المؤلفون: Fan Yang, Chenyang Yuan, Fanghui Chen, Zhaohui S. Qin, Nicole C. Schmitt, Gregory B. Lesinski, Nabil F. Saba, Yong Teng

مصطلحات موضوعية: Immunology, Head and neck cancer, NK cells, IL6 and CCR2, scRNA-seq, HPV, The tumor microenvironment, Double blockade

الوصف: Supplementary Material 1.

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_1_of_Combined_IL6_and_CCR2_blockade_potentiates_antitumor_activity_of_NK_cells_in_HPV-negative_head_and_neck_cancer/25389493Test

الإتاحة: https://doi.org/10.6084/m9.figshare.25389493.v1Test

المؤلفون: Thuy-Van P. Hang, Zachary Spiritos, Anthony M. Gamboa, Zhengjia Chen, Seth Force, Vaishali Patel, Saurabh Chawla, Steven Keilin, Nabil F. Saba, Bassel El-Rayes, Qiang Cai, Field F. Willingham

المصدر: Clinical Endoscopy, Vol 55, Iss 3, Pp 372-380 (2022)

مصطلحات موضوعية: adenocarcinoma, barrett’s esophagus, epidemiology, esophageal neoplasm, Internal medicine, RC31-1245, Diseases of the digestive system. Gastroenterology, RC799-869

الوصف: Background/Aims Endoscopic resection has become the preferred treatment approach for select early esophageal adenocarcinoma (EAC); however, the epidemiology of early stage disease has not been well defined. Methods Surveillance Epidemiology and End Results (SEER) data were analyzed to determine age-adjusted incidence rates among major epithelial carcinomas, including EAC, from 1973 to 2017. The percent change in incidence over time was compared according to tumor subtype. Early T-stage, node-negative EAC without metastasis was examined from 2004 to 2017 when precise T-stage data were available. Results The percent change in annual incidence from 1973 to 2017 was 767% for EAC. Joinpoint analysis showed that the average annual percent change in EAC from 1973 to 2017 was 5.11% (95% confidence interval, 4.66%–5.56%). The annual percent change appeared to plateau between 2004 and 2017; however, early EAC decreased from 2010 to 2017, with an annual percent change of –5.78%. Conclusions There has been a 7-fold increase in the incidence of EAC, which was significantly greater than that of the other major epithelial malignancies examined. More recently, the incidence of early EAC has been decreasing. Approximately one in five patients has node negative, potentially resectable early stage disease.

وصف الملف: electronic resource

العلاقة: http://www.e-ce.org/upload/pdf/ce-2021-152.pdfTest; https://doaj.org/toc/2234-2400Test; https://doaj.org/toc/2234-2443Test

الوصول الحر: https://doaj.org/article/45a192716d3a46b49ed640115c58e5eeTest

المؤلفون: Joanna M. Streck, Ju-Whei Lee, Angela Wangari Walter, Rachel L. Rosen, Ilana F. Gareen, Sheetal Mehta Kircher, Benjamin A. Herman, Ruth C. Carlos, Shaji Kumar, Ingrid A. Mayer, Nabil F. Saba, Timothy S. Fenske, Joel W. Neal, Michael B. Atkins, F. Stephen Hodi, Christos E. Kyriakopoulos, Clare Tempany, Tait D. Shanafelt, Lynne I. Wagner, Stephanie R. Land, Elyse R. Park, Jamie S. Ostroff

مصطلحات موضوعية: Cancer

الوصف: Supplemental Table 2 shows associations of baseline continuous participant characteristics with past 30-day tobacco product use

العلاقة: https://figshare.com/articles/journal_contribution/Supplemental_Table_2_from_Cigarette_and_Alternative_Tobacco_Product_Use_among_Adult_Cancer_Survivors_Enrolled_in_9_ECOG-ACRIN_Clinical_Trials/24473570Test

الإتاحة: https://doi.org/10.1158/1055-9965.24473570.v1Test
https://figshare.com/articles/journal_contribution/Supplemental_Table_2_from_Cigarette_and_Alternative_Tobacco_Product_Use_among_Adult_Cancer_Survivors_Enrolled_in_9_ECOG-ACRIN_Clinical_Trials/24473570Test

المؤلفون: Joanna M. Streck, Ju-Whei Lee, Angela Wangari Walter, Rachel L. Rosen, Ilana F. Gareen, Sheetal Mehta Kircher, Benjamin A. Herman, Ruth C. Carlos, Shaji Kumar, Ingrid A. Mayer, Nabil F. Saba, Timothy S. Fenske, Joel W. Neal, Michael B. Atkins, F. Stephen Hodi, Christos E. Kyriakopoulos, Clare Tempany, Tait D. Shanafelt, Lynne I. Wagner, Stephanie R. Land, Elyse R. Park, Jamie S. Ostroff

مصطلحات موضوعية: Cancer

الوصف: Supplemental Table 1 shows cancer types, patient accrual and survey completion rates for parent trials

العلاقة: https://figshare.com/articles/journal_contribution/Supplemental_Table_1_from_Cigarette_and_Alternative_Tobacco_Product_Use_among_Adult_Cancer_Survivors_Enrolled_in_9_ECOG-ACRIN_Clinical_Trials/24473573Test

الإتاحة: https://doi.org/10.1158/1055-9965.24473573.v1Test
https://figshare.com/articles/journal_contribution/Supplemental_Table_1_from_Cigarette_and_Alternative_Tobacco_Product_Use_among_Adult_Cancer_Survivors_Enrolled_in_9_ECOG-ACRIN_Clinical_Trials/24473573Test

المؤلفون: Karthik Nagaraja Rao, Prathamesh S. Pai, Prajwal Dange, Luiz P. Kowalski, Primož Strojan, Antti A. Mäkitie, Orlando Guntinas-Lichius, K. Thomas Robbins, Juan P. Rodrigo, Avraham Eisbruch, Robert P. Takes, Remco de Bree, Andrés Coca-Pelaz, Cesare Piazza, Carlos Chiesa-Estomba, Fernando López, Nabil F. Saba, Alessandra Rinaldo, Alfio Ferlito

المصدر: Biomedicines; Volume 11; Issue 8; Pages: 2128

مصطلحات موضوعية: laryngeal cancer, T3, organ preservation, head and neck cancer, total laryngectomy

الوصف: Background: The management of cT3 laryngeal cancers remains controversial, with studies recommending surgical or non-surgical approaches. Despite the many papers that have been published on the subject, there is a lack of studies showing which treatment has better results in terms of survival. Objective: To determine the difference in survival outcomes following total laryngectomy (TL), concurrent chemoradiation (CRT) or radiation therapy (RT) alone in T3 laryngeal cancers. Methods: Search of PubMed, Scopus, and Google Scholar databases from 1995 to 2023 employing specific keywords and Boolean operators to retrieve relevant articles. Statistical analysis was conducted using a random-effects model, and heterogeneity was evaluated using the Q-test and I2 statistic. Funnel plot asymmetry was assessed using rank correlation and regression tests. Results: The qualitative data synthesis comprised 10,940 patients from 16 included studies. TL was performed in 2149 (19.4%), CRT in 6723 (61.5%), RT in 295 (2.7%), while non-surgical treatment was not specified in 1773 (16.2%) patients. The pooled 2-year overall survival (OS) rates were TL = 73%, CRT = 74.7%, RT = 57.9%, 3-year OS rates were TL = 64.3%, CRT = 62.9%, RT = 52.4%, and 5-year OS rates were TL = 54.2%, CRT = 52.7%, RT = 40.8%. There was a significant heterogeneity in the included studies. There was no statistically significant difference in 2-year OS (logOR= −0.88 (95% confidence interval (CI): −1.99 to 0.23), p = 0.12), 3-year OS (logOR = −0.6 (95% CI: −1.34 to 0.15), p = 0.11), and 5-year OS (logOR = −0.54 (95% CI: −1.29 to 0.21), p = 0.16) between TL and CRT. Instead, there was significant difference in 2-year OS (logOR= −1.2383 (95% CI: −2.1679 to −0.3087), p = 0.009), 3-year OS (−1.1262 (95% CI: −1.6166 to −0.6358), p < 0.001), and 5-year OS (−0.99 (95% CI: −1.44 to −0.53)), p < 0.001) between TL and RT alone. Conclusions and Significance: TL followed with adjuvant (chemo)radiation on indication and CRT with salvage surgery in reserve appear to have ...

وصف الملف: application/pdf

العلاقة: Cancer Biology and Therapeutics; https://dx.doi.org/10.3390/biomedicines11082128Test

الإتاحة: https://doi.org/10.3390/biomedicines11082128Test

المؤلفون: Andrés Coca-Pelaz, Juan Pablo Rodrigo, Jatin P. Shah, Iain J. Nixon, Dana M. Hartl, K. Thomas Robbins, Luiz P. Kowalski, Antti A. Mäkitie, Marc Hamoir, Fernando López, Nabil F. Saba, Sandra Nuyts, Alessandra Rinaldo, Alfio Ferlito

المصدر: Cancers; Volume 15; Issue 10; Pages: 2692

مصطلحات موضوعية: differentiated thyroid cancer, salvage surgery, radioiodine therapy, targeted therapy, tyrosine kinase inhibitors

الوصف: Differentiated thyroid carcinomas (DTC) have an excellent prognosis, but this is sometimes overshadowed by tumor recurrences following initial treatment (approximately 15% of cases during follow-up), due to unrecognized disease extent at initial diagnosis or a more aggressive tumor biology, which are the usual risk factors. The possible sites of recurrence are local, regional, or distant. Local and regional recurrences can usually be successfully managed with surgery and radioiodine therapy, as are some isolated distant recurrences, such as bone metastases. If these treatments are not possible, other therapeutic options such as external beam radiation therapy or systemic treatments should be considered. Major advances in systemic treatments have led to improved progression-free survival in patients previously considered for palliative treatments; among these treatments, the most promising results have been achieved with tyrosine kinase inhibitors (TKI). This review attempts to give a comprehensive overview of the current treatment options suited for recurrences and the new treatments that are available in cases where salvage surgery is not possible or in cases resistant to radioiodine.

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/cancers15102692Test

الإتاحة: https://doi.org/10.3390/cancers15102692Test

المؤلفون: Nabil F. Saba, Saagar Pamulapati, Bhamini Patel, Mayur Mody, Primož Strojan, Robert Takes, Antti A. Mäkitie, Oded Cohen, Pia Pace-Asciak, Jan B. Vermorken, Carol Bradford, Arlene Forastiere, Yong Teng, Andreas Wieland, Alfio Ferlito

المصدر: Cancers; Volume 15; Issue 7; Pages: 1959

مصطلحات موضوعية: human papillomavirus, HPV, immunotherapy, vaccine therapy, immuno-oncology

الوصف: Head and neck cancer (HNC) is the seventh most common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) accounting for a majority of cases in the western world. While HNC accounts for only 5% of all cancers in the United States, the incidence of a subset of OPSCC caused by human papillomavirus (HPV) is increasing rapidly. The treatment for OPSCC is multifaceted, with a recently emerging focus on immunotherapeutic approaches. With the increased incidence of HPV-related OPSCC and the approval of immunotherapy in the management of recurrent and metastatic HNC, there has been rising interest in exploring the role of immunotherapy in the treatment of HPV-related OPSCC specifically. The immune microenvironment in HPV-related disease is distinct from that in HPV-negative OPSCC, which has prompted further research into various immunotherapeutics. This review focuses on HPV-related OPSCC, its immune characteristics, and current challenges and future opportunities for immunotherapeutic applications in this virus-driven cancer.

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/cancers15071959Test

الإتاحة: https://doi.org/10.3390/cancers15071959Test

المؤلفون: Carlos M. Chiesa-Estomba, Miguel Mayo-Yanez, Orlando Guntinas-Lichius, Vincent Vander-Poorten, Robert P. Takes, Remco de Bree, Gyorgy B. Halmos, Nabil F. Saba, Sandra Nuyts, Alfio Ferlito

المصدر: Biomedicines; Volume 11; Issue 3; Pages: 805

مصطلحات موضوعية: head, neck, hypopharynx, radiomics, treatment

الوصف: (1) Background: Hypopharyngeal squamous cell carcinomas usually present with locally advanced disease and a correspondingly poor prognosis. Currently, efforts are being made to improve tumor characterization and provide insightful information for outcome prediction. Radiomics is an emerging area of study that involves the conversion of medical images into mineable data; these data are then used to extract quantitative features based on shape, intensity, texture, and other parameters; (2) Methods: A systematic review of the peer-reviewed literature was conducted; (3) Results: A total of 437 manuscripts were identified. Fifteen manuscripts met the inclusion criteria. The main targets described were the evaluation of textural features to determine tumor-programmed death-ligand 1 expression; a surrogate for microvessel density and heterogeneity of perfusion; patient stratification into groups at high and low risk of progression; prediction of early recurrence, 1-year locoregional failure and survival outcome, including progression-free survival and overall survival, in patients with locally advanced HPSCC; thyroid cartilage invasion, early disease progression, recurrence, induction chemotherapy response, treatment response, and prognosis; and (4) Conclusions: our findings suggest that radiomics represents a potentially useful tool in the diagnostic workup as well as during the treatment and follow-up of patients with HPSCC. Large prospective studies are essential to validate this technology in these patients.

وصف الملف: application/pdf

العلاقة: Cancer Biology and Therapeutics; https://dx.doi.org/10.3390/biomedicines11030805Test

الإتاحة: https://doi.org/10.3390/biomedicines11030805Test

المؤلفون: Juan P. Rodrigo, Mario Sánchez-Canteli, Asterios Triantafyllou, Remco de Bree, Antti A. Mäkitie, Alessandro Franchi, Henrik Hellquist, Nabil F. Saba, Göran Stenman, Robert P. Takes, Cristina Valero, Nina Zidar, Alfio Ferlito

المصدر: Cancers; Volume 15; Issue 3; Pages: 802

مصطلحات موضوعية: oropharyngeal squamous cell carcinoma, meta-analysis, neutrophil-to-lymphocyte ratio, prognosis

الوصف: Neutrophil-to-lymphocyte ratio (NLR) has been associated with survival in various cancers, including head and neck cancer. However, there is limited information on its role in oropharyngeal squamous cell carcinomas (OPSCC) according to HPV status. This prompted the present meta-analysis. Studies were selected when the prognostic value of NLR prior to treatment was evaluated in OPSCC patients, the cutoff value of NLR was available, and the prognostic value of NLR was evaluated by time-to-event survival analysis. A total of 14 out of 492 articles, including 7647 patients, were analyzed. The results showed a worse prognosis for the patients with a high NLR: The combined hazard ratios (HR) for overall survival (OS) in patients with an elevated NLR was 1.56 (95% confidence interval (CI) 1.21–2.02; p = 0.0006), for disease-free survival was 1.52 (95% CI 1.34–1.73; p < 0.00001), and for recurrence-free survival was 1.86 (95% CI 1.50–2.30; p < 0.00001). This worse prognosis of high NLR was exclusive of HPV-positive patients: HR for OS in the HPV-positive subgroup was 4.05 (95% CI 1.90–8.62 (p = 0.0003), and in the HPV-negative subgroup 0.92 (95% CI 0.47–1.80; p = 0.82). The prognosis of NLR was not influenced by treatment: The HR for OS for patients treated with radiotherapy/chemoradiotherapy (RT/CRT) was 1.48 (95% CI 1.09–2.01; p = 0.01), and for patients treated with surgery (±RT/CRT) was 1.72 (95% CI 1.08–2.72; p = 0.02). In conclusion, an elevated NLR relates to worse outcomes in patients with HPV-positive OPSCC.

وصف الملف: application/pdf

العلاقة: Cancer Biomarkers; https://dx.doi.org/10.3390/cancers15030802Test

الإتاحة: https://doi.org/10.3390/cancers15030802Test

المؤلفون: Prashant Puttagunta, Saagar V. Pamulapati, James E. Bates, Jennifer H. Gross, William A. Stokes, Nicole C. Schmitt, Conor Steuer, Yong Teng, Nabil F. Saba

المصدر: Frontiers in Oncology, Vol 13 (2023)

مصطلحات موضوعية: squamous cell carcinoma of the head and neck, vascular endothelial growth factor, tyrosine kinase inhibitor, immune checkpoint inhibitors, human papillomavirus, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: As the prognosis for squamous cell carcinoma of the head and neck remains unsatisfactory when compared to other malignancies, novel therapies targeting specific biomarkers are a critical emerging area of great promise. One particular class of drugs that has been developed to impede tumor angiogenesis is vascular endothelial growth factor-tyrosine kinase inhibitors. As current data is primarily limited to preclinical and phase I/II trials, this review summarizes the current and future prospects of these agents in squamous cell carcinoma of the head and neck. In particular, the combination of these agents with immunotherapy is an exciting area that may be a promising option for patients with recurrent or metastatic disease, evidenced in recent trials such as the combination immune checkpoint inhibitors with lenvatinib and cabozantinib. In addition, the use of such combination therapy preoperatively in locally advanced disease is another area of interest.

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2023.1310106/fullTest; https://doaj.org/toc/2234-943XTest; https://doaj.org/article/7fc29365ef2a4c6d826053b8e11532f0Test

الإتاحة: https://doi.org/10.3389/fonc.2023.1310106Test
https://doaj.org/article/7fc29365ef2a4c6d826053b8e11532f0Test