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1دورية أكاديمية
المؤلفون: Agrusa, Jennifer E, Scull, Brooks P, Abhyankar, Harshal A, Lin, Howard, Ozuah, Nmazuo W, Chakraborty, Rikhia, Eckstein, Olive S, Gulati, Nitya, Fattah, Elmoataz Abdel, El-Mallawany, Nader K, Rouce, Rayne H, Dreyer, ZoAnn E, Brackett, Julienne, Margolin, Judith F, Lubega, Joseph, Horton, Terzah M, Bollard, Catherine M, Gramatges, M Monica, Kamdar, Kala Y, McClain, Kenneth L, Man, Tsz-Kwong, Allen, Carl E
المصدر: Pediatrics Faculty Publications
مصطلحات موضوعية: Pediatrics
العلاقة: https://hsrc.himmelfarb.gwu.edu/smhs_peds_facpubs/6182Test; http://dx.doi.org/10.3390/cancers12123603Test
الإتاحة: https://doi.org/10.3390/cancers12123603Test
https://hsrc.himmelfarb.gwu.edu/smhs_peds_facpubs/6182Test -
2دورية أكاديمية
المصدر: Journal of Biological Chemistry ; volume 288, issue 50, page 35886-35895 ; ISSN 0021-9258
مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry
الإتاحة: https://doi.org/10.1074/jbc.m113.514919Test
https://api.elsevier.com/content/article/PII:S0021925819543101?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925819543101?httpAccept=text/plainTest -
3دورية أكاديمية
المؤلفون: Liu, Xian-De, Ko, Soyoung, Xu, Yi, Fattah, Elmoataz Abdel, Xiang, Qian, Jagannath, Chinnaswamy, Ishii, Tetsuro, Komatsu, Masaaki, Eissa, N. Tony
المصدر: Journal of Biological Chemistry ; volume 287, issue 23, page 19687-19698 ; ISSN 0021-9258
مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry
الإتاحة: https://doi.org/10.1074/jbc.m112.350934Test
https://api.elsevier.com/content/article/PII:S0021925820500288?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820500288?httpAccept=text/plainTest -
4دورية أكاديمية
المؤلفون: Tyryshkin, Alexey, Gorgun, F.Murat, Fattah, Elmoataz Abdel, Mazumdar, Tuhina, Pandit, Lavannya, Zeng, Shenyan, Eissa, N.Tony
المصدر: Journal of Biological Chemistry ; volume 285, issue 1, page 784-792 ; ISSN 0021-9258
مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry
الإتاحة: https://doi.org/10.1074/jbc.m109.055038Test
https://api.elsevier.com/content/article/PII:S0021925820661646?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820661646?httpAccept=text/plainTest -
5دورية أكاديمية
المؤلفون: Tabata, Ken-ichi, Watanabe, Masami, Satoh, Takefumi, Tian, Wei-hau, Wang, Hongyu, Fattah, ElMoataz Abdel, Yang, Guang, Floryk, Daniel, Kadmon, Dov, Thompson, Timothy C.
المصدر: Molecular Therapy ; volume 13, page S106 ; ISSN 1525-0016
مصطلحات موضوعية: Drug Discovery, Pharmacology, Genetics, Molecular Biology, Molecular Medicine
الإتاحة: https://doi.org/10.1016/j.ymthe.2006.08.332Test
https://api.elsevier.com/content/article/PII:S1525001606005892?httpAccept=text/plainTest
https://api.elsevier.com/content/article/PII:S1525001606005892?httpAccept=text/xmlTest -
6دورية أكاديمية
المؤلفون: Fujita, Tetsuo, Teh, Bin S., Timme, Terry L., Mai, Wei-Yuan, Satoh, Takefumi, Kusaka, Nobuyuki, Naruishi, Koji, Fattah, Elmoataz Abdel, Aguilar-Cordova, Estuardo, Butler, E. Brian, Thompson, Timothy C.
المصدر: Journal of Urology ; volume 173, issue 4S, page 59-60 ; ISSN 0022-5347 1527-3792
الإتاحة: https://doi.org/10.1016/s0022-5347Test(18)34481-1
https://api.elsevier.com/content/article/PII:S0022534718344811?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022534718344811?httpAccept=text/plainTest -
7دورية أكاديمية
المصدر: Tuberculosis ; volume 93, page S33-S37 ; ISSN 1472-9792
مصطلحات موضوعية: Infectious Diseases, Microbiology (medical), Immunology, Microbiology
الإتاحة: https://doi.org/10.1016/s1472-9792Test(13)70008-8
https://api.elsevier.com/content/article/PII:S1472979213700088?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1472979213700088?httpAccept=text/plainTest -
8دورية أكاديمية
المؤلفون: Fujita, Tetsuo, Teh, Bin S., Timme, Terry L., Mai, Wei-Yuan, Satoh, Takefumi, Kusaka, Nobuyuki, Naruishi, Koji, Fattah, Elmoataz Abdel, Aguilar-Cordova, Estuardo, Butler, E. Brian, Thompson, Timothy C.
المصدر: International Journal of Radiation Oncology*Biology*Physics ; volume 65, issue 1, page 84-90 ; ISSN 0360-3016
مصطلحات موضوعية: Cancer Research, Radiology, Nuclear Medicine and imaging, Oncology, Radiation
الإتاحة: https://doi.org/10.1016/j.ijrobp.2005.11.009Test
https://api.elsevier.com/content/article/PII:S0360301605028671?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0360301605028671?httpAccept=text/plainTest -
9دورية أكاديمية
المؤلفون: Qin Wei, Youbao Sha, Bhattacharya, Abhisek, Fattah, Elmoataz Abdel, Bonilla, Diana, Jyothula, Soma S. S. K., Pandit, Lavannya, Khurana Hershey, Gurjit K., Eissa, N. Tony
المصدر: American Journal of Respiratory & Critical Care Medicine; 1/1/2014, Vol. 189 Issue 1, p1-11, 11p
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10دورية أكاديمية
المؤلفون: Jin Na Shin1, Fattah, Elmoataz Abdel1, Bhattacharya, Abhisek1, Soyoung Ko1, Eissa, N. Tony1 teissa@bcm.edu
المصدر: Journal of Biological Chemistry. 12/13/2013, Vol. 288 Issue 50, p35886-35895. 10p.
مصطلحات موضوعية: *OLIGOMERS, *AUTOPHAGY, *INFLAMMATION, *PROTEIN folding, *REACTIVE oxygen species
مستخلص: The association between altered proteostasis and inflammatory disorders has been increasingly recognized, but the underlying mechanisms are not well understood. In this study, we show that deficiency of either autophagy or sequestosome 1 (p62 or SQSTM) led to inflammasome hyperactivation in response to LPS and ATP in primary macrophages and in mice in vivo. Importantly, induction of protein misfolding by puromycin, thapsigargin, or geldanamycin resulted in inflammasome activation that was more pronounced in autophagy- or p62-deficientmacrophages. Accumulation of misfolded proteins caused inflammasome activation by inducing generation of nonmitochondrial reactive oxygen species and lysosomal damage, leading to release of cathepsin B. Our results suggest that altered proteostasis results in inflammasome activation and thus provide mechanisms for the association of altered proteostasis with inflammatory disorders. [ABSTRACT FROM AUTHOR]