المؤلفون: Soriguer, Federico, Gutiérrez-Repiso, Carolina, Rubio-Martin, Elehazara, Linares, Francisca, Cardona, Isabel, López-Ojeda, Jaime, Pacheco, Marta, González-Romero, Stella, Garriga, Maria J., Velasco, Ines, Santiago, Piedad, García-Fuentes, Eduardo

المساهمون: Soriguer,F, González-Romero,S, García-Fuentes,E Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya, Málaga, Spain. Soriguer,F, Rubio-Martin,E CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Málaga, Spain. Gutiérrez-Repiso,C, Linares,F, Cardona,I, García-Fuentes,E Fundación IMABIS, Málaga, Spain. López-Ojeda,J, Pacheco, M Servicio de Radiología, Hospital Regional Universitario Carlos Haya, Málaga, Spain. Garriga, MJ Servicio de Análisis Clínicos, Hospital Regional Universitario Carlos Haya, Málaga, Spain. Velasco,I Servicio de Obstetricia y Ginecología, Hospital de Riotinto, Huelva, Spain. Santiago,P Servicio de Endocrinología y Nutrición, Hospital General, Jaen, Spain. García-Fuentes,E CIBER Fisiopaptología de la Obesidad y Nutrición (CIBERobn), Málaga, Spain. Laboratorio de Investigación, Málaga, Spain., The present study was supported in part by grants from the Instituto de Salud Carlos III (CP04/00133). CIBER FisiopatologÍa de la Obesidad y NutriciÓn (CIBEROBN) and CIBER de Diabetes y Enfermedades MetabÓlicas Asociadas (CIBERDEM)are ISCIII projects.

مصطلحات موضوعية: Iodine, Thyroid function, Urinary iodine, Antioxidants, Mujeres Embarazadas, Adulto, Marcadores biológicos, Estrés Oxidativo, Inflamación, Proteínas de fase aguda, Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Halogens::Iodine, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants, Medical Subject Headings::Named Groups::Persons::Women::Pregnant Women, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers, Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Acute-Phase Proteins

الوصف: Little information is available as to whether doses of iodide similar to those recommended in clinical practice for the prevention of iodine deficiency in pregnant women affect thyroid function. The aim of the present study was to analyse whether doses of iodide can affect thyroid function in adults, and evaluate its effect on plasma markers of oxidative stress, inflammation and acute-phase proteins. A total of thirty healthy volunteers (ten men and twenty women) with normal thyroid function were randomly assigned to three groups (n 10). Each group received a daily dose of 100, 200 or 300 μg of iodide in the form of KI for 6 months. Free tetraiodothyronine (FT4) levels at day 60 of the study were higher in the groups treated with 200 and 300 μg (P = 0·01), and correlated with the increase in urinary iodine (r 0·50, P = 0·007). This correlation lost its significance after adjustment for the baseline FT4. The baseline urinary iodine and FT4 correlated positively with the baseline glutathione peroxidase. On day 60, urinary iodine correlated with C-reactive protein (r 0·461, P = 0·018), and free triiodothyronine correlated with IL-6 (r - 0·429, P = 0·025). On day 60, the changes produced in urinary iodine correlated significantly with the changes produced in α1-antitrypsin (r 0·475, P = 0·014) and ceruloplasmin (r 0·599, P = 0·001). The changes in thyroid-stimulating hormone correlated significantly with the changes in α1-antitrypsin (r - 0·521, P = 0·005) and ceruloplasmin (r - 0·459, P = 0·016). In conclusion, the administration of an iodide supplement between 100 and 300 μg/d did not modify thyroid function in a population with adequate iodine intake. The results also showed a slight anti-inflammatory and antioxidative action of iodide. ; Yes

وصف الملف: application/pdf

العلاقة: http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8286421&fulltextType=RA&fileId=S0007114510005568Test; Soriguer F, Gutiérrez-Repiso C, Rubio-Martin E, Linares F, Cardona I, López-Ojeda J, et al. Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects. Br J Nutr. 2011;105 (12):1783-90.; http://hdl.handle.net/10668/1210Test

الإتاحة: https://doi.org/10.1017/S0007114510005568Test
http://hdl.handle.net/10668/1210Test

المؤلفون: García‐Arnés, Juan A., García‐Casares, Natalia, Soler, Jorge, Garín, Jorge M., Garriga, María J., León, Myriam

المصدر: Clinical Endocrinology ; volume 80, issue 4, page 613-614 ; ISSN 0300-0664 1365-2265

الإتاحة: https://doi.org/10.1111/cen.12250Test

المؤلفون: Soriguer, Federico, Valdes, Sergio, Morcillo, Sonsoles, Esteva, Isabel, Almaraz, Maria C., de Adana, Maria S. R., Tapia, Maria J., Dominguez, Marta, Gutierrez-Repiso, Carolina, Rubio-Martin, Elehazara, Garrido-Sanchez, Lourdes, Perez, Vidal, Garriga, Maria J., Rojo-Martinez, Gemma, Garcia-Fuentes, Eduardo

المصدر: European Journal of Clinical Investigation ; volume 41, issue 11, page 1202-1209 ; ISSN 0014-2972

الإتاحة: https://doi.org/10.1111Test/j.1365-2362.2011.02526.x

المؤلفون: Soriguer, Federico, Gutierrez-Repiso, Carolina, Gonzalez-Romero, Stella, Olveira, Gabriel, Garriga, Maria J., Velasco, Ines, Santiago, Piedad, de Escobar, Gabriella M., Garcia-Fuentes, Eduardo

المصدر: Clinical Nutrition ; volume 30, issue 1, page 44-48 ; ISSN 0261-5614

مصطلحات موضوعية: Critical Care and Intensive Care Medicine, Nutrition and Dietetics

الإتاحة: https://doi.org/10.1016Test/j.clnu.2010.07.001
https://api.elsevier.com/content/article/PII:S0261561410001305?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0261561410001305?httpAccept=text/plainTest

المؤلفون: Velasco, Ines, Carreira, Monica, Santiago, Piedad, Antonio Muela, José, García-Fuentes, Eduardo, Sánchez-Muñoz, Baltasar, Garriga, Maria J., González-Fernández, Maria C., Rodríguez, Álvaro, Caballero, Francisco F., Machado, Alberto, González-Romero, Stella, Anarte, Maria T., Soriguer, Federico

المصدر: Journal of Clinical Endocrinology & Metabolism; Sep 2009, Vol. 94 Issue 9, p3234-3241, 8p