المؤلفون: Türkan Acar, Esra Acıman Demirel, Nazire Afşar, Aylin Akçalı, Gülşen Akman Demir, Aybala Neslihan Alagöz, Tuğçe Angın Mengi, Ethem Murat Arsava, Semih Ayta, Nerses Bebek, Başar Bilgiç, Cavit Boz, Arman Çakar, Neşe Çelebisoy, Mehmet Uğur Çevik, Firuze Delen, Hacer Durmuş Tekçe, Hakan Ekmekçi, Ayşe Deniz Elmalı, Oğuz Osman Erdinç, Füsun Ferda Erdoğan, Fettah Eren, Ufuk Ergün, Yeşim Gülşen Parman, Haluk Gümüş, Demet İlhan Algın, Rana Karabudak, Ömer Karadaş, Özlem Kayım Yıldız, Emine Rabia Koç, Demet Özbabalık Adapınar, Atilla Özcan Özdemir, Şerefnur Öztürk, Ayşe Sağduyu Kocaman, Şevki Şahin, Esen Saka Topçuoğlu, Özden Şener, F. İrsel Tezer, Rıfat Erdem Toğrol, Ayşe Bora Tokçaer, Mehmet Akif Topçuoğlu, Neşe Tuncer, Ali Ulvi Uca, Kayıhan Uluç, Erdem Yaka, Mehmet İlker Yön

المصدر: Türk Nöroloji Dergisi, Vol 26, Iss 2, Pp 58-108 (2020)

مصطلحات موضوعية: covid-19, nöroloji, covid-19 pandemisi, Medicine, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

العلاقة: http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-73669Test; https://doaj.org/toc/1309-2545Test

الوصول الحر: https://doaj.org/article/9e059a592187495c841789571449a527Test

المؤلفون: Burcu Altunrende, Erkingül Birday, Mithat Kasap, Gülşen Akman Demir

المصدر: Türk Nöroloji Dergisi, Vol 23, Iss 4, Pp 176-185 (2017)

مصطلحات موضوعية: Multiple sclerosis, fingolimod, sphingosine-1 phosphate, efficacy, safety, Medicine, Neurology. Diseases of the nervous system, RC346-429

الوصف: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system and is characterized by inflammation, demyelination, and axonal loss. Fingolimod is the first oral drug for the treatment of MS approved by the United States Food and Drug Administration, European Union countries, and various other countries. The compound exerts its effect via interaction with lysophospholipid receptors known as sphingosine-1 phosphate receptors. Although fingolimod has a very convenient daily oral dosing, it may cause development of bradycardia at the first dose, macular edema, infection, all of which require attention. Randomized double-blind clinical trials have shown that fingolimod significantly reduces relapse rates and is beneficial in brain magnetic resonance imaging measures when compared with both placebo and intramuscular interferon β-1a. This review describes the characteristics of fingolimod concerning its efficacy, safety, and tolerability in the clinical context of the management of MS

وصف الملف: electronic resource

العلاقة: http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-62144Test; https://doaj.org/toc/1301-062XTest; https://doaj.org/toc/1309-2545Test

الوصول الحر: https://doaj.org/article/2e0e55ded7ff4ac69f63f666b54929ceTest

المؤلفون: Murat KÜRTÜNCÜ, Burcu ALTUNRENDE, Gülşen AKMAN DEMİR

المصدر: Archives of Epilepsy, Vol 22, Iss 1, Pp 53-56 (2016)

مصطلحات موضوعية: behçet’s disease, celiac disease, diabetes mellitus, epilepsy, granulomatous angitis, hashimoto disease, inflammatory bowel diseases, rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, systemic autoimmune diseases, sjögren’s syndrome, Neurology. Diseases of the nervous system, RC346-429, Medicine

الوصف: Involvement of the central nervous system (CNS) during the course of systemic autoimmune diseases is not rare. Connective tissue disorders such as systemic lupus erythematosus (SLE), rheumatoid arthritis, Behçet’s disease; granulomatous disorders such as sarcoidosis, granulomatous angitis; autoimmune bowel disorders such as inflammatory bowel and Celiac diseases; thyroid disorders such as Hashimoto and Graves diseases are best examples of the autoimmune diseases in this category. Epileptic seizures may be observed in patients with and without any obvious lesions in these disorders. In this review, we will summarize patterns of neurological involvement in systemic autoimmune diseases associated with epilepsy.

وصف الملف: electronic resource

العلاقة: http://archepilepsy.org/archives/archive-detail/article-preview/autoimmune-diseases-associated-with-epilepsy/55036Test; https://doaj.org/toc/2792-0550Test

الوصول الحر: https://doaj.org/article/fdc7378af18d4d5b9ec2c32d70453851Test

المؤلفون: Işık Görker, Gülşen Akman Demir, Nuray Gürel Polat, Rukiye Eker Ömeroğlu, Sema İçöz, Piraye Serdaroğlu, Ümran Tüzün

المصدر: Balkan Medical Journal, Vol 28, Iss 04, Pp 440-444 (2011)

مصطلحات موضوعية: Tic disorders, obsessive compulsive disorder, PANDAS, autoimmunity, child, Medicine

الوصف: streptococcus infections in the development of tic and obsessive compulsive disorders (OCD) is controversial. The autoimmune hypothesis states that during infection, formation of autoantibodies leads to an autoimmune disorder, which in turn results in movement disorders, tic disorders and/or OCD. In order to test this hypothesis, we assayed these antibodies in children and adolescents diagnosed with tic disorders and/or OCD.Material and Methods: Children and adolescents who were diagnosed with either tic disorders or OCD according to DSM-IV criteria (n=28), were compared with healthy controls (n=15) having similar age and gender characteristics. Regardless of a streptococcus infection history, serum samples of all patients and controls underwent antinuclear, cytoskeletal, and antineuronal antibody assay using indirect immunofluorescence.Results: The rates of antinuclear antibody positivity were 21% and 20% in the patient and control groups respectively (p>0.05). Antineuronal antibody was positive in 2 (7%) of 28 patients versus in 1 (6%) of 15 controls (p>0.05).Conclusion: These results suggest that such antibodies may not be involved in the pathogenesis of tic disorders/OCD.

وصف الملف: electronic resource

العلاقة: http://balkanmedicaljournal.org/text.php3?id=809Test; https://doaj.org/toc/2146-3123Test; https://doaj.org/toc/2146-3131Test

الوصول الحر: https://doaj.org/article/1115b20e37d84c77af7c10a7a83caca5Test

المؤلفون: Hacer Durmuş, Murat Kürtüncü, Erdem Tüzün, Bora Akalın, Melike Mutlu, Gülşen Akman Demir, Mefküre Eraksoy

المصدر: Türk Nöroloji Dergisi, Vol 15, Iss 3, Pp 119-123 (2009)

مصطلحات موضوعية: Optic neuritis, multiple sclerosis, demyelinating diseases, Medicine, Neurology. Diseases of the nervous system, RC346-429

الوصف: OBJECTIVE: Optic neuritis (ON) is inflammation of the optic nerve that generally leads to transient loss of vision. Unilateral optic neuritis is quite common upon first presentation in multiple sclerosis (MS) patients, but it may also remain as a clinically isolated syndrome. In this study we aimed to determine what factors are associated with the development of MS in isolated ON patients. METHODS: Medical charts of patients followed-up at Istanbul University, Faculty of Medicine, Department of Neurology between 1987 and 2003 were screened for patients with isolated ON at first presentation. A cohort of 90 patients was thusly obtained. Clinical and demographic features, visual evoked potential, cerebrospinal fluid (CSF), and magnetic resonance imaging findings, and time to definitive MS according to McDonald’s criteria were recorded. RESULTS: In all, 50% of the patients developed definitive MS after 13 months (95% CI: 4.4-19.6). Two of the patients developed neuromyelitis optica during the course of their follow-up. The development of MS was significantly associated with the presence of a T2 lesion (p= 0.001), oligoclonal bands (OCBs) in the CSF (p= 0.002), absence of papilledema (p= 0.027), absence of severe visual impairment (p= 0.016), and subacute (> 1 day) visual impairment (p= 0.005), as per log rank testing. According to the Cox proportional hazard regression model, the presence of a T2 lesion (hazard ratio: 4.8; 95% CI: 1.5-15.4) and OCBs (hazard ratio: 3.6; 95% CI: 1.1-11.5) are strongly predictive of the progression to MS. CONCLUSION: As some previous studies have noted, the risk of developing MS after ON is significantly higher in the presence of a T2 lesion and OCBs in the CSF. We think that this should be taken into account before starting early treatment for MS. Recent studies on the pathogenesis of MS have suggested that early treatment of MS reduces neurological disability in the long term. Our results might aid patient selection for early treatment and the determination of prognosis

وصف الملف: electronic resource

العلاقة: http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-25238Test; https://doaj.org/toc/1301-062XTest; https://doaj.org/toc/1309-2545Test

الوصول الحر: https://doaj.org/article/f0847606adee421f88925b1391fb0adcTest

المؤلفون: Murat Kürtüncü, Tuncay Gündüz, Sadık Server, Cem İsmail Küçükali, Onur Özyurt, Gülşen Akman-Demir

المصدر: Archives of Neuropsychiatry.

مصطلحات موضوعية: Psychiatry and Mental health, General Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2fd971e4558b78872bbb8e4466c728ecTest
https://doi.org/10.29399/npa.28366Test

المؤلفون: Selen Gür Özmen, Haşmet Hanağasi, Hakan Gürvit, Murat Emre, Gülşen Akman Demir

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.noropsikiyatriarsivi.com/sayilar/429/buyuk/200-201.pdfTest.

الوصف: Behçet' s disease (BD) was described as a three-symptom complex comprising uveitis, oral aphthae, and genital ulcerations. It is a multisystemic, recurrent, inflammatory disorder and it is of unknown cause. NeuroBehçet (NB) is present in 5%-7% of BD. Movement disorders have rarely been reported in NB. Here, we report a case of chronic parenchymal NB presenting with chorea. Keywords: Neuro-Behçet' s disease, chorea, movement disorders ABSTRACT 200

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1062.4458Test; http://www.noropsikiyatriarsivi.com/sayilar/429/buyuk/200-201.pdfTest

الإتاحة: http://www.noropsikiyatriarsivi.com/sayilar/429/buyuk/200-201.pdfTest

المؤلفون: Seema Kalra, Alan J. Silman, Gülşen Akman‐Demir, Saeed Bohlega, Afshin Borhani‐Haghighi, Cris S. Constantinescu, H. Houman, Alfred Mahr, Carlo Salvarani, Petros P. Sfikakis, Aksel Sıva, Adnan Al-Araji

مصطلحات موضوعية: Epidemiology and Management of Ocular Inflammatory Diseases, Ophthalmology, Medicine, Health Sciences, Diagnosis and Management of Cerebral Vein Thrombosis, Neurology, Ocular Manifestations of COVID-19, Neuroimaging, Intensive care medicine, Neuroradiology, Disease, Disease management, Differential diagnosis, Behcet disease, Pathology, Psychiatry, Parkinson's disease

الوصف: Neuro-Behçet's disease (NBD) is one of the more serious manifestations of Behçet's disease (BD), which is a relapsing inflammatory multisystem disease with an interesting epidemiology. Though NBD is relatively uncommon, being potentially treatable, neurologists need to consider it in the differential diagnosis of inflammatory, infective, or demyelinating CNS disorders. Evidence-based information on key issues of NBD diagnosis and management is scarce, and planning for such studies is challenging. We therefore initiated this project to develop expert consensus recommendations that might be helpful to neurologists and other clinicians, created through an extensive literature review and wide consultations with an international advisory panel, followed by a Delphi exercise. We agreed on consensus criteria for the diagnosis of NBD with two levels of certainty in addition to recommendations on when to consider NBD in a neurological patient, and on the use of various paraclinical tests. The management ... : مرض Neuro - Behçet (NBD) هو أحد المظاهر الأكثر خطورة لمرض Behçet (BD)، وهو مرض التهابي متعدد الأنظمة ناكس مع وبائيات مثيرة للاهتمام. على الرغم من أن التنوع البيولوجي غير شائع نسبيًا، إلا أنه يمكن علاجه، إلا أن أطباء الأعصاب بحاجة إلى مراعاته في التشخيص التفريقي لاضطرابات الجهاز العصبي المركزي الالتهابية أو المعدية أو المزيلة للميالين. المعلومات القائمة على الأدلة حول القضايا الرئيسية لتشخيص بنك دبي الوطني وإدارته نادرة، والتخطيط لمثل هذه الدراسات يمثل تحديًا. لذلك بدأنا هذا المشروع لتطوير توصيات إجماع الخبراء التي قد تكون مفيدة لأطباء الأعصاب وغيرهم من الأطباء، والتي تم إنشاؤها من خلال مراجعة شاملة للأدبيات ومشاورات واسعة مع لجنة استشارية دولية، تليها تمرين دلفي. اتفقنا على معايير إجماعية لتشخيص مرض الزهايمر المزمن بمستويين من اليقين بالإضافة إلى توصيات بشأن متى يجب النظر في مرض الزهايمر المزمن في مريض عصبي، وبشأن استخدام مختلف الاختبارات شبه السريرية. تضمنت توصيات الإدارة علاج الخثار الوريدي المتني والتخثر الوريدي الدماغي، واستخدام العلاجات المعدلة للمرض، والعوامل التنبؤية، ومقاييس النتائج، والصداع في ...

العلاقة: https://dx.doi.org/10.60692/9stqm-kpc15Test

الإتاحة: https://doi.org/10.60692/v02tg-gan1310.60692/9stqm-kpc15Test

المؤلفون: Rifat Erdem Togrol, Nerses Bebek, Hakan Ekmekçi, Türkan Acar, Ayse Deniz Elmali, Tuğçe Mengi, Ethem Murat Arsava, Hacer Durmuş Tekçe, Nazire Afsar, Ufuk Ergün, Gülşen Akman Demir, Şerefnur Öztürk, Demet Ilhan Algin, Erdem Yaka, Yesim Parman, E. Koc, Atilla Özcan Özdemir, Aylin Akcali, Ömer Karadaş, Ozden Sener, Fettah Eren, Sevki Sahin, Arman Çakar, Esra Aciman Demirel, Mehmet Ilker Yon, Aybala Neslihan Alagöz, Füsun Erdoğan, Başar Bilgiç, Firuze Delen, Mehmet Uğur Çevik, Ali Ulvi Uca, Rana Karabudak, Özlem Kayım Yıldız, F. Irsel Tezer, Semih Ayta, Haluk Gümüş, Ayse Sagduyu Kocaman, Oğuz Osman Erdinç, Cavit Boz, Demet Özbabalık Adapınar, Kayihan Uluc, Nese Tuncer, Ayşe Bora Tokçaer, Neşe Çelebisoy, Esen Saka Topcuoglu, Mehmet Akif Topcuoglu

المساهمون: KKÜ, Maltepe Üniversitesi, Tıp Fakültesi, Acar, Turkan, Demirel, Esra Aciman, Afsar, Nazire, Akcali, Aylin, Demir, Gulsen Akman, Alagoz, Aybala Neslihan, Mengi, Tugce Angin, Arsava, Ethem Murat, Ayta, Semih, Bebek, Nerses, Bilgic, Basar, Boz, Cavit, Cakar, Arman, Celebisoy, Nese, Cevik, Mehmet Ugur, Delen, Firuze, Tekce, Hacer Durmus, Ekmekci, Hakan, Elmali, Ayse Deniz, Erdinc, Oguz Osman, Erdogan, Fusun Ferda, Eren, Fettah, Ergun, Ufuk, Parman, Yesim Gulsen, Gumus, Haluk, Algin, Demet Ilhan, Karabudak, Rana, Karadas, Omer, Yildiz, Ozlem Kayim, Koc, Emine Rabia, Adapinar, Demet Ozbabalik, Ozdemir, Atilla Ozcan, Ozturk, Serefnur, Kocaman, Ayse Sagduyu, Sahin, Sevki, Topcuoglu, Esen Saka, Sener, Ozden, Tezer, F. Irsel, Togrol, Rifat Erdem, Tokcaer, Ayse Bora, Topcuoglu, Mehmet Akif, Tuncer, Nese, Uca, Ali Ulvi, Uluc, Kayihan, Yaka, Erdem, Yon, Mehmet Ilker, Acibadem University Dspace, Ege Üniversitesi

المصدر: Türk Nöroloji Dergisi, Vol 26, Iss 2, Pp 56-57 (2020)
Türk Nöroloji Dergisi, Vol 26, Iss 2, Pp 58-108 (2020)

مصطلحات موضوعية: PNEUMONIA, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Disease, CORONAVIRUS INFECTION, GUIDELINES, DISEASE, CHINA, HOSPITALIZED-PATIENTS, nöroloji, MANAGEMENT, Neurological manifestation, Medicine, TELEMEDICINE, Intensive care medicine, RC346-429, business.industry, Meningoencephalitis, covid-19 pandemisi, medicine.disease, N95 RESPIRATORS, Clinical neurology, Pneumonia, covid-19, Neurology (clinical), Neurology. Diseases of the nervous system, business, ACUTE RESPIRATORY SYNDROME, SYSTEM

الوصف: Objective. Comparison of ultrasound (US)-guided erector spinae plane block (ESPB) and serratus anterior plane block (SAPB) in video-assisted thoracic surgery (VATS) patients. The primary outcome was to compare perioperative and postoperative (48 hours) opioid consumption. Methods. A total of 60 patients were randomized into two groups (N =30): an ESPB group and an SAPB group. All the patients received intravenous patient-controlled postoperative analgesia and ibuprofen 400 mg intravenously every eight hours. Visual analog scale (VAS) scores, opioid consumption, and adverse events were recorded. Results. Intraoperative and postoperative opioid consumption at 0-8, 8-16, and 16-24 hours and rescue analgesic use were significantly lower in the ESPB group (P< 0.05). Static/dynamic VAS scores were significantly lower in the ESPB group (P< 0.05). There was no significant difference between static VAS scores at the fourth hour. There were no differences between adverse effects. Block procedure time and one-time puncture success were similar between groups (P > 0.05 each). Conclusion. US-guided ESPB may provide better pain control than SAPB after VATS. Question. Even though there are studies about analgesia management after VATS, clinicians want to perform the technique that is both less invasive and more effective. Findings. This randomized trial showed that US-guided ESPB provides effective analgesia compared with SAPB. Meaning. Performing single-injection ESPB reduces VAS scores and opioid consumption compared with SAPB.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8703429fa1b504201a7f07791d35ce30Test
https://hdl.handle.net/20.500.12587/12678Test

المؤلفون: Burcu Altunrende, Ahmet Yabalak, Gülşen Akman Demir

المصدر: Archives of Neuropsychiatry

مصطلحات موضوعية: Cognitive evaluation theory, Pediatrics, medicine.medical_specialty, Neuromyelitis optica, business.industry, General Neuroscience, Neuropsychology, Beck Depression Inventory, Cognition, medicine.disease, Psychiatry and Mental health, Quality of life, depression, medicine, Memory impairment, business, BRB-N, Depression (differential diagnoses), ACE-R, Research Article, cognitive impairment

الوصف: Introduction: There are few studies on cognitive impairment in neuromyelitis optica (NMO). The purpose of this study is to assess the factors that may be related with the frequency and level of cognitive impairment in Turkish NMO patients. Methods: 22 patients with the diagnosis of NMO are evaluated retrospectively. Cognitive function was evaluated with Brief Repeatable Battery of Neuropsychological tests (BRB-N), Beck Depression Inventory (BDI) and Addenbrooke Cognitive Evaluation (ACE-R). The groups with and without cognitive impairment were compared according to age, sex, level of education, pathologic findings on cranial MRI, NMO Ig existence and EDSS score. The relation of the clinical, radiological and demographic values and patients’ depression level was evaluated. The specificity and sensitivity of ACE-R test on detecting cognitive impairment were assessed through ACE-R test results. Results: The mean age of the patients was 42.8±10.9.45.5% (n=10) of the patients had cognitive impairment and 50% (n=11) had depression. The group with cognitive impairment had significantly older age, lower educational status, higher EDSS and BDI scores (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e9249698649c13084da7f317ec51daTest
https://pubmed.ncbi.nlm.nih.gov/34526842Test