المؤلفون: Cottin, V., Wemeau, L., Chardès, B., Rudant, J., Ellebode, V., Fievez, S., Assi, N., Schmidt, A., Denis, H., Uzunhan, Y.

المصدر: Revue des Maladies Respiratoires Actualités ; volume 16, issue 1, page 20-21 ; ISSN 1877-1203

مصطلحات موضوعية: Pulmonary and Respiratory Medicine

الإتاحة: https://doi.org/10.1016/j.rmra.2023.11.033Test
https://api.elsevier.com/content/article/PII:S1877120323002719?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1877120323002719?httpAccept=text/plainTest

المؤلفون: Lemaitre, M, Fouad, F, Vanhems, P, Gavazzi, G, Barbut, F, Paccalin, M, Lilliu, H, Bougeois, M, Fievez, S, Nuttens, C, Moïsi, J

المصدر: Value in Health ; volume 25, issue 12, page S222 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2022.09.1085Test
https://api.elsevier.com/content/article/PII:S1098301522032909?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1098301522032909?httpAccept=text/plainTest

المؤلفون: Blanc, E, Chaize, G, Fievez, S, Féger, C, Herquelot, E, Vainchtock, A, Timsit, J, F, Gaillat, J

المساهمون: Pfizer, VYOO Agency, EMIBiotech Paris (EMIB), AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Centre Hospitalier Annecy-Genevois Saint-Julien-en-Genevois

المصدر: ISSN: 1471-2334 ; BMC Infectious Diseases ; https://inserm.hal.science/inserm-03356877Test ; BMC Infectious Diseases, 2021, 21 (1), pp.949. ⟨10.1186/s12879-021-06669-5⟩.

مصطلحات موضوعية: Community-acquired pneumonia, Pneumococcal pneumonia, At-risk comorbidities, High-risk comorbidities, Comorbidities stacking, Long-term mortality, Prognostic factors, Severe pneumonia, Elderly, Nonagenarians, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Background: The prognosis of patients hospitalized with community-acquired pneumonia (CAP) with regards to intensive care unit (ICU) admission, short-and long-term mortality is correlated with patient's comorbidities. For patients hospitalized for CAP, including P-CAP, we assessed the prognostic impact of comorbidities known as at-risk (AR) or high-risk (HR) of pneumococcal CAP (P-CAP), and of the number of combined comorbidities. Methods: Data on hospitalizations for CAP among the French 50+ population were extracted from the 2014 French Information Systems Medicalization Program (PMSI), an exhaustive national hospital discharge database maintained by the French Technical Agency of Information on Hospitalization (ATIH). Their admission diagnosis, comorbidities (nature, risk type and number), other characteristics, and their subsequent hospital stays within the year following their hospitalization for CAP were analyzed. Logistic regression models were used to assess the associations between ICU transfer, short-and 1-year in-hospital mortality and all covariates. Results: From 182,858 patients, 149,555 patients aged ≥ 50 years (nonagenarians 17.8%) were hospitalized for CAP in 2014, including 8270 with P-CAP. Overall, 33.8% and 90.5% had ≥ 1 HR and ≥ 1 AR comorbidity, respectively. Cardiac diseases were the most frequent AR comorbidity (all CAP: 77.4%). Transfer in ICU occurred for 5.4% of CAP patients and 19.4% for P-CAP. Short-term and 1-year in-hospital mortality rates were 10.9% and 23% of CAP patients, respectively, significantly lower for P-CAP patients: 9.2% and 19.8% (HR 0.88 [95% CI 0.84-0.93], p < .0001). Both terms of mortality increased mostly with age, and with the number of comorbidities and combination of AR and HR comorbidities, in addition of specific comorbidities. Conclusions: Not only specific comorbidities, but also the number of combined comorbidities and the combination of AR and HR comorbidities may impact the outcome of hospitalized CAP and P-CAP patients.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34521380; inserm-03356877; https://inserm.hal.science/inserm-03356877Test; https://inserm.hal.science/inserm-03356877/documentTest; https://inserm.hal.science/inserm-03356877/file/s12879-021-06669-5.pdfTest; PUBMED: 34521380; PUBMEDCENTRAL: PMC8442401

الإتاحة: https://doi.org/10.1186/s12879-021-06669-5Test
https://inserm.hal.science/inserm-03356877Test
https://inserm.hal.science/inserm-03356877/documentTest
https://inserm.hal.science/inserm-03356877/file/s12879-021-06669-5.pdfTest

المؤلفون: Damy, T, Bourel, G, Slama, M, Algalarrondo, V, Lairez, O, Pelcot, F, Durand-Zaleski, I, Lilliu, H, Bartoli, M, Fievez, S, Granghaud, A, Rudant, J, De Neuville, B, Rault, C, Charron, P

المصدر: European Heart Journal ; volume 42, issue Supplement_1 ; ISSN 0195-668X 1522-9645

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Transthyretin (TTR) Amyloid Cardiomyopathy (ATTR-CM) is a rare, progressively debilitating, fatal disease with poor prognosis caused by amyloid deposition of fibrils derived from the serum protein TTR in the extracellular matrix of the heart. As amyloid infiltration in the heart progresses, atrial and ventricular walls thicken and become restrictive, resulting in diastolic dysfunction and further progression leads to heart failure, usually with preserved ejection fraction. Systolic dysfunction occurs in the late stages of the disease. Cardiac symptoms and conduction abnormalities also become increasingly clinically apparent (e.g. fatigue, shortness of breath, syncope or arrhythmias) with progression over time. Epidemiology of ATTR-CM is poorly understood as there are few existing studies that estimate its frequency in the general population. We aimed to estimate the prevalence and the incidence of ATTR-CM in France between 2011 and 2017, to describe demographic characteristics of incident cases and to assess patient survival. We used data from the SNDS database, which collects all national health insurance and hospital discharge data. As there is no specific ICD-10 marker code for ATTR -CM used in the SNDS, ATTR-CM diagnosis required both an amyloidosis and a cardiovascular condition, not necessarily reported at the same visit. Diagnostic date was defined when the features from amyloidosis and cardiovascular conditions were selected as events. Patients with a probable AL form of the disease were excluded. To remain conservative, patients younger than 50 yo were also excluded. Between 2011 and 2017, 4,815 patients with incident ATTR-CM were identified. Incidence rate was multiplied by more than 3 times, from 0.5 / 100,000 person-year in 2011 to 1.8 / 100,000 person-year in 2017, reaching 1,225 new cases in 2017. Sex-ratio remained stable (2:1). Most of the 4,815 identified patients were older than 70 yo. In the group ATTR CM >70 y.o, there were 3 times more men than women. Median age at diagnosis ...

الإتاحة: https://doi.org/10.1093/eurheartj/ehab724.3131Test
https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.3131/41056680/ehab724.3131.pdfTest

المؤلفون: Pozzar, M., Petrica, N, Ben Romdhane, H., Fievez, S, Crepey, P., Mongazon-Cazavet, M.

المساهمون: Pfizer France, Pfizer, Arènes: politique, santé publique, environnement, médias (ARENES), Université de Rennes (UR)-Institut d'Études Politiques IEP - Rennes-École des Hautes Études en Santé Publique EHESP (EHESP)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS), École des Hautes Études en Santé Publique EHESP (EHESP)

المصدر: ISPOR Europe 2023 ; https://hal.science/hal-04512943Test ; ISPOR Europe 2023, Nov 2023, Copenhagen, Denmark. ⟨10.1016/j.jval.2023.09.1220⟩

مصطلحات موضوعية: Covid 19, France, PMSI, [SDV]Life Sciences [q-bio]

جغرافية الموضوع: Copenhagen, Denmark

الوصف: International audience ; ObjectivesThis study aims to assess the burden of the disease and management in medical, surgical and obstetrics (MSO) and home care (HC) hospitalizations for COVID-19 in France (2020-2022) by patients’ risk status and epidemic waves.MethodsThis is a retrospective study based on French national hospital database (PMSI). All patients hospitalized for COVID-19 (MSO or HC) were identified between 2020 and 2022. The disease management includes the admissions in intensive care unit (ICU) and the use of mechanical ventilation (MV) during the hospitalization. High-risk patients (HRP) were defined according to the French HTA methodology. Epidemic waves were defined according to the incidence peak observed. Mortality is based on deaths during hospital stays.ResultsOverall, 800,093 admissions for COVID-19 (97% MSO) and 687,027 patients were recorded. A peak in HC hospitalizations was observed in 2020 (14,117), followed by a decrease of 40% per year. In MSO, the peak occurs in 2021 (300,813), followed by a decrease of 27% in 2022. The average age was 65 (±22) years in MSO and 85 (±13) years in HC. The proportion of hospitalizations of HRP in MSO was between 62% and 78% depending on the year. Conversely, the proportion of HRP remains constant over time in HC, around 95%. The most observed HRP sub-group was the elderly patients (65+). The most important epidemic wave (alpha variant) was observed between March-April 2021 (132,104 hospitalizations). Among MSO hospitalizations 17% were managed in ICU, including 40.3% with MV. The proportions were similar between HRP sub-groups. Death proportion was between 9.7% and 33.1% depending on the disease management and was systematically higher in HRP.ConclusionsThis study provided a national understanding of the clinical burden of COVID-19 in the French hospital system, which were congested during the crisis. Economic burden and the role of the vaccination remains to be assessed.

العلاقة: hal-04512943; https://hal.science/hal-04512943Test

الإتاحة: https://doi.org/10.1016/j.jval.2023.09.1220Test
https://hal.science/hal-04512943Test

المؤلفون: Slama, M., Charron, P., Algalarrondo, V., Lairez, O., Pelcot, F., Durand-Zaleski, I., Lilliu, H., Bartoli, M., Famelart, V., Fievez, S., Geffroy, C., de Neuville, B., Rault, C., Bourel, G., Damy, T.

المصدر: Value in Health ; volume 23, page S486-S487 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2020.08.496Test
https://api.elsevier.com/content/article/PII:S1098301520327522?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1098301520327522?httpAccept=text/plainTest

المؤلفون: Damy, T., Bourel, G., Slama, M., Algalarrondo, V., Lairez, O., Pelcot, F., Durand-Zaleski, I., Lilliu, H., Bartoli, M., Fievez, S., Granghaud, A., Rudant, J., de Neuville, B., Rault, C., Charron, P.

المصدر: Value in Health ; volume 23, page S498-S499 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2020.08.558Test
https://api.elsevier.com/content/article/PII:S109830152032814X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S109830152032814X?httpAccept=text/plainTest

المؤلفون: Slama, M., Charron, P., Algalarrondo, V., Lairez, O., Pelcot, F., Durand-Zaleski, I., Lilliu, H., Bartoli, M., Fievez, S., Rudant, J., Salvi, L., de Neuville, B., Rault, C., Bourel, G., Damy, T.

المصدر: Value in Health ; volume 23, page S487 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2020.08.498Test
https://api.elsevier.com/content/article/PII:S1098301520327546?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1098301520327546?httpAccept=text/plainTest

المؤلفون: Nuttens, C., Barbet, V., Watier, L., Loubet, P., Casalegno, J.S., Vanhems, P., Lilliu, H., Fiévez, S., Fahfouhi, Y., Blanc, E., Begier, E., Lemaitre, M.

المصدر: Value in Health ; volume 26, issue 12, page S246 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2023.09.1274Test
https://api.elsevier.com/content/article/PII:S1098301523044042?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1098301523044042?httpAccept=text/plainTest

المؤلفون: Fahfouhi, Y., Fiévez, S., Blanc, E., Marié, L., Densari, Z., Chillotti, L., Cancalon, C., Kernaleguen, C., Nuttens, C.

المصدر: Value in Health ; volume 26, issue 12, page S204-S205 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2023.09.1055Test
https://api.elsevier.com/content/article/PII:S1098301523041852?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1098301523041852?httpAccept=text/plainTest