المؤلفون: Guadalupe Echeverría, Bárbara Samith, Andrea von Schultzendorf, Victoria Pinto, Ximena Martínez, Daniela Sara, Mariana Calzada, Josefina Pacheco, Gianella Plaza, Francesca Scott, Javiera Romero, Camila Mateo, María Verónica Julio, Yildy Utreras-Mendoza, María Victoria Binder, Florencia Gutiérrez, María Emilia Riquelme, Margarita Cuevas, Rosario Willatt, Omayra Sánchez, Aracelli Keilendt, Patricia Butrón, Alessandra Jarufe, Isidora Huete, Josefina Tobar, Sofía Martin, Valentina Alfaro, Matilde Olivos, Nuria Pedrals, Marcela Bitran, Ivette Ávalos, Chiara Ruini, Carol Ryff, Druso Pérez, Loni Berkowitz, Attilio Rigotti

المصدر: Contemporary Clinical Trials Communications, Vol 35, Iss , Pp 101167- (2023)

مصطلحات موضوعية: Mediterranean diet, Psychological well-being, Metabolic syndrome, Medicine (General), R5-920

الوصف: Psychosocial status and lifestyle are key risk factors of non-communicable diseases (NCDs), which, in turn, are main drivers of healthcare costs and morbimortality worldwide, including Chile. Mediterranean diet (MedDiet) is one of the healthiest dietary patterns under study. However, its impact on high-risk conditions, such as metabolic syndrome (MetS), and NCDs outside the Mediterranean Basin remains mostly unexplored. Even though Central Chile has an environment, food production, and culinary traditions comparable to those present in Mediterranean countries, few studies -some with significant methodological limitations- have evaluated the effect of MedDiet on health and/or disease in Chilean subjects. Importantly, a Mediterranean lifestyle is a modus vivendi that integrates physical health with mental and social well-being. Psychological well-being (PWB) is associated with healthy behaviors, positive health outcomes, and longevity, thereby emerging as a novel healthcare goal. We report here an ongoing randomized controlled clinical trial in Chilean patients with MetS seeking to test whether (1) a PWB theory-based intervention facilitates induction to and increases long-term adherence to a locally adapted MedDiet, and (2) a MedDiet intervention -implemented alone or combined with well-being promotion- is more effective at reversing MetS compared to individuals following a low-fat diet without psychological support. The CHILEan MEDiterranean (CHILEMED) diet intervention study is a 1-year trial including patients with MetS living in Chile. Participants will be assigned randomly by a computer-generated random number sequence to one of the three intervention arms: a) low-fat diet as control group, b) MedDiet alone, and c) MedDiet plus well-being support. Patients will be followed-up by individual and/or group online nutritional sessions or phone cal as well as 6- and 12-month in-person re-assessment of medical history, medication use, food intake, PWB, anthropometrics/physical exam, and blood collection for laboratory analysis. The primary outcome of the trial will be the effect of the MedDiet -with or without PWB intervention- on overall reversal of MetS compared to low-fat diet alone. Based on a statistical superiority trial, expected impact, and patient loss, the estimated study sample is 339 subjects (113 individuals per arm in 3 equal-sized groups). Currently, we have enrolled 179 patients, predominantly women, evenly distributed by age (group means ranging from 45.7 to 48,9 years-old), 3/4 are obese with almost all of them showing abdominal obesity, 70% are hypertensive, whereas

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2451865423001138Test; https://doaj.org/toc/2451-8654Test

الوصول الحر: https://doaj.org/article/87bd149ea60a45028133455200220134Test

المؤلفون: Nina Holden, Claire Black, Francesca Scott, Roman Klapaukh, Alison Gordon

المصدر: Physiotherapy

مصطلحات موضوعية: Airway clearance, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), SARS-CoV-2, business.industry, Staffing, COVID-19, Physical Therapy, Sports Therapy and Rehabilitation, Workload, Respiration, Artificial, Article, Physical Therapists, Intensive Care Units, Single centre, Emergency medicine, Bronchial Secretion, Humans, Medicine, Sputum, In patient, medicine.symptom, business, Physical Therapy Modalities

الوصف: Bronchial secretion management was not an anticipated clinical problem in patients intubated and ventilated with COVID-19. Yet 63 (62%) of our intubated and ventilated patients demonstrated a moderate or greater sputum load, as recorded by physiotherapists on 5 or more days of the patient's ICU stay. The efficacy of airway clearance in these patients was further compounded by ineffective or absent cough and increased secretion tenacity, dramatically increasing the workload of critical care physiotherapists. We provide data to support the modelling of critical care physiotherapy staffing for future COVID-19 surges.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dae984c83a49cd06ac8b50a0deae6b9Test
https://doi.org/10.1016/j.physio.2021.03.010Test

المؤلفون: Felicitas Mück, Francesca Scotti, Quentin Mauvisseau, Birgitte Lisbeth Graae Thorbek, Helle Wangensteen, Hugo J. de Boer

المصدر: Frontiers in Pharmacology, Vol 15 (2024)

مصطلحات موضوعية: chemical fingerprinting, DNA barcoding, endometriosis, pharmacovigilance, Traditional Chinese Medicine, women’s healthcare, Therapeutics. Pharmacology, RM1-950

الوصف: Traditional Chinese Medicine (TCM) herbal products are increasingly used in Europe, but prevalent authentication methods have significant gaps in detection. In this study, three authentication methods were tested in a tiered approach to improve accuracy on a collection of 51 TCM plant ingredients obtained on the European market. We show the relative performance of conventional barcoding, metabarcoding and standardized chromatographic profiling for TCM ingredients used in one of the most diagnosed disease patterns in women, endometriosis. DNA barcoding using marker ITS2 and chromatographic profiling are methods of choice reported by regulatory authorities and relevant national pharmacopeias. HPTLC was shown to be a valuable authentication tool, combined with metabarcoding, which gives an increased resolution on species diversity, despite dealing with highly processed herbal ingredients. Conventional DNA barcoding as a recommended method was shown to be an insufficient tool for authentication of these samples, while DNA metabarcoding yields an insight into biological contaminants. We conclude that a tiered identification strategy can provide progressive qualitative and quantitative insight in an integrative approach for quality control of processed herbal ingredients.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2024.1353434/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/8914d59f318241049fa58bb6e957b84aTest

المؤلفون: Felicitas Mück, Francesca Scotti, Quentin Mauvisseau, Ancuţa Cristina Raclariu-Manolică, Audun Schrøder-Nielsen, Helle Wangensteen, Hugo J. de Boer

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: chemical fingerprinting, DNA metabarcoding, endometriosis, pharmacovigilance, Traditional Chinese Medicine, women’s healthcare, Therapeutics. Pharmacology, RM1-950

الوصف: Traditional Chinese Medicine (TCM) is popular for the treatment of endometriosis, a complex gynecological disease that affects 10% of women globally. The growing market for TCMs has yielded a significant incentive for product adulteration, and although emerging technologies show promise to improve their quality control, many challenges remain. We tested the authenticity of two traditional Chinese herbal formulae used in women’s healthcare for the treatment of endometriosis, known as Gui Zhi Fu Ling Wan (FL) and Ge Xia Zhu Yu Tang (GX). Dual-locus DNA metabarcoding analysis coupled with high-performance thin-layer chromatography (HPTLC) were used to authenticate 19 FL and six GX commercial herbal products, as well as three ad hoc prepared artificial mixtures. HPTLC was able to detect most of the expected ingredients via comparative component analysis. DNA metabarcoding was able to detect an unexpected species diversity in the products, including 38 unexpected taxa. Chromatography has a resolution for all species indirectly through the identification of marker compounds for the different species ingredients. Metabarcoding on the other hand yields an overview of species diversity in each sample, but interpretation of the results can be challenging. Detected species might not be present in quantities that matter, and without validated quantification, some detected species can be hard to interpret. Comparative analysis of the two analytical approaches also reveals that DNA for species might be absent or too fragmented to amplify as the relevant chemical marker compounds can be detected but no amplicons are assigned to the same species. Our study emphasizes that integrating DNA metabarcoding with phytochemical analysis brings valuable data for the comprehensive authentication of Traditional Chinese Medicines ensuring their quality and safe use.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2023.1305410/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/71b32647ac1d4fb596a9fcf7ab4273c9Test

المؤلفون: Ulrike Grienke, Francesca Scotti, Judith M. Rollinger

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: ethnopharmacology, Momordica charantia, Entada africana, alkannin, palmatine, skin disorders, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2023.1224820/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/d23c6489bbf24f04bb69b43aa7862859Test

المؤلفون: Francesca Scott, Ji Won Chung, Kate Scarth

مصطلحات موضوعية: History, Insanity, media_common.quotation_subject, Body politic, Art history, Sensibility, Performance art, Long nineteenth century, Miasma theory, Iconography, Humanities, Feminism, media_common

الوصف: Introduction: Picturing Women's Health - Francesca Scott, Kate Scarth and Ji Won Chung 1 Sensibility and Good Health in Charlotte Smith's Ethelinde - Joseph Morrissey 2 Amazonian Fashions: Lady Delacour's (Re)Dress in Maria Edgeworth's Belinda - Andrew McInnes 3 Transforming the Body Politic: Food Reform and Feminism in Nineteenth-Century Britain - Sarah Richardson 4 Stagnation of Air and Mind: Picturing Trauma and Miasma in Charlotte Bronte's Villette - Alexandra Lewis 5 The Iconography of Anorexia Nervosa in the Long Nineteenth Century - Susannah Wilson 6 Kate Marsden's Leper Project: On Sledge and Horseback with an Outcast Missionary Nurse - Tabitha Sparks 7 Constructs of Female Insanity at the Fin de Siecle: The Lawn Hospital, Lincoln, 1882-1902 - Katherine Ford 8 The Fitness of the Female Medical Student, 1895-1910 - Claire Brock 9 Unstable Adolescence/Unstable Literature? Managing British Girls' Health around 1900 - Hilary Marland Notes Index

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8ecdd845a9ab594fe14a65ea4d0d1cedTest
https://doi.org/10.4324/9781315654508Test

الوصف: Women Telling Nations highlights how, from the 16th to the 19th centuries, European women, as readers and writers, contributed to the construction of national identities. The book, which presents twenty countries, is divided into four parts. First, we examine how women belonged to nations: they represented territories and political or religious communities in their own style. Second, we deal with the ways in which women wrote the nation: the network of relationships in which they were involved that were not necessarily national or territorial. The legitimation that women writers succeeded in finding is emphasised in the third section, while in the fourth we analyse how and why women were open to the outside world, beyond the country's borders. Women Telling Nations underlines the quantitative importance of the circulation of these women's writings and demonstrates the extent as well as the impact of the international cross-fertilisation of nations, especially by and for women: focusing on routes rather than roots.

المؤلفون: Amelia Sanz, Francesca Scott, Suzan van Dijk

نوع المادة: eBook.

الموضوعات: Literature--Women authors--History and criticism, Women authors--Political activity

تصنيفات: SOCIAL SCIENCE / Gender Studies, LAW / Discrimination, LITERARY CRITICISM / Women Authors

المؤلفون: Amelia Sanz, Francesca Scott, Susan Van Dijk

مصطلحات موضوعية: Politics, Women's history, Legitimation, Political science, Section (typography), Gender studies, Circulation (currency), National Identities, Social science, Style (sociolinguistics)

الوصف: Women Telling Nations highlights how, from the 16th to the 19th centuries, European women, as readers and writers, contributed to the construction of national identities. The book, which presents twenty countries, is divided into four parts. First, we examine how women belonged to nations: they represented territories and political or religious communities in their own style. Second, we deal with the ways in which women wrote the nation: the network of relationships in which they were involved that were not necessarily national or territorial. The legitimation that women writers succeeded in finding is emphasised in the third section, while in the fourth we analyse how and why women were open to the outside world, beyond the country's borders. Women Telling Nations underlines the quantitative importance of the circulation of these women's writings and demonstrates the extent as well as the impact of the international cross-fertilisation of nations, especially by and for women: focusing on routes rather than roots.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9495b3a2d6df881af8e08a70d225c355Test
https://doi.org/10.1163/9789401211123Test

المؤلفون: Francesca Scott

المصدر: Vital. 7:27-27

مصطلحات موضوعية: Medical education, business.industry, Oral health education, Optometry, Medicine, General Medicine, business

الوصف: BDA Education Services Administrator Francesca Scott spoke to Natalie Murray about her experiences on the online oral health education course.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::eb2321f031b110f770114178be1fcec2Test
https://doi.org/10.1038/vital1284Test

المؤلفون: Michael Heinrich, Francesca Scotti, Adolfo Andrade-Cetto, Monica Berger-Gonzalez, Javier Echeverría, Fabio Friso, Felipe Garcia-Cardona, Alan Hesketh, Martin Hitziger, Caroline Maake, Matteo Politi, Carmenza Spadafora, Rita Spadafora

المصدر: Frontiers in Pharmacology, Vol 11 (2020)

مصطلحات موضوعية: Nagoya Protocol, benefit sharing, traditional medicine, Access and Benefit Sharing (ABS), natural products, biological resources, Therapeutics. Pharmacology, RM1-950

الوصف: BackgroundGlobal challenges related to access and benefit sharing (ABS) of biological resources have become a key concern in the area of research on herbal medicines, ethnopharmacology, drug discovery, and the development of other high value products for which Intellectual Property protection can be secured. While the Convention on Biological Diversity (CBD, Rio 1992) has been recognized as a huge step forward, the implementation of the Nagoya Protocol (NP) and of new forms of collaboration often remain unresolved, especially in the context of “the fair and equitable sharing of benefits arising from the utilization of genetic resources” (Convention on Biological Diversity, 2011). The vision and the specific implementation of this international treaty vary from country to country, which poses additional challenges.AimsUsing a case study approach, in this analysis we aim at understanding the specific opportunities and challenges for implementing international collaborations regarding ABS in six Latin American countries—Chile, Colombia, Guatemala, México, Panama, and Peru. Based on that analysis, we provide recommendations for the path ahead regarding international collaborations under ABS agreements in ethnopharmacological research.Results and DiscussionsThe implementation of the NP varies in the six countries; and while they are all rich in biodiversity, access and benefit sharing mechanisms differ considerably. There is a need to engage in a consultation process with stakeholders, but this has often come to a halt. Institutional infrastructures to implement national policies are weak, and the level of knowledge about the NP and the CBD within countries remains limited.ConclusionsDifferent policies in the six countries result in very diverse strategies and opportunities relating to the equitable use of biodiversity. A long-term strategy is required to facilitate a better understanding of the treaties and the resulting opportunities for a fairer development and implementation of transparent national polices, which currently differ in the six countries. So far, the benefits envisioned by the CBD and the NP remain unfulfilled for all stakeholders involved including local communities.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fphar.2020.00765/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/41c2a43ea97b4b95bcca6ebe2ffc5e1bTest