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    دورية أكاديمية
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    كتاب

    المصدر: OSCEs in Obstetrics and Maternal-Fetal Medicine ; page 731-743 ; ISBN 9781108975780 9781108972185

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    كتاب

    المصدر: OSCEs in Obstetrics and Maternal-Fetal Medicine ; page 744-760 ; ISBN 9781108975780 9781108972185

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    دورية أكاديمية
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    دورية أكاديمية
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    دورية أكاديمية

    المصدر: BMJ Case Reports ; volume 15, issue 11, page e251451 ; ISSN 1757-790X

    مصطلحات موضوعية: General Medicine

    الوصف: Plurihormonal pituitary adenomas are rare forms of pituitary adenomas that express more than one hormone. The most common association is with growth hormone (GH) and prolactin. Cosecretion of GH and adrenocorticotrophic hormone (ACTH) is rare with only 25 reported cases in literature. Most presented with features of GH excess, and only four presented with Cushing’s disease. We report a case of a woman in her 30s with recurrent plurihormonal pituitary macroadenoma cosecreting GH and ACTH, diagnosed during workup for polycystic ovarian syndrome, and both times presenting uniquely with Cushing’s disease. Biochemical testing showed GH excess and hypercortisolism. She underwent transsphenoidal surgery twice and immunohistochemistry showed positive staining for GH and ACTH on both occasions. We aim to raise more awareness of this rare type of pituitary adenoma, shed light on the importance of recognising rare presentations and highlight the necessity of rigorous follow-up given morbidity and potentially higher mortality risk.

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    دورية أكاديمية
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    دورية أكاديمية
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    دورية أكاديمية
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    دورية أكاديمية