المؤلفون: Inada, Ken, Saito, Yoshitaka, Baba, Kenji, Fukui, Daisuke, Masuda, Yuriko, Inoue, Sachie, Masuda, Takahiro

المساهمون: Sumitomo Pharma Co. Ltd.

المصدر: BMC Psychiatry ; volume 24, issue 1 ; ISSN 1471-244X

مصطلحات موضوعية: Psychiatry and Mental health

الوصف: Background Premature mortality, frequent relapse that easily leads to hospitalization, and discontinuous employment are key challenges for the treatment of schizophrenia. We evaluated risk factors for important clinical outcomes (death, hospitalization, resignation, and sick leave from work) in patients with schizophrenia in Japan. Methods A nested case–control study was conducted for patients with schizophrenia identified in a Japanese claims database. For each outcome, the case was matched with up to four controls of the same age, sex, index year, and enrollment status (employee or dependent family). Potential risk factors were defined by prescriptions or diagnoses within 3 months prior to or in the month of the event. The association among potential risk factors and each outcome was evaluated using multivariable conditional logistic regression analysis with stepwise variable selection. Results The number of cases and eligible patients for each outcome were 144 and 38,451 (death), 1,520 and 35,225 (hospitalization), 811 and 18,770 (resignation), and 4,590 and 18,770 (sick leave), respectively. Depression was a risk factor for death (odds ratio [OR]: 1.92; 95% confidence interval [CI]: 1.12, 3.29), hospitalization (OR: 1.22; 95% CI: 1.05, 1.42), and sick leave from work (OR: 1.46; 95% CI: 1.36, 1.57). Other risk factors for death were hospitalization history, Charlson Comorbidity Index (CCI) score, and prescription for laxatives. Prescriptions for hypnotics, laxatives, and anticholinergics were risk factors for hospitalization. Prescriptions for hypnotics and anticholinergics were risk factors for resignation. CCI score, prescription for hypnotics, laxatives, and antidiabetics were risk factors for sick leave from work. Conclusions Our findings suggest that depression and some physical symptoms, such as constipation and extrapyramidal symptoms, are risk factors for important clinical outcomes in patients with schizophrenia. Attention should be paid to both depression and physical symptoms for the ...

الإتاحة: https://doi.org/10.1186/s12888-023-05474-5Test

المؤلفون: 福井, 大介, Fukui, Daisuke

وصف الملف: application/pdf

الوصول الحر: https://ndlsearch.ndl.go.jp/books/R100000039-I13116852Test

Degree: 博士(工学) -- 東京工業大学

المؤلفون: Morihiro, Kunihiko, Tomida, Yasuhiro, Fukui, Daisuke, Hasegawa, Manami, Okamoto, Akimitsu

المساهمون: Japan Society for the Promotion of Science

المصدر: Angewandte Chemie ; volume 135, issue 44 ; ISSN 0044-8249 1521-3757

الوصف: Many microRNAs (miRNAs) are characteristically found in cancer cells, making miRNAs promising marker biomolecules for cancer diagnosis and therapeutics. However, it is challenging to use miRNA as a cancer signature because it is difficult to convert the nucleic acid sequence information into molecular functionality. To address this challenge, we realize nucleic acid‐to‐small molecule converters using hairpin DNA circuits. Harnessing a Staudinger reduction as a trigger for the conversion, we constructed hybridization chain reaction (HCR) and catalytic hairpin assembly (CHA) circuits that respond to oncogenic miR‐21. Fluorophore and dye molecules were released in response to miR‐21 through the HCR, providing fluorogenic and chromogenic readouts. Selective cytotoxicity in miR‐21‐abundant cells was realized by the CHA to release the anticancer drug SN‐38. This would be the first example of selective activation of a small‐molecule prodrug triggered by oncogenic miRNA in human living cells.

الإتاحة: https://doi.org/10.1002/ange.202306587Test

المؤلفون: Fukui, Daisuke, Nishiyama, Daisuke, Yamanaka, Manabu, Tamai, Hidenobu, Nishio, Naoko, Kawakami, Mamoru, Yamada, Hiroshi

المساهمون: JSPS KAKENHI

المصدر: CARTILAGE ; ISSN 1947-6035 1947-6043

مصطلحات موضوعية: Physical Therapy, Sports Therapy and Rehabilitation, Biomedical Engineering, Immunology and Allergy

الوصف: Objective The medial meniscus extrusion (MME) is associated with increased stress on the knee joint, which leads to cartilage degeneration. To evaluate the etiology of knee osteoarthritis, it is extremely important to create animal models of the disease that more closely resemble actual clinical conditions in terms of symptomatology, molecular biology, and histology. This study aimed to create a clinically relevant model of MME in rats. Design Behavioral, molecular biological, and histological changes in the newly developed rat MME model were compared with those in sham and medial meniscus transection and medial collateral ligament transection (MMT) models to examine the characteristics of this model. Results In the MME rat model, behavioral evaluation shows abnormalities in gait compared with the other 2 groups, and molecular biological evaluation of the infrapatellar synovia of rats shows that gene expression of inflammatory cytokines, matrix-degrading enzymes, and pain-related nerve growth factor was increased compared with the sham group. Furthermore, histological evaluation reveals that cartilage degeneration was the most severe in the MME group. Conclusions The newly developed MME model reproduced the characteristic pathology of MME in clinical practice, such as severe pain, inflammation, and rapid progression of osteoarthritis. The MME model, which might more closely mimic human knee osteoarthritis (OA), could be a useful model for elucidating the pathophysiology and considering therapeutic management for knee OA.

الإتاحة: https://doi.org/10.1177/19476035231205680Test

المؤلفون: Tamai, Hidenobu, Yamanaka, Manabu, Taniguchi, Wataru, Nishio, Naoko, Fukui, Daisuke, Nakatsuka, Terumasa, Yamada, Hiroshi

المساهمون: Japan Society for the Promotion of Science

المصدر: Biochemistry and Biophysics Reports ; volume 34, page 101470 ; ISSN 2405-5808

مصطلحات موضوعية: Biochemistry, Biophysics

الإتاحة: https://doi.org/10.1016/j.bbrep.2023.101470Test
https://api.elsevier.com/content/article/PII:S2405580823000511?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2405580823000511?httpAccept=text/plainTest

المؤلفون: Sakai, Kino¹ (AUTHOR) skino243@g.ecc.u-tokyo.ac.jp, Fukui, Daisuke² (AUTHOR), Shirouzu, Hiroshi³ (AUTHOR), Watanabe, Yurie³ (AUTHOR), Inamori, Daiki³ (AUTHOR), Funasaka, Noriko⁴ (AUTHOR), Aoki, Kagari^1,5 (AUTHOR), Sakamoto, Kentaro Q.¹ (AUTHOR)

المصدر: Animal Biotelemetry. 6/21/2024, Vol. 12 Issue 1, p1-12. 12p.

مستخلص: Background: To reduce heat loss underwater, marine mammals cover their bodies with insulation. Cetaceans in particular rely solely on blubber for insulation which has low conductivity. Blubber establishes a great thermal gradient between the warmer body core and cooler body surface, reducing heat transfer to the environment. A temperature gradient within the blubber determines the conductive heat transfer from the body trunk, where conduction and convection are the primary heat transfer mechanisms in cetaceans. Therefore, measuring the temperature at the innermost part of the blubber, i.e., the temperature at the muscle–blubber interface (Tmbi), can enhance our understanding of thermoregulatory mechanisms in cetaceans. In thermoregulation, activity-induced heat produced by increased muscle metabolism is another factor that plays an important role, however, the effects of activity on Tmbi have not been investigated in cetaceans. To assess this relationship in free-swimming cetaceans, we measured Tmbi and activity levels in a captive Risso's dolphin (Grampus griseus) using an implantable biologging device. Results: Tmbi and activity data were analyzed for 11 days. The average Tmbi was 35.1 ± 0.6 ºC and the temperature gradient between Tmbi and the water temperature was 13.0 ± 0.7 ºC. Tmbi was higher during the daytime and lower in the early morning. The variation in Tmbi was best explained by both the activity levels and time of day. Tmbi did not simply increase with activity levels; it appeared to remain relatively constant at most activity levels. However, Tmbi appeared to decrease when the animal was inactive and increase when it was intensely active. Conclusion: Our results provide important insights into how a dolphin regulates its body temperature underwater. Thermal insulation by blubber and heat production by activity were suggested to play important roles in thermoregulation. Whole-body heat dissipation might be used to regulate temperature increases when heat production is excessive due to intense activity. During inactive periods, decreasing temperature gradient may help reduce heat loss from the body. [ABSTRACT FROM AUTHOR]

المؤلفون: Kozaki, Takuhei, Fukui, Daisuke, Yamamoto, Ei, Nishiyama, Daisuke, Yamanaka, Manabu, Murata, Akimasa, Yamada, Hiroshi

المصدر: Journal of Experimental Orthopaedics ; volume 9, issue 1 ; ISSN 2197-1153

الوصف: Purpose Although it has been recognized that the medial meniscus extrusion (MME) leads to progressive cartilage loss and osteoarthritis (OA), about 20% of cases with MME had minor symptoms and poor progression of knee OA. However, it is still unclear which patients will have minimal symptoms or will not progress to degeneration. The purpose of this study is to compare the effect of the relationship between the MME and Joint line convergence angle (JLCA) on knee stress with the finite element (FE) analysis method. Methods The 65 year-old female was taken computer tomography (CT) from thigh to ankle. A 3-dimentional nonlinear FE model was constructed from the patient’s DICOM data. We made the six models, which was different from JLCA and MME. Contact stresses on the surfaces between femoral and tibial cartilages and both side of meniscus are analyzed. Results As the JLCA or MME increased, the stress load on the medial compartment increased. The effect of MME was stronger on the femoral side, while the effect of JLCA was stronger for the tibia and meniscus. If the JLCA was tilted valgus, the stress in the medial compartment did not increase even in the presence of MME. Conclusions This study revealed that the MME is associated with increased a stress loading on medial compartment structures. Furthermore, this change was enhanced by the varus tilt of the JLCA. In the case of valgus alignment, the contact pressure of the medial compartment did not increase so much even if with the MME. Level of evidence Level V

الإتاحة: https://doi.org/10.1186/s40634-022-00490-yTest

المؤلفون: Tashiro, Hideki, Koyanagi, Samon, Honda, Akihiro, Nonaka, Toshikatu, Ohkubo, Youhei, Naganuma, Chisana, Fukui, Daisuke, Ichimura, Kenichi, Sakai, Terufumi

المصدر: Journal of Medical Ultrasonics ; volume 49, issue 4, page 689-693 ; ISSN 1346-4523 1613-2254

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, General Medicine

الوصف: Purpose Because the posterior wall of the aorta and left atrium are interlocked, the amplitude of motion of the aortic wall (AMAW) may reflect cardiac and vessel functions. This study examined the relationship between cardiac and vessel functions and AMAW. Methods Patients with cardiovascular diseases or patients undergoing health examinations who visited a participating hospital and underwent echocardiography and brachial–ankle pulse-wave velocity (baPWV) examinations were registered. The correlations between echocardiographic indices, ankle–brachial index, and baPWV and AMAW on M-mode echocardiography were analyzed. Results Overall, 184 patients were enrolled. Heart rate ( r = − 0.1587), ejection fraction (EF; r = 0.3240), wall thickness ( r = − 0.1598), peak early diastolic mitral annular velocity (E) to peak early diastolic mitral annular velocity ratio (e’; r = − 0.2463), and baPWV ( r = − 0.1928) significantly correlated with AMAW. In the stratified multiple regression analysis, E/e’ (standardized partial regression coefficients = − 0.1863) and mean baPWV (standardized partial regression coefficients = − 0.1917) in patients with an EF of ≥ 60% ( n = 114) significantly correlated with AMAW. In patients with an EF of < 60% ( n = 70), E/e’ (standardized partial regression coefficients = − 0.2443) significantly correlated with AMAW. Conclusion Because E/e’ correlated with AMAW in patients with an EF of < 60% or ≥ 60%, AMAW might be an indicator of left atrial pressure elevation. Moreover, because AMAW correlated with baPWV in patients with an EF of ≥ 60%, changes in the restricted left atrial volume might influence diastolic dysfunction. AMAW may be related to cardiac and vessel functions.

الإتاحة: https://doi.org/10.1007/s10396-022-01238-yTest

المؤلفون: Hirose, Yuko, Fukui, Daisuke, Sunahara, Nanae, Narita, Yoshitaka, Horibuchi, Yuzo

المصدر: Neuro-Oncology Advances ; volume 4, issue Supplement_3, page iii26-iii26 ; ISSN 2632-2498

مصطلحات موضوعية: Surgery, Oncology, Neurology (clinical)

الوصف: Background and Purpose Glioblastoma is the most is the poorest prognosis tumor of all carcinomas. Various factors contribute to deterioration for glioblastoma such as age, KPS, and surgical removal level. The most important factors for poor prognosis are that half of patients with glioblastoma have a KPS ≤ 70 at the start of treatment because glioblastoma progresses rapidly. There have been no comprehensive reports on the trends in visits and time to initiation of treatment for patients with glioblastoma. We analyzed the actual clinical course of malignant brain tumor patients using the receipt database with the aim of raising awareness of prompt diagnosis and treatment. Methods Because this study included patient-visit transitions, we utilized receipt data from JMDC Inc., which can be tracked through changes of medical facilities. We analyzed for data for the period January 1, 2005, to March 31, 2022. Results and Discussion The study included 493 patients with malignant neoplasms of brain, aged 18 years or older, who underwent surgery and received radiation or temozolomide. The medical departments that visited for the first time before surgery were general internal medicine, neurosurgery, followed by ophthalmologist, orthopedics, and otolaryngology. The period from the date of the first visit to surgery was 21 days for neurosurgery and 46 days for general internal medicine. The mean time from MRI to surgery was 11 days when surgery was performed at the MRI site, and 22 days when the patient was referred to another hospital after MRI. This study clarified the actual situation when patients with malignant brain tumors visit a department besides neurosurgery. In order to facilitate prompt diagnosis and treatment, it is necessary to raise awareness of the disease among the departments where patients are likely to visit for the first time.

الإتاحة: https://doi.org/10.1093/noajnl/vdac167.104Test
https://academic.oup.com/noa/article-pdf/4/Supplement_3/iii26/47562647/vdac167.104.pdfTest

المؤلفون: Fukui, Daisuke, Kawahito, Yuki, Miyazawa, Naoki, Nakada, Nobuo

المساهمون: PRESTO

المصدر: Materials Characterization ; volume 191, page 112157 ; ISSN 1044-5803

مصطلحات موضوعية: Mechanical Engineering, Mechanics of Materials, Condensed Matter Physics, General Materials Science

الإتاحة: https://doi.org/10.1016/j.matchar.2022.112157Test
https://api.elsevier.com/content/article/PII:S1044580322004399?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1044580322004399?httpAccept=text/plainTest