المؤلفون: Ramonda R, Marchesoni A, Carletto A, Bianchi G, Cutolo M, Ferracioli G, Fusaro E, De Vita S, Galeazzi M, Gerli R, Matucci-Cerinic M, Minisola G, Montecucco C, Pellerito R, Salaffi F, Paolazzi G, Sarzi-Puttini P, Scarpa R, Bagnato G, Triolo G, Valesini G, Punzi L, Olivieri I, Ortolan A, Lorenzin M, Frallonardo P, Giollo A, Locaputo A, Paolino S, Simone D, Quartuccio L, Bartoloni E, Luca R. D, Bartoli F, Sensi F, Caporali R, Carlo M. D, Roberto B, Atzeni F, Costa L, Ciccia F, Perrotta F, Gilio M

المساهمون: Ramonda, R, Marchesoni, A, Carletto, A, Bianchi, G, Cutolo, M, Ferracioli, G, Fusaro, E, De Vita, S, Galeazzi, M, Gerli, R, Matucci-Cerinic, M, Minisola, G, Montecucco, C, Pellerito, R, Salaffi, F, Paolazzi, G, Sarzi-Puttini, P, Scarpa, R, Bagnato, G, Triolo, G, Valesini, G, Punzi, L, Olivieri, I, Ortolan, A, Lorenzin, M, Frallonardo, P, Giollo, A, Locaputo, A, Paolino, S, Simone, D, Quartuccio, L, Bartoloni, E, Luca, R. D., Bartoli, F, Sensi, F, Caporali, R, Carlo, M. D., Roberto, B, Atzeni, F, Costa, L, Ciccia, F, Perrotta, F, Gilio, M

مصطلحات موضوعية: Spondyloarthritis, Survey, Absenteeism, Presenteeism, WPI

الوصف: Background: The aim was to establish how patients experience the impact of spondyloarthritis (SpA) on work disability and working life. Methods: The survey was performed in 17/20 regions in Italy (1 January to 31 March 2013). A multiple-choice questionnaire was published on the official website of the sponsor - the National Association of Rheumatic Patients (ANMAR) - and hard-copies were distributed at outpatient clinics for rheumatic patients. Results: Respondents (n = 770) were of both sexes (56 % men), educated (62 % at high school or more), of working age (75 % aged ≤60 years), and affected by SpA. The most common types diagnosed were ankylosing spondylitis (AS) (39 %) and psoriatic arthritis (PsA) (36 %). Respondents were working full-time (45 %), part-time (8 %) or had retired (22 %); 15 % were unemployed (for reasons linked to the disease or for other reasons, students or housewives). Patients reported disability (39 %), were receiving disability benefits (34 %), were experiencing important limitations that were hindering their professional development/career (36 %) and some had to change/leave their job or lost it because of SpA (21 %). Employed respondents (n = 383) had worked on average 32.2 h in the last 7 days. More hours of work were lost over the last 7 days due to SpA (2.39 h vs 1.67 h). The indirect costs of the disease amounted to €106/week for patients reporting well-being/good physical conditions/improvement and €216/week for those reporting permanent impairment. Conclusions: Most patients were in the midst of their productive years and were experiencing considerable difficulties in carrying out their job because of the disease: half of them reported disability and one third were experiencing important limitations in their career perspective.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27037139; info:eu-repo/semantics/altIdentifier/wos/WOS:000373319400003; volume:1;18; firstpage:78; lastpage:78; numberofpages:1; journal:ARTHRITIS RESEARCH & THERAPY; http://hdl.handle.net/11567/848500Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84977660030

الإتاحة: https://doi.org/10.1186/s13075-016-0977-2Test
http://hdl.handle.net/11567/848500Test

المؤلفون: Cooke A., Ferracioli G., Hermann M., Schulze C., Zampieri S., Doria A., ROMANI, Luigina

المساهمون: Cooke, A., Ferracioli, G., Hermann, M., Romani, Luigina, Schulze, C., Zampieri, S., Doria, A.

الوصف: It is thought that in genetically predisposed individuals, autoimmune diseases can be promoted and/or exacerbated by viruses, bacteria, or parasitic infectious agents. Pathogens can activate innate immune response interacting with Toll-like receptors that recognize pathogen-associated molecules. As a consequence of infections, a prolonged inflammatory response may occur leading to chronic inflammation with activation of adaptive immune response. In addition, the defective clearance of apoptotic infected cells, which progress- es to secondary necrosis, can foster the autoimmune reactions. Although numerous data from humans and/or animal models support the hypothesis of a direct contribution of pathogens to the induction of the disease, some infectious agents are able to prevent autoimmune disorders. In this review, data on the innate and adaptive immune response induced by pathogens are summarized, focusing on the possible protective or non-protective role of infections in the development of autoimmune diseases.

العلاقة: volume:26; issue:1 Suppl 48; firstpage:S1; lastpage:S7; journal:CLINICAL AND EXPERIMENTAL RHEUMATOLOGY; http://hdl.handle.net/11391/158214Test

الإتاحة: http://hdl.handle.net/11391/158214Test

المؤلفون: Sfriso, P., Botsios, C., Raffainer, B., Ferracioli, G., Ferri, C., Gerli, R., Giacomelli, Roberto, Grassi, W., Gorla, R., Marchesoni, A., Salaffi, F., Triolo, G., Trotta, F., Sarzi Puttini, P., Lapadula, G., Punzi, L.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______3983::c963fb5860e2cf4a02e10fa166eece11Test
http://hdl.handle.net/11697/22591Test

المؤلفون: Tomietto, P., Gremese, E., barbara tolusso, Venturini, P., Vita, S., Ferracioli, G.

المصدر: Scopus-Elsevier

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cdf7bd75b10def18cc9603ec432a895eTest
http://www.scopus.com/inward/record.url?eid=2-s2.0-9144272642&partnerID=MN8TOARSTest