المؤلفون: Di Bonaventura, Maria Vittoria Micioni, Martinelli, Ileania, Moruzzi, Michele, Di Bonaventura, Emanuela Micioni, Giusepponi, Maria Elena, Polidori, Carlo, Lupidi, Giulio, Tayebati, Seyed Khosrow, Amenta, Francesco, Cifani, Carlo, Tomassoni, Daniele

مصطلحات موضوعية: Diet-Induced Obese Rats, high fat diet, brain, neuroinflammation, obesity, tart cherries, info:eu-repo/classification/ddc/610, ddc:610

الوصف: Evidence suggests that obesity adversely affects brain function. High body mass index, hypertension, dyslipidemia, insulin resistance, and diabetes are risk factors for increasing cognitive decline. Tart cherries (Prunus Cerasus L.) are rich in anthocyanins and components that modify lipid metabolism. This study evaluated the effects of tart cherries on the brain in diet-induced obese (DIO) rats. DIO rats were fed with a high-fat diet alone or in association with a tart cherry seeds powder (DS) and juice (DJS). DIO rats were compared to rats fed with a standard diet (CHOW). Food intake, body weight, fasting glycemia, insulin, cholesterol, and triglycerides were measured. Immunochemical and immunohistochemical techniques were performed. Results showed that body weight did not differ among the groups. Blood pressure and glycemia were decreased in both DS and DJS groups when compared to DIO rats. Immunochemical and immunohistochemical techniques demonstrated that in supplemented DIO rats, the glial fibrillary acid protein expression and microglial activation were reduced in both the hippocampus and in the frontal cortex, while the neurofilament was increased. Tart cherry intake modified aquaporin 4 and endothelial inflammatory markers. These findings indicate the potential role of this nutritional supplement in preventing obesity-related risk factors, especially neuroinflammation.

العلاقة: 623

الإتاحة: https://ul.qucosa.de/id/qucosa%3A84845Test
https://ul.qucosa.de/api/qucosa%3A84845/attachment/ATT-0Test/

المؤلفون: Steiner, Michel A, Toeroek-Schafroth, Michael, Giusepponi, Maria Elena, Dacome, Lisa, Tessari, Michela

المساهمون: Idorsia Pharmaceuticals

المصدر: Journal of Psychopharmacology ; volume 37, issue 12, page 1249-1260 ; ISSN 0269-8811 1461-7285

مصطلحات موضوعية: Pharmacology (medical), Psychiatry and Mental health, Pharmacology

الوصف: Background: Drugs that act on the central nervous system (CNS) and have sedative effects can lead to abuse in humans. New CNS-active drugs often require evaluation of their abuse potential in dedicated animal models before marketing approval. Daridorexant is a new dual orexin receptor antagonist (DORA) with sleep-promoting properties in animals and humans. It was approved in 2022 in the United States and Europe for the treatment of insomnia disorder. Aims: Nonclinical evaluation of abuse potential of daridorexant using three specific rat models assessing reinforcement, interoception, and withdrawal. Methods: Reinforcing effects of daridorexant were assessed in an operant rat model of intravenous drug self-administration. Similarity of interoceptive effects to those of the commonly used sleep medication zolpidem was tested in an operant drug discrimination task. Withdrawal signs indicative of physical dependence were evaluated upon sudden termination of chronic daridorexant treatment. Rat experiments were conducted at a dose range resulting in daridorexant plasma concentrations equaling or exceeding those achieved at the clinically recommended dose of 50 mg in humans. Results: Daridorexant had no reinforcing effects, was dissimilar to zolpidem in the drug discrimination task, and did not induce any withdrawal-related signs upon treatment discontinuation that would be indicative of physical dependence. Outcomes: Daridorexant showed no signs of abuse or dependence potential in rats. Our data indicate that daridorexant, like other DORAs, has a low potential for abuse in humans.

الإتاحة: https://doi.org/10.1177/02698811231215415Test

المؤلفون: Romano, Adele, Micioni Di Bonaventura, Maria Vittoria, Gallelli, Cristina Anna, Koczwara, Justyna Barbara, Smeets, Dorien, Giusepponi, Maria Elena, De Ceglia, Marialuisa, Friuli, Marzia, Micioni Di Bonaventura, Emanuela, Scuderi, Caterina, Vitalone, Annabella, Tramutola, Antonella, Altieri, Fabio, Lutz, Thomas A, Giudetti, Anna Maria, Cassano, Tommaso, Cifani, Carlo, Gaetani, Silvana

المساهمون: Romano, Adele, Micioni Di Bonaventura, Maria Vittoria, Gallelli, Cristina Anna, Koczwara, Justyna Barbara, Smeets, Dorien, Giusepponi, Maria Elena, De Ceglia, Marialuisa, Friuli, Marzia, Micioni Di Bonaventura, Emanuela, Scuderi, Caterina, Vitalone, Annabella, Tramutola, Antonella, Altieri, Fabio, Lutz, Thomas A, Giudetti, Anna Maria, Cassano, Tommaso, Cifani, Carlo, Gaetani, Silvana

مصطلحات موضوعية: oleoylethanolamide, eating disorder, dopamine, oxytocin, crf

الوصف: Binge eating disorder (BED) is the most frequent eating disorder, for which current pharmacotherapies show poor response rates and safety concerns, thus highlighting the need for novel treatment options. The lipid-derived messenger oleoylethanolamide (OEA) acts as a satiety signal inhibiting food intake through the involvement of central noradrenergic and oxytocinergic neurons. We investigated the anti-binge effects of OEA in a rat model of binge-like eating, in which, after cycles of intermittent food restrictions/refeeding and palatable food consumptions, female rats show a binge-like intake of palatable food, following a 15-min exposure to their sight and smell ("frustration stress"). Systemically administered OEA dose-dependently (2.5, 5, and 10 mg kg(-1)) prevented binge-like eating. This behavioral effect was associated with a decreased activation (measured by mapping the expression of c-fos, an early gene widely used as a marker of cellular activation) of brain areas responding to stress (such as the nucleus accumbens and amygdala) and to a stimulation of areas involved in the control of food intake, such as the VTA and the PVN. These effects were paralleled, also, to the modulation of monoamine transmission in key brain areas involved in both homeostatic and hedonic control of eating. In particular, a decreased dopaminergic response to stress was observed by measuring dopamine extracellular concentrations in microdialysates from the nucleus accumbens shell, whereas an increased serotonergic and noradrenergic tone was detected in tissue homogenates of selected brain areas. Finally, a decrease in corticotropin-releasing factor (CRF) mRNA levels was induced by OEA in the central amygdala, while an increase in oxytocin mRNA levels was induced in the PVN. The restoration of a normal oxytocin receptor density in the striatum paralleled the oxytocinergic stimulation produced by OEA. In conclusion, we provide evidence suggesting that OEA might represent a novel potential pharmacological target for the treatment ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32353860; info:eu-repo/semantics/altIdentifier/wos/WOS:000530976300002; volume:11; issue:45; firstpage:1931; lastpage:1941; numberofpages:11; journal:NEUROPSYCHOPHARMACOLOGY; http://hdl.handle.net/11573/1402452Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85085874970

الإتاحة: https://doi.org/10.1038/s41386-020-0686-zTest
http://hdl.handle.net/11573/1402452Test

المؤلفون: Cifani, Carlo, Avagliano, Carmen, Micioni Di Bonaventura, Emanuela, Giusepponi, Maria Elena, De Caro, Carmen, Cristiano, Claudia, La Rana, Giovanna, Botticelli, Luca, Romano, Adele, Calignano, Antonio, Gaetani, Silvana, Micioni Di Bonaventura, Maria Vittoria, Russo, Roberto

المساهمون: Ministero dell’Istruzione, dell’Università e della Ricerca

المصدر: Frontiers in Pharmacology ; volume 11 ; ISSN 1663-9812

مصطلحات موضوعية: Pharmacology (medical), Pharmacology

الإتاحة: https://doi.org/10.3389/fphar.2020.00266Test

المؤلفون: TOMASSONI, Daniele, MICIONI DI BONAVENTURA, Maria Vittoria, FRUGANTI, Alessandro, DINI, Fabrizio, MARCHEGIANI, ANDREA, MORUZZI, MICHELE, GIUSEPPONI, MARIA ELENA, TURCHETTI, LUCIA, MARINI, Carlotta, GABRIELLI, Maria Gabriella, POLIDORI, Carlo, TAYEBATI, Seyed Khosrow, AMENTA, Francesco, CIFANI, Carlo

المساهمون: Tomassoni, Daniele, MICIONI DI BONAVENTURA, Maria Vittoria, Fruganti, Alessandro, Dini, Fabrizio, Marchegiani, Andrea, Moruzzi, Michele, Giusepponi, MARIA ELENA, Turchetti, Lucia, Marini, Carlotta, Gabrielli, Maria Gabriella, Polidori, Carlo, Tayebati, Seyed Khosrow, Amenta, Francesco, Cifani, Carlo

الوصف: Increased food intake, reduced physical activity and altered metabolic processes are the variables that affect energy balance inducing obesity. Obesity is now considered an increas-ingly medical challenge. Actually, the prevalence of obesity has increased dramatically worldwide over the last decades and has now reached epidemic proportions. On the other hand, obesity is associated with the development of chronic diseases such as cerebrovascu-lar disease promoting the cognitive decline. Caloric-dense diet induced obesity (DIO), provides a useful animal model sharing several common features with human obesity. DIO rats of 7 weeks of age are expose to high fat (45 %) diet ad libitum and after 5 weeks the obese phenotype starts to be develop. To clarify the possible relationships between obesity and nervous system changes, DIO rats were studied after 5 weeks and 17 weeks of hypercaloric diet compared to the control rats with not fat diet (Chow). Memory performance were measured using different cognitive tests. Moreover, ultrasonographic (US) and computed tomography (CT) evaluations were per-formed to detect adipose tissue changes. Magnetic resonance imaging (MRI) to highlight brain morphological alterations was used. Morphological changes of brain areas (frontal cor-tex, hippocampus) were evaluated by immunohistochemical analysis. The results confirmed the developed of obesity after 5 weeks of fat diet. At long-term (17 weeks) high fat diet exposure, rats increased significantly their body weight in comparison to the control group and the youngest DIO rats. The US and CT analysis indicated an increase of deposition of both visceral and subcutaneous adipose tissue and evidences a decrease of hepatic attenuation in the older DIO rats.MRI images did not show vascular and morphologi-cal alterations in brain. Instead, immuhistochemical and immunochemical analysis, revealed an increase expression of glial-fibrillary acidic protein (GFAP) in the older DIO rats compared to the age- matched Chow rats both in frontal cortex ...

وصف الملف: STAMPA

العلاقة: 70° Congresso della Società Italiana di Anatomia e Istologia; issue:121; firstpage:190; lastpage:190; numberofpages:1; journal:ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY; http://hdl.handle.net/11581/400308Test; http://www.fupress.net/index.php/ijae/article/view/21827Test

الإتاحة: http://hdl.handle.net/11581/400308Test
http://www.fupress.net/index.php/ijae/article/view/21827Test

المؤلفون: MICIONI DI BONAVENTURA, Maria Vittoria, UBALDI, Massimo, GIUSEPPONI, Maria Elena, RICE, Kenner C, MASSI, Maurizio, CICCOCIOPPO, Roberto, CIFANI, Carlo

المساهمون: MICIONI DI BONAVENTURA, Maria Vittoria, Ubaldi, Massimo, Giusepponi, Maria Elena, Rice, Kenner C, Massi, Maurizio, Ciccocioppo, Roberto, Cifani, Carlo

الوصف: OBJECTIVE: The present study evaluated the effect of systemic injection of the CRF1 receptor antagonist R121919, the corticosterone synthesis inhibitor metyrapone and central amygdala (CeA) injections of the nonselective CRF antagonist D-Phe-CRF(12-41) in rats in which binge eating was evoked by stress and cycles of food restriction. METHOD: Female rats were subjected or not to repeated cycles of regular chow food restriction/ad libitum feeding during which they were also given limited access (2 h) to palatable food. On the test day, rats were either exposed or not to the sight of the palatable food for 15 min without allowing access, before assessing food consumption. RESULTS: Systemic injections of R121919, but not of the metyrapone, blocked binge-like eating behavior. Restricted and stressed rats showed up-regulation of crh1 receptor mRNA signal in the bed nucleus of the stria terminalis and CeA but not in basolateral amygdala (BLA) or in the paraventricular nucleus. Injection D-Phe-CRF(12-41) in CeA but not in the BLA-blocked binge-like eating behavior. DISCUSSION: These findings demonstrate that extra-hypothalamic CRF1 receptors, rather than those involved in endocrine functions, are involved in binge eating and the crucial role of CRF receptors in CeA. CRF1 receptor antagonism may represent a novel pharmacological treatment for binge-related eating disorders.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28833350; info:eu-repo/semantics/altIdentifier/wos/WOS:000412304300009; volume:50; issue:10; firstpage:1194; lastpage:1204; numberofpages:11; journal:INTERNATIONAL JOURNAL OF EATING DISORDERS; http://hdl.handle.net/11581/404119Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85030666421

الإتاحة: https://doi.org/10.1002/eat.22767Test
http://hdl.handle.net/11581/404119Test

المؤلفون: Micioni Di Bonaventura, Maria Vittoria, Martinelli, Ilenia, Moruzzi, Michele, Micioni Di Bonaventura, Emanuela, Giusepponi, Maria Elena, Polidori, Carlo, Lupidi, Giulio, Tayebati, Seyed Khosrow, Amenta, Francesco, Cifani, Carlo, Tomassoni, Daniele

المصدر: Nutrients; Jun2024, Vol. 16 Issue 11, p1574, 2p

مستخلص: A correction is presented to the article "Brain Alterations in High Fat Diet Induced Obesity: Effects of Tart Cherry Seeds and Juice" which appeared in the previous issue of the periodical.

المؤلفون: CIFANI, Carlo, MICIONI DI BONAVENTURA, Maria Vittoria, Pucci, Mariangela, GIUSEPPONI, MARIA ELENA, Romano, Adele, DI FRANCESCO, ANDREA, Maccarrone, Mauro, D'Addario, Claudio

المساهمون: Cifani, Carlo, MICIONI DI BONAVENTURA, Maria Vittoria, Pucci, Mariangela, Giusepponi, MARIA ELENA, Romano, Adele, DI FRANCESCO, Andrea, Maccarrone, Mauro, D'Addario, Claudio

الوصف: Several factors play a role in obesity (i.e., behavior, environment, and genetics) and epigenetic regulation of gene expression has emerged as a potential contributor in the susceptibility and development of obesity. To investigate the individual sensitivity to weight gain/resistance, we here studied gene transcription regulation of several hypothalamic neuropeptides involved in the control of energy balance in rats developing obesity (diet-induced obesity, DIO) or not (diet resistant, DR), when fed with a high fat diet. Rats have been followed up to 21 weeks of high fat diet exposure. After 5 weeks high fat diet exposure, the obese phenotype was developed and we observed a selective down-regulation of the orexigenic neuropeptide Y (NPY) and peroxisome proliferator-activated receptor gamma (PPAR-γ) genes. No changes were observed in the expression of the agouti-related protein (AgRP), as well as for all the anorexigenic genes under study. After long-term high fat diet exposure (21 weeks), NPY and PPAR-γ, as well as most of the genes under study, resulted not be different between DIO and DR, whereas a lower expression of the anorexigenic pro-opio-melanocortin (POMC) gene was observed in DIO rats when compared to DR rats. Moreover we observed that changes in NPY and POMC mRNA were inversely correlated with gene promoters DNA methylation. Our findings suggest that selective alterations in hypothalamic peptide genes regulation could contribute to the development of overweight in rats and that environmental factor, as in this animal model, might be partially responsible of these changes via epigenetic mechanism.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26106286; info:eu-repo/semantics/altIdentifier/wos/WOS:000361996000001; volume:9; firstpage:1; lastpage:9; numberofpages:9; journal:FRONTIERS IN NEUROSCIENCE; http://hdl.handle.net/11581/388305Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84930633202; https://www.frontiersin.org/articles/10.3389/fnins.2015.00187/fullTest

الإتاحة: https://doi.org/10.3389/fnins.2015.00187Test
http://hdl.handle.net/11581/388305Test

المؤلفون: Marniquet, Xavier, Dajon, Marion, Montegut, Julie, Giusepponi, Maria Elena, Pecoraro, Michela, Vicentini, Elena, Morandini, Francesca, Zanderigo, Floriana, Federico, Denise, Bonnin, Odile, Neveu, Gregory, Blanc, Charlotte, Marcou, Christelle, Lavaux, Juliette, Didier, Michel, Boldina, Galina, Dumas, Jacques, Bouqin, Thomas, Milla, Annabelle, Watson, Hugh, Carter, Kara, Alam, Antoine

المصدر: Journal of Hepatology ; volume 77, page S872 ; ISSN 0168-8278

مصطلحات موضوعية: Hepatology

الإتاحة: https://doi.org/10.1016/s0168-8278Test(22)02038-4
https://api.elsevier.com/content/article/PII:S0168827822020384?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0168827822020384?httpAccept=text/plainTest

المؤلفون: Micioni Di Bonaventura, Maria Vittoria, UbaldI, Massimo, Giusepponi, Maria Elena, Rice, Kenner C., Massi, Maurizio, Ciccocioppo, Roberto, Cifani, Carlo

المساهمون: Micioni Di Bonaventura, Maria Vittoria, Ubaldi, Massimo, Giusepponi, Maria Elena, Rice, Kenner C., Massi, Maurizio, Ciccocioppo, Roberto, Cifani, Carlo

الوصف: The interaction between dieting and stress is a key factor for triggering binge episodes on palatable food in human binge eaters. Corticotropin releasing factor (CRF) mechanisms are known to play a pivotal role in the regulation of this maladaptive behavior. The present study evaluated the effect of the CRF1 receptor antagonist R121919 and the corticosterone synthesis inhibitor metyrapone in female rats in which binge eating was evoked by stress and cycles of food restrictions. Rats were first subjected or not to repeated cycles of regular chow food restriction/refeeding during which they were also given limited access (2 h) to palatable food. On the test day, rats were either exposed or not to the sight of the palatable food for 15 minutes without allowing access (frustration stress), before assessing food consumption for 2 h. Systemic injections of the CRF1 receptor antagonist R121919, but not of the metyrapone, blocked binge-like eating behavior. Moreover, corticosterone injection did not induce binge eating in non-stressed rats. Restricted and stressed rats showed upregulation of crh1 receptor mRNA signal in the bed nucleus of the stria terminalis (BNST) and central amygdala (CeA) but not in basolateral amygdala (BLA) or in the paraventricular nucleus. Injection of CRF receptor antagonist D-Phe-CRF(12e 41) in CeA but not in the BLA blocked binge-like eating behavior. These findings demonstrate that extra-hypothalamic CRF1 receptors, rather than those involved in endocrine functions, are involved in binge eating. CRF1 receptor antagonism may represent a novel pharmacological treatment for binge-related eating disorders

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000401205300171; ispartofbook:Epigenetics; Alcoholism and Stress: A Framework for Future Treatment Strategies; volume:60; issue:60; firstpage:239; lastpage:239; numberofpages:1; journal:ALCOHOL; http://hdl.handle.net/11581/405476Test; https://www.sciencedirect.com/science/article/pii/S0741832917306754?via%3DihubTest

الإتاحة: https://doi.org/10.1016/j.alcohol.2017.02.336Test
http://hdl.handle.net/11581/405476Test
https://www.sciencedirect.com/science/article/pii/S0741832917306754?via%3DihubTest