المؤلفون: Ansari, Shakila, Mohammadifard, Noushin, Hajihashemi, Parisa, Haghighatdoost, Fahimeh, Zarepur, Ehsan, Mahmoudi, Shirin, Nouri, Fatemeh, Nouhi, Fereydoon, Kazemi, Tooba, Salehi, Nahid, Solati, Kamal, Ghaffari, Samad, Gholipour, Mahboobeh, Dehghani, Mostafa, Cheraghi, Mostafa, Heybar, Habib, Alikhasi, Hassan, Sarrafzadegan, Nizal

المساهمون: Isfahan University of Medical Sciences

المصدر: Food Science & Nutrition ; ISSN 2048-7177 2048-7177

الوصف: Dairy products may affect hypertension (HTN) risk. The aim of this study was to examine the association between fermented and nonfermented dairy foods and HTN in a sample of premature coronary artery disease (PCAD) subjects. This cross‐sectional study was performed on 1854 PCAD patients. A 110‐item food frequency questionnaire was used to assess dietary intakes. HTN was considered if systolic blood pressure was 140 mmHg and higher and/or diastolic blood pressure was 90 mmHg and higher. The odds ratio of HTN across the quartiles of different types of dairy products was evaluated by binary logistic regression. The mean (SD) of dairy products consumption was 339.8 (223.5) g/day, of which 285.4 g/day was fermented dairy products. In the crude model, participants in the fourth quartile of fermented dairy products had lesser risk of HTN compared to the bottom quartile (OR = 0.70, 95% CI: 0.52, 0.96; p for trend = .058). However, after considering the possible confounders, the significance disappeared. Subjects in the top quartile of high‐fat fermented dairy products had 34% lower risk for HTN compared to the bottom quartile (95% CI: 0.49, 0.88; p for trend < .001). Adjustment for potential risk factors weakened the association but remained significant (OR = 0.73, 95% CI: 0.53, 1.01; p for trend = .001). Nonsignificant relation was detected between low‐fat fermented, low‐fat nonfermented, and high‐fat nonfermented dairy products and HTN. Moderate consumption of high‐fat fermented dairy products, in a population with low consumption of dairy foods, might relate to reduced likelihood of HTN.

الإتاحة: https://doi.org/10.1002/fsn3.3998Test

المؤلفون: Sadegh-Zadeh, Seyed-Ali, Sakha, Hanie, Movahedi, Sobhan, Fasihi Harandi, Aniseh, Ghaffari, Samad, Javanshir, Elnaz, Ali, Syed Ahsan, Hooshanginezhad, Zahra, Hajizadeh, Reza

الوصف: Background Acute pulmonary embolism (PE) is a critical medical emergency that necessitates prompt identification and intervention. Accurate prognostication of early mortality is vital for recognizing patients at elevated risk for unfavourable outcomes and administering suitable therapy. Machine learning (ML) algorithms hold promise for enhancing the precision of early mortality prediction in PE patients. Objective To devise an ML algorithm for early mortality prediction in PE patients by employing clinical and laboratory variables. Methods This study utilized diverse oversampling techniques to improve the performance of various machine learning models including ANN, SVM, DT, RF, and AdaBoost for early mortality prediction. Appropriate oversampling methods were chosen for each model based on algorithm characteristics and dataset properties. Predictor variables included four lab tests, eight physiological time series indicators, and two general descriptors. Evaluation used metrics like accuracy, F1_score, precision, recall, Area Under the Curve (AUC) and Receiver Operating Characteristic (ROC) curves, providing a comprehensive view of models' predictive abilities. Results The findings indicated that the RF model with random oversampling exhibited superior performance among the five models assessed, achieving elevated accuracy and precision alongside high recall for predicting the death class. The oversampling approaches effectively equalized the sample distribution among the classes and enhanced the models' performance. Conclusions The suggested ML technique can efficiently prognosticate mortality in patients afflicted with acute PE. The RF model with random oversampling can aid healthcare professionals in making well-informed decisions regarding the treatment of patients with acute PE. The study underscores the significance of oversampling methods in managing imbalanced data and emphasizes the potential of ML algorithms in refining early mortality prediction for PE patients.

وصف الملف: text

العلاقة: https://eprints.staffs.ac.uk/8065/1/Advancing%20prognostic%20precision%20in%20pulmonary%20embolism.pdfTest; Sadegh-Zadeh, Seyed-Ali , Sakha, Hanie, Movahedi, Sobhan, Fasihi Harandi, Aniseh, Ghaffari, Samad, Javanshir, Elnaz, Ali, Syed Ahsan, Hooshanginezhad, Zahra and Hajizadeh, Reza (2023) Advancing prognostic precision in pulmonary embolism: A clinical and laboratory-based artificial intelligence approach for enhanced early mortality risk stratification. Computers in Biology and Medicine, 167. p. 107696. ISSN 1879-0534

الإتاحة: https://doi.org/10.1016/j.compbiomed.2023.107696Test
http://eprints.staffs.ac.uk/8065Test/
https://eprints.staffs.ac.uk/8065/1/Advancing%20prognostic%20precision%20in%20pulmonary%20embolism.pdfTest

المؤلفون: Nakhlband, Ailar, Garjani, Alireza, Saeedi, Nazli, Omidi, Yadollah, Ghaffari, Samad, Barar, Jaleh, Eskandani, Morteza

المصدر: HPD Articles

مصطلحات موضوعية: Marrubiin, Cardioprotection, Intracellular ROS, Apoptosis, Cardiovascular diseases, Medicine and Health Sciences, Pharmacy and Pharmaceutical Sciences

الوصف: Introduction: Atherosclerosis is a complicated cascade of inflammatory processes, oxidative stress, and apoptosis, making it the most prevalent cardiovascular disease. The onset and progression of cardiovascular diseases are greatly influenced by oxidative stress. Targeting oxidative stress is an effective strategy for treating such diseases. Marrubiin is a bioactive furan labdane diterpenoid acts as a strong antioxidant to protect against oxidative damage. This study aimed to investigate the protective effects of marrubiin against oxidative stress and apoptosis in a cellular model of the vascular system. Methods: Human umbilical vein endothelial cells were treated with varying concentration of marrubiin and its IC50 value was determined. The antioxidant potential of marrubiin was assessed by measuring the intracellular level of glutathione (GSH) using a colorimetric technique. Since apoptosis plays a significant role in the plaque rupture, the study also evaluated the protective effects of marrubiin on the expression of key genes involved in apoptotic pathways. Results: Cells treated with marrubiin showed increased GSH levels compared to cell therapy control cells, indicating marrubiin’s ability to counteract the effects of TNF-α’s on GSH levels. Furthermore real-time PCR analysis demonstrated that marrubiin upregulated Bcl-xl while downregulating caspase3 and Nox4 in treated cells. These findings suggest that marrubiin protects against apoptosis and oxidative stress. Conclusion: Based on our findings, marrubiin is recommended as a preventive/therapeutic treatment for diseases caused by elevated intracellular reactive oxygen species levels in cardiovascular diseases.

وصف الملف: application/pdf

العلاقة: https://nsuworks.nova.edu/hpd_facarticles/366Test; https://nsuworks.nova.edu/context/hpd_facarticles/article/1400/viewcontent/jcvtr_15_174.pdfTest

الإتاحة: https://doi.org/10.34172/jcvtr.2023.31704Test
https://nsuworks.nova.edu/hpd_facarticles/366Test
https://nsuworks.nova.edu/context/hpd_facarticles/article/1400/viewcontent/jcvtr_15_174.pdfTest

المؤلفون: Babahajiani, Media, Zarepur, Ehsan, Khosravi, Alireza, Mohammadifard, Noushin, Noohi, Feridoun, Alikhasi, Hasan, Nasirian, Shima, Moezi Bady, Seyed Ali, Janjani, Parisa, Solati, Kamal, Lotfizadeh, Masoud, Ghaffari, Samad, Javanmardi, Elmira, Salari, Arsalan, Gholipour, Mahboobeh, Dehghani, Mostafa, Cheraghi, Mostafa, Assareh, Ahmadreza, Haybar, Habib, Namayandeh, Seyedeh Mahdieh, Madadi, Reza, Kojuri, Javad, Mansourian, Marjan, Sarrafzadegan, Nizal

المصدر: BMC Cardiovascular Disorders ; volume 23, issue 1 ; ISSN 1471-2261

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background Diverse ethnic groups that exist in Iran may differ regarding the risk factors such as hypertension, hyperlipidemia, dyslipidemia, diabetes mellitus, and family history of non-communicable disease. Premature Coronary Artery Disease (PCAD) is more endemic in Iran than before. This study sought to assess the association between ethnicity and lifestyle behaviors in eight major Iranian ethnic groups with PCAD. Methods In this study, 2863 patients aged ≤ 70 for women and ≤ 60 for men who underwent coronary angiography were recruited in a multi-center framework. All the patients’ demographic, laboratory, clinical, and risk factor data were retrieved. Eight large ethnicities in Iran, including the Farses, the Kurds, the Turks, the Gilaks, the Arabs, the Lors, the Qashqai, and the Bakhtiari were evaluated for PCAD. Different lifestyle components and having PCAD were compared among the ethnical groups using multivariable modeling. Results The mean age of the 2863 patients participated was 55.66 ± 7.70 years. The Fars ethnicity with 1654 people, was the most subject in this study. Family history of more than three chronic diseases (1279 (44.7%) was the most common risk factor. The Turk ethnic group had the highest prevalence of ≥ 3 simultaneous lifestyle-related risk factors (24.3%), and the Bakhtiari ethnic group had the highest prevalence of no lifestyle-related risk factors (20.9%). Adjusted models showed that having all three abnormal lifestyle components increased the risk of PCAD (OR = 2.28, 95% CI: 1.04–1.06). The Arabs had the most chance of getting PCAD among other ethnicities (OR = 2.26, 95%CI: 1.40–3.65). While, the Kurds with a healthy lifestyle showed the lowest chance of getting PCAD (OR = 1.96, 95%CI: 1.05–3.67)). Conclusions This study found there was heterogeneity in having PACD and a diverse distribution in its well-known traditional lifestyle-related risk factors among major Iranian ethnic groups.

الإتاحة: https://doi.org/10.1186/s12872-023-03192-0Test

المؤلفون: Ansari, Shakila, Mohammadifard, Noushin, Haghighatdoost, Fahimeh, Zarepur, Ehsan, Mahmoudi, Shirin, Nouri, Fatemeh, Nouhi, Fereidoon, Alikhasi, Hassan, Sharifianjazi, Fariborz, Tavamaishvili, Ketevan, Shirani, Shahin, Kazemi, Tooba, Azdaki, Nahid, Salehi, Nahid, Lotfizadeh, Masoud, Solati, Kamal, Ghaffari, Samad, Javanmardi, Elmira, Salari, Arsalan, Dehghani, Mostafa, Cheraghi, Mostafa, Assareh, Ahmadreza, Haybar, Habib, Namayandeh, Seyedeh M., Madadi, Reza, Sarrafzadegan, Nizal

المصدر: Frontiers in Nutrition ; volume 10 ; ISSN 2296-861X

الوصف: Background Ultra-processed foods (UPF) consumption may affect the risk of PCAD through affecting cardio metabolic risk factors. This study aimed to evaluate the association between UPFs consumption and premature coronary artery disease (PCAD). Methods A case–control study was conducted on 2,354 Iranian adults (≥ 19 years). Dietary intake was assessed using a validated 110-item food frequency questionnaire (FFQ) and foods were classified based on the NOVA system, which groups all foods according to the nature, extent and purposes of the industrial processes they undergo. PCAD was defined as having an stenosis of at least single coronary artery equal and above 75% or left main coronary of equal or more than 50% in women less than 70 and men less than 60 years, determined by angiography. The odds of PCAD across the tertiles of UPFs consumption were assessed by binary logistic regression. Results After adjustment for potential confounders, participants in the top tertile of UPFs were twice as likely to have PCAD compared with those in the bottom tertile (OR: 2.52; 95% CI: 1.97–3.23). Moreover, those in the highest tertile of the UPFs consumption had more than two times higher risk for having severe PCAD than those in the first tertile (OR: 2.64; 95% CI: 2.16–3.22). In addition, there was a significant upward trend in PCAD risk and PCAD severity as tertiles increased (P-trend < 0.001 for all models). Conclusion Higher consumption of UPFs was related to increased risk of PCAD and higher chance of having severe PCAD in Iranian adults. Although, future cohort studies are needed to confirm the results of this study, these findings indicated the necessity of reducing UPFs intake.

الإتاحة: https://doi.org/10.3389/fnut.2023.1145762Test

المؤلفون: Karimi, Raheleh, Zarepur, Ehsan, Khosravi, Alireza, Mohammadifard, Noushin, Nouhi, Fereidoon, Alikhasi, Hasan, Nasirian, Shima, Sadeghi, Masoumeh, Roohafza, Hamidreza, Moezi Bady, Seyed Ali, Parisa janjani, Solati, Kamal, Lotfizadeh, Masoud, Ghaffari, Samad, Javanmardi, Elmira, Gholipour, Mahboobeh, Mostafa dehghani, Cheraghi, Mostafa, Assareh, Ahmadreza, Haybar, Habib, Namayandeh, Seyedeh Mahdieh, Reza madadi, Kojuri, Javad, Mansourian, Marjan, Sarrafzadegan, Nizal

المصدر: International Journal of Cardiology Cardiovascular Risk and Prevention ; volume 16, page 200168 ; ISSN 2772-4875

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Internal Medicine

الإتاحة: https://doi.org/10.1016/j.ijcrp.2023.200168Test
https://api.elsevier.com/content/article/PII:S2772487523000016?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2772487523000016?httpAccept=text/plainTest

المؤلفون: Mohammadifard, Noushin, Alavi Tabatabaei, Ghazaal, Haghighatdoost, Fahimeh, Zarepur, Ehsan, Nouri, Fatemeh, Javanbakht, Sahel, Nouhi, Fereidoon, Alikhasi, Hassan, Kazemi, Tooba, Azdaki, Nahid, Salehi, Nahid, Solati, Kamal, Lotfizadeh, Masoud, Ghaffari, Samad, Javanmardi, Elmira, Salari, Arsalan, Dehghani, Mostafa, Cheraghi, Mostafa, Assareh, Ahmadreza, Haybar, Habib, Namayandeh, Seyedeh Mahdieh, Madadi, Reza, Sarrafzadegan, Nizal

المصدر: Public Health Nutrition ; volume 26, issue 12, page 2771-2779 ; ISSN 1368-9800 1475-2727

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Nutrition and Dietetics, Medicine (miscellaneous)

الوصف: Objective: The cardioprotective effects of nuts are well established. However, the positive impacts of nuts in preventing CVD at a younger age, a condition known as premature coronary artery disease (PCAD), is still debated. Therefore, we aim to determine the association between nuts and PCAD occurrence and its severity in different Iranian ethnicities. Design: This case–control study was conducted within the framework of the Iran-premature coronary artery disease (I-PAD) study, an ongoing multi-centric study on Iranian patients of different ethnicities. Setting: This multi-centric case–control study was conducted in among 3253 persons under the age of 70 years in women and 60 years in men from different ethnicities in Iran. Participants: Information on nut consumption was collected using a validated FFQ. Subjects were selected from among the candidates for angiography. Cases were those whose coronary angiography showed stenosis of more than 75 % in at least one vessel or more than 50 % of the left main artery, while the control group participants had normal angiography results. Results: In the crude model, compared to the first quartile, the highest quartile of nut consumption was significantly associated with a lower risk of PCAD (OR = 0·26, 95 % CI (0·21, 0·32); P for trend = 0·001). In the top quartile of nut intake, a substantial decrease in PCAD was observed after controlling for putative confounders (OR = 0·32; 95 % CI (0·24, 0·43); P for trend = 0·001). Additionally, a 75 % decrease in the risk of severe PCAD was observed in the participants in the highest quartile of nut intake. Conclusion: A significant inverse association was observed between nut intake and the risk and severity of PCAD in the Iranian population. Large-scale clinical trials are required to confirm these findings.

الإتاحة: https://doi.org/10.1017/s1368980023002392Test
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S1368980023002392Test

المؤلفون: Javanshir, Elnaz, Ebrahimi, Zahra Javadpour, Mirzohreh, Seyedeh Tarlan, Ghaffari, Samad, Banisefid, Erfan, Alamdari, Naimeh Mesri, Roshanravan, Neda

المصدر: Molecular Biology Reports; 6/1/2024, Vol. 51 Issue 1, p1-10, 10p

مستخلص: Introduction: Coronary artery disease (CAD) in young adults can have devastating consequences. The cardiac developmental gene MEIS1 plays important roles in vascular networks and heart development. This gene effects on the regeneration capacity of the heart. Considering role of MEIS1 in cardiac tissue development and the progression of myocardial infarction this study investigated the expression levels of the MEIS1, HIRA, and Myocardin genes in premature CAD patients compared to healthy subjects and evaluated the relationships between these genes and possible inflammatory factors. Methods and results: The study conducted a case-control design involving 35 CAD patients and 35 healthy individuals. Peripheral blood mononuclear cells (PBMCs) were collected, and gene expression analysis was performed using real-time PCR. Compared with control group, the number of PBMCs in the CAD group exhibited greater MEIS1 and HIRA gene expression, with fold changes of 2.45 and 3.6. The expression of MEIS1 exhibited a negative correlation with IL-10 (r= -0.312) expression and positive correlation with Interleukin (IL)-6 (r = 0.415) and tumor necrosis factor (TNF)-α (r = 0.534) gene expression. Moreover, there was an inverse correlation between the gene expression of HIRA and that of IL-10 (r= -0.326), and a positive correlation was revealed between the expression of this gene and that of the IL-6 (r = 0.453) and TNF-α (r = 0.572) genes. Conclusion: This research demonstrated a disparity in expression levels of MEIS1, HIRA, and Myocardin, between CAD and healthy subjects. The results showed that, MEIS1 and HIRA play significant roles in regulating the synthesis of proinflammatory cytokines, namely, TNF-α and IL-6. [ABSTRACT FROM AUTHOR]

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المؤلفون: Alemzadeh-Ansari, Mohammad Javad, Alizadehasl, Azin, Amin, Ahmad, Azarfarin, Rasoul, Chitsazan, Mitra, Farsad, Bahram Fariborz, Fazelifar, Amir Farjam, Firouzi, Ata, Ghaemmaghami, Zahra, Ghaffari, Samad, Ghavidel, Alireza Alizadeh, Haghjoo, Majid, Hosseini, Saeid, Hosseini, Zahra, Kamali, Farzad, Khajali, Zahra, Kiani, Reza, Kyavar, Majid, Madadi, Shabnam, Mahdieh, Nejat, Malek, Hadi, Maleki, Alireza, Maleki, Majid, Mehr, Ali Zahed, Mohebbi, Bahram, Mojibian, Hamid, Moosavi, Jamal, Naderi, Nasim, Noohi, Feridoun, Norouzi, Zeinab, Pouraliakbar, Hamidreza, Rabbani, Bahareh, Sadeghi, Hasan Allah, Sadeghipour, Parham, Sadeghpour, Anita, Saedi, Sedigheh, Salehi, Hanieh, Sanati, Hamidreza, Shafe, Omid, Shakerian, Farshad, Tabiban, Samira, Talasaz, Azita Haj Hossein, Yousefi-Nooraie, Reza

المصدر: Practical Cardiology ; page xix-xxi

الإتاحة: https://doi.org/10.1016/b978-0-323-80915-3.09990-7Test
https://api.elsevier.com/content/article/PII:B9780323809153099907?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:B9780323809153099907?httpAccept=text/plainTest

المؤلفون: Mokhtari, Behnaz, Jessri, Amirhossein, Ghaffari, Samad, Badalzadeh, Reza

المصدر: Advanced Pharmaceutical Bulletin ; ISSN 2228-5881 2251-7308

الوصف: Purpose: Lethal ventricular arrhythmias are a significant clinical concern following reperfusion therapies in elderly patients with myocardial infarction. The combination of multi-target therapies to achieve optimal anti-arrhythmogenesis and improve the chances of successful translation for patient benefit has prompted considerable interest. This study examined the anti-arrhythmic effect of nicotinamide mononucleotide (NMN)/ubiquinol combination treatment following myocardial ischemia/reperfusion (IR) injury in aged rats, with an emphasis on the role of oxidative stress and nitric oxide (NO). Methods: Male Wistar rats (n=30, 22-24 months old, 400-450g) were randomized into five groups with or without IR and/or NMN and ubiquinol, either alone or in combination. NMN (100mg/kg/48hours) was administered intraperitoneally for 28 days before IR, and ubiquinol (30mg/kg) was injected intravenously at early reperfusion. Electrocardiographic signals were recorded during the ischemia and the first 30 minutes of reperfusion. Two hours after reperfusion, myocardial hemodynamic and LDH release were measured, and the left ventricle samples were obtained to evaluate oxidative stress markers and NO levels. Results: NMN/ubiquinol combination treatment significantly minimized the occurrence and severity of IR-induced arrhythmias, improved myocardial function, and reduced LDH release (P<.05). It also decreased MDA content, increased SOD, GPx, and CAT activities, and enhanced NO formation (P<.05). This combined treatment showed greater efficacy than the single treatments. Conclusion: This study revealed the anti-arrhythmic effect of NMN/ubiquinol combination treatment in IR-treated aged rats, which may be associated with reduced oxidative stress and increased NO formation. This combinational approach deserves more investigation due to its potential to confer better anti-arrhythmic effect during aging.

الإتاحة: https://doi.org/10.34172/apb.2024.044Test
https://apb.tbzmed.ac.ir/Inpress/apb-42116.pdfTest