المؤلفون: Mai, Elias K, Goldschmidt, Hartmut, Miah, Kaya, Bertsch, Uta, Besemer, Britta, Hänel, Mathias, Krzykalla, Julia, Fenk, Roland, Schlenzka, Jana, Munder, Markus, Dürig, Jan, Blau, Igor W, Huhn, Stefanie, Hose, Dirk, Jauch, Anna, Kunz, Christina, Mann, Christoph, Weinhold, Niels, Scheid, Christof, Schroers, Roland, von Metzler, Ivana, Schieferdecker, Aneta, Thomalla, Jörg, Reimer, Peter, Mahlberg, Rolf, Graeven, Ullrich, Kremers, Stephan, Martens, Uwe M, Kunz, Christian, Hensel, Manfred, Benner, Axel, Seidel-Glätzer, Andrea, Weisel, Katja C, Raab, Marc S, Salwender, Hans J, Adrian, Nicole, Bernhard, Helga, Böck, Hans-Peter, Bolling, Claus, Dingeldein, Gerrit, Emde, Till-Oliver, Ferstl, Barbara, Fietz, Thomas, Fronhoffs, Stefan, Fuhrmann, Stephan, Fuxius, Stefan, Geer, Thomas, Görner, Martin, Guenther, Barbara, Hartmann, Frank

المساهمون: Bristol-Myers Squibb Company, Chugai Pharmaceuticals Co Ltd

المصدر: The Lancet Haematology ; volume 11, issue 2, page e101-e113 ; ISSN 2352-3026

مصطلحات موضوعية: Hematology

الإتاحة: https://doi.org/10.1016/s2352-3026Test(23)00366-6
https://api.elsevier.com/content/article/PII:S2352302623003666?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352302623003666?httpAccept=text/plainTest

المؤلفون: Wong, Sandy W., Bar, Noffar, Victoria Mateos, María, Ribas, Paz, Hansson, Markus, Paris, Laura, Hofmeister, Craig, Rodriguez-Otero, Paula, Aranzazu Bermúdez, Maria, Santoro, Armando, Yee, Andrew J., Creignou, Maria, Encinas, Cristina, Cerchione, Claudio, de la Rubia, Javier, Oriol, Albert, Ferstl, Barbara, Besemer, Britta, Chen, Jinjie, Chung, Alexander, Boss, Isaac W., Gaudy, Allison, LI, Shaoyi, Hsu, Kevin, Godwin, Colin, Burgess, Michael R., San-Miguel, Jesús, Jose Costa, Luciano

المصدر: HemaSphere ; volume 7, issue S3, page e1220745 ; ISSN 2572-9241

الإتاحة: https://doi.org/10.1097/01.hs9.0000970436.12207.45Test

المؤلفون: Mackensen, Andreas, Haanen, John B.A.G., Koenecke, Christian, Alsdorf, Winfried, Wagner-Drouet, Eva, Borchmann, Peter, Heudobler, Daniel, Ferstl, Barbara, Klobuch, Sebastian, Bokemeyer, Carsten, Desuki, Alexander, Lüke, Florian, Kutsch, Nadine, Müller, Fabian, Smit, Eveline, Hillemanns, Peter, Karagiannis, Panagiotis, Wiegert, Erol, He, Ying, Ho, Thang, Kang-Fortner, Qing, Schlitter, Anna Melissa, Schulz-Eying, Catrine, Finlayson, Andrew, Flemmig, Carina, Kühlcke, Klaus, Preußner, Liane, Rengstl, Benjamin, Türeci, Özlem, Şahin, Uğur

المصدر: Nature Medicine ; volume 29, issue 11, page 2844-2853 ; ISSN 1078-8956 1546-170X

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology, General Medicine

الوصف: The oncofetal antigen Claudin 6 (CLDN6) is highly and specifically expressed in many solid tumors, and could be a promising treatment target. We report dose escalation results from the ongoing phase 1/2 BNT211-01 trial evaluating the safety and feasibility of chimeric antigen receptor (CAR) T cells targeting the CLDN6 with or without a CAR-T cell-amplifying RNA vaccine (CARVac) at two dose levels (DLs) in relapsed/refractory CLDN6-positive solid tumors. The primary endpoints were safety and tolerability, maximum tolerated dose and recommended phase 2 dose (RP2D). Secondary endpoints included objective response rate (ORR) and disease control rate. We observed manageable toxicity, with 10 out of 22 patients (46%) experiencing cytokine release syndrome including one grade 3 event and 1 out of 22 (5%) with grade 1 immune effector cell-associated neurotoxicity syndrome. Dose-limiting toxicities occurred in two patients at the higher DL, resolving without sequelae. CAR-T cell engraftment was robust, and the addition of CARVac was well tolerated. The unconfirmed ORR in 21 evaluable patients was 33% (7 of 21), including one complete response. The disease control rate was 67% (14 of 21), with stable disease in seven patients. Patients with germ cell tumors treated at the higher DL exhibited the highest response rate (ORR 57% (4 of 7)). The maximum tolerated dose and RP2D were not established as the trial has been amended to utilize an automated manufacturing process. A repeat of the dose escalation is ongoing and will identify a RP2D for pivotal trials. ClinicalTrials.gov Identifier: NCT04503278 .

الإتاحة: https://doi.org/10.1038/s41591-023-02612-0Test
https://www.nature.com/articles/s41591-023-02612-0.pdfTest
https://www.nature.com/articles/s41591-023-02612-0Test

المؤلفون: Breakell, Thomas, Waibel, Heidi, Schliep, Stefan, Ferstl, Barbara, Erdmann, Michael, Berking, Carola, Heppt, Markus V.

مصطلحات موضوعية: ddc:610

الوصف: Intravascular large B-cell lymphoma (IVLBCL) is an aggressive Non-Hodgkin lymphoma (NHL) characterised by the presence of neoplastic lymphoid cells within small- and medium-sized blood vessels. According to the clinical presentation, the current WHO classification distinguishes the ‘classic’ (formerly ‘Western’) from a hemophagocytic syndrome-associated (formerly ‘Asian’) variant. A third ‘cutaneous’ variant has been proposed, characterised by a good prognosis and unique clinical features. While laboratory findings can hint at diagnosis, symptoms are rather nonspecific, and deep skin biopsy supported by further measures such as bone marrow aspiration and positron emission tomography-computed tomography scanning is needed to make a definite diagnosis. Treatment is comprised of anthracycline-based chemotherapy supplemented with rituximab and central nervous system prophylaxis. While there are various prognostic models for NHL, only one is specific to IVLBCL, which does not sufficiently represent some patient groups, especially regarding the lack of differentiation within the patient collective with skin involvement. This underlines the necessity for the establishment of further prognostic models in particular for IVLBCL patients with cutaneous manifestations.

وصف الملف: application/pdf

العلاقة: https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/20626Test; urn:nbn:de:bvb:29-opus4-206260; https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-206260Test; https://doi.org/10.3390/curroncol29050237Test; https://opus4.kobv.de/opus4-fau/files/20626/curroncol-29-00237.pdfTest

الإتاحة: https://doi.org/10.3390/curroncol29050237Test
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/20626Test
https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-206260Test
https://opus4.kobv.de/opus4-fau/files/20626/curroncol-29-00237.pdfTest

المؤلفون: Costa, Luciano, Bar, Noffar, Mateos, Maria-Victoria, Ribas, Paz, Hansson, Markus, Paris, Laura, Hofmeister, Craig, Rodriguez-Otero, Paula, Bermúdez, Maria Aranzazu, Santoro, Armando, Yee, Andrew, Creignou, Maria, Encinas, Cristina, Cerchione, Claudio, de la Rubia, Javier, Oriol, Albert, Ferstl, Barbara, Besemer, Britta, Chen, Jinjie, Boss, Isaac, Gaudy, Allison, Hsu, Kevin, Godwin, Colin, San-Miguel, Jesús, Wong, Sandy

المصدر: Clinical Lymphoma Myeloma and Leukemia ; volume 23, page S52-S53 ; ISSN 2152-2650

مصطلحات موضوعية: Cancer Research, Oncology, Hematology

الإتاحة: https://doi.org/10.1016/s2152-2650Test(23)01652-x
https://api.elsevier.com/content/article/PII:S215226502301652X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S215226502301652X?httpAccept=text/plainTest

المؤلفون: Goldschmidt, Hartmut, Mai, Elias K, Bertsch, Uta, Fenk, Roland, Nievergall, Eva, Tichy, Diana, Besemer, Britta, Dürig, Jan, Schroers, Roland, von Metzler, Ivana, Hänel, Mathias, Mann, Christoph, Asemissen, Anne M, Heilmeier, Bernhard, Weinhold, Niels, Huhn, Stefanie, Kriegsmann, Katharina, Luntz, Steffen P, Holderried, Tobias A W, Trautmann-Grill, Karolin, Gezer, Deniz, Klaiber-Hakimi, Maika, Müller, Martin, Khandanpour, Cyrus, Knauf, Wolfgang, Scheid, Christof, Munder, Markus, Geer, Thomas, Riesenberg, Hendrik, Thomalla, Jörg, Hoffmann, Martin, Raab, Marc S, Salwender, Hans J, Weisel, Katja C, Behringer, Joachim, Bernhard, Helga, Bernhardt, Christiane, Blau, Igor W, Bolling, Claus, Debatin, Daniel, Dingeldein, Gerrit, Ferstl, Barbara, Fest, Claudia, Fronhoffs, Stefan, Fuhrmann, Stephan

المصدر: The Lancet Haematology ; volume 9, issue 11, page e810-e821 ; ISSN 2352-3026

مصطلحات موضوعية: Hematology

الإتاحة: https://doi.org/10.1016/s2352-3026Test(22)00263-0
https://api.elsevier.com/content/article/PII:S2352302622002630?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352302622002630?httpAccept=text/plainTest

المؤلفون: Liebers, Nora, Roider, Tobias, Bohn, Jan-Paul, Haberbosch, Isabella, Pircher, Andreas, Ferstl, Barbara, Ebnöther, Monika, Wendtner, Clemens-Martin, Dearden, Claire, Follows, George A, Ho, Anthony D, Müller-Tidow, Carsten, Dreger, Peter, Troussard, Xavier, Zenz, Thorsten, Dietrich, Sascha

المصدر: Liebers, Nora; Roider, Tobias; Bohn, Jan-Paul; Haberbosch, Isabella; Pircher, Andreas; Ferstl, Barbara; Ebnöther, Monika; Wendtner, Clemens-Martin; Dearden, Claire; Follows, George A; Ho, Anthony D; Müller-Tidow, Carsten; Dreger, Peter; Troussard, Xavier; Zenz, Thorsten; Dietrich, Sascha (2020). BRAF inhibitor treatment in classic hairy cell leukemia: a long-term follow-up study of patients treated outside clinical trials. Leukemia, 34(5):1454-1457.

مصطلحات موضوعية: Clinic for Oncology and Hematology, 610 Medicine & health

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/180155/1/s41375-019-0646-y.pdfTest; info:pmid/31740808; urn:issn:0887-6924

الإتاحة: https://doi.org/10.5167/uzh-18015510.1038/s41375-019-0646-yTest
https://www.zora.uzh.ch/id/eprint/180155Test/
https://www.zora.uzh.ch/id/eprint/180155/1/s41375-019-0646-y.pdfTest

المؤلفون: Raab, Marc S., Engelhardt, Monika, Blank, Antje, Goldschmidt, Hartmut, Agis, Hermine, Blau, Igor W., Einsele, Hermann, Ferstl, Barbara, Schub, Natalie, Röllig, Christoph, Weisel, Katja, Winderlich, Mark, Griese, Janine, Härtle, Stefan, Weirather, Johannes, Jarutat, Tiantom, Peschel, Christian, Chatterjee, Manik

المصدر: The Lancet. Haematology. - 7, 5 (2020) , e381-e394, ISSN: 2352-3026

العلاقة: https://freidok.uni-freiburg.de/data/167079Test

الإتاحة: https://doi.org/10.1016/S2352-3026Test(19)30249-2
https://freidok.uni-freiburg.de/data/167079Test

المؤلفون: Liebers, Nora, Roider, Tobias, Bohn, Jan-Paul, Haberbosch, Isabella, Pircher, Andreas, Ferstl, Barbara, Ebnöther, Monika, Wendtner, Clemens-Martin, Dearden, Claire, Follows, George A., Ho, Anthony D., Müller-Tidow, Carsten, Dreger, Peter, Troussard, Xavier, Zenz, Thorsten, Dietrich, Sascha

المساهمون: Heidelberg Research Centre for Molecular Medicine, physician scientist fellowship of the Medical Faculty of the University Heidelberg, Hairy Cell Leukemia Foundation, HRCMM (Heidelberg Research Center for Molecular Medicine), BMBF junior group grant by the BMBF within the e:Med initiative, Hairy Cell Leukemia Foundation

المصدر: Leukemia ; volume 34, issue 5, page 1454-1457 ; ISSN 0887-6924 1476-5551

مصطلحات موضوعية: Oncology, Cancer Research, Hematology

الإتاحة: https://doi.org/10.1038/s41375-019-0646-yTest
http://www.nature.com/articles/s41375-019-0646-y.pdfTest
http://www.nature.com/articles/s41375-019-0646-yTest

المؤلفون: Wong, Sandy W., Bar, Noffar, Paris, Laura, Hofmeister, Craig C, Hansson, Markus, Santoro, Armando, Mateos, Maria-Victoria, Rodríguez-Otero, Paula, Lund, Johan, Encinas, Cristina, Yee, Andrew J., Oriol, Albert, Cerchione, Claudio, de la Rubia, Javier, Ferstl, Barbara, Carlson, Kristina, Ribas, Paz, Bermúdez, Arancha, Boss, Isaac W., Gaudy, Allison, Li, Shaoyi, Hsu, Kevin, Godwin, Colin D., Burgess, Michael R., San-Miguel, Jesús, Costa, Luciano J.

المصدر: Blood; November 2022, Vol. 140 Issue: Supplement 1 p400-402, 3p