المؤلفون: Tavares, A.M., Alves, I., Moreira, R., Louro, H., Ladeira, Carina, Viegas, Susana, Loureiro, S., Santonen, T., Göen, T., Kortenkamp, A., Luijten, M., Silva, M.J.A.

مصطلحات موضوعية: Occupational health, Occupational exposure, Metals, Risk assessment, HBM4EU Initiative (GA 733032), FCT_UIDB/00009/2020, FCT_UIDP/00009/2020

الوصف: Funded by the HBM4EU Initiative (GA 733032). ChemMix (IDI&CA, IPL, 2019). FCT_UIDB/00009/2020. FCT_UIDP/00009/2020. ; The environment within industrial settings is commonly characterized by the existence of a complex mixture of chemicals from different raw materials and transformation processes. Occupational co-exposure to chromium (Cr), Nickel (Ni), and Polycyclic Aromatic Hydrocarbons (PAHs) may occur in diverse workplaces, such as aeronautic and waste management, (e.g incineration) sectors. Such co-exposure raises concern in terms of occupational health, as these substances are recognized lung carcinogens and mainly act by genotoxic mechanisms, increasing the likelihood of interactive toxic effects. The fact that current regulatory practices are usually focused on single chemical substances, without integrating the possibility of combined or aggregated exposures and effects, may lead to a risk underestimation. This work, developed under the scope of HBM4EU Initiative (https://www.hbm4eu.euTest), a literature-based mixture risk assessment (MRA) exercise for occupational exposure to metals and PAHs was performed. In addition, in vitro toxicity data was obtained for the same mixtures to provide support to its hazard assessment. Human biomonitoring (HBM) data on Cr(VI), Ni, and/or PAHs were extracted from occupational studies conducted in the European Union and searched in literature databases. Selected reference values were used to calculate risk quotients (RQ) for each substance based on the retrieved exposure data; the combined risk was given by the sum of the RQ, i.e., the Background Exposure Exceedance Score(BEES). In parallel, we evaluated the combined cyto- and genotoxicity of the same chemicals (assessed by the MTT and micronucleus assays) in the human alveolar A549 cell line. In most of the analyzed studies, we observed that BEES levels, estimated from the exposure to metals mixture or to metals and PAHs, exceeded RQ levels considered acceptable for the individual substances. Only two studies, conducted ...

العلاقة: HBM4EU Initiative (GA 733032); FCT_UIDB/00009/2020; FCT_UIDP/00009/2020; https://www.sciencedirect.com/science/article/pii/S0378427421007293?via%3DihubTest; Tavares AM, Alves I, Moreira R, Louro H, Ladeira C, Viegas S, et al. Occupational exposure to metals and PAHs: combining literature-based exposure and in vitro hazard data towards a mixture risk assessment. Toxicol Lett. 2021;350(Suppl):S210.; http://hdl.handle.net/10400.21/13863Test

الإتاحة: https://doi.org/10.1016/S0378-4274Test(21)00729-3
http://hdl.handle.net/10400.21/13863Test

المؤلفون: Govarts, E, Gilles, L, Rodriguez Martin, L, Santonen, T, Apel, P, Alvito, P, Anastasi, E, Andersen, HR, Andersson, AM, Andryskova, L, Antignac, JP, Appenzeller, B, Barbone, F, Barnett-Itzhaki, Z, Barouki, R, Berman, T, Bil, W, Borges, T, Buekers, J, Cañas-Portilla, A, Covaci, A, Csako, Z, Den Hond, E, Dvorakova, D, Fabelova, L, Fletcher, T, Frederiksen, H, Gabriel, C, Ganzleben, C, Göen, T, Halldorsson, TI, Haug, LS, Horvat, M, Huuskonen, P, Imboden, M, Jagodic Hudobivnik, M, Janasik, B, Janev Holcer, N, Karakitsios, S, Katsonouri, A, Klanova, J, Kokaraki, V, Kold Jensen, T, Koponen, J, Laeremans, M, Laguzzi, F, Lange, R, Lemke, N, Lignell, S, Lindroos, AK, Lobo Vicente, J, Luijten, M, Makris, KC, Mazej, D, Melymuk, L, Meslin, M, Mol, H, Montazeri, P, Murawski, A, Namorado, S, Niemann, L, Nübler, S, Nunes, B, Olafsdottir, K, Palkovicova Murinova, L, Papaioannou, N, Pedraza-Diaz, S, Piler, P, Plichta, V, Poteser, M, Probst-Hensch, N, Rambaud, L, Rauscher-Gabernig, E, Rausova, K, Remy, S, Riou, M, Rosolen, V, Rousselle, C, Rüther, M, Sarigiannis, D, Silva, MJ, Šlejkovec, Z, Snoj Tratnik, J, Stajnko, A, Szigeti, T, Tarazona, JV, Thomsen, C, Tkalec, Ž, Tolonen, H, Trnovec, T, Uhl, M, Van Nieuwenhuyse, A, Vasco, E, Verheyen, VJ, Viegas, S, Vinggaard, AM, Vogel, N, Vorkamp, K, Wasowicz, W, Weber, T, Wimmerova, S, Woutersen, M, Zimmermann, P, Zvonar, M, Koch, H, Kolossa-Gehring, M, Esteban López, M, Castaño, A, Stewart, L, Sepai, O, Schoeters, G

المصدر: International journal of hygiene and environmental health. 249:114119

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:236773580Test

المؤلفون: Hoppe, H W, Fest, U, Eckert, E, Müller, J, Göen, T, Hartwig, A, MAK Commission, Arand, Michael

المصدر: Hoppe, H W; Fest, U; Eckert, E; Müller, J; Göen, T; Hartwig, A; MAK Commission; Arand, Michael; et al (2023). Glyphosat – Bestimmung von Glyphosat und AMPA in Urin mittels GC-MS/MS. The MAK Collection for Occupational Health and Safety, 8(2):Doc051.

مصطلحات موضوعية: Institute of Pharmacology and Toxicology, 610 Medicine & health, 570 Life sciences, biology

الوصف: The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area developed and verified the presented biomonitoring method. Glyphosate (N-phosphonomethylglycine) is a synthetic phosphonic acid derivative which has been used as a broad-spectrum herbicide since 1974. Its only known metabolite is aminomethylphosphonic acid (AMPA). Exposure in occupational settings is predominantly due to inhalation and dermal contact with glyphosate. The general population is exposed to glyphosate and AMPA via both dietary (plant and animal products) and environmental (soils, surface water, and groundwater) exposure. The aim of this work was to develop a selective method for the determination of glyphosate and AMPA in urine. The method has been comprehensively validated, and the reliability data have been confirmed by replication and verification of the procedure in a second, independent laboratory. The analytes are directly derivatised in the dried urine sample with trifluoroacetic anhydride and trifluoroethanol without an initial extraction step. Calibration is performed using aqueous calibration standards processed analogously to the samples. As internal standards, glyphosate-d2 and 13C,15N-AMPA are added to the urine samples and calibration standards. The derivatives are measured after capillary gas-chromatographic separation with tandem mass-spectrometric detection (GC-MS/MS) using negative chemical ionisation (NCI). The good precision and accuracy data show that the method provides reliable and accurate analytical results. The method is both selective and sensitive, and the quantitation limit of 0.1 μg/l urine for glyphosate and AMPA is sufficient to determine occupational exposure as well as higher background levels in the general population.

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/256072/1/Glyphosat___Bestimmung_von_Glyphosat.pdfTest; urn:issn:2509-2383

الإتاحة: https://doi.org/10.5167/uzh-256072Test
https://doi.org/10.34865/bi107183d8_2orTest
https://www.zora.uzh.ch/id/eprint/256072Test/
https://www.zora.uzh.ch/id/eprint/256072/1/Glyphosat___Bestimmung_von_Glyphosat.pdfTest

المؤلفون: Weistenhöfer, W, Göen, T, Drexler, H, Hartwig, A, MAK Commission, Arand, Michael

المصدر: Weistenhöfer, W; Göen, T; Drexler, H; Hartwig, A; MAK Commission; Arand, Michael (2023). Anforderungen an einen geeigneten Humanbiomonitoringparameter. The MAK Collection for Occupational Health and Safety, 8(4):Doc083.

مصطلحات موضوعية: Institute of Pharmacology and Toxicology, 570 Life sciences, biology, 610 Medicine & health

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/256144/1/Anforderungen_an_einen_geeigneten.pdfTest; urn:issn:2509-2383

الإتاحة: https://doi.org/10.5167/uzh-256144Test
https://www.zora.uzh.ch/id/eprint/256144Test/
https://www.zora.uzh.ch/id/eprint/256144/1/Anforderungen_an_einen_geeigneten.pdfTest

المؤلفون: Jäger, T, Bader, M, Kuhlmann, L, Göen, T, Hartwig, A, MAK Commission, Arand, Michael

المصدر: Jäger, T; Bader, M; Kuhlmann, L; Göen, T; Hartwig, A; MAK Commission; Arand, Michael (2023). 2-Phenoxyethanol – Bestimmung von Phenoxyessigsäure und 4-Hydroxyphenoxyessigsäure in Urin mittels UPLC-ESI-MS/MS. The MAK Collection for Occupational Health and Safety, 8(4):Doc091.

مصطلحات موضوعية: Institute of Pharmacology and Toxicology, 610 Medicine & health, 570 Life sciences, biology

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/256154/1/Phenoxyethanol___Bestimmung.pdfTest; urn:issn:2509-2383

الإتاحة: https://doi.org/10.5167/uzh-256154Test
https://doi.org/10.34865/bi12299d8_4orTest
https://www.zora.uzh.ch/id/eprint/256154Test/
https://www.zora.uzh.ch/id/eprint/256154/1/Phenoxyethanol___Bestimmung.pdfTest

المؤلفون: Jäger, T, Bader, M, Kuhlmann, L, Göen, T, Hartwig, A, MAK Commission, Arand, Michael

المصدر: Jäger, T; Bader, M; Kuhlmann, L; Göen, T; Hartwig, A; MAK Commission; Arand, Michael (2023). 2-Phenoxyethanol – Determination of phenoxyacetic acid and 4-hydroxyphenoxyacetic acid in urine by UPLC-ESI-MS/MS. The MAK Collection for Occupational Health and Safety, 8(4):Doc093.

مصطلحات موضوعية: Institute of Pharmacology and Toxicology, 570 Life sciences, biology, 610 Medicine & health

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/256156/1/2_Phenoxyethanol___Determination_2.pdfTest; urn:issn:2509-2383

الإتاحة: https://doi.org/10.5167/uzh-256156Test
https://doi.org/10.34865/bi12299e8_4orTest
https://www.zora.uzh.ch/id/eprint/256156Test/
https://www.zora.uzh.ch/id/eprint/256156/1/2_Phenoxyethanol___Determination_2.pdfTest

المؤلفون: Scherer, G, Hagendorn, H W, Hoppe, H W, Dadanski, P, Seidel, A, Göen, T, Hartwig, A, MAK Commission, Arand, Michael

المصدر: Scherer, G; Hagendorn, H W; Hoppe, H W; Dadanski, P; Seidel, A; Göen, T; Hartwig, A; MAK Commission; Arand, Michael (2023). Benzo[a]pyrene – Determination of 3-hydroxybenzo[a]pyrene in urine by LC-MS/MS. The MAK Collection for Occupational Health and Safety, 8(4):Doc092.

مصطلحات موضوعية: Institute of Pharmacology and Toxicology, 610 Medicine & health, 570 Life sciences, biology

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/256155/1/Benzo_a_pyrene___Determination_of_3_hydroxy.pdfTest; urn:issn:2509-2383

الإتاحة: https://doi.org/10.5167/uzh-256155Test
https://doi.org/10.34865/bi13345e8_4orTest
https://www.zora.uzh.ch/id/eprint/256155Test/
https://www.zora.uzh.ch/id/eprint/256155/1/Benzo_a_pyrene___Determination_of_3_hydroxy.pdfTest

المؤلفون: Scherer, G, Hagedorn, H W, Hoppe, H W, Dadanski, P, Seidel, A, Göen, T, Hartwig, A, MAK Commission, Arand, Michael

المصدر: Scherer, G; Hagedorn, H W; Hoppe, H W; Dadanski, P; Seidel, A; Göen, T; Hartwig, A; MAK Commission; Arand, Michael (2023). Benzo[a]pyren – Bestimmung von 3-Hydroxy - benzo[a]pyren in Urin mittels LC-MS/MS. The MAK Collection for Occupational Health and Safety, 8(4):Doc090.

مصطلحات موضوعية: Institute of Pharmacology and Toxicology, 610 Medicine & health, 570 Life sciences, biology

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/256151/1/Benzo_a_pyren___Bestimmung_von_3_Hydroxy.pdfTest; urn:issn:2509-2383

الإتاحة: https://doi.org/10.5167/uzh-256151Test
https://doi.org/10.34865/bi13345d8_4orTest
https://www.zora.uzh.ch/id/eprint/256151Test/
https://www.zora.uzh.ch/id/eprint/256151/1/Benzo_a_pyren___Bestimmung_von_3_Hydroxy.pdfTest

المؤلفون: Weistenhöfer, W, Göen, T, Drexler, H, Hartwig, A, MAK Commission, Arand, Michael

المصدر: Weistenhöfer, W; Göen, T; Drexler, H; Hartwig, A; MAK Commission; Arand, Michael (2023). Requirements for suitable human biomonitoring parameters. The MAK Collection for Occupational Health and Safety, 8(4):Doc085.

مصطلحات موضوعية: Institute of Pharmacology and Toxicology, 610 Medicine & health, 570 Life sciences, biology

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/256146/1/Requirements_for_suitable_human.pdfTest; urn:issn:2509-2383

الإتاحة: https://doi.org/10.5167/uzh-256146Test
https://www.zora.uzh.ch/id/eprint/256146Test/
https://www.zora.uzh.ch/id/eprint/256146/1/Requirements_for_suitable_human.pdfTest

المؤلفون: Christ, T, Ellrich, D, Leng, G, Schmidtkunz, C, Gries, W, Pilz, F, Scherer, G, Göen, T, Hartwig, A, MAK Commission, Arand, Michael

المصدر: Christ, T; Ellrich, D; Leng, G; Schmidtkunz, C; Gries, W; Pilz, F; Scherer, G; Göen, T; Hartwig, A; MAK Commission; Arand, Michael (2023). Alkylierende Substanzen – Bestimmung von Hämoglobin-Addukten als N-Methylvalin, N-Ethylvalin, N-Propylvalin, N-Butylvalin, N-(2-Hydroxypropyl)valin, N-(2-Hydroxyethyl)- valin, N-(2-Cyanoethyl)valin, N-Benzylvalin und N-(2-Carbamoylethyl)valin in der Erythrozytenfraktion des Vollblutes mittels GC-MS/MS. The MAK Collection for Occupational Health and Safety, 8(3):Doc073.

مصطلحات موضوعية: Institute of Pharmacology and Toxicology, 610 Medicine & health, 570 Life sciences, biology

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/256134/1/Alkylierende_Substanzen___Bestimmung.pdfTest; urn:issn:2509-2383

الإتاحة: https://doi.org/10.5167/uzh-256134Test
https://doi.org/10.34865/bi33488d8_3orTest
https://www.zora.uzh.ch/id/eprint/256134Test/
https://www.zora.uzh.ch/id/eprint/256134/1/Alkylierende_Substanzen___Bestimmung.pdfTest