المؤلفون: Jyotirmay Biswas, Nipun Bagrecha, Puja Maitra

المصدر: TNOA Journal of Ophthalmic Science and Research, Vol 59, Iss 2, Pp 137-147 (2021)

مصطلحات موضوعية: aneurysms and neuroretinitis (idiopathic retinal vasculitis, aneurysms, and neuroretinitis), covid 19 vasculitis, cytomegalovirus retinitis, eales, idiopathic retinitis, post pyrexial vasculitis, retinal vasculitis, sarcoidosis behcet's, systemic lupus erythematosus, takayasu's arteritis, toxoplasmic retinochoroiditis, vasculitis, widefield fundus fluorescein angiogram, Ophthalmology, RE1-994

الوصف: Retinal vasculitis is a sight-threatening inflammatory condition affecting the retinal vessels. It can occur due to several etiologies and spectrum of other ocular inflammatory conditions. It can occur as an isolated idiopathic condition, as a complication of infective or neoplastic disorders, or in association with systemic inflammatory disease. The various known etiologies have been discussed here with their characteristic features. Etiological diagnosis of retinal vasculitis can be challenging. Clinical examination, tailored laboratory investigations and multimodal imaging with fundus photography, fundus autofluorescence, fundus fluorescein angiography, indocyanine green angiography, swept-source optical coherence tomography (OCT), OCT angiography, B scan ultrasonography and in recent years widefield fundus fluorescein angiogram, imaging aids in the early diagnosis, monitoring and provides newer insights about these diseases. Newer treatment modalities and therapies such as immunomodulators and biologics have been added to the armamentarium against these sight-threatening conditions. Anti-vascular endothelial growth factor agents and laser photocoagulation are particularly beneficial to arrest the neovascularization process. The diagnosis of vasculitis may uncover an unknown underlying systemic cause. Early, effective, and prompt management can be vision saving and can minimize comorbidities. We feel that there is a necessity to update our knowledge on existing and newer trends in diagnosis, investigations, and management of retinal vasculitis. This review focuses on some of the basic concepts related to retinal vasculitis with an update.

وصف الملف: electronic resource

العلاقة: http://www.tnoajosr.com/article.asp?issn=2589-4528;year=2021;volume=59;issue=2;spage=137;epage=147;aulast=BiswasTest; https://doaj.org/toc/2589-4528Test; https://doaj.org/toc/2589-4536Test

الوصول الحر: https://doaj.org/article/cf96f9c737354efda78d91aa7747917fTest

المؤلفون: Mani Kruthika Mantha, Tarun Kumar Suvvari, Lakshmoji Naidu Kotipalli, Tejaswi Kota

المصدر: MGM Journal of Medical Sciences, Vol 8, Iss 3, Pp 303-307 (2021)

مصطلحات موضوعية: bevacizumab, central retinal vein occlusion (crvo), diabetes, fluorescein angiogram, macular edema, unilateral ischemic crvo, Medicine

الوصف: Central retinal vein occlusion (CRVO) is a significant cause of marked or total loss of vision in the middle-aged and elderly population. The patient was a 54-year-old man with a history of uncontrolled diabetes and was given seven intravitreal bevacizumab (Avastin) injections as treatment. The patient was advised to follow-up during the next 6 months, including gonioscopy and undilated examination of the iris to look for the iris/disc neovascularization. We presented a classic case of unilateral ischemic CRVO with macular edema, in whom diabetes is the leading risk factor. Close follow-up and diabetes control are advisable to prevent a similar scenario.

وصف الملف: electronic resource

العلاقة: http://www.mgmjms.com/article.asp?issn=2347-7946;year=2021;volume=8;issue=3;spage=303;epage=307;aulast=ManthaTest; https://doaj.org/toc/2347-7946Test; https://doaj.org/toc/2347-7962Test

الوصول الحر: https://doaj.org/article/b9784a14ab2f416197c8cf6e151e574dTest

المؤلفون: Sumit Laha, Rodney LaLonde, Austin E. Carmack, Hassan Foroosh, John C. Olson, Saad Shaikh, Ulas Bagci

المصدر: Frontiers in Computer Science, Vol 2 (2020)

مصطلحات موضوعية: capsule networks, retinal vessel segmentation, Eulerian video magnification, haar wavelets registration, fluorescein angiogram, Electronic computers. Computer science, QA75.5-76.95

الوصف: Objective: The aim of this research is to present a novel computer-aided decision support tool in analyzing, quantifying, and evaluating the retinal blood vessel structure from fluorescein angiogram (FA) videos.Methods: The proposed method consists of three phases: (i) image registration for large motion removal from fluorescein angiogram videos, followed by (ii) retinal vessel segmentation, and lastly, (iii) segmentation-guided video magnification. In the image registration phase, individual frames of the video are spatiotemporally aligned using a novel wavelet-based registration approach to compensate for the global camera and patient motion. In the second phase, a capsule-based neural network architecture is employed to perform the segmentation of retinal vessels for the first time in the literature. In the final phase, a segmentation-guided Eulerian video magnification is proposed for magnifying subtle changes in the retinal video produced by blood flow through the retinal vessels. The magnification is applied only to the segmented vessels, as determined by the capsule network. This minimizes the high levels of noise present in these videos and maximizes useful information, enabling ophthalmologists to more easily identify potential regions of pathology.Results: The collected fluorescein angiogram video dataset consists of 1, 402 frames from 10 normal subjects (prospective study). Experimental results for retinal vessel segmentation show that the capsule-based algorithm outperforms a state-of-the-art convolutional neural networks (U-Net), obtaining a higher dice coefficient (85.94%) and sensitivity (92.36%) while using just 5% of the network parameters. Qualitative analysis of these videos was performed after the final phase by expert ophthalmologists, supporting the claim that artificial intelligence assisted decision support tool can be helpful for providing a better analysis of blood flow dynamics.Conclusions: The authors introduce a novel computational tool, combining a wavelet-based video registration method with a deep learning capsule-based retinal vessel segmentation algorithm and a Eulerian video magnification technique to quantitatively and qualitatively analyze FA videos. To authors' best knowledge, this is the first-ever development of such a computational tool to assist ophthalmologists with analyzing blood flow in FA videos.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fcomp.2020.00024/fullTest; https://doaj.org/toc/2624-9898Test

الوصول الحر: https://doaj.org/article/0335139048ac4981b7b0cac15db069c4Test

المؤلفون: Aditya Verma, Vikas Khetan

المصدر: Indian Journal of Ophthalmology, Vol 66, Iss 3, Pp 468-471 (2018)

مصطلحات موضوعية: Fundus fluorescein angiogram, intravitreal steroid implant, ischemic maculopathy, radiation maculopathy, Ophthalmology, RE1-994

الوصف: Diabetic retinopathy (DR) is a well-known risk factor in the development of radiation maculopathy (RM). Steroids have been shown to improve the vision and reduce the macular thickness in patients with RM. This observational case report highlights altered course of DR after a course of radiotherapy for orbital lymphoma, after a single dose of intravitreal dexamethasone implant showed a dramatic revascularization of the ischemic macula, with a significant reduction in the size of ischemic area. This appears to be the first case in literature corroborating the favorable effect on steroids on retinal vasculature, seen angiographically.

وصف الملف: electronic resource

العلاقة: http://www.ijo.in/article.asp?issn=0301-4738;year=2018;volume=66;issue=3;spage=468;epage=471;aulast=VermaTest; https://doaj.org/toc/0301-4738Test; https://doaj.org/toc/1998-3689Test

الوصول الحر: https://doaj.org/article/c7eaf7197db04f6e9ebacf6c16461d42Test

المؤلفون: Radha Shenoy, Milind Suryawanshi, Roshini Isaac, Santhosh K Philip

المصدر: Oman Journal of Ophthalmology, Vol 9, Iss 1, Pp 59-62 (2016)

مصطلحات موضوعية: B-scan ultrasonography, fundus fluorescein angiogram, optical coherence tomogram, posterior scleritis, Ophthalmology, RE1-994

الوصف: Posterior scleritis is rare in both the adult and pediatric age groups. Increased awareness and availability of advanced diagnostic facilities aid in early diagnosis and management. Visual recovery is possible with systemic steroids and immunosuppression. We report the case of a 12-year-old male child who presented with poor vision in his right eye and was found to have retinal striae and disc edema due to posterior scleritis.

وصف الملف: electronic resource

العلاقة: http://www.ojoonline.org/article.asp?issn=0974-620X;year=2016;volume=9;issue=1;spage=59;epage=62;aulast=ShenoyTest; https://doaj.org/toc/0974-620XTest

الوصول الحر: https://doaj.org/article/90571c73a38748eda052746ac93316b1Test

المؤلفون: Mohamad Kamil Muhammad-Ikmal, Abdul Satar Huwaina, Muda Rosiah, Ahmad Tajudin Liza-Sharmini

المصدر: Malaysian Journal of Ophthalmology. 3:175-182

مصطلحات موضوعية: medicine.medical_specialty, Melioidosis, genetic structures, biology, Burkholderia pseudomallei, Retinal vasculitis, business.industry, Endemic area, Fundus (eye), medicine.disease, biology.organism_classification, Dermatology, eye diseases, medicine.anatomical_structure, medicine, Fluorescein angiogram, Eyelid, Presentation (obstetrics), business

الوصف: Burkholderia pseudomallei is a known great mimicker responsible for melioidosis. Ocular involvement in melioidosis is unusual, with eyelid and orbital infection as the commonest presentation. We describe a 41-year-old, healthy woman who complained of reduced vision in her left eye. On examination, vision in the left eye was 6/9. There was evidence of occlusive retinal vasculitis on fundoscopy examination. Fundus fluorescein angiogram showed extensive capillary fallout. Diagnosis was established by a rise in the serum antibody titre for the bacterium and further supported by clinical improvement of vision after completion of treatment antibiotics. Sectoral panretinal photocoagulation at the capillary fallout area successfully arrested the sequelae of retinal ischaemia. Occlusive retinal vasculitis is a rare presentation of melioidosis. Early prompt diagnosis in an immunocompetent individual helps prevent visual-related morbidity. The ability of this bacteria to cause recurrent infection in an endemic area should not be underestimated.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::44ba793159b5f8b4d2f4801cb1b3a789Test
https://doi.org/10.35119/myjo.v3i3.214Test

المؤلفون: Annabelle A. Okada, Alastair K Denniston, Andrew D. Dick, Peter McCluskey, Russell W. Read, Alan G. Palestine, Brett Trusko, Jennifer E. Thorne, Douglas A. Jabs, Michal Kramer, Neal Oden, James P. Dunn

المصدر: Am J Ophthalmol

مصطلحات موضوعية: Adult, Male, Vogt–Koyanagi–Harada disease, Pediatrics, medicine.medical_specialty, Training set, Fundus Oculi, business.industry, Middle Aged, Fundus (eye), medicine.disease, Article, eye diseases, Confidence interval, Ophthalmology, medicine, Humans, Fluorescein angiogram, Female, Fluorescein Angiography, Uveomeningoencephalitic Syndrome, business, Tomography, Optical Coherence

الوصف: Purpose To determine classification criteria for Vogt-Koyanagi-Harada (VKH) disease Design Machine learning of cases with VKH disease and 5 other panuveitides. Methods Cases of panuveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Machine learning using multinomial logistic regression was used on the training set to determine a parsimonious set of criteria that minimized the misclassification rate among the panuveitides. The resulting criteria were evaluated on the validation set. Results One thousand twelve cases of panuveitides, including 156 cases of early-stage VKH and 103 cases of late-stage VKH, were evaluated. Overall accuracy for panuveitides was 96.3% in the training set and 94.0% in the validation set (95% confidence interval 89.0, 96.8). Key criteria for early-stage VKH included: 1) exudative retinal detachment with characteristic appearance on fluorescein angiogram or optical coherence tomography or 2) panuveitis with ≥2 of 5 neurologic symptoms/signs. Key criteria for late-stage VKH included history of early-stage VKH and either: 1) sunset glow fundus or 2) uveitis and ≥1 of 3 cutaneous signs. The misclassification rates in the learning and validation sets for early-stage VKH were 8.0% and 7.7%, respectively, and for late-stage VKH 1.0% and 12%, respectively. Conclusions The criteria for VKH had a reasonably low misclassification rate and appeared to perform sufficiently well for use in clinical and translational research.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977d5837d86ff53966c8d7bbfcc72869Test
https://doi.org/10.1016/j.ajo.2021.03.036Test

المؤلفون: Joseph Raevis, Elzbieta Mechel, Ksenia Denisova, Eric M. Shrier

المصدر: RETINAL Cases & Brief Reports. 15:214-217

مصطلحات موضوعية: medicine.medical_specialty, genetic structures, Visual Acuity, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Retinal Diseases, Optical coherence tomography, Ophthalmology, medicine, Humans, Fluorescein Angiography, 0101 mathematics, Axial myopia, Tessellation, medicine.diagnostic_test, Mosaicism, business.industry, 010102 general mathematics, Retinal, General Medicine, Optical coherence tomography angiography, Middle Aged, eye diseases, Axial Length, Eye, Left eye, medicine.anatomical_structure, chemistry, 030221 ophthalmology & optometry, Fluorescein angiogram, Female, sense organs, Choroid, business, Tomography, Optical Coherence

الوصف: BACKGROUND/PURPOSE Report a case of markedly asymmetric retinal tessellations and propose mosaicism as a mechanism. METHODS AND RESULTS A 59-year-old pseudophakic woman presented with uncorrected 20/20 vision and was found to have markedly different retinal tessellation appearances in both eyes. The axial lengths were 25.66 mm and 25.88 mm in the right and left eyes, respectively, and no significant asymmetrical choroidal thinning was seen on optical coherence tomography or optical coherence tomography angiography. Fluorescein angiogram showed significant hyperfluorescence, representing the underlying choroid, which correlated with the tessellation patterns in the left eye. She had no other ocular or systemic findings such as stripes or whorled skin. CONCLUSION This is the first reported case of markedly asymmetric retinal tessellation patterns that are not due to asymmetric axial myopia or choroidal thinning. We propose that mosaicism is a possible mechanism causing this finding.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b20d119a6aa8869b51d9f3ee666bc35Test
https://doi.org/10.1097/icb.0000000000000770Test

المؤلفون: Manish Tandon, Abhishek Gupta, Priyanka Singh, Gnanavelu N Subathra

المصدر: Indian Journal of Ophthalmology, Vol 64, Iss 10, Pp 772-774 (2016)

مصطلحات موضوعية: Fluorescein angiogram, fundus autofluorescence, hand, foot, and mouth disease, hemorrhagic maculopathy, indocyanine green angiogram, optical coherence tomogram, Ophthalmology, RE1-994

الوصف: Hand, foot, and mouth disease (HFD) is a common systemic infection occurring in childhood or immunocompromised adults caused by enteroviruses, the most common being coxsackievirus A16 and enterovirus 71. It is characterized by maculopapular eruptions over the hands and feet and ulcerative stomatitis. Ocular involvement is a rare complication and commonly manifests as inflammatory macular pathology. We report a case of HFD in an immunocompetent adult male with unilateral ocular involvement presenting as hemorrhagic maculopathy and its management with complete anatomical and functional recovery.

وصف الملف: electronic resource

العلاقة: http://www.ijo.in/article.asp?issn=0301-4738;year=2016;volume=64;issue=10;spage=772;epage=774;aulast=TandonTest; https://doaj.org/toc/0301-4738Test; https://doaj.org/toc/1998-3689Test

الوصول الحر: https://doaj.org/article/e1fb0b7b67e34b9fa776a46b399da854Test

المؤلفون: Lakshmoji Naidu Kotipalli, Mani Kruthika Mantha, Tarun Kumar Suvvari, Tejaswi Kota

المصدر: MGM Journal of Medical Sciences, Vol 8, Iss 3, Pp 303-307 (2021)

مصطلحات موضوعية: medicine.medical_specialty, Bevacizumab, genetic structures, fluorescein angiogram, bevacizumab, central retinal vein occlusion (crvo), Central retinal vein occlusion, Diabetes mellitus, Ophthalmology, Gonioscopy, medicine, Iris (anatomy), Intravitreal bevacizumab, Risk factor, Macular edema, macular edema, medicine.diagnostic_test, diabetes, business.industry, General Medicine, medicine.disease, eye diseases, medicine.anatomical_structure, unilateral ischemic crvo, Medicine, business, medicine.drug

الوصف: Central retinal vein occlusion (CRVO) is a significant cause of marked or total loss of vision in the middle-aged and elderly population. The patient was a 54-year-old man with a history of uncontrolled diabetes and was given seven intravitreal bevacizumab (Avastin) injections as treatment. The patient was advised to follow-up during the next 6 months, including gonioscopy and undilated examination of the iris to look for the iris/disc neovascularization. We presented a classic case of unilateral ischemic CRVO with macular edema, in whom diabetes is the leading risk factor. Close follow-up and diabetes control are advisable to prevent a similar scenario.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f0d46ff2646f13dc65942a841b8cc9Test
http://www.mgmjms.com/article.asp?issn=2347-7946;year=2021;volume=8;issue=3;spage=303;epage=307;aulast=ManthaTest