المؤلفون: Gauthier, N. B., Goes, F. S., Quaresma, L., Pedrosa, V. F., Roselet, F., Romano, L. A., Cavalli, R. O.

المصدر: Brazilian Journal of Biology. January 2022 82

مصطلحات موضوعية: aquaculture, bivalve, broodstock management, yellow clam

الوصف: The yellow clam is a sand-burrowing bivalve that inhabits the dissipative beaches from southern Brazil to the north coast of Argentina. In the last decades, populations of this species have been impacted by mass mortality events, overfishing and other anthropogenic activities. The production of juveniles in captivity would allow feasibility studies to be carried out to restore the natural stock as well as the production in aquaculture systems. Given the scarcity of studies on the maintenance of this species in captivity, a culture system and a management protocol were developed and tested. Wild-caught clams (total length ≥50 mm) were used in a series of 14 day-long trials. Survival was higher in clams that were allowed to bury into the sand. A permanent ink marker covered with a thin layer of a quick-hardening adhesive proved to be a reliable method to tag clams. The maintenance of yellow clams in this system resulted in high survival and growth, increases in the condition factor and oocyte diameter, and a relative advancement of gonadal development.

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842022000100215Test

المؤلفون: Herrera-Rivero M., Adli M., Akiyama K., Akula N., Amare A. T., Ardau R., Arias B., Aubry J. -M., Backlund L., Bellivier F., Benabarre A., Bengesser S., Bhattacharjee A. K., Biernacka J. M., Birner A., Cearns M., Cervantes P., Chen H. -C., Chillotti C., Cichon S., Clark S. R., Colom F., Cruceanu C., Czerski P. M., Dalkner N., Degenhardt F., Del Zompo M., DePaulo J. R., Etain B., Falkai P., Ferensztajn-Rochowiak E., Forstner A. J., Frank J., Frisen L., Frye M. A., Fullerton J. M., Gallo C., Gard S., Garnham J. S., Goes F. S., Grigoroiu-Serbanescu M., Grof P., Hashimoto R., Hasler R., Hauser J., Heilbronner U., Herms S., Hoffmann P., Hou L., Hsu Y. -H., Jamain S., Jimenez E., Kahn J. -P., Kassem L., Kato T., Kelsoe J., Kittel-Schneider S., Kuo P. -H., Kusumi I., Konig B., Laje G., Landen M., Lavebratt C., Leboyer M., Leckband S. G., Maj M., Manchia M., Marie-Claire C., Martinsson L., McCarthy M. J., McElroy S. L., Millischer V., Mitjans M., Mondimore F. M., Monteleone P., Nievergelt C. M., Novak T., Nothen M. M., O'Donovan C., Ozaki N., Papiol S., Pfennig A., Pisanu C., Potash J. B., Reif A., Reininghaus E., Richard-Lepouriel H., Roberts G., Rouleau G. A., Rybakowski J. K., Schalling M., Schofield P. R., Schubert K. O., Schulte E. C., Schweizer B. W., Severino G., Shekhtman T., Shilling P. D., Shimoda K., Simhandl C., Slaney C. M., Squassina A., Stamm T., Stopkova P., Streit F., Tekola-Ayele F., Thalamuthu A., Tortorella A., Turecki G., Veeh J., Vieta E., Viswanath B., Witt S. H., Zandi P. P., Alda M., Bauer M., McMahon F. J., Mitchell P. B., Rietschel M., Schulze T. G., Baune B. T.

المساهمون: Herrera-Rivero, M., Adli, M., Akiyama, K., Akula, N., Amare, A. T., Ardau, R., Arias, B., Aubry, J. -M., Backlund, L., Bellivier, F., Benabarre, A., Bengesser, S., Bhattacharjee, A. K., Biernacka, J. M., Birner, A., Cearns, M., Cervantes, P., Chen, H. -C., Chillotti, C., Cichon, S., Clark, S. R., Colom, F., Cruceanu, C., Czerski, P. M., Dalkner, N., Degenhardt, F., Del Zompo, M., Depaulo, J. R., Etain, B., Falkai, P., Ferensztajn-Rochowiak, E., Forstner, A. J., Frank, J., Frisen, L., Frye, M. A., Fullerton, J. M., Gallo, C., Gard, S., Garnham, J. S., Goes, F. S., Grigoroiu-Serbanescu, M., Grof, P., Hashimoto, R., Hasler, R., Hauser, J., Heilbronner, U., Herms, S., Hoffmann, P., Hou, L., Hsu, Y. -H., Jamain, S., Jimenez, E., Kahn, J. -P., Kassem, L., Kato, T., Kelsoe, J., Kittel-Schneider, S., Kuo, P. -H., Kusumi, I., Konig, B., Laje, G., Landen, M., Lavebratt, C., Leboyer, M., Leckband, S. G., Maj, M., Manchia, M., Marie-Claire, C., Martinsson, L., Mccarthy, M. J., Mcelroy, S. L., Millischer, V., Mitjans, M., Mondimore, F. M., Monteleone, P., Nievergelt, C. M., Novak, T., Nothen, M. M., O'Donovan, C., Ozaki, N., Papiol, S., Pfennig, A., Pisanu, C., Potash, J. B., Reif, A., Reininghaus, E., Richard-Lepouriel, H., Roberts, G., Rouleau, G. A., Rybakowski, J. K., Schalling, M., Schofield, P. R., Schubert, K. O., Schulte, E. C., Schweizer, B. W., Severino, G., Shekhtman, T., Shilling, P. D., Shimoda, K., Simhandl, C.

مصطلحات موضوعية: Bipolar disorder, Comorbidity, Genetic, Lithium treatment, Psychiatric symptoms

الوصف: Background: Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have beneficial effects on disease-associated conditions, including sleep and cardiovascular disorders. However, the individual responses to Li treatment vary within and between diagnostic subtypes of BP (e.g. BP-I and BP-II) according to the clinical presentation. Moreover, long-term Li treatment has been linked to adverse side-effects that are a cause of concern and non-adherence, including the risk of developing chronic medical conditions such as thyroid and renal disease. In recent years, studies by the Consortium on Lithium Genetics (ConLiGen) have uncovered a number of genetic factors that contribute to the variability in Li treatment response in patients with BP. Here, we leveraged the ConLiGen cohort (N = 2064) to investigate the genetic basis of Li effects in BP. For this, we studied how Li response and linked genes associate with the psychiatric symptoms and polygenic load for medical comorbidities, placing particular emphasis on identifying differences between BP-I and BP-II. Results: We found that clinical response to Li treatment, measured with the Alda scale, was associated with a diminished burden of mania, depression, substance and alcohol abuse, psychosis and suicidal ideation in patients with BP-I and, in patients with BP-II, of depression only. Our genetic analyses showed that a stronger clinical response to Li was modestly related to lower polygenic load for diabetes and hypertension in BP-I but not BP-II. Moreover, our results suggested that a number of genes that have been previously linked to Li response variability in BP differentially relate to the psychiatric symptomatology, particularly to the numbers of manic and depressive episodes, and to the polygenic load for comorbid conditions, including diabetes, hypertension and hypothyroidism. Conclusions: Taken ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38865039; volume:12; firstpage:20; lastpage:31; numberofpages:12; journal:INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS; https://hdl.handle.net/11386/4870732Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85195907759

الإتاحة: https://doi.org/10.1186/s40345-024-00341-yTest
https://hdl.handle.net/11386/4870732Test

المؤلفون: Herrera-Rivero M., Gutierrez-Fragoso K., Kurtz J., Baune B. T., Thalamuthu A., Amare A. T., Adli M., Akiyama K., Akula N., Ardau R., Arias B., Aubry J. -M., Backlund L., Bellivier F., Benabarre A., Bengesser S., Bhattacharjee A. K., Biernacka J. M., Birner A., Cearns M., Cervantes P., Chen H. -C., Chillotti C., Cichon S., Clark S. R., Colom F., Cruceanu C., Czerski P. M., Dalkner N., Degenhardt F., Del Zompo M., DePaulo J. R., Etain B., Falkai P., Ferensztajn-Rochowiak E., Forstner A. J., Frank J., Frisen L., Frye M. A., Fullerton J. M., Gallo C., Gard S., Garnham J. S., Goes F. S., Grigoroiu-Serbanescu M., Grof P., Hashimoto R., Hasler R., Hauser J., Heilbronner U., Herms S., Hoffmann P., Hou L., Hsu Y. -H., Jamain S., Jimenez E., Kahn J. -P., Kassem L., Kato T., Kelsoe J., Kittel-Schneider S., Kuo P. -H., Kusumi I., Konig B., Laje G., Landen M., Lavebratt C., Leboyer M., Leckband S. G., Maj M., Manchia M., Marie-Claire C., Martinsson L., McCarthy M. J., McElroy S. L., Millischer V., Mitjans M., Mondimore F. M., Monteleone P., Nievergelt C. M., Novak T., Nothen M. M., O'Donovan C., Ozaki N., Papiol S., Pfennig A., Pisanu C., Potash J. B., Reif A., Reininghaus E., Richard-Lepouriel H., Roberts G., Rouleau G. A., Rybakowski J. K., Schalling M., Schofield P. R., Schubert K. O., Schulte E. C., Schweizer B. W., Severino G., Shekhtman T., Shilling P. D., Shimoda K., Simhandl C., Slaney C. M., Squassina A., Stamm T., Stopkova P., Streit F., Tekola-Ayele F., Tortorella A., Turecki G., Veeh J., Vieta E., Viswanath B., Witt S. H., Zandi P. P., Alda M., Bauer M., McMahon F. J., Mitchell P. B., Rietschel M., Schulze T. G.

المساهمون: Herrera-Rivero, M., Gutierrez-Fragoso, K., Kurtz, J., Baune, B. T., Thalamuthu, A., Amare, A. T., Adli, M., Akiyama, K., Akula, N., Ardau, R., Arias, B., Aubry, J. -M., Backlund, L., Bellivier, F., Benabarre, A., Bengesser, S., Bhattacharjee, A. K., Biernacka, J. M., Birner, A., Cearns, M., Cervantes, P., Chen, H. -C., Chillotti, C., Cichon, S., Clark, S. R., Colom, F., Cruceanu, C., Czerski, P. M., Dalkner, N., Degenhardt, F., Del Zompo, M., Depaulo, J. R., Etain, B., Falkai, P., Ferensztajn-Rochowiak, E., Forstner, A. J., Frank, J., Frisen, L., Frye, M. A., Fullerton, J. M., Gallo, C., Gard, S., Garnham, J. S., Goes, F. S., Grigoroiu-Serbanescu, M., Grof, P., Hashimoto, R., Hasler, R., Hauser, J., Heilbronner, U., Herms, S., Hoffmann, P., Hou, L., Hsu, Y. -H., Jamain, S., Jimenez, E., Kahn, J. -P., Kassem, L., Kato, T., Kelsoe, J., Kittel-Schneider, S., Kuo, P. -H., Kusumi, I., Konig, B., Laje, G., Landen, M., Lavebratt, C., Leboyer, M., Leckband, S. G., Maj, M., Manchia, M., Marie-Claire, C., Martinsson, L., Mccarthy, M. J., Mcelroy, S. L., Millischer, V., Mitjans, M., Mondimore, F. M., Monteleone, P., Nievergelt, C. M., Novak, T., Nothen, M. M., O'Donovan, C., Ozaki, N., Papiol, S., Pfennig, A., Pisanu, C., Potash, J. B., Reif, A., Reininghaus, E., Richard-Lepouriel, H., Roberts, G., Rouleau, G. A., Rybakowski, J. K., Schalling, M., Schofield, P. R., Schubert, K. O., Schulte, E. C., Schweizer, B. W., Severino, G.

الوصف: The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we performed an exploratory study of the contributions of immune-relevant genetic factors to the response to lithium (Li) treatment and the clinical presentation of BP. First, we assessed the association of a large collection of immune-related genes (4925) with Li response, defined by the Retrospective Assessment of the Lithium Response Phenotype Scale (Alda scale), and clinical characteristics in patients with BP from the International Consortium on Lithium Genetics (ConLi(+)Gen, N = 2374). Second, we calculated here previously published polygenic scores (PGSs) for immune-related traits and evaluated their associations with Li response and clinical features. Overall, we observed relatively weak associations (p < 1 x 10(-4)) with BP phenotypes within immune-related genes. Network and functional enrichment analyses of the top findings from the association analyses of Li response variables showed an overrepresentation of pathways participating in cell adhesion and intercellular communication. These appeared to converge on the well-known Li-induced inhibition of GSK-3 beta. Association analyses of age-at-onset, number of mood episodes, and presence of psychosis, substance abuse and/or suicidal ideation suggested modest contributions of genes such as RTN4, XKR4, NRXN1, NRG1/3 and GRK5 to disease characteristics. PGS analyses returned weak associations (p < 0.05) between inflammation markers and the studied BP phenotypes. Our results suggest a modest relationship between immunity and clinical features in BP. More research is needed to assess the potential therapeutic relevance.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38570518; info:eu-repo/semantics/altIdentifier/wos/WOS:001197258100001; volume:14; issue:1; firstpage:174; lastpage:184; numberofpages:11; journal:TRANSLATIONAL PSYCHIATRY; https://hdl.handle.net/11386/4864052Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85189466658

الإتاحة: https://doi.org/10.1038/s41398-024-02865-4Test
https://hdl.handle.net/11386/4864052Test

المؤلفون: Ou A. H., Rosenthal S. B., Adli M., Akiyama K., Akula N., Alda M., Amare A. T., Ardau R., Arias B., Aubry J. -M., Backlund L., Bauer M., Baune B. T., Bellivier F., Benabarre A., Bengesser S., Bhattacharjee A. K., Biernacka J. M., Cervantes P., Chen G. -B., Chen H. -C., Chillotti C., Cichon S., Clark S. R., Colom F., Cousins D. A., Cruceanu C., Czerski P. M., Dantas C. R., Dayer A., Del Zompo M., Degenhardt F., DePaulo J. R., Etain B., Falkai P., Fellendorf F. T., Ferensztajn-Rochowiak E., Forstner A. J., Frisen L., Frye M. A., Fullerton J. M., Gard S., Garnham J. S., Goes F. S., Grigoroiu-Serbanescu M., Grof P., Gruber O., Hashimoto R., Hauser J., Heilbronner U., Herms S., Hoffmann P., Hofmann A., Hou L., Jamain S., Jimenez E., Kahn J. -P., Kassem L., Kato T., Kittel-Schneider S., Konig B., Kuo P. -H., Kusumi I., Lackner N., Laje G., Landen M., Lavebratt C., Leboyer M., Leckband S. G., Jaramillo C. A. L., MacQueen G., Maj M., Manchia M., Marie-Claire C., Martinsson L., Mattheisen M., McCarthy M. J., McElroy S. L., McMahon F. J., Mitchell P. B., Mitjans M., Mondimore F. M., Monteleone P., Nievergelt C. M., Nothen M. M., Novak T., Osby U., Ozaki N., Papiol S., Perlis R. H., Pisanu C., Potash J. B., Pfennig A., Reich-Erkelenz D., Reif A., Reininghaus E. Z., Rietschel M., Rouleau G. A., Rybakowski J. K., Schalling M., Schofield P. R., Schubert K. O., Schulze T. G., Schweizer B. W., Seemuller F., Severino G., Shekhtman T., Shilling P. D., Shimoda K., Simhandl C., Slaney C. M., Squassina A., Stamm T., Stopkova P., Tighe S. K., Tortorella A., Turecki G., Vieta E., Volkert J., Witt S., Wray N. R., Wright A., Young L. T., Zandi P. P., Kelsoe J. R.

المساهمون: Ou, A. H., Rosenthal, S. B., Adli, M., Akiyama, K., Akula, N., Alda, M., Amare, A. T., Ardau, R., Arias, B., Aubry, J. -M., Backlund, L., Bauer, M., Baune, B. T., Bellivier, F., Benabarre, A., Bengesser, S., Bhattacharjee, A. K., Biernacka, J. M., Cervantes, P., Chen, G. -B., Chen, H. -C., Chillotti, C., Cichon, S., Clark, S. R., Colom, F., Cousins, D. A., Cruceanu, C., Czerski, P. M., Dantas, C. R., Dayer, A., Del Zompo, M., Degenhardt, F., Depaulo, J. R., Etain, B., Falkai, P., Fellendorf, F. T., Ferensztajn-Rochowiak, E., Forstner, A. J., Frisen, L., Frye, M. A., Fullerton, J. M., Gard, S., Garnham, J. S., Goes, F. S., Grigoroiu-Serbanescu, M., Grof, P., Gruber, O., Hashimoto, R., Hauser, J., Heilbronner, U., Herms, S., Hoffmann, P., Hofmann, A., Hou, L., Jamain, S., Jimenez, E., Kahn, J. -P., Kassem, L., Kato, T., Kittel-Schneider, S., Konig, B., Kuo, P. -H., Kusumi, I., Lackner, N., Laje, G., Landen, M., Lavebratt, C., Leboyer, M., Leckband, S. G., Jaramillo, C. A. L., Macqueen, G., Maj, M., Manchia, M., Marie-Claire, C., Martinsson, L., Mattheisen, M., Mccarthy, M. J., Mcelroy, S. L., Mcmahon, F. J., Mitchell, P. B., Mitjans, M., Mondimore, F. M., Monteleone, P., Nievergelt, C. M., Nothen, M. M., Novak, T., Osby, U., Ozaki, N., Papiol, S., Perlis, R. H., Pisanu, C., Potash, J. B., Pfennig, A., Reich-Erkelenz, D., Reif, A., Reininghaus, E. Z., Rietschel, M., Rouleau, G. A., Rybakowski, J. K., Schalling, M.

الوصف: Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38395906; info:eu-repo/semantics/altIdentifier/wos/WOS:001184990300003; volume:14; issue:1; firstpage:109; lastpage:118; numberofpages:10; journal:TRANSLATIONAL PSYCHIATRY; https://hdl.handle.net/11386/4864053Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85185915765

الإتاحة: https://doi.org/10.1038/s41398-024-02811-4Test
https://hdl.handle.net/11386/4864053Test

المؤلفون: Cearns M., Amare A. T., Schubert K. O., Thalamuthu A., Frank J., Streit F., Adli M., Akula N., Akiyama K., Ardau R., Arias B., Aubry J. M., Backlund L., Bhattacharjee A. K., Bellivier F., Benabarre A., Bengesser S., Biernacka J. M., Birner A., Brichant-Petitjean C., Cervantes P., Chen H. C., Chillotti C., Cichon S., Cruceanu C., Czerski P. M., Dalkner N., Dayer A., Degenhardt F., Zompo M. D., Depaulo J. R., Étain B., Falkai P., Forstner A. J., Frisen L., Frye M. A., Fullerton J. M., Gard S., Garnham J. S., Goes F. S., Grigoroiu-Serbanescu M., Grof P., Hashimoto R., Hauser J., Heilbronner U., Herms S., Hoffmann P., Hofmann A., Hou L., Hsu Y. H., Jamain S., Jiménez E., Kahn J. P., Kassem L., Kuo P. H., Kato T., Kelsoe J., Kittel-Schneider S., Kliwicki S., König B., Kusumi I., Laje G., Landén M., Lavebratt C., Leboyer M., Leckband S. G., Maj M., Manchia M., Martinsson L., McCarthy M. J., McElroy S., Colom F., Mitjans M., Mondimore F. M., Monteleone P., Nievergelt C. M., Nöthen M. M., Novák T., O'Donovan C., Ozaki N., Millischer V., Papiol S., Pfennig A., Pisanu C., Potash J. B., Reif A., Reininghaus E., Rouleau G. A., Rybakowski J. K., Schalling M., Schofield P. R., Schweizer B. W., Severino G., Shekhtman T., Shilling P. D., Shimoda K., Simhandl C., Slaney C. M., Squassina A., Stamm T.

المساهمون: Cearns, M., Amare, A. T., Schubert, K. O., Thalamuthu, A., Frank, J., Streit, F., Adli, M., Akula, N., Akiyama, K., Ardau, R., Arias, B., Aubry, J. M., Backlund, L., Bhattacharjee, A. K., Bellivier, F., Benabarre, A., Bengesser, S., Biernacka, J. M., Birner, A., Brichant-Petitjean, C., Cervantes, P., Chen, H. C., Chillotti, C., Cichon, S., Cruceanu, C., Czerski, P. M., Dalkner, N., Dayer, A., Degenhardt, F., Zompo, M. D., Depaulo, J. R., Étain, B., Falkai, P., Forstner, A. J., Frisen, L., Frye, M. A., Fullerton, J. M., Gard, S., Garnham, J. S., Goes, F. S., Grigoroiu-Serbanescu, M., Grof, P., Hashimoto, R., Hauser, J., Heilbronner, U., Herms, S., Hoffmann, P., Hofmann, A., Hou, L., Hsu, Y. H., Jamain, S., Jiménez, E., Kahn, J. P., Kassem, L., Kuo, P. H., Kato, T., Kelsoe, J., Kittel-Schneider, S., Kliwicki, S., König, B., Kusumi, I., Laje, G., Landén, M., Lavebratt, C., Leboyer, M., Leckband, S. G., Maj, M., Manchia, M., Martinsson, L., Mccarthy, M. J., Mcelroy, S., Colom, F., Mitjans, M., Mondimore, F. M., Monteleone, P., Nievergelt, C. M., Nöthen, M. M., Novák, T., O'Donovan, C., Ozaki, N., Millischer, V., Papiol, S., Pfennig, A., Pisanu, C., Potash, J. B., Reif, A., Reininghaus, E., Rouleau, G. A., Rybakowski, J. K., Schalling, M., Schofield, P. R., Schweizer, B. W., Severino, G., Shekhtman, T., Shilling, P. D., Shimoda, K., Simhandl, C., Slaney, C. M., Squassina, A., Stamm, T.

مصطلحات موضوعية: Esketamine, antidepressant, corrigendum, depression, ketamine, suicide

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35505515; info:eu-repo/semantics/altIdentifier/wos/WOS:000792194800001; volume:221; issue:2; firstpage:494; lastpage:494; numberofpages:1; journal:BRITISH JOURNAL OF PSYCHIATRY; https://hdl.handle.net/11584/368765Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85131305556

الإتاحة: https://doi.org/10.1192/bjp.2022.55Test
https://hdl.handle.net/11584/368765Test

المؤلفون: Schubert K. O., Thalamuthu A., Amare A. T., Frank J., Streit F., Adl M., Akula N., Akiyama K., Ardau R., Arias B., Aubry J. -M., Backlund L., Bhattacharjee A. K., Bellivier F., Benabarre A., Bengesser S., Biernacka J. M., Birner A., Marie-Claire C., Cearns M., Cervantes P., Chen H. -C., Chillotti C., Cichon S., Clark S. R., Cruceanu C., Czerski P. M., Dalkner N., Dayer A., Degenhardt F., Del Zompo M., DePaulo J. R., Etain B., Falkai P., Forstner A. J., Frisen L., Frye M. A., Fullerton J. M., Gard S., Garnham J. S., Goes F. S., Grigoroiu-Serbanescu M., Grof P., Hashimoto R., Hauser J., Heilbronner U., Herms S., Hoffmann P., Hou L., Hsu Y. -H., Jamain S., Jimenez E., Kahn J. -P., Kassem L., Kuo P. -H., Kato T., Kelsoe J., Kittel-Schneider S., Ferensztajn-Rochowiak E., Konig B., Kusumi I., Laje G., Landen M., Lavebratt C., Leboyer M., Leckband S. G., Maj M., Manchia M., Martinsson L., McCarthy M. J., McElroy S., Colom F., Mitjans M., Mondimore F. M., Monteleone P., Nievergelt C. M., Nothen M. M., Novak T., O'Donovan C., Ozaki N., Osby U., Papiol S., Pfennig A., Pisanu C., Potash J. B., Reif A., Reininghaus E., Rouleau G. A., Rybakowski J. K., Schalling M., Schofield P. R., Schweizer B. W., Severino G., Shekhtman T., Shilling P. D., Shimoda K., Simhandl C., Slaney C. M., Squassina A., Stamm T., Stopkova P., Tekola-Ayele F., Tortorella A., Turecki G., Veeh J., Vieta E., Witt S. H., Roberts G., Zandi P. P., Alda M., Bauer M., McMahon F. J., Mitchell P. B., Schulze T. G., Rietschel M., Baune B. T.

المساهمون: Schubert, K. O., Thalamuthu, A., Amare, A. T., Frank, J., Streit, F., Adl, M., Akula, N., Akiyama, K., Ardau, R., Arias, B., Aubry, J. -M., Backlund, L., Bhattacharjee, A. K., Bellivier, F., Benabarre, A., Bengesser, S., Biernacka, J. M., Birner, A., Marie-Claire, C., Cearns, M., Cervantes, P., Chen, H. -C., Chillotti, C., Cichon, S., Clark, S. R., Cruceanu, C., Czerski, P. M., Dalkner, N., Dayer, A., Degenhardt, F., Del Zompo, M., Depaulo, J. R., Etain, B., Falkai, P., Forstner, A. J., Frisen, L., Frye, M. A., Fullerton, J. M., Gard, S., Garnham, J. S., Goes, F. S., Grigoroiu-Serbanescu, M., Grof, P., Hashimoto, R., Hauser, J., Heilbronner, U., Herms, S., Hoffmann, P., Hou, L., Hsu, Y. -H., Jamain, S., Jimenez, E., Kahn, J. -P., Kassem, L., Kuo, P. -H., Kato, T., Kelsoe, J., Kittel-Schneider, S., Ferensztajn-Rochowiak, E., Konig, B., Kusumi, I., Laje, G., Landen, M., Lavebratt, C., Leboyer, M., Leckband, S. G., Maj, M., Manchia, M., Martinsson, L., Mccarthy, M. J., Mcelroy, S., Colom, F., Mitjans, M., Mondimore, F. M., Monteleone, P., Nievergelt, C. M., Nothen, M. M., Novak, T., O'Donovan, C., Ozaki, N., Osby, U., Papiol, S., Pfennig, A., Pisanu, C., Potash, J. B., Reif, A., Reininghaus, E., Rouleau, G. A., Rybakowski, J. K., Schalling, M., Schofield, P. R., Schweizer, B. W., Severino, G., Shekhtman, T., Shilling, P. D., Shimoda, K., Simhandl, C., Slaney, C. M., Squassina, A., Stamm, T.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35817769; info:eu-repo/semantics/altIdentifier/wos/WOS:000824887300001; volume:12; issue:1; numberofpages:1; journal:TRANSLATIONAL PSYCHIATRY; https://hdl.handle.net/11584/368843Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85133808312

الإتاحة: https://doi.org/10.1038/s41398-022-02037-2Test
https://hdl.handle.net/11584/368843Test

المؤلفون: Cearns M., Amare A. T., Schubert K. O., Thalamuthu A., Frank J., Streit F., Adli M., Akula N., Akiyama K., Ardau R., Arias B., Aubry J. -M., Backlund L., Bhattacharjee A. K., Bellivier F., Benabarre A., Bengesser S., Biernacka J. M., Birner A., Brichant-Petitjean C., Cervantes P., Chen H. -C., Chillotti C., Cichon S., Cruceanu C., Czerski P. M., Dalkner N., Dayer A., Degenhardt F., Zompo M. D., Depaulo J. R., Etain B., Falkai P., Forstner A. J., Frisen L., Frye M. A., Fullerton J. M., Gard S., Garnham J. S., Goes F. S., Grigoroiu-Serbanescu M., Grof P., Hashimoto R., Hauser J., Heilbronner U., Herms S., Hoffmann P., Hofmann A., Hou L., Hsu Y. -H., Jamain S., Jimenez E., Kahn J. -P., Kassem L., Kuo P. -H., Kato T., Kelsoe J., Kittel-Schneider S., Kliwicki S., Konig B., Kusumi I., Laje G., Landen M., Lavebratt C., Leboyer M., Leckband S. G., Maj M., Manchia M., Martinsson L., McCarthy M. J., McElroy S., Colom F., Mitjans M., Mondimore F. M., Monteleone P., Nievergelt C. M., Nothen M. M., Novak T., O'Donovan C., Ozaki N., Millischer V., Papiol S., Pfennig A., Pisanu C., Potash J. B., Reif A., Reininghaus E., Rouleau G. A., Rybakowski J. K., Schalling M., Schofield P. R., Schweizer B. W., Severino G., Shekhtman T., Shilling P. D., Shimoda K., Simhandl C., Slaney C. M., Squassina A., Stamm T., Stopkova P., Tekola-Ayele F., Tortorella A., Turecki G., Veeh J., Vieta E., Witt S. H., Roberts G., Zandi P. P., Alda M., Bauer M., McMahon F. J., Mitchell P. B., Schulze T. G., Rietschel M., Clark S. R., Baune B. T.

المساهمون: Cearns, M., Amare, A. T., Schubert, K. O., Thalamuthu, A., Frank, J., Streit, F., Adli, M., Akula, N., Akiyama, K., Ardau, R., Arias, B., Aubry, J. -M., Backlund, L., Bhattacharjee, A. K., Bellivier, F., Benabarre, A., Bengesser, S., Biernacka, J. M., Birner, A., Brichant-Petitjean, C., Cervantes, P., Chen, H. -C., Chillotti, C., Cichon, S., Cruceanu, C., Czerski, P. M., Dalkner, N., Dayer, A., Degenhardt, F., Zompo, M. D., Depaulo, J. R., Etain, B., Falkai, P., Forstner, A. J., Frisen, L., Frye, M. A., Fullerton, J. M., Gard, S., Garnham, J. S., Goes, F. S., Grigoroiu-Serbanescu, M., Grof, P., Hashimoto, R., Hauser, J., Heilbronner, U., Herms, S., Hoffmann, P., Hofmann, A., Hou, L., Hsu, Y. -H., Jamain, S., Jimenez, E., Kahn, J. -P., Kassem, L., Kuo, P. -H., Kato, T., Kelsoe, J., Kittel-Schneider, S., Kliwicki, S., Konig, B., Kusumi, I., Laje, G., Landen, M., Lavebratt, C., Leboyer, M., Leckband, S. G., Maj, M., Manchia, M., Martinsson, L., Mccarthy, M. J., Mcelroy, S., Colom, F., Mitjans, M., Mondimore, F. M., Monteleone, P., Nievergelt, C. M., Nothen, M. M., Novak, T., O'Donovan, C., Ozaki, N., Millischer, V., Papiol, S., Pfennig, A., Pisanu, C., Potash, J. B., Reif, A., Reininghaus, E., Rouleau, G. A., Rybakowski, J. K., Schalling, M., Schofield, P. R., Schweizer, B. W., Severino, G., Shekhtman, T., Shilling, P. D., Shimoda, K., Simhandl, C., Slaney, C. M., Squassina, A., Stamm, T.

مصطلحات موضوعية: bipolar affective disorder, depressive disorder, genetic, Mood stabiliser, outcome studies

الوصف: Background Response to lithium in patients with bipolar disorder is associated with clinical and transdiagnostic genetic factors. The predictive combination of these variables might help clinicians better predict which patients will respond to lithium treatment. Aims To use a combination of transdiagnostic genetic and clinical factors to predict lithium response in patients with bipolar disorder. Method This study utilised genetic and clinical data (n = 1034) collected as part of the International Consortium on Lithium Genetics (ConLi+Gen) project. Polygenic risk scores (PRS) were computed for schizophrenia and major depressive disorder, and then combined with clinical variables using a cross-validated machine-learning regression approach. Unimodal, multimodal and genetically stratified models were trained and validated using ridge, elastic net and random forest regression on 692 patients with bipolar disorder from ten study sites using leave-site-out cross-validation. All models were then tested on an independent test set of 342 patients. The best performing models were then tested in a classification framework. Results The best performing linear model explained 5.1% (P = 0.0001) of variance in lithium response and was composed of clinical variables, PRS variables and interaction terms between them. The best performing non-linear model used only clinical variables and explained 8.1% (P = 0.0001) of variance in lithium response. A priori genomic stratification improved non-linear model performance to 13.7% (P = 0.0001) and improved the binary classification of lithium response. This model stratified patients based on their meta-polygenic loadings for major depressive disorder and schizophrenia and was then trained using clinical data. Conclusions Using PRS to first stratify patients genetically and then train machine-learning models with clinical predictors led to large improvements in lithium response prediction. When used with other PRS and biological markers in the future this approach may help inform which ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35225756; info:eu-repo/semantics/altIdentifier/wos/WOS:000762249500001; volume:220; issue:4; firstpage:219; lastpage:228; numberofpages:10; journal:BRITISH JOURNAL OF PSYCHIATRY; https://hdl.handle.net/11584/368844Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85126276148

الإتاحة: https://doi.org/10.1192/bjp.2022.28Test
https://hdl.handle.net/11584/368844Test

المؤلفون: Mullins N., Kang J., Campos A. I., Coleman J. R. I., Edwards A. C., Galfalvy H., Levey D. F., Lori A., Shabalin A., Starnawska A., Su M. -H., Watson H. J., Adams M., Awasthi S., Gandal M., Hafferty J. D., Hishimoto A., Kim M., Okazaki S., Otsuka I., Ripke S., Ware E. B., Bergen A. W., Berrettini W. H., Bohus M., Brandt H., Chang X., Chen W. J., Chen H. -C., Crawford S., Crow S., DiBlasi E., Duriez P., Fernandez-Aranda F., Fichter M. M., Gallinger S., Glatt S. J., Gorwood P., Guo Y., Hakonarson H., Halmi K. A., Hwu H. -G., Jain S., Jamain S., Jimenez-Murcia S., Johnson C., Kaplan A. S., Kaye W. H., Keel P. K., Kennedy J. L., Klump K. L., Li D., Liao S. -C., Lieb K., Lilenfeld L., Liu C. -M., Magistretti P. J., Marshall C. R., Mitchell J. E., Monson E. T., Myers R. M., Pinto D., Powers A., Ramoz N., Roepke S., Rozanov V., Scherer S. W., Schmahl C., Sokolowski M., Strober M., Thornton L. M., Treasure J., Tsuang M. T., Witt S. H., Woodside D. B., Yilmaz Z., Zillich L., Adolfsson R., Agartz I., Air T. M., Alda M., Alfredsson L., Andreassen O. A., Anjorin A., Appadurai V., Soler Artigas M., Van der Auwera S., Azevedo M. H., Bass N., Bau C. H. D., Baune B. T., Bellivier F., Berger K., Biernacka J. M., Bigdeli T. B., Binder E. B., Boehnke M., Boks M. P., Bosch R., Braff D. L., Bryant R., Budde M., Byrne E. M., Cahn W., Casas M., Castelao E., Cervilla J. A., Chaumette B., Cichon S., Corvin A., Craddock N., Craig D., Degenhardt F., Djurovic S., Edenberg H. J., Fanous A. H., Foo J. C., Forstner A. J., Frye M., Fullerton J. M., Gatt J. M., Gejman P. V., Giegling I., Grabe H. J., Green M. J., Grevet E. H., Grigoroiu-Serbanescu M., Gutierrez B., Guzman-Parra J., Hamilton S. P., Hamshere M. L., Hartmann A., Hauser J., Heilmann-Heimbach S., Hoffmann P., Ising M., Jones I., Jones L. A., Jonsson L., Kahn R. S., Kelsoe J. R., Kendler K. S., Kloiber S., Koenen K. C., Kogevinas M., Konte B., Krebs M. -O., Landen M., Lawrence J., Leboyer M., Lee P. H., Levinson D. F., Liao C., Lissowska J., Lucae S., Mayoral F., McElroy S. L., McGrath P., McGuffin P., McQuillin A., Medland S. E., Mehta D., Melle I., Milaneschi Y., Mitchell P. B., Molina E., Morken G., Mortensen P. B., Muller-Myhsok B., Nievergelt C., Nimgaonkar V., Nothen M. M., O'Donovan M. C., Ophoff R. A., Owen M. J., Pato C., Pato M. T., Penninx B. W. J. H., Pimm J., Pistis G., Potash J. B., Power R. A., Preisig M., Quested D., Ramos-Quiroga J. A., Reif A., Ribases M., Richarte V., Rietschel M., Rivera M., Roberts A., Roberts G., Rouleau G. A., Rovaris D. L., Rujescu D., Sanchez-Mora C., Sanders A. R., Schofield P. R., Schulze T. G., Scott L. J., Serretti A., Shi J., Shyn S. I., Sirignano L., Sklar P., Smeland O. B., Smoller J. W., Sonuga-Barke E. J. S., Spalletta G., Strauss J. S., Swiatkowska B., Trzaskowski M., Turecki G., Vilar-Ribo L., Vincent J. B., Volzke H., Walters J. T. R., Shannon Weickert C., Weickert T. W., Weissman M. M., Williams L. M., Wray N. R., Zai C. C., Ashley-Koch A. E., Beckham J. C., Hauser E. R., Hauser M. A., Kimbrel N. A., Lindquist J. H., McMahon B., Oslin D. W., Qin X., Mattheisen M., Abdellaoui A., Adams M. J., Agerbo E., Andlauer T. F. M., Bacanu S. -A., Baekvad-Hansen M., Beekman A. T. F., Bryois J., Buttenschon H. N., Bybjerg-Grauholm J., Cai N., Christensen J. H., Clarke T. -K., Colodro-Conde L., Couvy-Duchesne B., Crawford G. E., Davies G., Derks E. M., Direk N., Dolan C. V., Dunn E. C., Eley T. C., Escott-Price V., Hassan Kiadeh F. F., Finucane H. K., Frank J., Gaspar H. A., Gill M., Goes F. S., Gordon S. D., Weinsheimer S. M., Wellmann J., Willemsen G., Wu Y., Xi H. S., Yang J., Zhang F., Arolt V., Boomsma D. I., Dannlowski U., de Geus E. J. C., Depaulo J. R., Domenici E., Domschke K., Esko T., Grove J., Hall L. S., Hansen C. S., Hansen T. F., Herms S., Hickie I. B., Homuth G., Horn C., Hottenga J. -J., Hougaard D. M., Howard D. M., Jansen R., Jorgenson E., Knowles J. A., Kohane I. S., Kraft J., Kretzschmar W. W., Kutalik Z., Li Y., Lind P. A., MacIntyre D. J., MacKinnon D. F., Maier R. M., Maier W., Marchini J., Mbarek H., Middeldorp C. M., Mihailov E., Milani L., Mondimore F. M., Montgomery G. W., Mostafavi S., Nauck M., Ng B., Nivard M. G., Nyholt D. R., O'Reilly P. F., Oskarsson H., Hayward C., Heath A. C., Lewis G., Li Q. S., Madden P. A. F., Magnusson P. K., Martin N. G., McIntosh A. M., Metspalu A., Mors O., Nordentoft M., Paciga S. A., Pedersen N. L., Painter J. N., Pedersen C. B., Pedersen M. G., Peterson R. E., Peyrot W. J., Posthuma D., Quiroz J. A., Qvist P., Rice J. P., Riley B. P., Mirza S. S., Schoevers R., Schulte E. C., Shen L., Sigurdsson E., Sinnamon G. C. B., Smit J. H., Smith D. J., Stefansson H., Steinberg S., Streit F., Strohmaier J., Tansey K. E., Teismann H., Teumer A., Thompson W., Thomson P. A., Thorgeirsson T. E., Traylor M., Treutlein J., Trubetskoy V., Uitterlinden A. G., Umbricht D., der Auwera S. V., van Hemert A. M., Viktorin A., Visscher P. M., Wang Y., Webb B. T., Perlis R. H., Porteous D. J., Schaefer C., Stefansson K., Tiemeier H., Uher R., Werge T., Lewis C. M., Breen G., Borglum A. D., Sullivan P. F., O'Connell K. S., Coombes B., Qiao Z., Als T. D., Borte S., Charney A. W., Drange O. K., Gandal M. J., Hagenaars S. P., Ikeda M., Kamitaki N., Krebs K., Panagiotaropoulou G., Schilder B. M., Sloofman L. G., Winsvold B. S., Won H. -H., Abramova L., Adorjan K., Al Eissa M., Albani D., Alliey-Rodriguez N., Antilla V., Antoniou A., Baek J. H., Bauer M., Beins E. C., Bergen S. E., Birner A., Boen E., Brum M., Brumpton B. M., Brunkhorst-Kanaan N., Byerley W., Cairns M., Cervantes P., Cruceanu C., Cuellar-Barboza A., Cunningham J., Curtis D., Czerski P. M., Dale A. M., Dalkner N., David F. S., Dobbyn A. L., Douzenis A., Elvsashagen T., Ferrier I. N., Fiorentino A., Foroud T. M., Forty L., Frei O., Freimer N. B., Frisen L., Gade K., Garnham J., Gelernter J., Gizer I. R., Gordon-Smith K., Greenwood T. A., Ha K., Haraldsson M., Hautzinger M., Heilbronner U., Hellgren D., Holmans P. A., Huckins L., Johnson J. S., Kalman J. L., Kamatani Y., Kittel-Schneider S., Koromina M., Kranz T. M., Kranzler H. R., Kubo M., Kupka R., Kushner S. A., Lavebratt C., Leber M., Lee H. -J., Levy S. E., Lewis C., Lundberg M., Magnusson S. H., Maihofer A., Malaspina D., Maratou E., Martinsson L., McGregor N. W., McKay J. D., Medeiros H., Millischer V., Moran J. L., Morris D. W., Muhleisen T. W., O'Brien N., O'Donovan C., Olde Loohuis L. M., Oruc L., Papiol S., Pardinas A. F., Perry A., Pfennig A., Porichi E., Raj T., Rapaport M. H., Regeer E. J., Rivas F., Roth J., Roussos P., Ruderfer D. M., Senner F., Sharp S., Shilling P. D., Slaney C., Sobell J. L., Artigas M. S., Spijker A. T., Stein D. J., Terao C., Toma C., Tooney P., Tsermpini E. -E., Vawter M. P., Vedder H., Xi S., Xu W., Kay Yang J. M., Young A. H., Young H., Zandi P. P., Zhou H., HUNT All-In Psychiatry, Babadjanova G., Backlund L., Bengesser S., Blackwood D. H. R., Carr V. J., Catts S., Dikeos D., Etain B., Ferentinos P., Gawlik M., Gershon E. S., Henskens F., Hillert J., Hong K. S., Hultman C. M., Hveem K., Iwata N., Jablensky A. V., Kirov G., Lochner C., Loughland C., Mathews C. A., McMahon F. J., Michie P., Mowry B., Neale B. M., Nievergelt C. M., Oedegaard K. J., Olsson T., Pantelis C., Patrinos G. P., Reininghaus E. Z., Saito T., Schall U., Schalling M., Scott R. J., Weickert C. S., Stordal E., Vaaler A. E., Vieta E., Waldman I. D., Zwart J. -A., Nurnberger J. I., Stahl E. A., Di Florio A., Adan R. A. H., Ando T., Aschauer H., Baker J. H., Bencko V., Birgegard A., Boden J. M., Boehm I., Boni C., Perica V. B., Buehren K., Bulik C. M., Burghardt R., Carlberg L., Cassina M., Clementi M., Cone R. D., Courtet P., Crowley J. J., Danner U. N., Davis O. S. P., de Zwaan M., Dedoussis G., Degortes D., DeSocio J. E., Dick D. M., Dina C., Dmitrzak-Weglarz M., Martinez E. D., Duncan L. E., Egberts K., Mattingsdal M., McDevitt S., Meulenbelt I., Micali N., Mitchell J., Mitchell K., Monteleone P., Monteleone A. M., Munn-Chernoff M. A., Nacmias B., Navratilova M., Ntalla I., Olsen C. M., O'Toole J. K., Padyukov L., Palotie A., Pantel J., Papezova H., Parker R., Pearson J. F., Ehrlich S., Escaramis G., Espeseth T., Estivill X., Farmer A., Favaro A., Fischer K., Floyd J. A. B., Focker M., Foretova L., Forzan M., Franklin C. S., Gambaro G., Giuranna J., Giusti-Rodriquez P., Gonidakis F., Gordon S., Mayora M. G., Guillaume S., Hanscombe K. B., Hatzikotoulas K., Hebebrand J., Helder S. G., Henders A. K., Herpertz-Dahlmann B., Herzog W., Hinney A., Horwood L. J., Hubel C., Petersen L. V., Purves K. L., Raevuori A., Reichborn-Kjennerud T., Ricca V., Ripatti S., Ritschel F., Roberts M., Rybakowski F., Santonastaso P., Scherag A., Schmidt U., Schork N. 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K., Pestian J., Gaziano J. M., Muralidhar S., Ramoni R., Beckham J., Chang K. -M., O'Donnell C. J., Tsao P. S., Breeling J., Huang G., Romero J. P. C., Moser J., Whitbourne S. B., Brewer J. V., Aslan M., Connor T., Argyres D. P., Stephens B., Brophy M. T., Humphries D. E., Selva L. E., Do N., Shayan S., Cho K., Pyarajan S., Hauser E., Sun Y., Zhao H., Wilson P., McArdle R., Dellitalia L., Mattocks K., Harley J., Zablocki C. J., Whittle J., Jacono F., Gutierrez S., Gibson G., Hammer K., Kaminsky L., Villareal G., Kinlay S., Xu J., Hamner M., Mathew R., Bhushan S., Iruvanti P., Godschalk M., Ballas Z., Ivins D., Mastorides S., Moorman J., Gappy S., Klein J., Ratcliffe N., Florez H., Okusaga O., Murdoch M., Sriram P., Yeh S. S., Tandon N., Jhala D., Aguayo S., Cohen D., Sharma S., Liangpunsakul S., Oursler K. A., Whooley M., Ahuja S., Constans J., Meyer P., Greco J., Rauchman M., Servatius R., Gaddy M., Wallbom A., Morgan T., Stapley T., Sherman S., Ross G., Tsao P., Strollo P., Boyko E., Meyer L., Gupta S., Huq M., Fayad J., Hung A., Lichy J., Hurley R., Robey B., Striker R., Erlangsen A., Kessler R. C., Porteous D., Ursano R. J., Wasserman D., Coon H., Demontis D., Docherty A. R., Kuo P. -H., Mann J. J., Renteria M. E., Stein M. B., Willour V.

المساهمون: Mullins N., Kang J., Campos A.I., Coleman J.R.I., Edwards A.C., Galfalvy H., Levey D.F., Lori A., Shabalin A., Starnawska A., Su M.-H., Watson H.J., Adams M., Awasthi S., Gandal M., Hafferty J.D., Hishimoto A., Kim M., Okazaki S., Otsuka I., Ripke S., Ware E.B., Bergen A.W., Berrettini W.H., Bohus M., Brandt H., Chang X., Chen W.J., Chen H.-C., Crawford S., Crow S., DiBlasi E., Duriez P., Fernandez-Aranda F., Fichter M.M., Gallinger S., Glatt S.J., Gorwood P., Guo Y., Hakonarson H., Halmi K.A., Hwu H.-G., Jain S., Jamain S., Jimenez-Murcia S., Johnson C., Kaplan A.S., Kaye W.H., Keel P.K., Kennedy J.L., Klump K.L., Li D., Liao S.-C., Lieb K., Lilenfeld L., Liu C.-M., Magistretti P.J., Marshall C.R., Mitchell J.E., Monson E.T., Myers R.M., Pinto D., Powers A., Ramoz N., Roepke S., Rozanov V., Scherer S.W., Schmahl C., Sokolowski M., Strober M., Thornton L.M., Treasure J., Tsuang M.T., Witt S.H., Woodside D.B., Yilmaz Z., Zillich L., Adolfsson R., Agartz I., Air T.M., Alda M., Alfredsson L., Andreassen O.A., Anjorin A., Appadurai V., Soler Artigas M., Van der Auwera S., Azevedo M.H., Bass N., Bau C.H.D., Baune B.T., Bellivier F., Berger K., Biernacka J.M., Bigdeli T.B., Binder E.B., Boehnke M., Boks M.P., Bosch R., Braff D.L.

مصطلحات موضوعية: Genetic correlation, Genome-wide association study, Pleiotropy, Polygenicity, Suicide, Suicide attempt

الوصف: Background: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34861974; info:eu-repo/semantics/altIdentifier/wos/WOS:000746060000012; volume:91; issue:3; firstpage:313; lastpage:327; numberofpages:15; journal:BIOLOGICAL PSYCHIATRY; https://hdl.handle.net/11585/898960Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85119273569; https://www.sciencedirect.com/science/article/pii/S0006322321015705?via=ihubTest

الإتاحة: https://doi.org/10.1016/j.biopsych.2021.05.029Test
https://hdl.handle.net/11585/898960Test
https://www.sciencedirect.com/science/article/pii/S0006322321015705?via=ihubTest

المؤلفون: Schubert K. O., Thalamuthu A., Amare A. T., Frank J., Streit F., Adl M., Akula N., Akiyama K., Ardau R., Arias B., Aubry J. -M., Backlund L., Bhattacharjee A. K., Bellivier F., Benabarre A., Bengesser S., Biernacka J. M., Birner A., Marie-Claire C., Cearns M., Cervantes P., Chen H. -C., Chillotti C., Cichon S., Clark S. R., Cruceanu C., Czerski P. M., Dalkner N., Dayer A., Degenhardt F., Del Zompo M., DePaulo J. R., Etain B., Falkai P., Forstner A. J., Frisen L., Frye M. A., Fullerton J. M., Gard S., Garnham J. S., Goes F. S., Grigoroiu-Serbanescu M., Grof P., Hashimoto R., Hauser J., Heilbronner U., Herms S., Hoffmann P., Hou L., Hsu Y. -H., Jamain S., Jimenez E., Kahn J. -P., Kassem L., Kuo P. -H., Kato T., Kelsoe J., Kittel-Schneider S., Ferensztajn-Rochowiak E., Konig B., Kusumi I., Laje G., Landen M., Lavebratt C., Leboyer M., Leckband S. G., Maj M., Manchia M., Martinsson L., McCarthy M. J., McElroy S., Colom F., Mitjans M., Mondimore F. M., Monteleone P., Nievergelt C. M., Nothen M. M., Novak T., O'Donovan C., Ozaki N., Osby U., Papiol S., Pfennig A., Pisanu C., Potash J. B., Reif A., Reininghaus E., Rouleau G. A., Rybakowski J. K., Schalling M., Schofield P. R., Schweizer B. W., Severino G., Shekhtman T., Shilling P. D., Shimoda K., Simhandl C., Slaney C. M., Squassina A., Stamm T., Stopkova P., Tekola-Ayele F., Tortorella A., Turecki G., Veeh J., Vieta E., Witt S. H., Roberts G., Zandi P. P., Alda M., Bauer M., McMahon F. J., Mitchell P. B., Schulze T. G., Rietschel M., Baune B. T.

المساهمون: Schubert, K. O., Thalamuthu, A., Amare, A. T., Frank, J., Streit, F., Adl, M., Akula, N., Akiyama, K., Ardau, R., Arias, B., Aubry, J. -M., Backlund, L., Bhattacharjee, A. K., Bellivier, F., Benabarre, A., Bengesser, S., Biernacka, J. M., Birner, A., Marie-Claire, C., Cearns, M., Cervantes, P., Chen, H. -C., Chillotti, C., Cichon, S., Clark, S. R., Cruceanu, C., Czerski, P. M., Dalkner, N., Dayer, A., Degenhardt, F., Del Zompo, M., Depaulo, J. R., Etain, B., Falkai, P., Forstner, A. J., Frisen, L., Frye, M. A., Fullerton, J. M., Gard, S., Garnham, J. S., Goes, F. S., Grigoroiu-Serbanescu, M., Grof, P., Hashimoto, R., Hauser, J., Heilbronner, U., Herms, S., Hoffmann, P., Hou, L., Hsu, Y. -H., Jamain, S., Jimenez, E., Kahn, J. -P., Kassem, L., Kuo, P. -H., Kato, T., Kelsoe, J., Kittel-Schneider, S., Ferensztajn-Rochowiak, E., Konig, B., Kusumi, I., Laje, G., Landen, M., Lavebratt, C., Leboyer, M., Leckband, S. G., Maj, M., Manchia, M., Martinsson, L., Mccarthy, M. J., Mcelroy, S., Colom, F., Mitjans, M., Mondimore, F. M., Monteleone, P., Nievergelt, C. M., Nothen, M. M., Novak, T., O'Donovan, C., Ozaki, N., Osby, U., Papiol, S., Pfennig, A., Pisanu, C., Potash, J. B., Reif, A., Reininghaus, E., Rouleau, G. A., Rybakowski, J. K., Schalling, M., Schofield, P. R., Schweizer, B. W., Severino, G., Shekhtman, T., Shilling, P. D., Shimoda, K., Simhandl, C., Slaney, C. M., Squassina, A., Stamm, T.

مصطلحات موضوعية: Bipolar Disorder, Depression, Depressive Disorder, Major, Genetic Predisposition to Disease, Human, Lithium, Multifactorial Inheritance, Risk Factor, Schizophrenia

الوصف: Lithium is the gold standard therapy for Bipolar Disorder (BD) but its effectiveness differs widely between individuals. The molecular mechanisms underlying treatment response heterogeneity are not well understood, and personalized treatment in BD remains elusive. Genetic analyses of the lithium treatment response phenotype may generate novel molecular insights into lithium’s therapeutic mechanisms and lead to testable hypotheses to improve BD management and outcomes. We used fixed effect meta-analysis techniques to develop meta-analytic polygenic risk scores (MET-PRS) from combinations of highly correlated psychiatric traits, namely schizophrenia (SCZ), major depression (MD) and bipolar disorder (BD). We compared the effects of cross-disorder MET-PRS and single genetic trait PRS on lithium response. For the PRS analyses, we included clinical data on lithium treatment response and genetic information for n = 2283 BD cases from the International Consortium on Lithium Genetics (ConLi+Gen; www.ConLiGen.org). Higher SCZ and MD PRSs were associated with poorer lithium treatment response whereas BD-PRS had no association with treatment outcome. The combined MET2-PRS comprising of SCZ and MD variants (MET2-PRS) and a model using SCZ and MD-PRS sequentially improved response prediction, compared to single-disorder PRS or to a combined score using all three traits (MET3-PRS). Patients in the highest decile for MET2-PRS loading had 2.5 times higher odds of being classified as poor responders than patients with the lowest decile MET2-PRS scores. An exploratory functional pathway analysis of top MET2-PRS variants was conducted. Findings may inform the development of future testing strategies for personalized lithium prescribing in BD.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34845190; info:eu-repo/semantics/altIdentifier/wos/WOS:000723663500001; volume:11; issue:1; numberofpages:8; journal:TRANSLATIONAL PSYCHIATRY; http://hdl.handle.net/11584/324453Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85120159497

الإتاحة: https://doi.org/10.1038/s41398-021-01702-2Test
http://hdl.handle.net/11584/324453Test

المؤلفون: Andlauer T. F. M., Guzman-Parra J., Streit F., Strohmaier J., Gonzalez M. J., Gil Flores S., Cabaleiro Fabeiro F. J., del Rio Noriega F., Perez F. P., Haro Gonzalez J., Orozco Diaz G., de Diego-Otero Y., Moreno-Kustner B., Auburger G., Degenhardt F., Heilmann-Heimbach S., Herms S., Hoffmann P., Frank J., Foo J. C., Treutlein J., Witt S. H., Cichon S., Kogevinas M., Stahl E. A., Breen G., Forstner A. J., McQuillin A., Ripke S., Trubetskoy V., Mattheisen M., Wang Y., Coleman J. R. I., Gaspar H. A., de Leeuw C. A., Steinberg S., Pavlides J. M. W., Trzaskowski M., Pers T. H., Holmans P. A., Abbott L., Agerbo E., Akil H., Albani D., Alliey-Rodriguez N., Als T. D., Anjorin A., Antilla V., Awasthi S., Badner J. A., Baekvad-Hansen M., Barchas J. D., Bass N., Bauer M., Belliveau R., Bergen S. E., Pedersen C. B., Boen E., Boks M., Boocock J., Budde M., Bunney W., Burmeister M., Bybjerg-Grauholm J., Byerley W., Casas M., Cerrato F., Cervantes P., Chambert K., Charney A. W., Chen D., Churchhouse C., Clarke T. -K., Coryell W., Craig D. W., Cruceanu C., Czerski P. M., Dale A. M., de Jong S., Del-Favero J., DePaulo J. R., Djurovic S., Dobbyn A. L., Dumont A., Elvsashagen T., Escott-Price V., Fan C. C., Fischer S. B., Flickinger M., Foroud T. M., Forty L., Fraser C., Freimer N. B., Frisen L., Gade K., Gage D., Garnham J., Giambartolomei C., Pedersen M. G., Goldstein J., Gordon S. D., Gordon-Smith K., Green E. K., Green M. J., Greenwood T. A., Grove J., Guan W., Parra J. G., Hamshere M. L., Hautzinger M., Heilbronner U., Hipolito M., Holland D., Huckins L., Jamain S., Johnson J. S., Jureus A., Kandaswamy R., Karlsson R., Kennedy J. L., Kittel-Schneider S., Knowles J. A., Koller A. C., Kupka R., Lavebratt C., Lawrence J., Lawson W. B., Leber M., Lee P. H., Levy S. E., Li J. Z., Liu C., Lucae S., Maaser A., MacIntyre D. J., Mahon P. B., Maier W., Martinsson L., McCarroll S., McGuffin P., McInnis M. G., McKay J. D., Medeiros H., Medland S. E., Meng F., Milani L., Montgomery G. W., Morris D. W., Muhleisen T. W., Mullins N., Nguyen H., Nievergelt C. M., Adolfsson A. N., Nwulia E. A., O'Donovan C., Loohuis L. M. O., Ori A. P. S., Oruc L., Osby U., Perlis R. H., Perry A., Pfennig A., Potash J. B., Purcell S. M., Regeer E. J., Reif A., Reinbold C. S., Rice J. P., Richards A. L., Rivas F., Rivera M., Roussos P., Ruderfer D. M., Ryu E., Sanchez-Mora C., Schatzberg A. F., Scheftner W. A., Schork N. J., Weickert C. S., Shehktman T., Shilling P. D., Sigurdsson E., Slaney C., Smeland O. B., Sobell J. L., Hansen C. S., Spijker A. T., Clair D. S., Steffens M., Strauss J. S., Szelinger S., Thompson R. C., EThorgeirsson T., Vedde H., Wang W., Watson S. J., Weickert T. W., Xi S., Xu W., Young A. H., Zandi P., Zhang P., Zollner S., Adolfsson R., Agartz I., Alda M., Backlund L., Baune B. T., Bellivier F., Berrettini W. H., Biernacka J. M., Blackwood D. H. R., Boehnke M., Borglum A. D., Corvin A., Craddock N., Daly M. J., Dannlowski U., Esko T., Etain B., Frye M., Fullerton J. M., Gershon E. S., Gill M., Goes F., Grigoroiu-Serbanescu M., Hauser J., Hougaard D. M., Hultman C. M., Jones I., Jones L. A., Kahn R. S., Kirov G., Landen M., Leboyer M., Lewis C. M., Li Q. S., Lissowska J., Martin N. G., Mayoral F., McElroy S. L., McIntosh A. M., McMahon F. J., Melle I., Metspalu A., Mitchell P. B., Morken G., Mors O., Mortensen P. B., Muller-Myhsok B., Myers R. M., Neale B. M., Nimgaonkar V., Nordentoft M., Nothen M. M., O'Donovan M. C., Oedegaard K. J., Owen M. J., Paciga S. A., Pato C., Pato M. T., Posthuma D., Ramos-Quiroga J. A., Ribases M., Rietschel M., Rouleau G. A., Schalling M., Schofield P. R., Schulze T. G., Serretti A., Smoller J. W., Stefansson H., Stefansson K., Stordal E., Sullivan P. F., Turecki G., Vaaler A. E., Vieta E., Vincent J. B., Werge T., Nurnberger J. I., Wray N. R., Florio A. D., Edenberg H. J., Ophoff R. A., Scott L. J., Andreassen O. A., Kelsoe J., Sklar P., Byrne E. M., Abdellaoui A., Adams M. J., Air T. M., Bacanu S. -A., Beekman A. T. F., Bigdeli T. B., Binder E. B., Bryois J., Buttenschon H. N., Cai N., Castelao E., Christensen J. H., Colodro-Conde L., Couvy-Duchesne B., Crawford G. E., Davies G., Deary I. J., Derks E. M., Direk N., Dolan C. V., Dunn E. C., Eley T. C., Kiadeh F. F. H., Finucane H. K., Goes F. S., Hall L. S., Hansen T. F., Hickie I. B., Homuth G., Horn C., Hottenga J. -J., Howard D. M., Ising M., Jansen R., Jorgenson E., Kohane I. S., Hill, Kraft J., Kretzschmar W. W., Kutalik Z., Li Y., Lind P. A., MacKinnon D. F., Maier R. M., Marchini J., Mbarek H., McGrath P., Mehta D., Middeldorp C. M., Mihailov E., Milaneschi Y., Mondimore F. M., Mostafavi S., Nauck M., Ng B., Nivard M. G., Nyholt D. R., O'Reilly P. F., Oskarsson H., Painter J. N., Peterson R. E., Pettersson E., Peyrot W. J., Pistis G., Quiroz J. A., Qvist P., Riley B. P., Mirza S. S., Schoevers R., Schulte E. C., Shen L., Shi J., Shyn S. I., Sinnamon G. C. B., Smit J. H., Smith D. J., Tansey K. E., Teismann H., Teumer A., Thompson W., Thomson P. A., Thorgeirsson T. E., Traylor M., Uitterlinden A. G., Umbricht D., Van der Auwera S., van Hemert A. M., Viktorin A., Visscher P. M., Webb B. T., Weinsheimer S. M., Wellmann J., Willemsen G., Wu Y., Xi H. S., Yang J., Zhang F., Arolt V., Berger K., Boomsma D. I., de Geus E. J. C., Domenici E., Domschke K., Grabe H. J., Hamilton S. P., Hayward C., Heath A. C., Kendler K. S., Kloiber S., Lewis G., Madden P. A. F., Magnusson P. K., Pedersen N. L., Penninx B. W. J. H., Porteous D. J., Preisig M., Schaefer C., Tiemeier H., Uher R., Volzke H., Weissman M. M., Levinson D. F.

المساهمون: Andlauer T.F.M., Guzman-Parra J., Streit F., Strohmaier J., Gonzalez M.J., Gil Flores S., Cabaleiro Fabeiro F.J., del Rio Noriega F., Perez F.P., Haro Gonzalez J., Orozco Diaz G., de Diego-Otero Y., Moreno-Kustner B., Auburger G., Degenhardt F., Heilmann-Heimbach S., Herms S., Hoffmann P., Frank J., Foo J.C., Treutlein J., Witt S.H., Cichon S., Kogevinas M., Stahl E.A., Breen G., Forstner A.J., McQuillin A., Ripke S., Trubetskoy V., Mattheisen M., Wang Y., Coleman J.R.I., Gaspar H.A., de Leeuw C.A., Steinberg S., Pavlides J.M.W., Trzaskowski M., Pers T.H., Holmans P.A., Abbott L., Agerbo E., Akil H., Albani D., Alliey-Rodriguez N., Als T.D., Anjorin A., Antilla V., Awasthi S., Badner J.A., Baekvad-Hansen M., Barchas J.D., Bass N., Bauer M., Belliveau R., Bergen S.E., Pedersen C.B., Boen E., Boks M., Boocock J., Budde M., Bunney W., Burmeister M., Bybjerg-Grauholm J., Byerley W., Casas M., Cerrato F., Cervantes P., Chambert K., Charney A.W., Chen D., Churchhouse C., Clarke T.-K., Coryell W., Craig D.W., Cruceanu C., Czerski P.M., Dale A.M., de Jong S., Del-Favero J., DePaulo J.R., Djurovic S., Dobbyn A.L., Dumont A., Elvsashagen T., Escott-Price V., Fan C.C., Fischer S.B., Flickinger M., Foroud T.M., Forty L., Fraser C., Freimer N.B., Frisen L., Gade K., Gage D., Garnham J., Giambartolomei C.

مصطلحات موضوعية: Case-Control Studie, Genetic Predisposition to Disease, Human, Bipolar Disorder, Depressive Disorder, Major, Schizophrenia

الوصف: Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31712721; info:eu-repo/semantics/altIdentifier/wos/WOS:000632144900019; volume:26; issue:4; firstpage:1286; lastpage:1298; numberofpages:13; journal:MOLECULAR PSYCHIATRY; https://hdl.handle.net/11585/850134Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85075169356; https://www.nature.com/articles/s41380-019-0558-2Test

الإتاحة: https://doi.org/10.1038/s41380-019-0558-2Test
https://hdl.handle.net/11585/850134Test
https://www.nature.com/articles/s41380-019-0558-2Test