المؤلفون: Giacomo Aringhieri, Gianfranco Di Salle, Silvia Catanese, Caterina Vivaldi, Francesca Salani, Saverio Vitali, Miriam Caccese, Enrico Vasile, Virginia Genovesi, Lorenzo Fornaro, Rachele Tintori, Francesco Balducci, Carla Cappelli, Dania Cioni, Gianluca Masi, Emanuele Neri

المصدر: Cancers, Vol 15, Iss 22, p 5391 (2023)

مصطلحات موضوعية: stomach neoplasms, tomography, X-ray computed, body composition, sarcopenia, disease-free survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Prognosis in advanced gastric cancer (aGC) is predicted by clinical factors, such as stage, performance status, metastasis location, and the neutrophil-to-lymphocyte ratio. However, the role of body composition and sarcopenia in aGC survival remains debated. This study aimed to evaluate how abdominal visceral and subcutaneous fat volumes, psoas muscle volume, and the visceral-to-subcutaneous (VF/SF) volume ratio impact overall survival (OS) and progression-free survival (PFS) in aGC patients receiving first-line palliative chemotherapy. We retrospectively examined CT scans of 65 aGC patients, quantifying body composition parameters (BCPs) in 2D and 3D. Normalized 3D BCP volumes were determined, and the VF/SF ratio was computed. Survival outcomes were analyzed using the Cox Proportional Hazard model between the upper and lower halves of the distribution. Additionally, response to first-line chemotherapy was compared using the χ2 test. Patients with a higher VF/SF ratio (N = 33) exhibited significantly poorer OS (p = 0.02) and PFS (p < 0.005) and had a less favorable response to first-line chemotherapy (p = 0.033), with a lower Disease Control Rate (p = 0.016). Notably, absolute BCP measures and sarcopenia did not predict survival. In conclusion, radiologically assessed VF/SF volume ratio emerged as a robust and independent predictor of both survival and treatment response in aGC patients.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2072-6694/15/22/5391Test; https://doaj.org/toc/2072-6694Test

الوصول الحر: https://doaj.org/article/84d17467d4b54c6d936971bb87ef75a3Test

المؤلفون: Salvatore C. Fanni, Maria Febi, Leonardo Colligiani, Federica Volpi, Ilaria Ambrosini, Lorenzo Tumminello, Gayane Aghakhanyan, Giacomo Aringhieri, Dania Cioni, Emanuele Neri

المصدر: Frontiers in Radiology, Vol 3 (2023)

مصطلحات موضوعية: testicular imaging, radiomics, radiomics quality score, germ cell tumors, seminoma, nonseminoma, Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: The aim of this systematic review was to evaluate the state of the art of radiomics in testicular imaging by assessing the quality of radiomic workflow using the Radiomics Quality Score (RQS) and the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). A systematic literature search was performed to find potentially relevant articles on the applications of radiomics in testicular imaging, and 6 final articles were extracted. The mean RQS was 11,33 ± 3,88 resulting in a percentage of 31,48% ± 10,78%. Regarding QUADAS-2 criteria, no relevant biases were found in the included papers in the patient selection, index test, reference standard criteria and flow-and-timing domain. In conclusion, despite the publication of promising studies, radiomic research on testicular imaging is in its very beginning and still hindered by methodological limitations, and the potential applications of radiomics for this field are still largely unexplored.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fradi.2023.1141499/fullTest; https://doaj.org/toc/2673-8740Test

الوصول الحر: https://doaj.org/article/a7f4305712ca4878b55386ed784bdac0Test

المؤلفون: Giovanni Fulvio, Rossana Izzetti, Giacomo Aringhieri, Valentina Donati, Francesco Ferro, Giovanna Gabbriellini, Marta Mosca, Chiara Baldini

المصدر: Diagnostics, Vol 13, Iss 17, p 2771 (2023)

مصطلحات موضوعية: ultra-high frequency ultrasound, Sjögren’s disease (SjD), exocrine glands, lacrimal glands, labial salivary glands, minor salivary glands, Medicine (General), R5-920

الوصف: Sjögren’s Disease (SjD) is a chronic autoimmune disorder that affects the salivary and lacrimal glands, leading to xerostomia and xerophthalmia. Ultrasonography of Major Salivary Glands (SGUS) is a well-established tool for the identification of the salivary glands’ abnormalities in SjD. Recently, a growing interest has arisen in the assessment of the other exocrine glands with ultrasonography: lacrimal glands (LGUS) and labial salivary glands (LSGUS). The objective of this study is to explore the practical applications of ultra-high frequency ultrasound (UHFUS) in the assessment of lacrimal glands and labial salivary glands. Indeed, UHFUS, with its improved spatial resolution compared to conventional ultrasonography, allows for the evaluation of microscopic structures and has been successfully applied in various medical fields. In lacrimal glands, conventional high-frequency ultrasound (HFUS) can detect characteristic inflammatory changes, atrophic alterations, blood flow patterns, and neoplastic lesions associated with SjD. However, sometimes it is challenging to identify lacrimal glands characteristics, thus making UHFUS a promising tool. Regarding labial salivary glands, limited research is available with conventional HFUS, but UHFUS proves to be a good tool to evaluate glandular inhomogeneity and to guide labial salivary glands biopsy. The comprehensive understanding of organ involvement facilitated by UHFUS may significantly improve the management of SjD patients.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2075-4418/13/17/2771Test; https://doaj.org/toc/2075-4418Test

الوصول الحر: https://doaj.org/article/3555d26ac5e94480818eb6ca61026b82Test

المؤلفون: Ana Sofia Linhares Moreira, Vera Ribeiro, Giacomo Aringhieri, Salvatore Claudio Fanni, Lorenzo Tumminello, Lorenzo Faggioni, Dania Cioni, Emanuele Neri

المصدر: Journal of Personalized Medicine, Vol 13, Iss 5, p 728 (2023)

مصطلحات موضوعية: endometrial cancer, magnetic resonance imaging, diffusion-weighted imaging, apparent diffusion coefficient, dynamic contrast-enhanced magnetic resonance imaging, staging, Medicine

الوصف: Purpose: To assess the ability of apparent diffusion coefficient (ADC) measurements in predicting the histological grade of endometrial cancer. A secondary goal was to assess the agreement between MRI and surgical staging as an accurate measurement. Methods: Patients with endometrial cancers diagnosed between 2018–2020 and having received both MRI and surgical staging were retrospectively enrolled. Patients were characterized according to histology, tumor size, FIGO stage (MRI and surgical stage), and functional MRI parameters (DCE and DWI/ADC). Statistical analysis was performed to determine if an association could be identified between ADC variables and histology grade. Secondarily, we assessed the degree of agreement between the MRI and surgical stages according to the FIGO classification. Results: The cohort included 45 women with endometrial cancer. Quantitative analysis of ADC variables did not find a statistically significant association with histological tumor grades. DCE showed higher sensitivity than DWI/ADC in the assessment of myometrial invasion (85.00% versus 65.00%) with the same specificity (80.00%). A good agreement between MRI and histopathology for the FIGO stage was found (kappa of 0.72, p < 0.01). Differences in staging between MRI and surgery were detected in eight cases, which could not be justified by the interval between MRI and surgery. Conclusions. ADC values were not useful for predicting endometrial cancer grade, despite the good agreement between MRI interpretation and histopathology of endometrial cancer staging at our center.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2075-4426/13/5/728Test; https://doaj.org/toc/2075-4426Test

الوصول الحر: https://doaj.org/article/023961ff515a4158b5fbb93a7b981057Test

المؤلفون: Marco Di Battista, Simone Barsotti, Saverio Vitali, Marco Palma, Giammarco Granieri, Teresa Oranges, Giacomo Aringhieri, Valentina Dini, Alessandra Della Rossa, Emanuele Neri, Marco Romanelli, Marta Mosca

المصدر: Diagnostics, Vol 13, Iss 8, p 1495 (2023)

مصطلحات موضوعية: systemic sclerosis, ultra-high frequency ultrasound, durometry, skin score, skin imaging, skin fibrosis, Medicine (General), R5-920

الوصف: Background: To assess skin involvement in a cohort of patients with systemic sclerosis (SSc) by comparing results obtained from modified Rodnan skin score (mRSS), durometry and ultra-high frequency ultrasound (UHFUS). Methods: SSc patients were enrolled along with healthy controls (HC), assessing disease-specific characteristics. Five regions of interest were investigated in the non-dominant upper limb. Each patient underwent a rheumatological evaluation of the mRSS, dermatological measurement with a durometer, and radiological UHFUS assessment with a 70 MHz probe calculating the mean grayscale value (MGV). Results: Forty-seven SSc patients (87.2% female, mean age 56.4 years) and 15 HC comparable for age and sex were enrolled. Durometry showed a positive correlation with mRSS in most regions of interest (p = 0.025, ρ = 0.34 in mean). When performing UHFUS, SSc patients had a significantly thicker epidermal layer (p < 0.001) and lower epidermal MGV (p = 0.01) than HC in almost all the different regions of interest. Lower values of dermal MGV were found at the distal and intermediate phalanx (p < 0.01). No relationships were found between UHFUS results either with mRSS or durometry. Conclusions: UHFUS is an emergent tool for skin assessment in SSc, showing significant alterations concerning skin thickness and echogenicity when compared with HC. The lack of correlations between UHFUS and both mRSS and durometry suggests that these are not equivalent techniques but may represent complementary methods for a full non-invasive skin evaluation in SSc.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2075-4418/13/8/1495Test; https://doaj.org/toc/2075-4418Test

الوصول الحر: https://doaj.org/article/ac82d9d4680a46eea24585b3b5d303dcTest

المؤلفون: Dania Cioni, Michela Gabelloni, Andrea Sanguinetti, Laura De Rosa, Giacomo Aringhieri, Rachele Tintori, Gianvito Candita, Maria Febi, Francesco Faita, Riccardo Lencioni, Emanuele Neri

المصدر: Frontiers in Oncology, Vol 12 (2022)

مصطلحات موضوعية: SteatoScore, non-alcoholic fatty liver disease, ultrasound, computed tomography, oncology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: PurposeThe aims of this study were to evaluate the reproducibility of a new multi-parametric steatoscore (new SteatoScore) in oncologic patients with non-alcoholic fatty liver disease (NAFLD) and to compare it with computed tomography (CT).Materials and MethodsFifty-one (31 men, 20 women) oncologic patients, with a mean age and weight of 63.9 years and 78.33 kg, respectively, were retrospectively enrolled in the study. Patients underwent ultrasound (US) and computed tomography (CT) examinations as part of their oncologic follow-up protocol. US examinations were performed by using a 3.5-MHz convex probe. During the US examination, three standardized clips were obtained in each patient. Two operators performed all measurements, one of whom repeated the processing twice in 1 year. Hepatic/renal ratio (HR), attenuation rate (AR), diaphragm visualization (DV), hepatic/portal vein ratio (HPV), and portal vein wall visualization (PVW) were acquired and calculated by using Matlab and inserted in a multi-parametric algorithm called new SteatoScore. On unenhanced CT scan, hepatic attenuation (HA), liver-spleen difference (L-S), and liver/spleen ratio (L/S) were measured by placement of a region of interest (ROI) within liver and spleen parenchyma, avoiding areas with vessels and biliary ducts.ResultsThe intra-observer variability was greater than the inter-observer one, with intraclass correlation coefficient (ICC) values of 0.94 and 0.97, respectively. Correlation between single US and CT parameters provided an agreement in no case exceeding 50%. New SteatoScore showed high reproducibility, and high coefficient of correlation with L-S (R = −0.64; p < 0.0001) and L/S (R = −0.62; p < 0.0001) at CT.ConclusionNew SteatoScore has a high reproducibility and shows a good correlation with unenhanced CT in evaluation of oncologic patients with NAFLD.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2022.873524/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/691e780e1f004e6cb719ec28aed550c8Test

المؤلفون: Giacomo Aringhieri, Salvatore Claudio Fanni, Maria Febi, Leonardo Colligiani, Dania Cioni, Emanuele Neri

المصدر: Diagnostics, Vol 12, Iss 12, p 3002 (2022)

مصطلحات موضوعية: radiomics, salivary glands, radiomics quality score, parotid, submandibular, sialadenitis, Medicine (General), R5-920

الوصف: Background: Radiomics of salivary gland imaging can support clinical decisions in different clinical scenarios, such as tumors, radiation-induced xerostomia and sialadenitis. This review aims to evaluate the methodological quality of radiomics studies on salivary gland imaging. Material and Methods: A systematic search was performed, and the methodological quality was evaluated using the radiomics quality score (RQS). Subgroup analyses according to the first author’s professional role (medical or not medical), journal type (radiological journal or other) and the year of publication (2021 or before) were performed. The correlation of RQS with the number of patients was calculated. Results: Twenty-three articles were included (mean RQS 11.34 ± 3.68). Most studies well-documented the imaging protocol (87%), while neither prospective validations nor cost-effectiveness analyses were performed. None of the included studies provided open-source data. A statistically significant difference in RQS according to the year of publication was found (p = 0.009), with papers published in 2021 having slightly higher RQSs than older ones. No differences according to journal type or the first author’s professional role were demonstrated. A moderate relationship between the overall RQS and the number of patients was found. Conclusions: Radiomics application in salivary gland imaging is increasing. Although its current clinical applicability can be affected by the somewhat inadequate quality of the papers, a significant improvement in radiomics methodologies has been demonstrated in the last year.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2075-4418/12/12/3002Test; https://doaj.org/toc/2075-4418Test

الوصول الحر: https://doaj.org/article/14a5f3fbd1a34c6f9fd4f977159b1867Test

المؤلفون: Giovanni Donato Aquaro, Carmelo De Gori, Lorenzo Faggioni, Maria Luisa Parisella, Giacomo Aringhieri, Dania Cioni, Riccardo Lencioni, Emanuele Neri

المصدر: Diagnostics, Vol 12, Iss 11, p 2652 (2022)

مصطلحات موضوعية: Fabry disease, cardiac magnetic resonance, T1 mapping, late gadolinium enhancement, feature tracking, Medicine (General), R5-920

الوصف: Fabry disease (FD) is an X-linked inheritable storage disease caused by a deficiency of alpha-galactosidase causing lysosomal overload of sphingolipids. FD cardiomyopathy is characterized by left ventricular (LV) hypertrophy and should be considered in differential diagnosis with all the other causes of LV hypertrophy. An early diagnosis of FD is very important because the enzyme replacement therapy (ERT) may change the fate of patients by blocking both cardiac and systemic involvement and improving prognosis. Diagnosis may be relatively easy in young patients with the typical signs and symptoms of FD, but in male patients with late onset of disease and in females, diagnosis may be very challenging. Morphological and functional aspects are not specific to FD, which cannot be diagnosed or excluded by echocardiography. Cardiac magnetic resonance (CMR) with tissue characterization capability is an accurate technique for the differential diagnosis of LV hypertrophy. The finding of decreased myocardial T1 value in LV hypertrophy is specific to FD. Late gadolinium enhancement (LGE) is found in the late stage of the disease, but it is useful to predict the cardiac response to ERT and to stratify the prognosis.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2075-4418/12/11/2652Test; https://doaj.org/toc/2075-4418Test

الوصول الحر: https://doaj.org/article/8e9a4b7741ba4969af56bae0233b4620Test

المؤلفون: Rosa Cervelli, Matteo Cencini, Guido Buonincontri, Francesco Campana, Andrea Cacciato Insilla, Giacomo Aringhieri, Paolo De Simone, Ugo Boggi, Daniela Campani, Michela Tosetti, Laura Crocetti

المصدر: European Radiology Experimental, Vol 4, Iss 1, Pp 1-10 (2020)

مصطلحات موضوعية: Liver cirrhosis, Liver steatosis, Liver transplantation, Magnetic resonance imaging, Pancreatic neoplasms, Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: Abstract The study focuses on radiological-pathological correlation between imaging of ex vivo samples obtained by a 7-T scanner and histological examination. The specimens will be derived from native explanted cirrhotic livers, liver grafts excluded from donation because of severe steatosis, and primary pancreatic tumours. Magnetic resonance imaging (MRI) examinations will be performed within 24 h from liver or pancreatic lesion surgical removal. The MRI protocol will include morphological sequences, quantitative T1, T2, and fat-, water-fraction maps with Cartesian k-space acquisition, and multiparametric methods based on a transient-state “MRI fingerprinting”. Finally, the specimen will be fixed by formalin. Qualitative imaging analysis will be performed by two independent blinded radiologists to assess image consistency score. Quantitative analysis will be performed by drawing regions of interest on different tissue zones to measure T1 and T2 relaxation times as well as fat- and water-fraction. The same tissue areas will be analysed by the pathologists. This study will provide the possibility to improve our knowledge about qualitative and quantitative abdominal imaging assessment at 7 T, by correlating imaging characteristics and the corresponding histological composition of ex vivo specimens, in order to identify imaging biomarkers. Trial registration: ClinicalTrials.gov : 13646. Registered 9 July 2019—retrospectively registered

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s41747-020-00185-yTest; https://doaj.org/toc/2509-9280Test

الوصول الحر: https://doaj.org/article/cbb3e4c714e84f1288881ef64f028614Test

المؤلفون: Giacomo Aringhieri, Virna Zampa, Michela Tosetti

المصدر: European Radiology Experimental, Vol 4, Iss 1, Pp 1-14 (2020)

مصطلحات موضوعية: Cartilage (articular), Magnetic resonance imaging, Magnetic resonance spectroscopy, Musculoskeletal system, Ultra-high field magnetic resonance imaging, Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: Abstract Ultra-high field magnetic resonance imaging (UHF-MRI) provides important diagnostic improvements in musculoskeletal imaging. The higher signal-to-noise ratio leads to higher spatial and temporal resolution which results in improved anatomic detail and higher diagnostic confidence. Several methods, such as T2, T2*, T1rho mapping, delayed gadolinium-enhanced, diffusion, chemical exchange saturation transfer, and magnetisation transfer techniques, permit a better tissue characterisation. Furthermore, UHF-MRI enables in vivo measurements by low-γ nuclei (23Na, 31P, 13C, and 39K) and the evaluation of different tissue metabolic pathways. European Union and Food and Drug Administration approvals for clinical imaging at UHF have been the first step towards a more routinely use of this technology, but some drawbacks are still present limiting its widespread clinical application. This review aims to provide a clinically oriented overview about the application of UHF-MRI in the different anatomical districts and tissues of musculoskeletal system and its pros and cons. Further studies are needed to consolidate the added value of the use of UHF-MRI in the routine clinical practice and promising efforts in technology development are already in progress.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s41747-020-00174-1Test; https://doaj.org/toc/2509-9280Test

الوصول الحر: https://doaj.org/article/c5518ee27e1d4e21966aa8e30e42552dTest