المؤلفون: LANDREVILLE, P., GERVAIS, P. W.

المصدر: Aging & Mental Health ; volume 1, issue 3, page 197-208 ; ISSN 1360-7863 1364-6915

الإتاحة: https://doi.org/10.1080/13607869757083Test

المؤلفون: Schleien, Charles L., Osmond, Martin H., Hickey, Robert, Hutchison, Jaime, Buunk, Gerba, Douglas, Ivor S., Gervais, Hendrik W., Wenzel, Volker

المصدر: Annals of Emergency Medicine; April 2001, Vol. 37 Issue: 4 pS182-S195, 14p

المؤلفون: Gervais, Gary W, Trujillo, Kathy, Robinson, Brian L, Peters, Wallace, Serrano, Adelfa E

المصدر: Experimental Parasitology; January 1999, Vol. 91 Issue: 1 p86-92, 7p

مستخلص: Gervais, G. W., Trujillo, K., Robinson, B. L., Peters, W., and Serrano, A. E. 1999.Plasmodium berghei:Identification of anmdr-like gene associated with drug resistance.Experimental Parasitology91,86–92. Amplification, mutations, or overexpression of thepfmdr1gene have been associated with multiple drug resistance in some strains ofPlasmodium falciparum.In order to better understand this potential mechanism of drug resistance, we are currently investigating putativemdrhomologuesin vivoin the rodent malariaPlasmodium berghei.We have identified and partially sequenced a gene that is amplified in a MFQ-resistant (MFQr) line. Using degenerate primers, a 579-bp fragment was amplified by PCR usingP. bergheigenomic DNA as template. The predicted amino acid sequence shares 66% identity with the previously reportedpfmdr1gene product (Pgh1) ofP. falciparum.Southern blots and slot blots of genomic DNA suggest that this gene is amplified two- to threefold in a MFQrline (N/1100), as has been previously reported in some MFQrstrains ofP. falciparum.TheP. bergheigene was mapped to chromosome 12 in all of the lines analyzed. Furthermore, the cloned PCR product also hybridizes to chromosome 5 of the MFQrstrain.

المؤلفون: Gervais, H. W., Eberle, B., Hennes, H.-J., Grimm, W., Kilian, A., Konietzke, D., Massing, C., Dick, W.

المصدر: Resuscitation; 1997, Vol. 34 Issue: 3 p255-262, 8p

المؤلفون: Gervais, H. W., Depta, A. L., Hiller, B. K., Tag, S., Kentner, R., Brachlow, J., Eberle, B., Grimm, W., Latorre, F., Heinrichs, W.

المصدر: Der Anaesthesist; 19961001, Vol. 45 Issue: 10 p941-949, 9p

مستخلص: Zusammenfassung: Gegenstand der vorliegenden Untersuchung im Schweinemodell ist der Einflu� einer pr�-isch�mischen Normo-, Hyper- oder Hypoglyk�mie auf H�modynamik, regionale Organdurchblutung und Reanimierbarkeit nach 3min�ti-gem unbehandelten Herz-Kreislauf-Stillstand und anschlie�ender kardiopulmonalen Reanimation (CPR). Hypoglyk�mie (Blutzuckerkonzentration von 34�2 mg/dl) war bereits vor der Reanimation mit einer deutlichen Beeintr�chtigung h�modynamischer Parameter assoziiert. Keines der hypoglyk�mischen Tiere konnte erfolgreich reanimiert werden, im Gegensatz zu den hyper- (Blutzucker 319�13 mg/dl) bzw. normoglyk�mischen Tieren, die keinen Unterschied hinsichtlich der Erfolgsrate der Reanimation aufwiesen. Weder vor noch w�hrend oder nach Reanimation unterschieden sich hyper- und normoglyk�mische Tiere in bezug auf H�modynamik oder regionale kardiale oder zerebrale Durchblutung. Somit bleibt festzuhalten, da� Hypoglyk�mie bei CPR mit einer schlechten kardialen Prognose assoziiert ist, w�hrend Hyperglyk�mie die kardiale Reanimation offenbar nicht beeintr�chtigt.

المؤلفون: de Almeida, M. C. S., Kleemann, P. P., Latorre, F., Gervais, H. W.

المصدر: Der Anaesthesist; 19961001, Vol. 45 Issue: 10 p903-906, 4p

مستخلص: Zusammenfassung: Bei alten Patienten kann die Wirkung von Muskelrelaxanzien ver�ndert sein. Wir untersuchten diesen Zusammenhang an 108 Patienten dreier Altersgruppen, die randomisiert klinisch �bliche Intubationsdosen von Atracurium, Rocuronium und Vecuronium erhielten. Anschlagszeit und Erholung von der neuromuskul�ren Blockade wurden mit dem evozierten EMG des M. adductor pollicis nach Stimulation des N. ulnaris (Einzelreizung, 0,1 Hz) ermittelt. Die Anschlagszeiten sind in allen drei Altersgruppen vergleichbar, die Erholungszeiten bei den alten Patienten nach allen drei Relaxanzien verl�ngert. Die verl�ngerte Erholungszeit f�r Rocuronium korreliert mit erh�hten Werten der berechneten Kreatinin-Clearance, was f�r eine im Vergleich mit Atracurium und Vecuronium vermehrte renale Elimination spricht. Die nicht vollst�ndige Erholung von der neuromuskul�ren Blockade bei einigen Patienten, auch nach l�ngerer Zeit, korreliert mit dem Alter. Eine Erkl�rung hierf�r kann nicht gegeben werden.

المؤلفون: Prengel, A. W., Lindner, K. H., Gervais, H. W.

المصدر: Der Anaesthesist; 19940501, Vol. 43 Issue: 5 p309-315, 7p

مستخلص: Abstract.: A strong consensus was reached for several changes in the guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiac care (ECC) in the 1992 conference on CPR and ECC held by the Emergency Cardiac Care Committee of the American Heart Association. These new recommendations, together with differing recommendations of the European Resuscitation Council, are described. An unresponsive person with spontaneous respirations should be placed in the recovery position if no cervical trauma is suspected. Compared with endotracheal intubation, other airway-protecting devices such as combination esophageal-tracheal tubes are of minor acceptance. During ventilation, the time for filling the lungs is increased to 1.5 – 2 s to decrease the likelihood of gastric insufflation. Delivery of IV drugs can be enhanced by an IV flush of sodium chloride. In endotracheal drug administration, higher doses and drug dilution are recommended in infants and children up to 6 years of age, the value of intraosseous drug administration is emphasized. For pulseless adult victims, the intitial dosage of epinephrine of 1 mg I.V. remains unchanged. For repeat doses, high-dose epinephrine up to 0.1 mg/kg is classified as of uncertain but possible efficacy. For lidocaine, the recommended I.V. dosage is 1.5 mg/kg. Sodium bicarbonate and calcium are not routinely recommended for resuscitation. For atropine, the maximum dose is 0.04 mg/kg. If hypomagnesaemia is present in recurrent and refractory ventricular fibrillation, it should be corrected by administration of 1 to 2 mg magnesium sulfate I.V. Thrombolytic agents are classified as useful and effective in acute myocardial infarction and should be administered as early as possible. Glucose-containing fluids are discouraged for resuscitative efforts.

المؤلفون: Gervais, Hendrik W.

المصدر: Intensivmedizin und Notfallmedizin; October 2000, Vol. 37 Issue: 7 p589-590, 2p

المؤلفون: Ferrer-Rodríguez, Iván¹, Pérez-Rosado, José¹, Gervais, Gary W.¹, Peters, Wallace¹, Robinson, Brian L.¹, Serrano, Adelfa E.¹

المصدر: Journal of Parasitology 90(1):152-160. 2004

المؤلفون: David, M., Markstaller, K., Depta, A. L., Karmrodt, J., Herweling, A., Kempski, O., Geisen, M., Gervais, H. W.

المصدر: BJA: British Journal of Anaesthesia; October 2006, Vol. 97 Issue: 4 p525-525, 1p

مستخلص: Background. Current practice at high-frequency oscillatory ventilation (HFOV) initiation is a stepwise increase of the constant applied airway pressure to achieve lung recruitment. We hypothesized that HFOV would lead to more adverse cerebral haemodynamics than does pressure controlled ventilation (PCV) in the presence of experimental intracranial hypertension (IH) and acute lung injury (ALI) in pigs with similar mean airway pressure settings. Methods. In 12 anesthetized pigs (24–27 kg) with IH and ALI, mean airway pressure (Pmean) was increased (to 20, 25, 30 cm H2O every 30 min), either with HFOV or with PCV. The order of the two ventilatory modes (cross-over) was randomized. Mean arterial pressure (MAP), intracranial pressure (ICP), cerebral perfusion pressure (CPP), cerebral blood flow (CBF) (fluorescent microspheres), cerebral metabolism, transpulmonary pressures (PT), and blood gases were determined at each Pmean setting. Our end-points of interest related to the cerebral circulation were ICP, CPP and CBF. Results. CBF and cerebral metabolism were unaffected but there were no differences between the values for HFOV and PCV. ICP increased slightly (HFOV median +1 mm Hg, P<0.05; PCV median +2 mm Hg, P<0.05). At Pmean setting of 30 cm H2O, CPP decreased during HFOV (median −13 mm Hg, P<0.05) and PCV (median −17 mm Hg, P<0.05) paralleled by a decrease of MAP (HFOV median −11 mm Hg, P<0.05; PCV median −13 mm Hg, P<0.05). PT increased (HFOV median +8 cm H2O, P<0.05; PCV median +8 cm H2O, P<0.05). Oxygenation improved and normocapnia maintained by HFOV and PCV. There were no differences between both ventilatory modes. Conclusions. In animals with elevated ICP and ALI, both ventilatory modes had effects upon cerebral haemodynamics. The effects upon cerebral haemodynamics were dependent of the PT level without differences between both ventilatory modes at similar Pmean settings. HFOV seems to be a possible alternative ventilatory strategy when MAP deterioration can be avoided.