المؤلفون: Chu, David Z.J., Hussey, Michael A, Alberts, David S, Meyskens, Frank L, Fenoglio-Preiser, Cecilia M, Rivkin, Saul E, Mills, Glenn M, Giguere, Jeffrey K, Blanke, Charles D, Goodman, Gary E

المصدر: Clinical Colorectal Cancer. 10(4)

مصطلحات موضوعية: Calcium carbonate, Metachronous adenomas, Synchronous adenomascalcium carbonate, placebo, adenoma, adult, aged, allergy, article, cancer surgery, chemoprophylaxis, colonoscopy, colorectal cancer, constipation, controlled study, diarrhea, dyspnea, female, follow up, human, hypercalcemia, major clinical study, male, nausea, patient compliance, proteinuria, randomized controlled trial, side effect, tumor recurrence, weight gain

الوصف: Background: Colorectal cancer is common worldwide and chemoprevention has the potential of reducing the number of individuals who may suffer and perish from this disease. Methods: A randomized placebo controlled pilot study in colorectal cancer patients was performed using calcium carbonate as the test agent in a multi-institutional oncology study group. Results: Two hundred twenty volunteers were randomized in the study. The primary goals of compliance, accrual, and toxicity monitoring are presented. Presence of multiple adenomas at study entry and subsequent development of metachronous adenomas were recorded and found to be associated with synchronous adenomas. The secondary endpoint of recurrent adenomas indicated lower rates of new adenoma in the volunteers randomized to the calcium group. Conclusion: This pilot study indicates the feasibility of enrolling survivors of colorectal cancer as study volunteers in a colorectal neoplasm chemoprevention clinical trial and oral calcium continues to be a potentially effective drug in reducing colorectal adenomas. © 2011 Elsevier Inc. All rights reserved.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7sc831skTest

المؤلفون: Liu, M.C., Oxnard, G.R., Klein, E.A., Swanton, C., Seiden, M.V., Liu, Minetta C., Oxnard, Geoffrey R., Klein, Eric A., Smith, David, Richards, Donald, Yeatman, Timothy J., Cohn, Allen L., Lapham, Rosanna, Clement, Jessica, Parker, Alexander S., Tummala, Mohan K., McIntyre, Kristi, Sekeres, Mikkael A., Bryce, Alan H., Siegel, Robert, Wang, Xuezhong, Cosgrove, David P., Abu-Rustum, Nadeem R., Trent, Jonathan, Thiel, David D., Becerra, Carlos, Agrawal, Manish, Garbo, Lawrence E., Giguere, Jeffrey K., Michels, Ross M., Harris, Ronald P., Richey, Stephen L., McCarthy, Timothy A., Waterhouse, David M., Couch, Fergus J., Wilks, Sharon T., Krie, Amy K., Balaraman, Rama, Restrepo, Alvaro, Meshad, Michael W., Rieger-Christ, Kimberly, Sullivan, Travis, Lee, Christine M., Greenwald, Daniel R., Oh, William, Tsao, Che-Kai, Fleshner, Neil, Kennecke, Hagen F., Khalil, Maged F., Spigel, David R.

المساهمون: GRAIL, Inc, Princess Margaret Cancer Centre’s McCain GU BioBank, Francis Crick Institute, Cancer Research UK, UK Medical Research Council, Wellcome Trust, CRUK Lung Cancer Centre of Excellence, Rosetrees Trust, Breast Cancer Research Foundation

المصدر: Annals of Oncology ; volume 31, issue 6, page 745-759 ; ISSN 0923-7534

الإتاحة: https://doi.org/10.1016/j.annonc.2020.02.011Test
https://api.elsevier.com/content/article/PII:S0923753420360580?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753420360580?httpAccept=text/plainTest

المؤلفون: Chu, David Z J, Chansky, Kari, Alberts, David S, Meyskens, Frank L, Jr, Fenoglio-Preiser, Cecilia M, Rivkin, Saul E, Mills, Glenn M, Giguere, Jeffrey K, Goodman, Gary E, Abbruzzese, James L, Lippman, Scott M

المصدر: Annals of surgical oncology. 10(8)

مصطلحات موضوعية: Adenoma: pathology, prevention & control, surgery, Adult, Aged, Aged, 80 and over, Calcium Carbonate: therapeutic use, Chi-Square Distribution, Colonoscopy, Colorectal Neoplasms: pathology, prevention & control, surgery, Double-Blind Method, Female, Humans, Logistic Models, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Neoplasms, Multiple Primary, Pilot Projects, Prospective Studies, Adenoma, Adenoma recurrence rate, Colorectal cancer, Synchronous adenomacalcium carbonate, placebo, calcium carbonate, adult, age, aged, article, cancer localization, cancer prevention, cancer recurrence, cancer staging, cancer surgery, chemoprophylaxis, clinical trial, colon resection, colonoscopy, colorectal adenoma, colorectal carcinoma, controlled clinical trial, controlled study, double blind procedure, female, human, major clinical study, male, pilot study, polyp, sex, adenoma, chi square distribution, colorectal tumor, middle aged, multiple cancer, pathology, prospective study, randomized controlled trial, statistical model, tumor recurrence, Adenoma, Adult, Aged, Aged, 80 and over, Calcium Carbonate, Chi-Square Distribution, Colonoscopy, Colorectal Neoplasms, Double-Blind Method, Female, Humans, Logistic Models, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Neoplasms, Multiple Primary, Pilot Projects, Prospective Studies

الوصف: Colorectal adenomas are the usual precursors to carcinoma in sporadic and hereditary colorectal cancers (CRC).A total of 220 CRC patients (stages 0, I, and II) were randomized prospectively in a double-blind pilot study of calcium chemoprevention by using recurrent colorectal adenomas as a surrogate end point. This trial is still in progress, and we report the preliminary findings on adenoma recurrence rates.Synchronous adenomas were present in 60% of patients, and cancer confined in a polyp was present in 23% of patients. The overall cumulative adenoma recurrence rate was 31% (19% in the first year, 29% for 2 years, and 35% for 3 years). The recurrence rates were greater for patients with synchronous adenomas: 38% at 3 years (P =.01). Lower stage was associated with higher adenoma recurrence rates (P =.04). Factors including age, sex, site of primary cancer, and whether the cancer was confined to a polyp were not significantly associated with differences in adenoma recurrence rates.The substantial adenoma recurrence rate in patients resected of CRC justifies colonoscopic surveillance on a periodic basis. Patients with higher rates of adenoma recurrences, such as CRC with synchronous adenomas, are ideal subjects for chemoprevention trials.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/40z471qrTest

المؤلفون: Kamen, Charles S., Quinn, Gwendolyn P., Asare, Matthew, Heckler, Charles E., Guido, Joseph J., Giguere, Jeffrey K., Gilliland, Kari, Liu, Jane Jijun, Geer, Jodi, Delacroix, Scott E., Morrow, Gary R., Jacobsen, Paul B.

المساهمون: Division of Cancer Prevention, National Cancer Institute, National Cancer Institute

المصدر: Cancer ; volume 124, issue 23, page 4504-4511 ; ISSN 0008-543X 1097-0142

الوصف: Background Supporting patients’ decision making about clinical trials may enhance trial participation. To date, few theory‐based interventions have been tested to address this issue. The objective of the current study was aimed to evaluate the effect of a multimedia psychoeducation (MP) intervention, relative to a print education (PE) intervention, on patients’ decision support needs and attitudes about clinical trials. Methods Patients with cancer who were eligible for participation in a National Cancer Institute therapeutic cancer clinical trial were recruited through the nationwide University of Rochester Cancer Center National Cancer Institute Community Oncology Research Program from 2014 to 2016 and were randomized to the MP or PE intervention. Assessments at baseline (before intervention), postintervention, and at a 2‐month follow‐up visit included patients’ decision support needs, attitudes regarding clinical trials, and clinical trial participation. Results In total, 418 patients with various types of cancer were recruited (ages 26‐89 years). Relative to the PE intervention, the MP intervention did not significantly affect decision support needs. However, patients in the MP arm reported significantly more positive attitudes about clinical trials and were more likely to participate in a clinical trial than those in the PE arm (69% vs 62%; P = .01). Furthermore, an improvement in attitudes about clinical trials significantly mediated the effect of the intervention on participation in clinical trials. Conclusions The MP intervention was able to improve patient attitudes toward clinical trials compared with the PE intervention, and this improvement led to increased rates of participation in trials. The MP intervention could be disseminated to improve attitudes about clinical trials among patients with cancer.

الإتاحة: https://doi.org/10.1002/cncr.31771Test

المؤلفون: Lund, Jennifer L., Duberstein, Paul R., Loh, Kah Poh, Gilmore, Nikesha, Plumb, Sandy, Lei, Lianlian, Keil, Alexander P., Islam, Jessica Y., Hanson, Laura C., Giguere, Jeffrey K., Vogel, Victor G., Burnette, Brian L., Mohile, Supriya G.

المساهمون: Patient-Centered Outcomes Research Institute, University of Rochester Wilmot Cancer Institute, National Institute on Aging, National Cancer Institute

المصدر: Journal of Geriatric Oncology ; volume 13, issue 2, page 176-181 ; ISSN 1879-4068

مصطلحات موضوعية: Geriatrics and Gerontology, Oncology

الإتاحة: https://doi.org/10.1016/j.jgo.2021.08.009Test
https://api.elsevier.com/content/article/PII:S1879406821001971?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1879406821001971?httpAccept=text/plainTest

المؤلفون: Gilmore, Nikesha, Kadambi, Sindhuja, Lei, Lianlian, Loh, Kah Poh, Mohamed, Mostafa, Magnuson, Allison, Cole, Sharon, Esparaz, Benjamin T., Giguere, Jeffrey K., Mohile, Supriya, Janelsins, Michelle

المساهمون: National Cancer Institute

المصدر: Journal of Geriatric Oncology ; volume 11, issue 3, page 423-430 ; ISSN 1879-4068

مصطلحات موضوعية: Geriatrics and Gerontology, Oncology

الإتاحة: https://doi.org/10.1016/j.jgo.2019.04.001Test
https://api.elsevier.com/content/article/PII:S187940681830345X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S187940681830345X?httpAccept=text/plainTest

المؤلفون: Robert, Nicholas J., Saleh, Mansoor N., Paul, Devchand, Generali, Daniele, Gressot, Laurent, Copur, Mehmet S., Brufsky, Adam M., Minton, Susan E., Giguere, Jeffrey K., Smith, John W., Richards, Paul D., Gernhardt, Diana, Huang, Xin, Liau, Katherine F., Kern, Kenneth A., Davis, John

المساهمون: Pfizer, Acumed

المصدر: Clinical Breast Cancer ; volume 11, issue 2, page 82-92 ; ISSN 1526-8209

مصطلحات موضوعية: Cancer Research, Oncology

الإتاحة: https://doi.org/10.1016/j.clbc.2011.03.005Test
https://api.elsevier.com/content/article/PII:S1526820911000061?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1526820911000061?httpAccept=text/plainTest

المؤلفون: Devlin, Elise J., Whitford, Hayley S., Peoples, Anita R., Morrow, Gary R., Katragadda, Sreedhar, Giguere, Jeffrey K., Naqvi, Bilal, Roscoe, Joseph

المصدر: European Journal of Cancer Care; Nov2021, Vol. 30 Issue 6, p1-9, 9p

مصطلحات موضوعية: BREAST tumor treatment, STRUCTURAL equation modeling, STATISTICS, INFERENTIAL statistics, NAUSEA, CONFIDENCE intervals, SAMPLE size (Statistics), CANCER chemotherapy, DOXORUBICIN, MULTIVARIATE analysis, SELF-evaluation, REGRESSION analysis, GOODNESS-of-fit tests, SEVERITY of illness index, CANCER patients, DISEASE susceptibility, DESCRIPTIVE statistics, CHI-squared test, EPIRUBICIN, CISPLATIN, MOTION sickness, STATISTICAL correlation, OXALIPLATIN, PATH analysis (Statistics), DATA analysis software, WOMEN'S health, SECONDARY analysis

مستخلص: Objective: Chemotherapy‐induced nausea is challenging to predict and treat. Research indicates that pretreatment psychological variables including patients' perceptions of their susceptibility to nausea, expectancies of treatment‐related nausea and nausea history (i.e., motion sickness, morning sickness and baseline levels of nausea) may aid in predicting nausea severity during chemotherapy. However, this research is dated and limited in quantity. We investigated whether psychological variables could improve prediction of nausea severity to inform interventions targeting chemotherapy‐induced nausea. Methods: In this secondary analysis, a subgroup of women receiving chemotherapy (for the first time) for breast cancer completed pretreatment measures: perceived nausea susceptibility, nausea expectancies, nausea history and baseline nausea. They rated subsequent nausea severity across 4‐days, during treatment and posttreatment in a self‐report diary. Structural Equation Modelling was used to explore associations. Results: Across the women (N = 481), perceived nausea susceptibility predicted subsequent nausea severity (β = 0.16), but nausea expectancies did not (β = 0.05). Nausea history variables demonstrated small‐moderate associations with perceived susceptibility (β = 0.21–0.32) and negligible‐small associations with nausea expectancies (β = 0.07–0.14). Conclusion: Perceived nausea susceptibility appears to capture patients' nausea history, to a degree, and is related to nausea severity during treatment. This is an important variable to include in pretreatment prediction of patients at risk of severe nausea. [ABSTRACT FROM AUTHOR]

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المؤلفون: Hesketh, Paul J., McCoy, Jason, Dunphy, Frank R., Bearden, James D., Weiss, Geoffrey R., Giguere, Jeffrey K., Atkins, James N., Dakhil, Shaker R., Kelly, Karen, Crowley, John J., Gandara, David R.

المصدر: Journal of Thoracic Oncology ; volume 1, issue 9, page 991-995 ; ISSN 1556-0864

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Oncology

الإتاحة: https://doi.org/10.1016/s1556-0864Test(15)31632-4
https://api.elsevier.com/content/article/PII:S1556086415316324?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1556086415316324?httpAccept=text/plainTest

المؤلفون: Miller, Antonius A., Case, Doug, Atkins, James N., Giguere, Jeffrey K., Bearden, James D.

المصدر: Journal of Thoracic Oncology ; volume 1, issue 8, page 832-836 ; ISSN 1556-0864

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Oncology

الإتاحة: https://doi.org/10.1016/s1556-0864Test(15)30413-5
https://api.elsevier.com/content/article/PII:S1556086415304135?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1556086415304135?httpAccept=text/plainTest