المؤلفون: Plante, Marie, Kwon, Janice, Ferguson, Sarah, Samouelian, Vanessa, Ferron, Gwenael, Maulard, Amandine, de Kroon, Cor, Van Driel, Willemien, Tidy, John, Mahner, Sven, Kommoss, Stefan, Marth, Christian, Goffin, Frédéric, Tamussimo, Karl, Eyjolfsdottir, Brynhildur, Kim, Jae-Weon, Gleeson, Noreen, Ubi, Juliana, Brotto, Lori, Tu, Dongsheng, Shepherd, Lois

المصدر: 2023, ASCO Annual Meeting, June 2-6

مصطلحات موضوعية: Human health sciences, Reproductive medicine (gynecology, andrology, obstetrics), Surgery, Oncology, Sciences de la santé humaine, Médecine de la reproduction (Gynécologie, andrologie, obstétrique), Chirurgie, Oncologie

الوصول الحر: https://orbi.uliege.be/handle/2268/313598Test

المؤلفون: Ferguson, Sarah, Plante, Marie, Tu, Donsheng, Kwon, Janice, Samouelian, Vanessa, Ferron, Gwenael, Maulard, Amandine, De Kroon, Cor, Van Driel, Willemien, Tidy, John, Williamson, Karin, Mahner, Sven, Kommos, Stefan, Goffin, Frédéric, Tamussino, Karl, Eyjolfsdottir, Brynhildur, Kim, Jae-Weon, Gleeson, Noreen, Shepherd, Lois, Lori Brotto, Lori

المصدر: ESGO 2023 Annual Meeting, spet 28-Oct 1er

مصطلحات موضوعية: Human health sciences, Reproductive medicine (gynecology, andrology, obstetrics), Surgery, Oncology, Sciences de la santé humaine, Médecine de la reproduction (Gynécologie, andrologie, obstétrique), Chirurgie, Oncologie

الوصول الحر: https://orbi.uliege.be/handle/2268/313599Test

المؤلفون: Plante, Marie, Kwon, Janice, Fergussen, Sarah, Samouëlian, Vanessa, Ferron, Gwanael, Maulard, Amandine, de Kroon, Cor, van Driel, Willemien, Tidy, John, Williamson, Karin, Mahner, Sven, Kommoss, Stefan, Goffin, Frédéric, Tamussino, Karl, Eyjolfsdottir, Brynhildur, Kim, Jae-Weon, Gleeson, Noreen, Brotto, Lori, Tu, Dongsheng, Shepherd, Lois

المصدر: New England Journal of Medicine, 390 (9), 819 - 829 (2024-02-29)

مصطلحات موضوعية: Pregnancy, Humans, Female, Canada, Neoplasm Recurrence, Local/epidemiology, Hysterectomy, Uterine Cervical Neoplasms/surgery, Urinary Incontinence, General Medicine, Human health sciences, Surgery, Oncology, Reproductive medicine (gynecology, andrology, obstetrics), Sciences de la santé humaine, Chirurgie, Oncologie, Médecine de la reproduction (Gynécologie, andrologie, obstétrique)

الوصف: [en] BACKGROUND: Retrospective data suggest that the incidence of parametrial infiltration is low in patients with early-stage low-risk cervical cancer, which raises questions regarding the need for radical hysterectomy in these patients. However, data from large, randomized trials comparing outcomes of radical and simple hysterectomy are lacking.METHODS: We conducted a multicenter, randomized, noninferiority trial comparing radical hysterectomy with simple hysterectomy including lymph-node assessment in patients with low-risk cervical cancer (lesions of ≤2 cm with limited stromal invasion). The primary outcome was cancer recurrence in the pelvic area (pelvic recurrence) at 3 years. The prespecified noninferiority margin for the between-group difference in pelvic recurrence at 3 years was 4 percentage points.RESULTS: Among 700 patients who underwent randomization (350 in each group), the majority had tumors that were stage IB1 according to the 2009 International Federation of Gynecology and Obstetrics (FIGO) criteria (91.7%), that had squamous-cell histologic features (61.7%), and that were grade 1 or 2 (59.3%). With a median follow-up time of 4.5 years, the incidence of pelvic recurrence at 3 years was 2.17% in the radical hysterectomy group and 2.52% in the simple hysterectomy group (an absolute difference of 0.35 percentage points; 90% confidence interval, -1.62 to 2.32). Results were similar in a per-protocol analysis. The incidence of urinary incontinence was lower in the simple hysterectomy group than in the radical hysterectomy group within 4 weeks after surgery (2.4% vs. 5.5%; P = 0.048) and beyond 4 weeks (4.7% vs. 11.0%; P = 0.003). The incidence of urinary retention in the simple hysterectomy group was also lower than that in the radical hysterectomy group within 4 weeks after surgery (0.6% vs. 11.0%; P<0.001) and beyond 4 weeks (0.6% vs. 9.9%; P<0.001).CONCLUSIONS: In patients with low-risk cervical cancer, simple hysterectomy was not inferior to radical hysterectomy with respect to the 3-year incidence of pelvic recurrence and was associated with a lower risk of urinary incontinence or retention. (Funded by the Canadian Cancer Society and others; ClinicalTrials.gov number, NCT01658930.).

العلاقة: http://www.nejm.org/doi/pdf/10.1056/NEJMoa2308900Test; urn:issn:0028-4793; urn:issn:1533-4406

الوصول الحر: https://orbi.uliege.be/handle/2268/313516Test

المؤلفون: Plante, Marie, Kwon, Janice S., Ferguson, Sarah, Samouëlian, Vanessa, Ferron, Gwenael, Maulard, Amandine, de Kroon, Cor, Van Driel, Willemien, Tidy, John, Williamson, Karin, Mahner, Sven, Kommoss, Stefan, Goffin, Frederic, Tamussino, Karl, Eyjólfsdóttir, Brynhildur, Kim, Jae-Weon, Gleeson, Noreen, Brotto, Lori, Tu, Dongsheng, Shepherd, Lois E., Luyckx, Mathieu

المساهمون: UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - (SLuc) Service de gynécologie et d'andrologie

المصدر: New England Journal of Medicine, Vol. 390, no.9, p. 819-829 (2024)

الوصف: Background: Retrospective data suggest that the incidence of parametrial infiltration is low in patients with early-stage low-risk cervical cancer, which raises questions regarding the need for radical hysterectomy in these patients. However, data from large, randomized trials comparing outcomes of radical and simple hysterectomy are lacking. Methods: We conducted a multicenter, randomized, noninferiority trial comparing radical hysterectomy with simple hysterectomy including lymph-node assessment in patients with low-risk cervical cancer (lesions of ≤2 cm with limited stromal invasion). The primary outcome was cancer recurrence in the pelvic area (pelvic recurrence) at 3 years. The prespecified noninferiority margin for the between-group difference in pelvic recurrence at 3 years was 4 percentage points. Results: Among 700 patients who underwent randomization (350 in each group), the majority had tumors that were stage IB1 according to the 2009 International Federation of Gynecology and Obstetrics (FIGO) criteria (91.7%), that had squamous-cell histologic features (61.7%), and that were grade 1 or 2 (59.3%). With a median follow-up time of 4.5 years, the incidence of pelvic recurrence at 3 years was 2.17% in the radical hysterectomy group and 2.52% in the simple hysterectomy group (an absolute difference of 0.35 percentage points; 90% confidence interval, -1.62 to 2.32). Results were similar in a per-protocol analysis. The incidence of urinary incontinence was lower in the simple hysterectomy group than in the radical hysterectomy group within 4 weeks after surgery (2.4% vs. 5.5%; P = 0.048) and beyond 4 weeks (4.7% vs. 11.0%; P = 0.003). The incidence of urinary retention in the simple hysterectomy group was also lower than that in the radical hysterectomy group within 4 weeks after surgery (0.6% vs. 11.0%; P<0.001) and beyond 4 weeks (0.6% vs. 9.9%; P<0.001). Conclusions: In patients with low-risk cervical cancer, simple hysterectomy was not inferior to radical hysterectomy with respect to the 3-year ...

العلاقة: info:eu-repo/grantAgreement/Canadian Cancer Society//; boreal:287063; http://hdl.handle.net/2078.1/287063Test; urn:ISSN:0028-4793; urn:EISSN:1533-4406

الإتاحة: https://doi.org/10.1056/nejmoa2308900Test
http://hdl.handle.net/2078.1/287063Test

المؤلفون: Mohamed, Bashir M., Ward, Mark P., Bates, Mark, Spillane, Cathy D., Kelly, Tanya, Martin, Cara, Gallagher, Michael, Heffernan, Sheena, Norris, Lucy, Kennedy, John, Saadeh, Feras Abu, Gleeson, Noreen, Brooks, Doug A., Brooks, Robert D., Selemidis, Stavros, O’Toole, Sharon, O’Leary, John J.

المصدر: Scientific Reports ; volume 13, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الوصف: Circulating tumour cells (CTCs) are a critical intermediate step in the process of cancer metastasis. The reliability of CTC isolation/purification has limited both the potential to report on metastatic progression and the development of CTCs as targets for therapeutic intervention. Here we report a new methodology, which optimises the culture conditions for CTCs using primary cancer cells as a model system. We exploited the known biology that CTCs thrive in hypoxic conditions, with their survival and proliferation being reliant on the activation of hypoxia-inducible factor 1 alpha (HIF-1α). We isolated epithelial-like and quasi-mesenchymal CTC phenotypes from the blood of a cancer patient and successfully cultured these cells for more than 8 weeks. The presence of CTC clusters was required to establish and maintain long-term cultures. This novel methodology for the long-term culture of CTCs will aid in the development of downstream applications, including CTC theranostics.

الإتاحة: https://doi.org/10.1038/s41598-023-30733-6Test
https://www.nature.com/articles/s41598-023-30733-6.pdfTest
https://www.nature.com/articles/s41598-023-30733-6Test

المؤلفون: Kwon, Janice S, Plante, Marie, Ferguson, Sarah, Mctaggart-Cowan, Helen, Samouëlian, Vanessa, Ferron, Gwenaël, Maulard, Amandine, Lambaudie, Eris, Tidy, John, Williamson, Karin, Gleeson, Noreen, Brotto, Lori, Yeung, Shirley, Khabra, Navdeep, Pataky, Reka, Chan, Kelvin, Cheung, Matthew, Ubi, Juliana, Tu, Dongsheng, Shepherd, Lois E

المصدر: Oral Sessions

الإتاحة: https://doi.org/10.1136/ijgc-2024-esgo.9Test

المؤلفون: O’Gorman, Catherine A, Minnock, Sorcha, Mulhall, Joseph, Gleeson, Noreen

المصدر: Women's Health ; volume 18, page 174550652110707 ; ISSN 1745-5065 1745-5065

مصطلحات موضوعية: General Medicine

الوصف: Objective: Women with gynaecological cancers are at an increased risk of cancer treatment–induced bone loss, which impacts on their quality of life and overall survival. Clinical cancer follow-up reviews focus on cancer status and fail to attend to important health and quality-of-life issues. We questioned whether there was a care-gap between tertiary clinicians and primary care physicians in the management of bone health in this cohort. Significant care-gaps in relation to bone health have been demonstrated in other oncologic settings. The objective of this study was to determine the level of attention to bone health in the care of women living with and beyond gynaecological cancer at a tertiary referral centre for gynaecological oncology. Methods: Retrospective, observational cohort study of attention to bone health in the management and follow-up of gynaecological cancers. Results: This study shows that there has been suboptimal attention from the carers at a cancer centre to bone health during the oncological follow up of women undergoing treatment for gynaecological cancer. In those at particular risk of cancer treatment–induced bone loss (iatrogenic menopause and/or external beam pelvic radiotherapy), 52% of women had no reference to bone health in their notes, and 57% had no assessment of bone mineral density. Conclusion: Tertiary cancer carers may underestimate the importance of bone health or believe that it falls outside the remit of their gynaecologic oncology service. Further research is needed to explore whether these findings are indicative of a true care gap and to gain insight into possible corrective measures.

الإتاحة: https://doi.org/10.1177/17455065211070747Test

المؤلفون: Freyne, Aoife, Donoghue, Niamh O., Shahabuddin, Yulia, Baker, Roisin, Murtagh, Claire, Gleeson, Noreen

المصدر: Gynecologic Oncology Reports ; volume 39, page 100902 ; ISSN 2352-5789

مصطلحات موضوعية: Obstetrics and Gynecology, Oncology

الإتاحة: https://doi.org/10.1016/j.gore.2021.100902Test
https://api.elsevier.com/content/article/PII:S235257892100206X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S235257892100206X?httpAccept=text/plainTest

المؤلفون: Mohamed, Bashir, Ward, Mark, Bates, Mark, Spillane, Cathy, Kelly, Tanya, Martin, Cara, Gallagher, Michael, Kennedy, John, Saadeh, Fears Abu, Gleeson, Noreen, Brooks, Doug A, Brooks, Robert D, Selemidis, Stavros, Hannify, Sean, Dixon, Eric P, O’toole, Sharon, O’leary, John J

المصدر: Translational research

الإتاحة: https://doi.org/10.1136/ijgc-2020-esgo.229Test

المؤلفون: Ward, Mark P., Saadeh, Feras Abu, O'Toole, Sharon A., O'Leary, John J., Gleeson, Noreen, Norris, Lucy A.

المساهمون: Health Research Board

المصدر: Thrombosis Research ; volume 200, page 91-98 ; ISSN 0049-3848

مصطلحات موضوعية: Hematology

الإتاحة: https://doi.org/10.1016/j.thromres.2021.01.012Test
https://api.elsevier.com/content/article/PII:S0049384821000311?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0049384821000311?httpAccept=text/plainTest