Mary

المصدر: Nature Biotechnology; August 2020, Vol. 38 Issue: 8 p927-931, 5p

المؤلفون: Goldman, Jacki P., Gullick, William J., Bray, Dennis, Johnson, Colin G.

المساهمون: Lamont, Gary

مصطلحات موضوعية: QA 76 Software, computer programming

الوصف: This paper describes ongoing work on a project to simulate the behaviour of epidermal growth factor receptors. These are structures which can be found on the surface of cells in the body, which receive and process chemical signals concerned with cell growth. We describe the implementation of a program which simulates the stimulation and clustering behaviour of these structures, discuss how we scale up this simulation so that we can simulate a whole cell on a tractable timescale, and discuss ongoing work in which we are calibrating our simulation against results from experiments.

وصف الملف: application/pdf; application/postscript

العلاقة: https://kar.kent.ac.uk/13817/1/IndiJacki.pdfTest; https://kar.kent.ac.uk/13817/2/Indi.psTest; Goldman, Jacki P. and Gullick, William J. and Bray, Dennis and Johnson, Colin G. (2002) Individual-based simulation of the clustering behaviour of epidermal growth factor receptors. In: Lamont, Gary, ed. Proceedings of the 2002 ACM Symposium on Applied Computing. ACM, New York, USA, pp. 127-131. ISBN 1-58113-445-2. (doi:10.1145/508791.508817 ) (KAR id:13817 )

الإتاحة: https://doi.org/10.1145/508791.508817Test
https://kar.kent.ac.uk/13817Test/
https://kar.kent.ac.uk/13817/1/IndiJacki.pdfTest
https://kar.kent.ac.uk/13817/2/Indi.psTest

المؤلفون: Goldman, Jacki P., Levin, Matthew D., Bray, Dennis

المصدر: Molecular BioSystems ; volume 5, issue 12, page 1853 ; ISSN 1742-206X 1742-2051

الإتاحة: https://doi.org/10.1039/b903397aTest
http://pubs.rsc.org/en/content/articlepdf/2009/MB/B903397ATest

المؤلفون: Goldman, Jacki P., Gullick, William J., Johnson, Colin G.

مصطلحات موضوعية: QA 76 Software, computer programming

الوصف: The paper describes ongoing work on a project to simulate the behavior of epidermal growth factor receptors. These are structures which can be found on the surface of cells in the body, which receive and process chemical signals concerned with cell growth. The implementation of a program which simulates the stimulation and clustering behavior of these structures is described, then the paper discusses how the simualtion can be scaled up so that a whole cell can be simulated on a tractable timescale. Finaly some early results are given which show the effect of changing parameters in the system, and discuss ongoning work on calibrating the simulation against results from experiments.

وصف الملف: application/pdf

العلاقة: https://kar.kent.ac.uk/14212/1/Individual-based_simulation_of_the_clustering.pdfTest; Goldman, Jacki P., Gullick, William J., Johnson, Colin G. (2004) Individual-based simulation of the clustering behaviour of epidermal growth factor receptors. Scientific Programming, 12 (1). pp. 25-43. ISSN 1058-9244. (doi:10.1155/2004/323981 ) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:14212 )

الإتاحة: https://doi.org/10.1155/2004/323981Test
https://kar.kent.ac.uk/14212Test/
https://kar.kent.ac.uk/14212/1/Individual-based_simulation_of_the_clustering.pdfTest

المؤلفون: Demaison, Christophe, Brouns, Gaby, Blundell, Michael P., Goldman, Jacki P., Levinsky, Roland J., Grez, Manuel, Kinnon, Christine, Thrasher, Adrian J.

المصدر: Human Gene Therapy ; volume 11, issue 1, page 91-100 ; ISSN 1043-0342 1557-7422

مصطلحات موضوعية: Genetics, Molecular Biology, Molecular Medicine

الإتاحة: https://doi.org/10.1089/10430340050016184Test

المؤلفون: Goldman, Jacki P, Blundell, Michael P, Lopes, Lucien, Kinnon, Christine, DI Santo, James P, Thrasher, Adrian J

المصدر: British Journal of Haematology ; volume 103, issue 2, page 335-342 ; ISSN 0007-1048 1365-2141

الوصف: Xenotransplantation of human cells into immunodeficient mice has been used to develop models of human haemopoiesis and lymphoid cell function. However, the utility of existing mouse strains can be limited by shortened life‐spans, spontaneous production of functional lymphocytes with ageing, and residual innate immunity leading to variable levels of engraftment. Mice with a deletion of the common cytokine receptor γ chain (γc) gene have reduced numbers of peripheral T and B lymphocytes, and absent natural killer cell (NK) activity. A genetic cross with a recombinase activating gene 2 (RAG2)‐deficient strain produced mice doubly homozygous for the γc and RAG2 null alleles (γc − /RAG2 − ). These mice have a stable phenotype characterized by the absence of all T lymphocyte, B lymphocyte and NK cell function. Injection of human B‐lymphoblastoid cells resulted in earlier fatal metastatic lymphoproliferative disease than in NOD/LtSz‐ scid controls. This was particularly evident in animals injected intravenously, possibly because of residual NK activity in NOD/LtSz‐ scid mice. Levels of engraftment with peripheral‐blood‐derived human lymphocytes were also increased and associated with higher CD4/CD8 ratios. These findings demonstrate that this new strain of immunodeficient mice has significant advantages over existing strains for engraftment of human cells, and may be useful for study of adoptive immunotherapy and novel therapies for GvHD and HIV infection.

الإتاحة: https://doi.org/10.1046/j.1365-2141.1998.00980.xTest