المؤلفون: Roy, Bhaswati, Choi, Sarah E, Freeby, Matthew J, Kumar, Rajesh

المصدر: Scientific reports. 13(1)

مصطلحات موضوعية: Brain, Humans, Brain Injuries, Diabetes Mellitus, Type 2, Cognition, Adult, Diffusion Tensor Imaging, Biomedical Imaging, Diabetes, Behavioral and Social Science, Mental Health, Clinical Research, Brain Disorders, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Neurological, Mental health

الوصف: Type 2 diabetes mellitus (T2DM) patients show brain tissue changes in mood and cognitive regulatory sites, but the nature and extent of tissue injury and their associations with symptoms are unclear. Our aim was to examine brain tissue damage in T2DM over controls using mean diffusivity (MD) computed from diffusion tensor imaging (DTI), and assess correlations with mood and cognitive symptoms in T2DM. We collected DTI series (MRI), mood, and cognitive data, from 169 subjects (68 T2DM and 101 controls). Whole-brain MD-maps were calculated, normalized, smoothed, and compared between groups, as well as correlated with mood and cognition scores in T2DM subjects. Type 2 diabetes patients showed altered cognitive and mood functions over control subjects. Multiple brain sites in T2DM patients showed elevated MD values, indicating chronic tissue changes, including the cerebellum, insula, and frontal and prefrontal cortices, cingulate, and lingual gyrus. Associations between MD values and mood and cognition scores appeared in brain sites mediating these functions. Type 2 diabetes patients show predominantly chronic brain tissue changes in areas mediating mood and cognition functions, and tissue changes from those regions correlate with mood and cognitive symptoms suggesting that the microstructural brain changes may account for the observed functional deficits.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8hx288q3Test

المؤلفون: Roy, Bhaswati, Ehlert, Luke, Mullur, Rashmi, Freeby, Matthew J, Woo, Mary A, Kumar, Rajesh, Choi, Sarah

المصدر: Scientific reports. 10(1)

الوصف: Patients with Type 2 diabetes mellitus (T2DM) show cognitive and mood impairment, indicating potential for brain injury in regions that control these functions. However, brain tissue integrity in cognition, anxiety, and depression regulatory sites, and their associations with these functional deficits in T2DM subjects remain unclear. We examined gray matter (GM) changes in 34 T2DM and 88 control subjects using high-resolution T1-weighted images, collected from a 3.0-Tesla magnetic resonance imaging scanner, and assessed anxiety [Beck Anxiety Inventory], depressive symptoms [Beck Depression Inventory-II], and cognition [Montreal Cognitive Assessment]. We also investigated relationships between GM status of cognitive and mood control sites and these scores in T2DM. Significantly increased anxiety (p = 0.003) and depression (p = 0.001), and reduced cognition (p = 0.002) appeared in T2DM over controls. Decreased GM volumes appeared in several regions in T2DM patients, including the prefrontal, hippocampus, amygdala, insular, cingulate, cerebellum, caudate, basal-forebrain, and thalamus areas (p

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2fn4w597Test

المؤلفون: Pyatak, Elizabeth A., Ali, Aina, Khurana, Anya R., Lee, Pey-Jiuan, Sideris, John, Fox, Steven, Diaz, Jesus, Granados, Gabrielle, Blanchard, Jeanine, McGuire, Riley, Salazar Plascencia, Elia, Salcedo-Rodriguez, Elizabeth, Flores-Garcia, Jaquelin, Linderman, Megan, Taylor, Elinor E., Tapia, Valerie, Nnoli, Ngozi, Sequeira, Paola A., Freeby, Matthew J., Raymond, Jennifer K.

المساهمون: University of Southern California Southern California Clinical and Translational Science Institute, National Institutes of Health, Abbott Diabetes Care, National Institute of Diabetes and Digestive and Kidney Diseases, Abbott Laboratories

المصدر: Contemporary Clinical Trials ; volume 135, page 107386 ; ISSN 1551-7144

مصطلحات موضوعية: Pharmacology (medical), General Medicine

الإتاحة: https://doi.org/10.1016Test/j.cct.2023.107386
https://api.elsevier.com/content/article/PII:S1551714423003099?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1551714423003099?httpAccept=text/plainTest

المؤلفون: Freeby, Matthew J., Kringas, Patricia, Goland, Robin S., Leibel, Rudolph L., Maffei, Antonella, Divgi, Chaitan, Ichise, Masanori, Harris, Paul E.

المصدر: Molecular Imaging and Biology ; volume 18, issue 2, page 292-301 ; ISSN 1536-1632 1860-2002

مصطلحات موضوعية: Cancer Research, Radiology, Nuclear Medicine and imaging, Oncology

الإتاحة: https://doi.org/10.1007/s11307-015-0888-7Test

المؤلفون: Cabrera-Mino, Cristina, Roy, Bhaswati, Woo, Mary A., Freeby, Matthew J., Kumar, Rajesh, Choi, Sarah E.

المساهمون: National Institute of Nursing Research

المصدر: Sleep and Vigilance ; volume 5, issue 2, page 289-297 ; ISSN 2510-2265

مصطلحات موضوعية: Psychiatry and Mental health, Neurology (clinical), Neurology

الإتاحة: https://doi.org/10.1007/s41782-021-00170-4Test

المؤلفون: Rhyu, Jane, Lambrechts, Sylvia, Han, Maria A., Freeby, Matthew J.

المصدر: Current Opinion in Endocrinology, Diabetes & Obesity ; volume 29, issue 1, page 29-33 ; ISSN 1752-296X 1752-2978

الوصف: Purpose of review Hemoglobin A1c testing provides a marker of glycemic control and is the standard for diabetes risk assessment. According to the Centers for Disease Control (CDC), only 67.3–71.4% of diabetic patients between 2011 and 2016 had at least two A1c levels tested per year. Moreover, 27.8% had uncontrolled diabetes with an A1c of ≥8.0%, increasing the risk of microvascular complications. Lack of monitoring presents a significant barrier, and improving ease of testing could improve glycemic control. Recent findings Point-of-care (POC) A1c testing, obtained via capillary blood with results provided in 5–6 min, is available and used frequently in endocrine clinics. However, POC A1c testing is not standard in primary care, where 90% of type 2 diabetes patients are treated. Barriers include access and costs of POC A1c machines and standardization of testing in the primary care setting. Review of literature, however, suggests that POC A1c testing in primary care may lead to A1c reduction whereas being potentially cost-effective and strengths the patient–physician relationship. Summary POC A1c testing in primary care, if widely available and integrated into workflow, has the potential to positively impact diabetes care. Real-time feedback may change patient and physician behaviors, allowing earlier therapeutic intensification.

الإتاحة: https://doi.org/10.1097/med.0000000000000700Test

المؤلفون: Rhyu, Jane, Lambrechts, Sylvia, Han, Maria A., Freeby, Matthew J.

المصدر: Current Opinion in Endocrinology, Diabetes & Obesity; Feb2022, Vol. 29 Issue 1, p29-33, 5p

المؤلفون: Juo, Yen-Yi, Freeby, Matthew J., Arguello, Vanessa, Liu, Linda, Huang, Emily, Dutson, Erik, Chen, Yijun

المصدر: Surgery for Obesity and Related Diseases ; volume 14, issue 9, page 1246-1253 ; ISSN 1550-7289

مصطلحات موضوعية: Surgery

الإتاحة: https://doi.org/10.1016Test/j.soard.2018.05.019
https://api.elsevier.com/content/article/PII:S1550728918302879?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1550728918302879?httpAccept=text/plainTest

المؤلفون: Freeby, Matthew J.

المصدر: Diabetes and Peripheral Vascular Disease ; page 27-38 ; ISBN 9781627031578 9781627031585

الإتاحة: https://doi.org/10.1007/978-1-62703-158-5_3Test

المؤلفون: Inabnet, William B., Milone, Luca, Harris, Paul, Durak, Evren, Freeby, Matthew J., Ahmed, Leaque, Sebastian, Manu, Lifante, Jean-Christophe, Bessler, Marc, Korner, Judith

المصدر: Surgery ; volume 147, issue 2, page 303-309 ; ISSN 0039-6060

مصطلحات موضوعية: Surgery

الإتاحة: https://doi.org/10.1016Test/j.surg.2009.08.005
https://api.elsevier.com/content/article/PII:S0039606009005017?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0039606009005017?httpAccept=text/plainTest