المؤلفون: G. Rager, H. J. Wagner, Th. Bandorski

المصدر: DMW - Deutsche Medizinische Wochenschrift. 122:999-1002

مصطلحات موضوعية: medicine.medical_specialty, Percutaneous, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Stent, General Medicine, Digital subtraction angiography, Amaurosis fugax, medicine.disease, Surgery, Catheter, Stenosis, medicine.artery, Angiography, cardiovascular system, medicine, cardiovascular diseases, Common carotid artery, medicine.symptom, business

الوصف: HISTORY AND CLINICAL FINDINGS A 63-year-old man developed recurrent transitory ischaemic episodes of vertigo and weakness in the legs 6 weeks before admission. 3 weeks later he had a left amaurosis fugax. A stenotic murmur was heard over the left carotid artery. INVESTIGATION Intraarterial digital subtraction angiography of the arteries to the head revealed occlusion of the right internal carotid artery (RICA) and marked narrowing at the origin of the left common carotid artery (LCCA), which could not be passed by catheter. TREATMENT AND COURSE As a catheter could not be passed into the LCCA, a stent was at operation placed retrogradely into it. Intraoperative angiography showed subtotal stenosis of the left ICA, which was treated by thrombendarterectomy and dacron patch-plasty. The postoperative course was without complication and the patient was free of symptoms. Follow-up angiography was unremarkable. CONCLUSION If a stenosis of the carotid artery cannot be passed by catheter, intraoperative retrograde placement of a stent is an alternative to percutaneous antegrade transluminal angioplasty or surgical bypass.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e74d28b69d74d681157fdf631f127a83Test
https://doi.org/10.1055/s-2008-1047720Test

المؤلفون: G. Rager, T. Voigt, Nicolas Bakinde, P. Yotovski

المصدر: Annals of Anatomy - Anatomischer Anzeiger. 187:149-152

مصطلحات موضوعية: Male, Proximal phalanx, business.industry, Accessory muscle, General Medicine, Anatomy, Hand, musculoskeletal system, Trunk, Functional Laterality, Tendon, Fingers, body regions, medicine.anatomical_structure, Abductor digiti minimi, medicine, Humans, Cadaver dissection, Muscle, Skeletal, business, Ulnar nerve, Hypothenar region, Aged, Developmental Biology

الوصف: Summary An accessory muscle was found in the hypothenar region on both hands during routine cadaver dissection. This muscle originated from the tendon of the flexor carpi radialis, crossed the palma manus region superficially and inserted together with the abductor digiti minimi muscle into the ulnar aspect of the basis of the fifth proximal phalanx. The muscle was supplied by one branch arising from the main trunk of the ulnar nerve. Abnormalities of the hypothenar muscles have been described by many authors with a focus on their structural aspects, but there is not enough data about the possible functions they could induce. In our study, we try to elucidate the functions of this accessory muscle. We did not name the variant muscle as it has various functions, each similar to that of individual hypothenar muscles.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723d8e873c9bf79c4c8a242c4c0c6831Test
https://doi.org/10.1016/j.aanat.2004.10.002Test

المؤلفون: G. Rager, Hans-Joachim Wagner

المصدر: RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren. 168:415-420

مصطلحات موضوعية: medicine.medical_specialty, Percutaneous, business.industry, Vascular disease, medicine.medical_treatment, Balloon catheter, Stent, Context (language use), medicine.disease, Popliteal artery, Surgery, Catheter, Angioplasty, medicine.artery, Medicine, Radiology, Nuclear Medicine and imaging, Radiology, business

الوصف: Although percutaneous transluminal angioplasty (PTA) has become established as an endovascular technique--in the more strict sense as a balloon dilatation but being increasingly supplemented by stent implantations--for many vascular regions, reports on infrapopliteal angioplasties are rather scarce. With the development of hydrophilically coated guide wires, improved catheter materials, and dedicated balloon catheters for infrapopliteal use, dilatation treatments distal of the popliteal artery are now standard procedures. Major advances in peri-interventional drug management have also made their contribution. The initial technical and clinical results obtained are excellent. For the majority of the patients, the main concern is for limb salvage. In this context, infrapopliteal PTA also achieves satisfactory results. However, the long-term results must still be considered as unsatisfactory since recurrences are frequent and require repeat interventions. Therefore new therapeutic strategies are required that can reduce re-stenoses especially in this peripheral vascular segment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::eb8c3082ad6f52725924db0c10e7ae27Test
https://doi.org/10.1055/s-2007-1015156Test

المؤلفون: U. Drenhaus, G. Rager

المصدر: The Anatomical Record. 234:605-617

مصطلحات موضوعية: Optic tract, education, Optic chiasm, Optic Nerve, Anatomy, Biology, Agricultural and Biological Sciences (miscellaneous), Axons, Microscopy, Electron, medicine.anatomical_structure, Optic Chiasm, health services administration, medicine, Optic nerve, Optic chiasma, Animals, Blood supply, Axon, Chickens, Neuroglia, health care economics and organizations

الوصف: In the hatched chick the fibers of the two optic nerves segregate into clearly defined bundles when they cross to the other side. These bundles run in horizontally oriented tiers. The tiers are demarcated by blood vessels and pial tissue. The organization of these tiers was investigated qualitatively and quantitatively using light and electron microscopy as well as tracer techniques. The fibers within the tiers cross to the contralateral optic tract without leaving their respective tier. The mean total number of tiers is 34 with a great individual variation. A preference in the superposition of one side over the other could not be observed. Comparing these data with our earlier study (Rager et al.: Anat. Embryol., 179:135–148, 1988) it can be concluded that neither the segregation of fibers into discrete bundles nor the variability in the number of alternating tiers seem to disturb the topography of fibers as it is achieved in the optic nerve. The pattern of vascularization correlates with the order of crossing axon bundles and contributes to the demarcation of the tiers. The chiasm is vascularized by the Aa. preopticae and the A. infundibularis.© Willey-Liss, Inc.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3eeab6be55fc0381260f08886c8a0dTest
https://doi.org/10.1002/ar.1092340416Test

المؤلفون: G. Rager, J. Kapfhammer, P. Eggli, J.D.H. Fasel, P. Groscurth, Jean-Pierre Hornung

المصدر: The Anatomical record. 265(6)

مصطلحات موضوعية: Models, Anatomic, medicine.medical_specialty, education, Radiology, Interventional, Surgical methods, Cadaver, medicine, Humans, natural sciences, Medical physics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Curriculum, medicine.diagnostic_test, business.industry, Interventional radiology, Agricultural and Biological Sciences (miscellaneous), Surgery, Education, Medical, Graduate, General Surgery, Gross anatomy, Embalming, Course development, Anatomy, business, Surgical curriculum, Switzerland

الوصف: The invention of new techniques for surgery and interventional radiology demand improved training for ongoing specialists. The Anatomical Institutes in Switzerland support these requirements by establishing hands-on practical training courses by using new procedures for cadaver embalming and model construction. Improvements allow courses to provide students with more realistic simulations of both established and experimental surgical methods. Through these changes, the value of in-depth gross anatomy is enhanced as a topic of fundamental importance for the postgraduate medical and surgical curriculum. The web site http://www.unifr.ch/sgahe/snga.htmlTest contains information on courses using the Thiel embalming solution. Details about training courses in Switzerland using anatomical models are available at http://www.heartlab.orgTest, http://www.vascular-international.orgTest, and http://www.elastrat.comTest.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0731728bfb79b1ef25a02a3b702742Test
https://pubmed.ncbi.nlm.nih.gov/11753916Test

المؤلفون: U, Drenhaus, K, Thomas, G, Rager

المصدر: Brain research. Developmental brain research. 121(1)

مصطلحات موضوعية: Microscopy, Electron, Growth Cones, Animals, Cell Count, Optic Nerve, Chick Embryo, Axons, Cellular Senescence

الوصف: The topographic position of growth cones (GCs) shows the course of ingrowing axons within the optic nerve and allows to draw conclusions with respect to the fiber order in this pathway. Therefore, the topographic distribution and frequency of GCs as well as the proximal and distal axon shaft segments were studied within cross-sections of the distal, middle, and prechiasmatic part of the nerve of 3-8-day-old embryos using electron microscopy. The ingrowth of GCs was not confined to a particular region. Initially, GCs were found near the ventral periphery. With increasing age, simultaneous ingrowth occurred within an area that expanded dorsally. In parallel, GCs also occurred in dorsal regions and eventually in the dorsal periphery. GCs intermingled everywhere with more mature axon profiles. However, youngest profiles predominated ventrally, oldest dorsally. Hence, maturity increased from ventral to dorsal. This indicated that the time of arrival of axons and the topographic position in the cross-section correlated significantly. It is concluded that axons are chronotopically organized, but in a probabilistic sense. The predominant ingrowth of axons in the ventral part may be associated largely with the first wave of neurogenesis of retinal ganglion cells. The ingrowth in dorsal regions of the cross section may be related to later generated axons that enter the nerve following older axons of the same retinal sector as well as axons of neighboring ganglion cells which continue to leave the mitotic cycle while the front of neurogenesis has spread into the periphery.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::fb9b8abea1edfbe610b35551adec59e6Test
https://pubmed.ncbi.nlm.nih.gov/10837891Test

المؤلفون: D, Grabs, M, Bergmann, G, Rager

المصدر: The European journal of neuroscience. 12(5)

مصطلحات موضوعية: Dynamins, Aging, Superior Colliculi, Membrane Glycoproteins, Transcription, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Calcium-Binding Proteins, Gene Expression Regulation, Developmental, Nerve Tissue Proteins, Chick Embryo, Retina, GTP Phosphohydrolases, Synaptotagmins, Protein Biosynthesis, Synapses, Animals, RNA, Messenger, Chickens, Dynamin III

الوصف: The role of amphiphysin in clathrin-mediated endocytosis of synaptic vesicles is well established. However, it is still uncertain if the protein is also involved in developmental mechanisms, e.g. axon outgrowth and synapse formation. To investigate the developmental changes in the expression of amphiphysin we used the retinotectal system of the chick, a highly ordered and easily accessible primary neuronal pathway. Reverse transcription polymerase chain reaction (RT-PCR) of total RNA from chick retina and tectum revealed first transcripts for amphiphysin, dynamin and synaptotagmin at embryonic day 5 (E5) for both regions. Surprisingly, Western blots of the retina revealed an increase of protein expression for amphiphysin only after E11 in the retina and the tectum. Immunofluorescence for amphiphysin was not detectable before E10 in the developing chick retina, while other presynaptic proteins like synaptotagmin showed already intense signals in the inner and outer plexiform layers. Subsequently, amphiphysin immunoreactivity follows the expression of synaptotagmin and synaptic vesicle protein 2 (SV2) as seen in the retina and the tectum, and exhibits the same staining as the other proteins in the mature chick brain. Ultrastructural data revealed for the first time that amphiphysin is not only limited to conventional synapses but is also abundant in retinal ribbon terminals. Taken together our data reveal that: (i) there is a developmental delay between mRNA transcription and protein expression for key proteins involved in endocytosis; (ii) amphiphysin gets upregulated after synapse formation; and (iii) amphiphysin is present in the synaptic vesicle cycle in retinal ribbon synapses.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::40709af0882add0091fea1034c78c9bbTest
https://pubmed.ncbi.nlm.nih.gov/10792432Test

المؤلفون: G, Rager, W, Singer

المصدر: The European journal of neuroscience. 10(5)

مصطلحات موضوعية: Flicker Fusion, Neurons, Mesencephalon, Oscillometry, Reticular Formation, Cats, Animals, Synaptic Transmission, Photic Stimulation, Retina, Visual Cortex

الوصف: We examined the possibility that neurons or groups of neurons along the retino-cortical transmission chain have properties of tuned oscillators: To this end, we studied the resonance properties of the retino-thalamo-cortical system of anaesthetized cats by entraining responses with flicker stimuli of variable frequency (2-50 Hz). Responses were assessed from multi-unit activity (MUA) and local field potentials (LFPs) with up to four spatially segregated electrodes placed in areas 17 and 18. MUA and LFP responses were closely related, units discharging with high preference during LFP negativity. About 300 ms after flicker onset, responses stabilized and exhibited a highly regular oscillatory patterning that was surprisingly similar at different recording sites due to precise stimulus locking. Fourier transforms of these steady state oscillations showed maximal power at the inducing frequency and consistently revealed additional peaks at harmonic frequencies. The frequency-dependent amplitude changes of the fundamental and harmonic response components suggest that the retino-cortical system is entrainable into steady state oscillations over a broad frequency range and exhibits preferences for distinct frequencies in the theta- or slow alpha-range, and in the beta- and gamma-band. Concomitant activation of the mesencephalic reticular formation increased the ability of cortical cells to follow high frequency stimulation, and enhanced dramatically the amplitude of first- and second-order harmonics in the gamma-frequency range between 30 and 50 Hz. Cross-correlations computed between responses recorded simultaneously from different sites revealed pronounced synchronicity due to precise stimulus locking. These results suggest that the retino-cortical system contains broadly tuned, strongly damped oscillators which altogether exhibit at least three ranges of preferred frequencies, the relative expression of the preferences depending on the central state. These properties agree with the characteristics of oscillatory responses evoked by non-temporally modulated stimuli, and they indicate that neuronal responses along the retino-cortical transmission chain can become synchronized with precision in the millisecond range not only by intrinsic interactions, but also by temporally structured stimuli.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::4700f5d8aa64f27fbf1e2ad250916860Test
https://pubmed.ncbi.nlm.nih.gov/9751156Test

المؤلفون: H J, Wagner, G, Rager

المصدر: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 168(5)

مصطلحات موضوعية: Tibial Arteries, Leg, Time Factors, Ischemia, Recurrence, Humans, Arterial Occlusive Diseases, Intermittent Claudication, Angioplasty, Balloon, Follow-Up Studies, Retrospective Studies

الوصف: Although percutaneous transluminal angioplasty (PTA) has become established as an endovascular technique--in the more strict sense as a balloon dilatation but being increasingly supplemented by stent implantations--for many vascular regions, reports on infrapopliteal angioplasties are rather scarce. With the development of hydrophilically coated guide wires, improved catheter materials, and dedicated balloon catheters for infrapopliteal use, dilatation treatments distal of the popliteal artery are now standard procedures. Major advances in peri-interventional drug management have also made their contribution. The initial technical and clinical results obtained are excellent. For the majority of the patients, the main concern is for limb salvage. In this context, infrapopliteal PTA also achieves satisfactory results. However, the long-term results must still be considered as unsatisfactory since recurrences are frequent and require repeat interventions. Therefore new therapeutic strategies are required that can reduce re-stenoses especially in this peripheral vascular segment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::361168c93bbeb6b4f1750cffbd026eb4Test
https://pubmed.ncbi.nlm.nih.gov/9617356Test

المؤلفون: T, Bandorski, G, Rager, H J, Wagner

المصدر: Deutsche medizinische Wochenschrift (1946). 122(33)

مصطلحات موضوعية: Male, Endarterectomy, Carotid, Humans, Carotid Stenosis, Stents, Middle Aged, Combined Modality Therapy, Carotid Artery, Internal, Thrombectomy

الوصف: A 63-year-old man developed recurrent transitory ischaemic episodes of vertigo and weakness in the legs 6 weeks before admission. 3 weeks later he had a left amaurosis fugax. A stenotic murmur was heard over the left carotid artery.Intraarterial digital subtraction angiography of the arteries to the head revealed occlusion of the right internal carotid artery (RICA) and marked narrowing at the origin of the left common carotid artery (LCCA), which could not be passed by catheter.As a catheter could not be passed into the LCCA, a stent was at operation placed retrogradely into it. Intraoperative angiography showed subtotal stenosis of the left ICA, which was treated by thrombendarterectomy and dacron patch-plasty. The postoperative course was without complication and the patient was free of symptoms. Follow-up angiography was unremarkable.If a stenosis of the carotid artery cannot be passed by catheter, intraoperative retrograde placement of a stent is an alternative to percutaneous antegrade transluminal angioplasty or surgical bypass.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::cd138fc6ffd7d2ffbd14863ba127f32cTest
https://pubmed.ncbi.nlm.nih.gov/9296934Test