نتائج البحث - "Gladman D."

الوصف: The Medical Outcomes Study Short Form 36 (SF-36) is recommended to assess quality of life (QOL) in systemic lupus erythematosus (SLE). The aim of the current study was to assess QOL over time in the first 5 years of a multicenter inception cohort of patients with SLE. ; An inception SLE cohort was assembled according to a standardized protocol between 2000 and 2012. In addition to clinical and laboratory assessments, patients completed the SF-36 at yearly intervals. Only patients who had ≥5 completed QOL questionnaires were included in these analyses. Generalized estimating equation models were run separately for each of the 8 subscales and for the physical and mental component summary scores, adjusting for repeated measures by patients. ; A total of 495 patients were included. The mean ± SD disease duration at the first visit was 5.3 ± 4.1 months. The mean ± SD age at enrollment was 35.8 ± 13.2 years. All 8 subscales and the 2 summary scores showed improvement in the first 2 years from enrollment. Between years 2 and 5, none of the subscales or summary scores showed any change. Minimum clinically important improvement was achieved by 35-56% of the patients and was influenced by demographic and disease factors. ; Unlike late-stage lupus, where QOL is stable over time, in patients with early disease, all subscales improve in early followup up to 2 years. Therefore, the SF-36 may be a sensitive outcome measure in early disease in patients with SLE. ; VoR ; SUNY Downstate ; Rheumatology ; N/A

العلاقة: Urowitz M, Gladman DD, Ibañez D, Sanchez-Guerrero J, Bae SC, Gordon C, Fortin PR, Clarke A, Bernatsky S, Hanly JG, Wallace DJ, Isenberg D, Rahman A, Merrill J, Ginzler E, Alarcón GS, Fessler B, Khamashta M, Steinsson K, Petri M, Dooley M, Bruce IN, Manzi S, Sturfelt G, Nived O, Ramsey-Goldman R, Zoma A, Maddison P, Kalunian K, van Vollenhoven R, Aranow C, Romero Diaz J, Stoll T. Changes in quality of life in the first 5 years of disease in a multicenter cohort of patients with systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2014 Sep;66(9):1374-9. doi:10.1002/acr.22299. PMID: 24497416.; http://hdl.handle.net/20.500.12648/8265Test; Arthritis care & research

الإتاحة: https://doi.org/20.500.12648/8265Test
https://doi.org/10.1002/acr.22299Test
https://hdl.handle.net/20.500.12648/8265Test

View record in BASE

النص الكامل

5

دورية أكاديمية

Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis: results from an international inception cohort study.

المصدر: Arthritis and rheumatism ; 58 ; 3 ; 843 ; 53 ; United Kingdom ; United States ; Canada

الوصف: To examine, in an inception cohort of systemic lupus erythematosus (SLE) patients, the association between neuropsychiatric (NP) events and anti-ribosomal P (anti-P), antiphospholipid (lupus anticoagulant [LAC], anticardiolipin), anti-beta2-glycoprotein I, and anti-NR2 glutamate receptor antibodies. ; NP events were identified using the American College of Rheumatology case definitions and clustered into central/peripheral and diffuse/focal events. Attribution of NP events to SLE was determined using decision rules of differing stringency. Autoantibodies were measured without knowledge of NP events or their attribution. ; Four hundred twelve patients were studied (87.4% female; mean +/- SD age 34.9 +/- 13.5 years, mean +/- SD disease duration 5.0 +/- 4.2 months). There were 214 NP events in 133 patients (32.3%). The proportion of NP events attributed to SLE varied from 15% to 36%. There was no association between autoantibodies and NP events overall. However, the frequency of anti-P antibodies in patients with central NP events attributed to SLE was 4 of 20 (20%), versus 3 of 107 (2.8%) in patients with other NP events and 24 of 279 (8.6%) in those with no NP events (P = 0.04). Among patients with diffuse NP events, 3 of 11 had anti-P antibodies (27%), compared with 4 of 111 patients with other NP events (3.6%) and 24 of 279 of those with no NP events (8.6%) (P = 0.02). Specific clinical-serologic associations were found between anti-P and psychosis attributed to SLE (P = 0.02) and between LAC and cerebrovascular disease attributed to SLE (P = 0.038). There was no significant association between other autoantibodies and NP events. ; Clinically distinct NP events attributed to SLE and occurring around the time of diagnosis were found to be associated with anti-P antibodies and LAC. This suggests that there are different autoimmune pathogenetic mechanisms, although low sensitivity limits the clinical application of testing for these antibodies. ; AM ; SUNY Downstate ; Rheumatology ; N/A

العلاقة: Hanly JG, Urowitz MB, Siannis F, Farewell V, Gordon C, Bae SC, Isenberg D, Dooley MA, Clarke A, Bernatsky S, Gladman D, Fortin PR, Manzi S, Steinsson K, Bruce IN, Ginzler E, Aranow C, Wallace DJ, Ramsey-Goldman R, van Vollenhoven R, Sturfelt G, Nived O, Sanchez-Guerrero J, Alarcón GS, Petri M, Khamashta M, Zoma A, Font J, Kalunian K, Douglas J, Qi Q, Thompson K, Merrill JT; Systemic Lupus International Collaborating Clinics. Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis: results from an international inception cohort study. Arthritis Rheum. 2008 Mar;58(3):843-53. doi:10.1002/art.23218. PMID: 18311802; PMCID: PMC4656035.; http://hdl.handle.net/20.500.12648/8238Test; Arthritis and rheumatism

الإتاحة: https://doi.org/20.500.12648/8238Test
https://doi.org/10.1002/art.23218Test
https://hdl.handle.net/20.500.12648/8238Test

View record in BASE

النص الكامل

6

دورية أكاديمية

Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohort.

المصدر: Arthritis care & research ; 64 ; 1 ; 132 ; 7 ; Canada ; United States

الوصف: We describe disease activity, damage, and the accrual of key autoantibodies in an inception systemic lupus erythematosus (SLE) cohort. ; The Systemic Lupus International Collaborating Clinics (SLICC) International Research Network, comprising 27 centers from 11 countries, has followed an inception cohort of SLE patients yearly according to a standardized protocol. Of these patients, 298 were followed for a minimum of 5 years and constitute the study population. Disease activity was assessed using the SLE Disease Activity Index 2000 (SLEDAI-2K) and damage was assessed using the SLICC/American College of Rheumatology Damage Index (SDI). Antinuclear antibody (ANA), anti-DNA, and anticardiolipin antibody (aCL) levels and lupus anticoagulant were assessed yearly. Descriptive statistics were generated and repeated-measures general linear models were used to evaluate SLEDAI-2K and SDI over time between whites and nonwhites. ; Of the 298 patients, 87% were women, 55% were white, 12% were African American, 14% were Asian, 16% were Hispanic, and 2% were categorized as "other." At enrollment, the mean age was 35.3 years, the mean SLEDAI-2K score was 5.9, and the mean disease duration was 5.5 months. Mean SLEDAI-2K scores decreased in the first year and then remained low. SLEDAI-2K scores were significantly lower at each year in whites compared to nonwhites. Mean SDI scores increased progressively over 5 years; there was no significant difference between whites and nonwhites. As expected, ANA positivity was high and anti-DNA positivity was relatively low at enrollment, and both increased over 5 years. Although lupus anticoagulant increased slightly over 5 years, aCL positivity did not. ; Disease activity in newly diagnosed patients decreases over their first 5 years, while damage increases. Antibody positivity ran variable courses over this period. ; VoR ; SUNY Downstate ; Rheumatology ; N/A

العلاقة: Urowitz MB, Gladman DD, Ibañez D, Fortin PR, Bae SC, Gordon C, Clarke A, Bernatsky S, Hanly JG, Isenberg D, Rahman A, Sanchez-Guerrero J, Wallace DJ, Ginzler E, Alarcón GS, Merrill JT, Bruce IN, Sturfelt G, Nived O, Steinsson K, Khamashta M, Petri M, Manzi S, Ramsey-Goldman R, Dooley MA, van Vollenhoven RF, Ramos M, Stoll T, Zoma A, Kalunian K, Aranow C. Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohort. Arthritis Care Res (Hoboken). 2012 Jan;64(1):132-7. doi:10.1002/acr.20648. PMID: 21954226.; http://hdl.handle.net/20.500.12648/8251Test; Arthritis care & research

الإتاحة: https://doi.org/20.500.12648/8251Test
https://doi.org/10.1002/acr.20648Test
https://hdl.handle.net/20.500.12648/8251Test

View record in BASE

النص الكامل

7

دورية أكاديمية

Atherosclerotic vascular events in a multinational inception cohort of systemic lupus erythematosus.

المصدر: Arthritis care & research ; 62 ; 6 ; 881 ; 7 ; United States ; United Kingdom ; Canada

الوصف: To describe vascular events during an 8-year followup in a multicenter systemic lupus erythematosus (SLE) inception cohort and their attribution to atherosclerosis. ; Clinical data, including comorbidities, were recorded yearly. Vascular events were recorded and attributed to atherosclerosis or not. All of the events met standard clinical criteria. Factors associated with atherosclerotic vascular events were analyzed using descriptive statistics, t-tests, and chi-square tests. Stepwise multivariate logistic regression was used to assess the association of factors with vascular events attributed to atherosclerosis. ; Since 2000, 1,249 patients have been entered into the cohort. There have been 97 vascular events in 72 patients, including: myocardial infarction (n = 13), angina (n = 15), congestive heart failure (n = 24), peripheral vascular disease (n = 8), transient ischemic attack (n = 13), stroke (n = 23), and pacemaker insertion (n = 1). Fifty of the events were attributed to active lupus, 31 events in 22 patients were attributed to atherosclerosis, and 16 events were attributed to other causes. The mean +/- SD time from diagnosis to the first atherosclerotic event was 2.0 +/- 1.5 years. Compared with patients followed for 2 years without atherosclerotic events (n = 615), at enrollment, patients with atherosclerotic vascular events were more frequently white, men, older at diagnosis of SLE, obese, smokers, hypertensive, and had a family history of coronary artery disease. On multivariate analysis, only male sex and older age at diagnosis were associated factors. ; In an inception cohort with SLE followed for up to 8 years, there were 97 vascular events, but only 31 were attributable to atherosclerosis. Patients with atherosclerotic events were more likely to be men and to be older at diagnosis of SLE. ; AM ; SUNY Downstate ; Rheumatology ; N/A

العلاقة: Urowitz MB, Gladman D, Ibañez D, Bae SC, Sanchez-Guerrero J, Gordon C, Clarke A, Bernatsky S, Fortin PR, Hanly JG, Wallace DJ, Isenberg D, Rahman A, Alarcón GS, Merrill JT, Ginzler E, Khamashta M, Nived O, Sturfelt G, Bruce IN, Steinsson K, Manzi S, Ramsey-Goldman R, Dooley MA, Zoma A, Kalunian K, Ramos M, Van Vollenhoven RF, Aranow C, Stoll T, Petri M, Maddison P; Systemic Lupus International Collaborating Clinics. Atherosclerotic vascular events in a multinational inception cohort of systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2010 Jun;62(6):881-7. doi:10.1002/acr.20122. PMID: 20535799; PMCID: PMC2989413.; http://hdl.handle.net/20.500.12648/8247Test; Arthritis care & research

الإتاحة: https://doi.org/20.500.12648/8247Test
https://doi.org/10.1002/acr.20122Test
https://hdl.handle.net/20.500.12648/8247Test

View record in BASE

النص الكامل

8

دورية أكاديمية

Race/ethnicity and cancer occurrence in systemic lupus erythematosus.

المؤلفون: Bernatsky, S, Boivin, J F, Joseph, L, Manzi, S, Ginzler, E, Urowitz, M, Gladman, D, Fortin, P, Gordon, C, Barr, S, Edworthy, S, Bae, S C, Petri, M, Sibley, J, Isenberg, D, Rahman, A, Steinsson, K, Aranow, C, Dooley, M A, Alarcon, G S, Hanly, J, Sturfelt, G, Nived, O, Pope, J, Ensworth, S, Rajan, R, El-Gabalawy, H, McCarthy, T, St Pierre, Y, Clarke, A, Ramsey-Goldman, R

المصدر: Arthritis and rheumatism ; 53 ; 5 ; 781 ; 4 ; United States

الوصف: VoR ; SUNY Downstate ; Rheumatology ; N/A

العلاقة: Bernatsky S, Boivin JF, Joseph L, Manzi S, Ginzler E, Urowitz M, Gladman D, Fortin P, Gordon C, Barr S, Edworthy S, Bae SC, Petri M, Sibley J, Isenberg D, Rahman A, Steinsson K, Aranow C, Dooley MA, Alarcon GS, Hanly J, Sturfelt G, Nived O, Pope J, Ensworth S, Rajan R, El-Gabalawy H, McCarthy T, St Pierre Y, Clarke A, Ramsey-Goldman R. Race/ethnicity and cancer occurrence in systemic lupus erythematosus. Arthritis Rheum. 2005 Oct 15;53(5):781-4. doi:10.1002/art.21458. PMID: 16208671.; http://hdl.handle.net/20.500.12648/8233Test; Arthritis and rheumatism

الإتاحة: https://doi.org/20.500.12648/8233Test
https://doi.org/10.1002/art.21458Test
https://hdl.handle.net/20.500.12648/8233Test

View record in BASE

النص الكامل

9

دورية أكاديمية

Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study.

المصدر: Arthritis and rheumatism ; 59 ; 5 ; 721 ; 9 ; United States ; United Kingdom ; Canada

الوصف: To determine the short-term outcome of neuropsychiatric (NP) events upon enrollment into an international inception cohort of patients with systemic lupus erythematosus (SLE). ; The study was performed by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis and NP events were characterized using the American College of Rheumatology case definitions. Decision rules were derived to identify NP events attributable to SLE. Physician outcome scores of NP events and patient-derived mental component summary (MCS) and physical component summary (PCS) scores of the Short Form 36 were recorded. ; There were 890 patients (88.7% female) with a mean +/- SD age of 33.8 +/- 13.4 years and mean disease duration of 5.3 +/- 4.2 months. Within the enrollment window, 271 (33.5%) of 890 patients had at least 1 NP event encompassing 15 NP syndromes. NP events attributed to SLE varied from 16.5% to 33.9% using alternate attribution models and occurred in 6.0-11.5% of patients. Outcome scores for NP events attributed to SLE were significantly better than for NP events due to non-SLE causes. Higher global disease activity was associated with worse outcomes. MCS scores were lower in patients with NP events, regardless of attribution, and were also lower in patients with diffuse and central NP events. There was a significant association between physician outcome scores and patient MCS scores only for NP events attributed to SLE. ; In SLE patients, the short-term outcome of NP events is determined by both the characteristics and attribution of the events. ; AM ; SUNY Downstate ; Rheumatology ; N/A

العلاقة: Hanly JG, Urowitz MB, Su L, Sanchez-Guerrero J, Bae SC, Gordon C, Wallace DJ, Isenberg D, Alarcón GS, Merrill JT, Clarke A, Bernatsky S, Dooley MA, Fortin PR, Gladman D, Steinsson K, Petri M, Bruce IN, Manzi S, Khamashta M, Zoma A, Font J, Van Vollenhoven R, Aranow C, Ginzler E, Nived O, Sturfelt G, Ramsey-Goldman R, Kalunian K, Douglas J, Qiufen Qi K, Thompson K, Farewell V; Systemic Lupus International Collaborating Clinics. Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study. Arthritis Rheum. 2008 May 15;59(5):721-9. doi:10.1002/art.23566. PMID: 18438902; PMCID: PMC4656032.; http://hdl.handle.net/20.500.12648/8241Test; Arthritis and rheumatism

الإتاحة: https://doi.org/20.500.12648/8241Test
https://doi.org/10.1002/art.23566Test
https://hdl.handle.net/20.500.12648/8241Test

View record in BASE

النص الكامل

10

دورية أكاديمية

Mortality in systemic lupus erythematosus.

المؤلفون: Bernatsky, S, Boivin, J-F, Joseph, L, Manzi, S, Ginzler, E, Gladman, D D, Urowitz, M, Fortin, P R, Petri, M, Barr, S, Gordon, C, Bae, S-C, Isenberg, D, Zoma, A, Aranow, C, Dooley, M-A, Nived, O, Sturfelt, G, Steinsson, K, Alarcón, G, Senécal, J-L, Zummer, M, Hanly, J, Ensworth, S, Pope, J, Edworthy, S, Rahman, A, Sibley, J, El-Gabalawy, H, McCarthy, T, St Pierre, Y, Clarke, A, Ramsey-Goldman, R

المصدر: Arthritis and rheumatism ; 54 ; 8 ; 2550 ; 7 ; United States

الوصف: To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. ; Our sample was a multisite international SLE cohort (23 centers, 9,547 patients). Deaths were ascertained by vital statistics registry linkage. Standardized mortality ratio (SMR; ratio of deaths observed to deaths expected) estimates were calculated for all deaths and by cause. The effects of sex, age, SLE duration, race, and calendar-year periods were determined. ; The overall SMR was 2.4 (95% confidence interval 2.3-2.5). Particularly high mortality was seen for circulatory disease, infections, renal disease, non-Hodgkin's lymphoma, and lung cancer. The highest SMR estimates were seen in patient groups characterized by female sex, younger age, SLE duration <1 year, or black/African American race. There was a dramatic decrease in total SMR estimates across calendar-year periods, which was demonstrable for specific causes including death due to infections and death due to renal disorders. However, the SMR due to circulatory diseases tended to increase slightly from the 1970s to the year 2001. ; Our data from a very large multicenter international cohort emphasize what has been demonstrated previously in smaller samples. These results highlight the increased mortality rate in SLE patients compared with the general population, and they suggest particular risk associated with female sex, younger age, shorter SLE duration, and black/African American race. The risk for certain types of deaths, primarily related to lupus activity (such as renal disease), has decreased over time, while the risk for deaths due to circulatory disease does not appear to have diminished. ; VoR ; SUNY Downstate ; Rheumatology ; N/A

العلاقة: Bernatsky S, Boivin JF, Joseph L, Manzi S, Ginzler E, Gladman DD, Urowitz M, Fortin PR, Petri M, Barr S, Gordon C, Bae SC, Isenberg D, Zoma A, Aranow C, Dooley MA, Nived O, Sturfelt G, Steinsson K, Alarcón G, Senécal JL, Zummer M, Hanly J, Ensworth S, Pope J, Edworthy S, Rahman A, Sibley J, El-Gabalawy H, McCarthy T, St Pierre Y, Clarke A, Ramsey-Goldman R. Mortality in systemic lupus erythematosus. Arthritis Rheum. 2006 Aug;54(8):2550-7. doi:10.1002/art.21955. PMID: 16868977.; http://hdl.handle.net/20.500.12648/8234Test; Arthritis and rheumatism

الإتاحة: https://doi.org/20.500.12648/8234Test
https://doi.org/10.1002/art.21955Test
https://hdl.handle.net/20.500.12648/8234Test

View record in BASE

النص الكامل

تنقيح النتائج