المؤلفون: Ciebiera, Michał, Madueke-Laveaux, Obianuju Sandra, Feduniw, Stepan, Ulin, Mara, Spaczyński, Robert, Zgliczyńska, Magdalena, Bączkowska, Monika, Zarychta, Elżbieta, Łoziński, Tomasz, Ali, Mohamed, Al-Hendy, Ayman

المصدر: Expert Opinion on Pharmacotherapy ; volume 24, issue 16, page 1799-1809 ; ISSN 1465-6566 1744-7666

الإتاحة: https://doi.org/10.1080/14656566.2023.2248890Test

المؤلفون: Grabowski, Bartlomiej, Feduniw, Stepan, Orzel, Anna, Drab, Marcin, Modzelewski, Jan, Pruc, Michal, Gaca, Zuzanna, Szarpak, Lukasz, Rabijewski, Michal, Baran, Arkadiusz, Scholz, Anna

المصدر: Healthcare (2227-9032); Jun2024, Vol. 12 Issue 12, p1176, 41p

مصطلحات موضوعية: AIR pollution, MEDICAL information storage & retrieval systems, SMALL for gestational age, PREGNANT women, SYSTEMATIC reviews, LOW birth weight, MEDLINE, ODDS ratio, DURATION of pregnancy, ENVIRONMENTAL exposure, GESTATIONAL age, POLLUTION, CARBON monoxide, BIRTH weight, FETAL development, ONLINE information services

مستخلص: Current evidence suggests that airborne pollutants have a detrimental effect on fetal growth through the emergence of small for gestational age (SGA) or term low birth weight (TLBW). The study's objective was to critically evaluate the available literature on the association between environmental pollution and the incidence of SGA or TLBW occurrence. A comprehensive literature search was conducted across Pubmed/MEDLINE, Web of Science, Cochrane Library, EMBASE, and Google Scholar using predefined inclusion and exclusion criteria. The methodology adhered to the PRISMA guidelines. The systematic review protocol was registered in PROSPERO with ID number: CRD42022329624. As a result, 69 selected papers described the influence of environmental pollutants on SGA and TLBW occurrence with an Odds Ratios (ORs) of 1.138 for particulate matter ≤ 10 μm (PM10), 1.338 for particulate matter ≤ 2.5 μm (PM2.5), 1.173 for ozone (O3), 1.287 for sulfur dioxide (SO2), and 1.226 for carbon monoxide (CO). All eight studies analyzed validated that exposure to volatile organic compounds (VOCs) is a risk factor for SGA or TLBW. Pregnant women in the high-risk group of SGA occurrence, i.e., those living in urban areas or close to sources of pollution, are at an increased risk of complications. Understanding the exact exposure time of pregnant women could help improve prenatal care and timely intervention for fetuses with SGA. Nevertheless, the pervasive air pollution underscored in our findings suggests a pressing need for adaptive measures in everyday life to mitigate worldwide environmental pollution. [ABSTRACT FROM AUTHOR]

: Copyright of Healthcare (2227-9032) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Feduniw, Stepan¹ (AUTHOR), Krupa, Izabela² (AUTHOR), Łagowska, Katarzyna² (AUTHOR), Laudański, Piotr^3,4,5 (AUTHOR), Tabarkiewicz, Jacek^2,6 (AUTHOR), Stawarz, Barbara⁷ (AUTHOR), Raba, Grzegorz⁸ (AUTHOR)

المصدر: Journal of Pregnancy. 5/7/2024, Vol. 2024, p1-10. 10p.

مصطلحات موضوعية: *CANNABINOID receptors, *PREMATURE labor, *PLACENTA, *GENETIC transcription, *CHILDBIRTH

مستخلص: Background: The cannabinoid receptor (CBR) plays a significant role in oogenesis, pregnancy, and childbirth. It might also play a significant role in preterm birth (PTB). The aim of the study was to investigate the association between the expression of the CBR in the placenta and the incidence of PTB. Methods: This prospective, observational, multicentre preliminary study was conducted on placental samples obtained from 109 women. The study included 95 patients hospitalized due to the high risk of PTB. They were divided into two groups: Group 1, where the expression of the CBR1 and CBR1a was analyzed, and Group 2, in which we examined CBR2 expression. The control group, that is, Group 3, consisted of 14 women who delivered at term, and their placentas were tested for the presence of all three receptor types (CBR1, CBR1a, and CBR2). Results: The study used reverse transcription and real-time PCR methods to assess the expression of CBRs in the placental tissues. The expression of the CBR2, CBR1, and CBR1a receptors was significantly lower in the placentas of women after PTB compared to those after term births, p = 0.038 , 0.033, and 0.034, respectively. Conclusions: The presence of CBR mRNA in the human placental tissue was confirmed. The decreased expression of CBRs could serve as an indicator in predicting PTB. [ABSTRACT FROM AUTHOR]

المؤلفون: Kajdy, Anna, Sys, Dorota, Pokropek, Artur, Shaw, Steven W., Chang, Tung-Yao, Calda, Pavel, Acharya, Ganesh, Ben-Zion, Maya, Biron-Shental, Tal, Borowski, Dariusz, Czuba, Bartosz, Etchegaray, Adolfo, Feduniw, Stepan, Garcia-Mandujano, Rosario, Santacruz, Monica Garcia, Gil, Maria M., Hassan, Sonia, Kwiatkowski, Sebastian, Martin-Arias, Arancha, Martinez-Portilla, Raigam Jafet, Prefumo, Federico, Rabijewski, Michal, Salomon, Laurent J., Tiller, Heidi, Verlohren, Stefan, Voon, Hian Yan, Yanque-Robles, Omar Fernando, Yong, Soon Leong, Poon, Liona C.

المساهمون: Kajdy, Anna, Sys, Dorota, Pokropek, Artur, Shaw, Steven W., Chang, Tung-Yao, Calda, Pavel, Acharya, Ganesh, Ben-Zion, Maya, Biron-Shental, Tal, Borowski, Dariusz, Czuba, Bartosz, Etchegaray, Adolfo, Feduniw, Stepan, Garcia-Mandujano, Rosario, Santacruz, Monica Garcia, Gil, Maria M., Hassan, Sonia, Kwiatkowski, Sebastian, Martin-Arias, Arancha, Martinez-Portilla, Raigam Jafet, Prefumo, Federico, Rabijewski, Michal, Salomon, Laurent J., Tiller, Heidi, Verlohren, Stefan, Voon, Hian Yan, Yanque-Robles, Omar Fernando, Yong, Soon Leong, Poon, Liona C.

مصطلحات موضوعية: anxiety, coronavirus disease 2019, cross-sectional studie, depression, economic statu, mental health, patient health questionnaire, pregnant women

الوصف: Objective To assess risk factors for anxiety and depression among pregnant women during the COVID-19 pandemic using Mind-COVID, a prospective cross-sectional study that compares outcomes in middle-income economies and high-income economies. Methods A total of 7102 pregnant women from 12 high-income economies and nine middle-income economies were included. The web-based survey used two standardized instruments, General Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9). Result Pregnant women in high-income economies reported higher PHQ-9 (0.18 standard deviation [SD], P < 0.001) and GAD-7 (0.08 SD, P = 0.005) scores than those living in middle-income economies. Multivariate regression analysis showed that increasing PHQ-9 and GAD-7 scales were associated with mental health problems during pregnancy and the need for psychiatric treatment before pregnancy. PHQ-9 was associated with a feeling of burden related to restrictions in social distancing, and access to leisure activities. GAD-7 scores were associated with a pregnancy-related complication, fear of adverse outcomes in children related to COVID-19, and feeling of burden related to finances. Conclusions According to this study, the imposed public health measures and hospital restrictions have left pregnant women more vulnerable during these difficult times. Adequate partner and family support during pregnancy and childbirth can be one of the most important protective factors against anxiety and depression, regardless of national economic status.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35932096; info:eu-repo/semantics/altIdentifier/wos/WOS:000842844200001; volume:160; issue:1; firstpage:167; lastpage:186; numberofpages:20; journal:INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS; https://hdl.handle.net/11379/568290Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85136458070

الإتاحة: https://doi.org/10.1002/IJGO.14388Test
https://hdl.handle.net/11379/568290Test

المؤلفون: Warejko, Urszula, Feduniw, Stepan, Bednarek-Jędrzejek, Magdalena, Kwiatkowski, Sebastian

المصدر: European Journal of Obstetrics & Gynecology and Reproductive Biology ; volume 293, page 102 ; ISSN 0301-2115

مصطلحات موضوعية: Obstetrics and Gynecology, Reproductive Medicine

الإتاحة: https://doi.org/10.1016/j.ejogrb.2023.08.285Test
https://api.elsevier.com/content/article/PII:S0301211523005912?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0301211523005912?httpAccept=text/plainTest

المؤلفون: Feduniw, Stepan, Krupa, Izabela, Łagowska, Katarzyna, Laudanski, Piotr, Tabarkiewicz, Jacek, Stawarz, Barbara, Raba, Grzegorz

الوصف: Background. The cannabinoid receptor (CBR) plays a significant role in oogenesis, pregnancy, and childbirth. It might also play a significant role in preterm birth (PTB). The aim of the study was to investigate the association between the expression of the cannabinoid receptor in the placenta and the incidence of preterm birth. Methods. This prospective, observational, multicentre preliminary study was conducted on placental samples obtained from 109 women. The study included 95 patients hospitalized due to the high risk of PTB. They were divided into two groups: Group 1, where the expression of the CBR1 and CBR1a was analyzed, and Group 2, in which we examined CBR2 expression. The control group, i.e., Group 3, consisted of 14 women who delivered at term and their placentas were tested for the presence of all three receptor types (CBR1, CBR1a, CBR2). Results. The study used reverse transcription and Real-Time PCR methods to assess the expression of CBRs in the placental tissues. The expression of the CBR2, CBR1 and CBR1a receptors was significantly lower in the placentas of women after preterm birth compared to those after term births, p = 0.038, 0.033 and 0.034, respectively. Conclusions. The presence of CBR mRNA in the human placental tissue was confirmed. The decreased expression of cannabinoid receptors could serve as an indicator in predicting PTB. KEYWORDS : Cannabinoid receptor; CBR1; CBR2; ECS; preterm birth; PTB.

الإتاحة: https://doi.org/10.22541/au.160683843.33793266/v2Test

المؤلفون: Kacperczyk-Bartnik, Joanna, Żeber-Lubecka, Natalia, Feduniw, Stepan, Bartnik, Paweł, Włodarczyk, Marta, Abramiuk, Monika, Ciebiera, Michał

المصدر: Journal of Endometriosis & Pelvic Pain Disorders; Dec2023, Vol. 15 Issue 3/4, p109-115, 7p

مصطلحات موضوعية: ENDOMETRIOSIS, BIOMARKERS, NEEDLE biopsy, HUMAN embryology, HUMAN reproduction, MYOMECTOMY

مستخلص: Previously, the gold standard for the diagnosis of endometriosis involved the performance of laparoscopic surgery, which allows the visualization and histological examination of the endometrial tissue. According to the latest guidelines published by the European Society of Human Reproduction and Embryology (ESHRE) in 2022, surgery is recommended only in patients with diagnostic difficulties associated with the use of non-invasive methods or in case of inappropriate or unsuccessful empirical treatment. At the same time, it is not recommended to use the measurement of biomarkers in the endometrial tissue, blood, menstrual or uterine fluids to diagnose endometriosis as the ESHRE guideline development group indicated the need of larger, multi-center prospective studies on this matter. The aim of this narrative review is to present advances in knowledge on non-invasive endometriosis diagnostic opportunities with emphasis on proteomics, the use of endometrial aspiration biopsy, iron metabolism, vitamin D-binding protein, extracellular matrix signaling pathways, epithelial−mesenchymal transformation, and other molecular pathways, together with a critical analysis of studies cited in the recent ESHRE guidelines. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Endometriosis & Pelvic Pain Disorders is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Feduniw, Stepan, Płaza, Olga, Paździor, Dominika, Kosińska-Kaczyńska, Katarzyna, Szymusik, Iwona, Wielgoś, Mirosław

مصطلحات موضوعية: depression risk factors, depressive symptoms, Edinburgh Postnatal Depression Scale, perinatal depression, pregnancy

الوصف: Introduction. It was established that intragestational depression is a common disease, with the estimated average prevalence of 10–25% in all expectant mothers worldwide. Aim of the study. The aim of the study was to evaluate the frequency of depressive symptoms in pregnant women in Poland and to identify which factors may be related to a higher risk of depressive symptoms during pregnancy. Material and methods. A prospective cross-sectional study was performed. Depressive symptoms were assessed with the validated Edinburgh Postnatal Depression Scale (EPDS). 346 women were enrolled in the study. Results. 130 women (37.6%) scored 13 or more points and were considered as presenting with depressive symptoms. Independent risk factors of depressive symptoms during pregnancy including mood disorders diagnosed before the current pregnancy (aOR=2.68, 95%CI 1.37-5.22), mental disorders confirmed in family members (aOR=2.72, 95%CI 1.24-5.98), unhappiness in their current relationship (aOR=4.0, 95%CI 1.77-9.01), lack of support from family members (aOR=2.73, 95%CI 1.51-4.96) increased the risk of DS and good financial status decreased the risk of DS occurrence (aOR=0.45, 95%CI: 0.25-0.80). Conclusions. Pregnant women commonly report depressive symptoms. The evaluation of relations with the family members, socio-economic status, former depressive symptoms and possible prenatal depression are essential for proper screening of depression in pregnant women.

وصف الملف: application/pdf

العلاقة: European Journal of Clinical and Experimental Medicine T. 18, z. 1 (2020), s. 10–15; http://repozytorium.ur.edu.pl/handle/item/5773Test

الإتاحة: https://doi.org/10.15584/ejcem.2020.1.2Test
http://repozytorium.ur.edu.pl/handle/item/5773Test

المؤلفون: Feduniw, Stepan, Sys, Dorota, Kwiatkowski, Sebastian, Kajdy, Anna

المساهمون: Lazarski University

المصدر: Medicine ; volume 99, issue 50, page e23681 ; ISSN 0025-7974 1536-5964

الوصف: The article presents a systematic review protocol. The aim of the study is an assessment of current studies regarding the application of artificial intelligence and neural networks in the screening for adverse perinatal outcomes. We intend to compare the reported efficacy of these methods to improve pregnancy care and outcomes. There are more and more studies that describe the role of machine learning in facilitating the diagnosis of adverse perinatal outcomes, like gestational diabetes or pregnancy hypertension. A systematic review of available literature seems to be crucial to compare the known efficacy and application. Publication of a systematic review in this category would improve the value of future studies. The studies reporting on artificial intelligence application will have a major impact on future prenatal practice.

الإتاحة: https://doi.org/10.1097/md.0000000000023681Test

المؤلفون: Kajdy, Anna, Feduniw, Stepan, Ajdacka, Urszula, Modzelewski, Jan, Baranowska, Barbara, Sys, Dorota, Pokropek, Artur, Pawlicka, Paulina, Kaźmierczak, Maria, Rabijewski, Michał, Jasiak, Hanna, Lewandowska, Roksana, Borowski, Dariusz, Kwiatkowski, Sebastian, Poon, Liona C.

المساهمون: Centre of Postgraduate Medical Education

المصدر: Medicine ; volume 99, issue 30, page e21279 ; ISSN 0025-7974 1536-5964

الوصف: Introduction: The article presents a protocol of a cross-sectional study of mental health of pregnant women in relation to the coronavirus disease 19 (COVID-19) pandemic. The primary aim is to compare differences in anxiety and depression scores of pregnant women between countries affected by the COVID-19 pandemic. The secondary aim is to assess demographic, economic, and social aspects affecting maternal anxiety and depression scores among pregnant women worldwide in the time of the COVID-19 pandemic. Finally, we will be able to compare differences in perception of the different aspects of the COVID-19 pandemic (social distancing, restrictions related to delivery) between countries and according to the epidemic status (number of infected patients, number of reported deaths). The comparisons will also be done according to the COVID-19 status of the participants. Methods and analysis: It is a web-based anonymous survey of pregnant women living in countries affected by the COVID-19 pandemic. The survey is comprised of 3 sections: Web-based recruitment for health research has proven to be cost-effective and efficient. At current times with the COVID-19 pandemic, limited resources and social distancing restrictions, performing a mental health study involving pregnant women on a large international scale cannot be safely conducted without involving social-media. The fears of pregnant women fall into 3 categories: the medical condition, the economic status and the organization of daily activity. The study has received approval of the medical ethics committee and has been registered on Clinicaltrials.gov. Results will be published in peer-reviewed journals and made public through all available media.

الإتاحة: https://doi.org/10.1097/md.0000000000021279Test