المؤلفون: Levin, Laura E, Shayegan, Leila H, Lucky, Anne W, Hook, Kristen P, Bruckner, Anna L, Feinstein, James A, Whittier, Susan, Lauren, Christine T, Pope, Elena, Lara‐Corrales, Irene, Wiss, Karen, McCuaig, Catherine C, Powell, Julie, Eichenfield, Lawrence F, Levy, Moise L, Diaz, Lucia, Glick, Sharon A, Paller, Amy S, Price, Harper N, Browning, John C, Morel, Kimberly D

المصدر: Pediatric Dermatology. 38(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Emerging Infectious Diseases, Biodefense, Infectious Diseases, Prevention, Vaccine Related, Antimicrobial Resistance, Clinical Research, Infection, Anti-Bacterial Agents, Canada, Epidermolysis Bullosa, Humans, Mupirocin, Retrospective Studies, Staphylococcal Infections, Staphylococcus aureus, cultures, epidermolysis bullosa, microbes, resistance, wound, Paediatrics and Reproductive Medicine, Dermatology & Venereal Diseases, Clinical sciences, Paediatrics

الوصف: Background/objectivesPatients with epidermolysis bullosa (EB) require care of wounds that are colonized or infected with bacteria. A subset of EB patients are at risk for squamous cell carcinoma, and bacterial-host interactions have been considered in this risk. The EB Clinical Characterization and Outcomes Database serves as a repository of information from EB patients at multiple centers in the United States and Canada. Access to this resource enabled broad-scale analysis of wound cultures.MethodsA retrospective analysis of 739 wound cultures from 158 patients from 13 centers between 2001 and 2018.ResultsOf 152 patients with a positive culture, Staphylococcus aureus (SA) was recovered from 131 patients (86%), Pseudomonas aeruginosa (PA) from 56 (37%), and Streptococcus pyogenes (GAS) from 34 (22%). Sixty-eight percent of patients had cultures positive for methicillin-sensitive SA, and 47%, methicillin-resistant SA (18 patients had cultures that grew both methicillin-susceptible and methicillin-resistant SA at different points in time). Of 15 patients with SA-positive cultures with recorded mupirocin susceptibility testing, 11 had mupirocin-susceptible SA and 6 patients mupirocin-resistant SA (2 patients grew both mupirocin-susceptible and mupirocin-resistant SA). SCC was reported in 23 patients in the entire database, of whom 10 had documented wound cultures positive for SA, PA, and Proteus species in 90%, 50%, and 20% of cases, respectively.ConclusionsSA and PA were the most commonly isolated bacteria from wounds. Methicillin resistance and mupirocin resistance were reported in 47% and 40% of patients tested, respectively, highlighting the importance of ongoing antimicrobial strategies to limit antibiotic resistance.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5qf3k1jmTest

المؤلفون: Feinstein, James A, Jambal, Purevsuren, Peoples, Kathleen, Lucky, Anne W, Khuu, Phuong, Tang, Jean Y, Lara-Corrales, Irene, Pope, Elena, Wiss, Karen, Hook, Kristen P, Levin, Laura E, Morel, Kimberly D, Paller, Amy S, McCuaig, Catherine C, Powell, Julie, Eichenfield, Lawrence F, Price, Harper, Levy, Moise L, Schachner, Lawrence A, Browning, John C, Bayliss, Susan, Jahnke, Marla, Shwayder, Tor, Glick, Sharon A, Bruckner, Anna L

المصدر: JAMA Dermatology. 155(2)

مصطلحات موضوعية: Pediatric, Congenital Structural Anomalies, Clinical Research, Good Health and Well Being, Adolescent, Age Distribution, Biopsy, Needle, Canada, Child, Child, Preschool, Cohort Studies, Databases, Factual, Disease Progression, Epidermolysis Bullosa, Female, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Immunohistochemistry, Incidence, Infant, Male, North America, Retrospective Studies, Risk Assessment, Severity of Illness Index, Sex Distribution, Survival Analysis, Young Adult, Clinical Sciences, Oncology and Carcinogenesis

الوصف: ImportanceChildren with epidermolysis bullosa (EB) comprise a rare population with high morbidity and mortality. An improved understanding of the clinical trajectory of patients with EB, including age at time of clinical diagnosis and major clinical events, is needed to refine best practices and improve quality of life and clinical outcomes for patients with EB.ObjectivesTo describe demographics, clinical characteristics, milestone diagnostic and clinical events (such as initial esophageal dilation), and outcomes in patients with EB using the Epidermolysis Bullosa Clinical Characterization and Outcomes Database and to determine what characteristics may be associated with overall EB severity and/or disease progression.Design, setting, and participantsThis cohort study included data on patients with EB who were enrolled in the Epidermolysis Bullosa Clinical Characterization and Outcomes Database from January 1, 2011, to June 30, 2017; 17 participating EB centers in the United States and Canada contributed data to this study.ExposuresType of EB, including recessive dystrophic epidermolysis bullosa (RDEB), junctional epidermolysis bullosa (JEB), dominant dystrophic epidermolysis bullosa (DDEB), and epidermolysis bullosa simplex (EBS).Main outcomes and measuresDemographic information, clinical characteristics (including age at onset of signs of EB and subsequent clinical diagnosis), types of diagnostic testing performed, and milestone clinical events for patients with RDEB.ResultsOf 644 enrolled patients from 17 sites included in this study, 323 were male (50.2%), with a mean (SD) age of 14.4 (11.7) years; 283 (43.9%) had RDEB, 194 (30.1%) had EBS, 104 (16.2%) had DDEB, and 63 (9.8%) had JEB. Signs of disease were present at birth in 202 patients with RDEB (71.4%), 39 with JEB (61.9%), 60 with DDEB (57.7%), and 74 with EBS (38.1%). For those with signs of disease at birth, a clinical diagnosis was made at the time of birth in 135 patients with RDEB (67.0%), 31 with DDEB (52.6%), 35 with EBS, (47.3%) and 18 with JEB (46.2%). Patients with JEB had the highest rate of any confirmatory testing (51 of 63 [81.0%]), followed by RDEB (218 of 283 [77.0%]), DDEB (71 of 104 [68.3%]), and EBS (100 of 194 [51.5%]). For all types of EB, both electron microscopy and immunofluorescence microscopy were performed at younger ages than genetic analysis. Among 283 patients with RDEB, 157 (55.5%) had esophageal dilation, 104 (36.7%) had gastrostomy tube placement, 62 (21.9%) had hand surgery, 18 (6.4%) developed squamous cell carcinoma, and 19 (6.7%) died.Conclusions and relevanceThe findings suggest that diagnostic testing for EB is more common for patients with severe phenotypes. Earlier diagnostic testing may enable improved characterizations of patients so that appropriate counseling and clinical care may be offered, especially pertaining to milestone events for those with RDEB.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3d01h9wwTest

المؤلفون: Ingrassia, Jenne P., Buontempo, Michael G., Alhanshali, Lina, Akoh, Christine C., Glick, Sharon, Shapiro, Jerry, Lo Sicco, Kristen

المصدر: International Journal of Women’s Dermatology ; volume 9, issue 4, page e118 ; ISSN 2352-6475

الإتاحة: https://doi.org/10.1097/jw9.0000000000000118Test

المؤلفون: Burshtein, Joshua, Buethe, Maria Gnarra, Ghias, Mondana H., Stein, Amy Buros, Glick, Sharon, Marmon, Shoshana

المصدر: JAAD International ; volume 12, page 3-11 ; ISSN 2666-3287

مصطلحات موضوعية: Dermatology

الإتاحة: https://doi.org/10.1016/j.jdin.2023.03.005Test
https://api.elsevier.com/content/article/PII:S2666328723000494?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666328723000494?httpAccept=text/plainTest

المؤلفون: Mathieu, Regine J, Vatanchi, Marjon, Heilman, Edward R, Glick, Sharon A

المصدر: Dermatology Online Journal. 23(7)

مصطلحات موضوعية: melanonychia, pediatric, subungual, melanoma, nail, pigmentation

الوصف: Pigmentation of the nail plate, or melanonychia, is typically a benign condition caused by melanocyte activation. Although rare, melanonychia may be the initial presentation of melanoma, thus all cases require an in-depth examination. Evaluation in pediatric patients can prove especially difficult as benign cases have a higher prevalence of atypia compared to adults. Lack of specific treatment guidelines in the pediatric population can make diagnosis and treatment challenging. We report a pediatric patient with melanonychia with atypical features that required significant evaluations and collaboration to ultimately reach a treatment plan.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3s54b25dTest

المؤلفون: Wang, Jennifer Y, Patel, Paras, Philip, Raichel, Kabakova, Margaret, Bitterman, David, Zafar, Kayla, Glick, Sharon A, Jagdeo, Jared

المصدر: J Drugs Dermatol ; ISSN:1545-9616 ; Volume:23 ; Issue:6

الوصف: Sunscreen is an essential way to protect against photodamage from ultraviolet (UV) radiation. Despite the recognized benefits of sunscreen in preventing skin damage from UV light, its use varies across different patient groups. This cross-sectional, questionnaire-based study aims to uncover the sunscreen usage patterns, preferences, and barriers among non-Hispanic White (NHW) and skin of color (SOC) individuals. Our findings demonstrate that NHW individuals are more likely to wear sunscreen daily (31% NHW vs 25% SOC) and reapply sunscreen at least once a day (76% NHW vs 45% SOC) compared with SOC individuals. SOC individuals demonstrate a willingness to use sunscreen, but they face barriers such as cost (2% NHW vs 16% SOC), lack of knowledge in finding suitable products (22% NHW vs 41% SOC), and concerns about white cast (7% NHW vs 25% SOC). SOC individuals are less likely to know the difference between mineral and chemical sunscreen (49% NHW vs 29% SOC), less likely to learn about sunscreen from dermatologists (36% NHW vs 22% SOC), and more likely to prefer sunscreen from brands owned by people of color (13% NHW vs 47% SOC).  In addition to analyzing the broader categories of NHW and SOC, subgroup analysis was conducted on specific subgroups, including Black, Asian, and Hispanic groups. Herein, we highlight differences in motivations, sunscreen preferences, sources of information, and knowledge levels about sun protection between NHW and SOC individuals. By uncovering the unique needs and challenges faced by SOC individuals, we aim to improve culturally competent patient education and promote effective sun protection practices across diverse populations. J Drugs Dermatol. 2024;23(6):456-462.     doi:10.36849/JDD.8268.

العلاقة: https://doi.org/10.36849/JDD.8268Test; https://pubmed.ncbi.nlm.nih.gov/38834222Test

الإتاحة: https://doi.org/10.36849/JDD.8268Test
https://pubmed.ncbi.nlm.nih.gov/38834222Test

المؤلفون: Molnar, Brenda Abreu, Levin, Laura, Yun, Duri, Morel, Kimberly, Wiss, Karen, Wieser, Julie, Ward, Christopher, Trice, Haley, Garcia-Romero, Maria Teresa, Stephenson, Allison, Provost, Adrienne, Price, Harper N., Perman, Marissa J., Moxon, Morgan, Moeves, Beth, McCuaig, Catherine C., McCarthy, Christine, Lucky, Anne W., Levy, Moise L., Lee, Michelle, Lara-Corrales, Irene, Henner, Natalia, Halliburton, Nichole, Griffith, Emily, Gorell, Emily, Glick, Sharon, Eichenfield, Lawrence, Collins, Clara, Bruckner, Anna L., Boulrice, Brenda, Bayliss, Susan, Badger, Kellie, Paller, Amy S.

المصدر: Journal of the American Academy of Dermatology ; ISSN 0190-9622

مصطلحات موضوعية: Dermatology

الإتاحة: https://doi.org/10.1016/j.jaad.2024.04.014Test
https://api.elsevier.com/content/article/PII:S0190962224005838?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0190962224005838?httpAccept=text/plainTest

المؤلفون: Martinez-Cabriales, Sylvia, Coulombe, Jerome, Aaron, Michelle, Hussain, Sadaf H., Linggonegoro, Danny, Lara-Corrales, Irene, Barootes, Hailey, Brandling-Bennett, Heather, Covelli, Isabela, Kirkorian, Anna Yasmine, Shah, Nidhi, Castelo-Soccio, Leslie, McKenzie, Paige, Arkin, Lisa M., Heinze, Adam, Liy-Wong, Carmen, Travis, Nicole, Rieder, Michael, Del Pozzo-Magana, Blanca R., Schoch, Jennifer J., Monir, Reesa, Glick, Sharon A., Uwakwe, Laura, Skillman, Sarah, Hekman, Dan P., Lethebe, Brendan C., Ramien, Michele L.

المصدر: Journal of the American Academy of Dermatology ; volume 90, issue 3, page 635-637 ; ISSN 0190-9622

مصطلحات موضوعية: Dermatology

الإتاحة: https://doi.org/10.1016/j.jaad.2023.08.112Test
https://api.elsevier.com/content/article/PII:S0190962223031146?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0190962223031146?httpAccept=text/plainTest

المؤلفون: Moran, Shannon, Derrick, Kristina M., McGovern, John, Glick, Sharon A.

المصدر: The Journal of Pediatrics ; volume 266, page 113857 ; ISSN 0022-3476

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1016/j.jpeds.2023.113857Test
https://api.elsevier.com/content/article/PII:S0022347623007217?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022347623007217?httpAccept=text/plainTest

المؤلفون: Xu, Michelle, Flamm, Alexandra, Shagalov, Devorah, Hsu, Emily, Glick, Sharon A

المصدر: Dermatology Online Journal. 22(6)

الوصف: Linear vesicles or papules in a newborn can be a presenting sign of incontinentia pigmenti (IP). In this report, we present two cases of neonates with cutaneous manifestations of incontinentia pigmenti. In one case, mild peripheral eosinophilia was noted. No extra-cutaneous manifestations were noted otherwise in both cases after complete ophthalmological and neurological evaluations. These cases serve as a reminder for clinicians to consider IP in newborns presenting with linear vesicles or papules.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6ph9f9c8Test