المؤلفون: Mohanty, S, Trivedi, C, Della Rocca, D.G, Gianni, C, Salwan, A, Macdonald, B, Mayedo, A, Bassiouny, M, Gallinghouse, G.J, Burkhardt, J.D, Horton, R, Al-Ahmad, A, Di Biase, L.D, Natale, A

المصدر: European Heart Journal ; volume 41, issue Supplement_2 ; ISSN 0195-668X 1522-9645

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background Progression from paroxysmal (PAF) to persistent atrial fibrillation (PerAF) following effective PV isolation (PVI) has important clinical implications, as it is relevant for subsequent management of the arrhythmia. Objective We evaluated risk factors responsible for progression of PAF to PerAF following successful PVI. Methods Consecutive AF patients that received their first catheter ablation as well as the first redo at our center were identified (n=1352). Patients were included in group 1 if the diagnosis was PAF at both first and redo procedure (PAF to PAF) and group 2 if PAF at index progressed to PerAF at redo. All patients received PVI plus isolation of LA posterior wall and SVC at the first procedure. Results A total of 822 patients remained as PAF at redo, whereas 530 (39%) progressed from PAF to PerAF. Clinical characteristics of the study population are presented in table 1. In multivariate analysis, BMI (OR 1.02, 1.01–1.04, p=0.04), hypertension (1.4, 1.08–1.8, p=0.01), heart failure (1.67, 1.03–2.69, p=0.03), LA size (2.75, 2.29–3.31, p<0.001) were independent predictors of progression of PAF to PerAF. Data on serum-transthyretin level was available for 37 and 48 patients in group 1 and 2 respectively. It was <18 mg/dL (normal) in 33 (68.7%) patients in group 2 vs 6 (16.2%) in group 1 (p<0.001). Conclusion In our patients, after successful PVI, progression of PAF to PerAF was mediated by independent risk factors such as high BMI, heart failure, hypertension, larger LA size and lower LVEF. Funding Acknowledgement Type of funding source: None

الإتاحة: https://doi.org/10.1093/ehjci/ehaa946.0592Test
http://academic.oup.com/eurheartj/article-pdf/41/Supplement_2/ehaa946.0592/34518193/ehaa946.0592.pdfTest

المؤلفون: Gianni', C., Balsi, M., Esposito, S., Fallavollita, P.

المساهمون: Gianni', C., Balsi, M., Esposito, S., Fallavollita, P.

مصطلحات موضوعية: Data fusion, obstacle avoidance, UAV, information system, geography, planning and development

الوصف: Obstacle detection is a fundamental task for Unmanned Aerial Vehicles (UAV) as a part of a Sense and Avoid system. In this study, we present a method of multi-sensor obstacle detection that demonstrated good results on different kind of obstacles. This method can be implemented on low-cost platforms involving a DSP or small FPGA. In this paper, we also present a study on the typical targets that can be tough to detect because of their characteristics of reflectivity, form factor, heterogeneity and show how data fusion can often overcome the limitations of each technology.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000425670500019; ispartofbook:International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences - ISPRS Archives; 4th ISPRS International Conference on Unmanned Aerial Vehicles in Geomatics, UAV-g 2017; volume:42; issue:2W6; firstpage:127; lastpage:134; numberofpages:8; http://hdl.handle.net/11573/1015752Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85030219647; http://www.isprs.org/proceedings/XXXVIII/4-W15Test/

الإتاحة: https://doi.org/10.5194/isprs-archives-XLII-2-W6-127-2017Test
http://hdl.handle.net/11573/1015752Test
http://www.isprs.org/proceedings/XXXVIII/4-W15Test/

المؤلفون: Piervincenzi, C., Petsas, N., Viganò, A., Mancini, V., Mastria, G., Puma, M., Giannì, C., Di Piero, V., Pantano, P.

المصدر: Neurological sciences, vol. 44, no. 1, pp. 305-317

مصطلحات موضوعية: Humans, Alice in Wonderland Syndrome/diagnostic imaging, Alice in Wonderland Syndrome/etiology, Migraine Disorders/diagnosis, Cerebral Cortex, Magnetic Resonance Imaging, Alice in Wonderland syndrome (AIWS), Functional connectivity (FC), Migraine with aura (MA), Resting-state functional MRI

الوصف: Alice in Wonderland syndrome (AIWS) is a neurological disorder characterized by erroneous perception of the body schema or surrounding space. Migraine is the primary cause of AIWS in adults. The pathophysiology of AIWS is largely unknown, especially regarding functional abnormalities. In this study, we compared resting-state functional connectivity (FC) of migraine patients experiencing AIWS, migraine patients with typical aura (MA) and healthy controls (HCs). Twelve AIWS, 12 MA, and 24 HCs were enrolled and underwent 3 T MRI scanning. Independent component analysis was used to identify RSNs thought to be relevant for AIWS: visual, salience, basal ganglia, default mode, and executive control networks. Dual regression technique was used to detect between-group differences in RSNs. Finally, AIWS-specific FC alterations were correlated with clinical measures. With respect to HCs, AIWS and MA patients both showed significantly lower (p < 0.05, FDR corrected) FC in lateral and medial visual networks and higher FC in salience and default mode networks. AIWS patients alone showed higher FC in basal ganglia and executive control networks than HCs. When directly compared, AIWS patients showed lower FC in visual networks and higher FC in all other investigated RSNs than MA patients. Lastly, AIWS-specific FC alterations in the executive control network positively correlated with migraine frequency. AIWS and MA patients showed similar FC alterations in several RSNs, although to a different extent, suggesting common pathophysiological underpinnings. However, AIWS patients showed additional FC alterations, likely due to the complexity of AIWS symptoms involving high-order associative cortical areas.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36114397; info:eu-repo/semantics/altIdentifier/eissn/1590-3478; https://serval.unil.ch/notice/serval:BIB_C1C800585A5DTest; urn:issn:1590-1874

الإتاحة: https://doi.org/10.1007/s10072-022-06404-1Test
https://serval.unil.ch/notice/serval:BIB_C1C800585A5DTest

المؤلفون: Mohanty, S, Della Rocca, D G, Chierchia, G B, Dello Russo, A, Casella, M, Gianni, C A R O L A, Macdonald, B, Mayedo, A, La Fazia, V M, Torlapati, P G, Bassiouny, M, Gallinghouse, G J, Horton, R, De Asmundis, C, Natale, A N D R E A

المصدر: European Heart Journal ; volume 44, issue Supplement_2 ; ISSN 0195-668X 1522-9645

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Introduction Studies have reported development of stiff LA syndrome, defined as pulmonary hypertension (PH) secondary to reduced LA compliance, in some patients following AF ablation. Purpose We compared the risk of worsening of baseline PH in non-paroxysmal AF (persistent and long-standing persistent AF) patients undergoing repeat procedures, either pulse-field ablation (PFA) or standard radiofrequency ablation (RFA). Methods This multicenter study included 28 non-paroxysmal AF patients with PH, undergoing PFA-based ablation procedure after >1 failed radiofrequency ablations (RFA). A cohort of 28 AF patients with PH that were scheduled for repeat RF ablation were identified. Propensity scores were computed using multivariate logistic model. Twenty-eight patients from the RFA cohort were selected by 1:1 propensity score matching with the PFA group. Right heart catheterization was performed pre- and post-procedure to assess the Pulmonary artery pressure (PAP). PH was defined as resting mean PAP of ≥20 mmHg. The follow-up PAP and change from baseline were compared between PFA and RFA groups, after controlling for baseline PAP in an ANCOVA model. Results Baseline characteristics of PFA (age 62.21 ± 9.3 yrs, male 19 (67.9%), LAD 3.7 ± 0.66 cm) and propensity-matched RF groups (age 62.39 ± 9.3 yrs, male 18 (64.3%), LAD 3.7 ± 0.74 cm) were comparable. The mean pulmonary artery pressure (PAP) assessments at baseline, follow-up and change from baseline are presented in table below. The groups had comparable baseline PAP (p= 0.157). At follow-up, RF group reported 19.81 mm Hg increase in PAP (within-group p <0.001). In PFA group, follow-up PAP showed a decreasing trend (-1.67 mm Hg, within-group p= 0.114). Compared to PFA, the change was significantly higher in RFA (p <0.0001) after controlling for baseline PAP). Conclusion In this propensity-matched population, pulse-field ablation was demonstrated to be a safer option in terms of post-ablation worsening of PAP, compared to the RF ablation ...

الإتاحة: https://doi.org/10.1093/eurheartj/ehad655.372Test
https://academic.oup.com/eurheartj/article-pdf/44/Supplement_2/ehad655.372/53591129/ehad655.372.pdfTest

المؤلفون: La Fazia, V, Gianni, C, Pierucci, N, Della Rocca, D G, Mohanty, S, Macdonald, B, Mayedo, A, Torlapati, G, Bassiouny, M, Al-Ahmad, A, Gallinghouse, G J, Burkhardt, J D, Horton, R, Di Biase, L, Natale, A

المصدر: European Heart Journal ; volume 44, issue Supplement_2 ; ISSN 0195-668X 1522-9645

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background Incomplete left atrial appendage (LAA) occlusion due to residual leaks may occur after percutaneous closure procedure with Watchman FLX. Before release of device PASS (position, anchor, size and seal) criteria must be verified. Optimal compression rate for watchman FLX device is between 10-30% according to company recommendations. Purpose The aim of this study is to evaluate the correlation between compression rate and leak presence after left atrial appendage closure. Methods This is an observational retrospective study including patients that underwent LAA closure under transesophageal echocardiography (TEE) with at least one follow-up where complete LAA closure was assessed by TEE in our center between January 2021 and August 2022. TEE images were reviewed by the first author. Compression rate was calculated based on intraprocedural TEE images using the following formula: (original device size—size after deployment)/original device size*100. Patients were divided into 2 groups based on the compression rate: group 1: 10-30%; group 2: >30%. The rate of leak between groups was compared using the Chi-square test. Results 203 patients (mean age 79± 8 years) were included in the study. The implanted device size was 20 mm in 7 (3.4%), 24 mm in 30 (14.8%), 27 mm in 49 (24.1%), 31 mm in 75 (36.9%) and 35 mm in 42 (20.7%) patients. Based on the compression rate, patients were classified into group 1: >30% [n=37 (18.2%)] and group 2: ≤30% [n=166 (81.8%)]. Mean compression rate was 38.5% and 21.3% in group 1 and 2 respectively. At follow-up TEE, 1 (2.7%) patient in group 1 and 32 (19.3%) patients in group 2 were found to have a residual leak of >1 mm. When comparing leaks between the two groups, there was 1 leak in group 1 whereas in group 2 there were 32 leaks (1/37 vs 32/166, p value 0.01, RR 0.14, 95% CI, 0.02-0.74). Conclusion Devices with compression rate ≤30% were associated with significantly higher risk of residual leak.

الإتاحة: https://doi.org/10.1093/eurheartj/ehad655.557Test
https://academic.oup.com/eurheartj/article-pdf/44/Supplement_2/ehad655.557/53602149/ehad655.557.pdfTest

المؤلفون: Mohanty, S, La Fazia, V M, Torlapati, P G, Gianni, C A R O L A, Macdonald, B, Mayedo, A, Della Rocca, D G, Bassiouny, M, Gallinghouse, G J, Burkhardt, J D, Horton, R, Al-Ahmad, A, Di Biase, L, Natale, A N D R E A

المصدر: European Heart Journal ; volume 44, issue Supplement_2 ; ISSN 0195-668X 1522-9645

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Introduction Having a common embryologic origin with the pulmonary veins (PVs), left atrial posterior wall (LAPW) is considered to be a source of non-PV triggers that facilitate maintenance of atrial fibrillation (AF). However, the benefits of electrical isolation of the posterior wall (PWI) is still debated with contradictory data originating from different ablation approaches. Purpose We report the distribution of triggers in the LAPW area in AF patients undergoing repeat ablation. Methods Consecutive AF patients undergoing catheter ablation between 2015 and 2022 were included in this analysis. PVs were isolated first. Next, high-dose isoproterenol challenge (up to 30µg/min) was used to disclose triggers in the PW by moving the circular mapping catheter along the PW down to the level of coronary sinus, which were targeted using additional RF energy. We defined lower part of LAPW as the area between the line joining the inferior borders of the inferior PV-encircling lesions and the coronary sinus. The endpoint was to achieve electrical isolation, as documented by absence of any electrical activity in the PW. Results Of the 10,963 AF ablations performed during the specified time period, 6249 (57%) had triggers mapped and ablated in the LAPW area. Triggers were seen to be originating from the part of the PW between the PVs in 4124 (66%) and from the lower part of the PW in 2125 (34%) patients. Of these, 1624 (26%) patients had focal triggers detected in both the area between the PVs and the lower PW. All triggers from in between PVs were targeted for ablation, whereas lower PW sites were ablated in 1296 (61%) and not targeted for ablation the remaining 829 (39%). Figure 1 demonstrates the triggers arising from lower PW. At 1 year, amongst patients with lower PW triggers, 1049/1296 (81%) vs 326/829 (39.3%) (p<0.001) were arrhythmia-free. Conclusion Ectopic triggers in the LAPW were documented to be arising from the lower part of the PW in approximately 1/3rd of cases and ablation of those sites ...

الإتاحة: https://doi.org/10.1093/eurheartj/ehad655.374Test
https://academic.oup.com/eurheartj/article-pdf/44/Supplement_2/ehad655.374/53591124/ehad655.374.pdfTest

المؤلفون: La Fazia, V, Gianni, C, Pierucci, N, Della Rocca, D G, Mohanty, S, Torlapati, G, Al-Ahmad, A, Bassiouny, M, Gallinghouse, G J, Horton, R, Burkhardt, J D, Lakkireddy, D, Forleo, G B, Di Biase, L, Natale, A

المصدر: European Heart Journal ; volume 44, issue Supplement_2 ; ISSN 0195-668X 1522-9645

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background Tricuspid regurgitation (TR) has been reported as a complication of transvenous pacemaker lead implantation. However, the potential risk of TR is not known in case of leadless devices. Purpose We describe a case series of moderate to severe TR following implantation of the leadless Micra device. Methods We performed a multicenter (n=6) cross-sectional survey across the United States and Italy. Patient data were obtained by chart review and only patients with baseline and follow-up echo Doppler data were included in this analysis. All images were reviewed by the first author. Results A total of 158 patients receiving Micra implant were screened of which 6 (3.8%) cases of moderate to severe TR were identified by the Doppler echo. The most common presenting symptom were shortness of breath (6/6, 100%) and fatigue (5/6, 83.3%). Prominent jugular venous pulsation was observed in 1/6 (16.7%) patients indicating severe TR. Median time to development of symptoms and detection of TR was 9±3 months. None of the 6 patients developed symptoms immediately after the procedure. Figure 1 illustrates severe TR in one of the six patients included in the study (off axis view). Conclusion In this small series, we observed new-onset moderate-severe TR following implantation of leadless device in approximately 4% of patients. Whether this is related to the positioning of the device, needs to be ascertained by future studies.Severe TR after Micra implant

الإتاحة: https://doi.org/10.1093/eurheartj/ehad655.703Test
https://academic.oup.com/eurheartj/article-pdf/44/Supplement_2/ehad655.703/53600521/ehad655.703.pdfTest

المؤلفون: Magnocavallo M., Vetta G., Della Rocca D. G., Gianni C., Mohanty S., Bassiouny M., Di Lullo L., Del Prete A., Cirone D., Lavalle C., Chimenti C., Al-Ahmad A., Burkhardt J. D., Gallinghouse G. J., Sanchez J. E., Horton R. P., Di Biase L., Natale A.

المساهمون: Magnocavallo, M., Vetta, G., Della Rocca, D. G., Gianni, C., Mohanty, S., Bassiouny, M., Di Lullo, L., Del Prete, A., Cirone, D., Lavalle, C., Chimenti, C., Al-Ahmad, A., Burkhardt, J. D., Gallinghouse, G. J., Sanchez, J. E., Horton, R. P., Di Biase, L., Natale, A.

مصطلحات موضوعية: COVID-19, supraventricular arrhythmia, atrial fibrillation, catheter ablation, atrial flutter, rhythm control

الوصف: COVID-19 mainly affects the respiratory system but has been correlated with cardiovascular manifestations such as myocarditis, heart failure, acute coronary syndromes, and arrhythmias. Cardiac arrhythmias are the second most frequent complication affecting about 30% of patients. Several mechanisms may lead to an increased risk of cardiac arrhythmias during COVID-19 infection, ranging from direct myocardial damage to extracardiac involvement. The aim of this review is to describe the role of COVID-19 in the pathogenesis of cardiac arrhythmias and provide a comprehensive guidance for their monitoring and management.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35221076; volume:14; issue:1; firstpage:1; lastpage:9; numberofpages:9; journal:CARDIAC ELECTROPHYSIOLOGY CLINICS; https://hdl.handle.net/11573/1634468Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85123385069

الإتاحة: https://doi.org/10.1016/j.ccep.2021.10.001Test
https://hdl.handle.net/11573/1634468Test

المؤلفون: Conteduca V., Scarpi E., Wetterskog D., Brighi N., Ferroni F., Rossi A., Romanel A., Gurioli G., Bleve S., Gianni C., Schepisi G., Lolli C., Cortesi P., Matteucci F., Barone D., Paganelli G., Demichelis F., Beltran H., Attard G., De Giorgi U.

المساهمون: Conteduca, V., Scarpi, E., Wetterskog, D., Brighi, N., Ferroni, F., Rossi, A., Romanel, A., Gurioli, G., Bleve, S., Gianni, C., Schepisi, G., Lolli, C., Cortesi, P., Matteucci, F., Barone, D., Paganelli, G., Demichelis, F., Beltran, H., Attard, G., De Giorgi, U.

مصطلحات موضوعية: AR-directed signaling inhibitor, biomarker, metastatic castration-resistant prostate cancer, plasma tumor DNA, venous thromboembolism

الوصف: Cancer is a risk factor for venous thromboembolism (VTE). Plasma tumor DNA (ptDNA) is an independent predictor of outcome in metastatic castration-resistant prostate cancer (mCRPC). We aimed to investigate the association between ptDNA and VTE in mCRPC. This prospective biomarker study included 180 mCRPC patients treated with abiraterone and enzalutamide from April 2013 to December 2018. We excluded patients with a previous VTE history and/or ongoing anticoagulation therapy. Targeted next-generation sequencing was performed to determine ptDNA fraction from pretreatment plasma samples. VTE risk based on survival analysis was performed using cumulative incidence function and estimating sub-distributional hazard ratio (SHR). At a median follow-up of 58 months (range 0.5-111.0), we observed 21 patients who experienced VTE with a cumulative incidence at 12 months of 17.1% (95% confidence interval [CI] 10.3-23.9). Elevated ptDNA, visceral metastasis, prior chemotherapy and lactate dehydrogenase (LDH) were significantly associated with higher VTE incidence compared to patients with no thrombosis (12-month estimate, 18.6% vs 3.5%, P =.0003; 44.4% vs 14.8%, P =.015; 24.7% vs 4.5%, P =.006; and 30.0% vs 13.5%, P =.05, respectively). In the multivariate analysis including ptDNA level, visceral metastases, number of lesions and serum LDH, high ptDNA fraction was the only independent factor associated with the risk of thrombosis (HR 5.78, 95% CI 1.63-20.44, P =.006). These results first suggest that baseline ptDNA fraction in mCRPC patients treated with abiraterone or enzalutamide may be associated with increased VTE risk. These patients may be followed-up more closely for the VTE risk, and the need for a primary thromboprophylaxis should be taken into account in mCRPC with elevated ptDNA.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34605002; info:eu-repo/semantics/altIdentifier/wos/WOS:000706794700001; volume:150; issue:7; firstpage:1166; lastpage:1173; numberofpages:8; journal:INTERNATIONAL JOURNAL OF CANCER; http://hdl.handle.net/11392/2472686Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85117089336

الإتاحة: https://doi.org/10.1002/ijc.33834Test
http://hdl.handle.net/11392/2472686Test

المؤلفون: Tommasin S, Iakovleva V, Rocca MA, Giannì C, Tedeschi G, De Stefano N, Pozzilli C, Filippi M, Pantano P, INNI network, BISECCO, Alvino

المساهمون: Tommasin, S, Iakovleva, V, Rocca, Ma, Giannì, C, Tedeschi, G, De Stefano, N, Pozzilli, C, Filippi, M, Pantano, P, Inni, Network, Bisecco, Alvino

العلاقة: journal:EUROPEAN JOURNAL OF NEUROLOGY; http://hdl.handle.net/11591/467641Test

الإتاحة: http://hdl.handle.net/11591/467641Test