المؤلفون: Szentgyorgyi, Andrew, Baldwin, Daniel, Barnes, Stuart, Bean, Jacob, Ben-Ami, Sagi, Brennan, Patricia, Budynkiewicz, Jamie, Chun, Moo-Young, Conroy, Charlie, Crane, Jeffrey D., Epps, Harland, Evans, Ian, Evans, Janet, Foster, Jeff, Frebel, Anna, Gauron, Thomas, Guzmán, Dani, Hare, Tyson, Jang, Bi-Ho, Jang, Jeong-Gyun, Jordan, Andres, Kim, Jihun, Kim, Kang-Miin, Mendes de Oliveira, Claudia Mendes, Lopez-Morales, Mercedes, McCracken, Kenneth, McMuldroch, Stuart, Miller, Joseph, Mueller, Mark, Oh, Jae Sok, Onyuksel, Cem, Ordway, Mark, Park, Byeong-Gon, Park, Chan, Park, Sung-Joon, Paxson, Charles, Phillips, David, Plummer, David, Podgorski, William, Seifahrt, Andreas, Stark, Daniel, Steiner, Joao, Uomoto, Alan, Walsworth, Ronald, Yu, Young-Sam

مرشدي الرسالة: Univ Arizona, Steward Observ, Harvard-Smithsonian Ctr. for Astrophysics (United States), Univ. of Chicago (United States), Korea Astronomy and Space Science Institute (Korea, Republic of), The Observatories of the Carnegie Institution for Science (United States), Lick Observatory, Univ. of California, Santa Cruz (United States), Massachusetts Institute of Technology (United States), Pontificia Univ. Católica de Chile (Chile), Univ. de São Paulo (Brazil), Steward Observatory, Univ. of Arizona (United States)

مصطلحات موضوعية: Echelle spectrograph, precision radial velocity, G-CLEF, GMT, high dispersion spectroscopy, ELTs

الوصف: The GMT-Consortium Large Earth Finder (G-CLEF) will be a cross-dispersed, optical band echelle spectrograph to be delivered as the first light scientific instrument for the Giant Magellan Telescope (GMT) in 2022. G-CLEF is vacuumenclosed and fiber-fed to enable precision radial velocity (PRV) measurements, especially for the detection and characterization of low-mass exoplanets orbiting solar-type stars. The passband of G-CLEF is broad, extending from 3500 angstrom to. This passband provides good sensitivity at blue wavelengths for stellar abundance studies and deep red response for observations of high-redshift phenomena. The design of G-CLEF incorporates several novel technical innovations. We give an overview of the innovative features of the current design. G-CLEF will be the first PRV spectrograph to have a composite optical bench so as to exploit that material's extremely low coefficient of thermal expansion, high in-plane thermal conductivity and high stiffness-to-mass ratio. The spectrograph camera subsystem is divided into a red and a blue channel, split by a dichroic, so there are two independent refractive spectrograph cameras. The control system software is being developed in model-driven software context that has been adopted globally by the GMT. G-CLEF has been conceived and designed within a strict systems engineering framework. As a part of this process, we have developed a analytical toolset to assess the predicted performance of G-CLEF as it has evolved through design phases.

الإتاحة: http://hdl.handle.net/10150/622810Test
http://arizona.openrepository.com/arizona/handle/10150/622810Test

المؤلفون: Baldwin, Dan, Szentgyorgyi, Andrew, Barnes, Stuart, Bean, Jacob, Ben-Ami, Sagi, Brennan, Patricia, Budynkiewicz, Jamie, Chun, Moo-Young, Conroy, Charlie, Crane, Jeffrey D., Epps, Harland, Evans, Ian, Evans, Janet, Foster, Jeff, Frebel, Anna, Gauron, Thomas, Guzman, Dani, Hare, Tyson, Jang, Bi-Ho, Jang, Jeong-Gyun, Jordan, Andres, Kim, Jihun, Kim, Kang-Min, Mendes de Oliveira, Claudia, Lopez-Morales, Mercedes, McCracken, Kenneth, McMuldroch, Stuart, Miller, Joseph, Mueller, Mark, Oh, Jae Sok, Ordway, Mark, Park, Byeong-Gon, Park, Chan, Park, Sung-Joon, Paxson, Charles, Phillips, David, Plummer, David, Podgorski, William, Seifahrt, Andreas, Stark, Daniel, Steiner, Joao, Uomoto, Alan, Walsworth, Ronald, Yu, Young-Sam

مرشدي الرسالة: Univ Arizona, Steward Observ, Harvard-Smithsonian Ctr. for Astrophysics (United States), The Univ. of Chicago (United States), Korea Astronomy and Space Science Institute (Korea, Republic of), The Observatories of the Carnegie Institute for Science (United States), Univ. of California, Santa Cruz (United States), Kavli Institute for Astrophysics and Space Research (United States), Pontificia Univ. Católica de Chile (Chile), The Observatories of the Carnegie Institution of Science (United States), Univ. de São Paulo (Brazil), The Univ. of Arizona (United States), The Observatories of the Carnegie Institution for Science (United States)

مصطلحات موضوعية: Echelle spectrograph, precision radial velocity, G -CLEF, GMT, composite optical bench, thermal stability, mechanical stability, low CIE

الوصف: The GMT-Consortium Large Earth Finder (G-CLEF) is an echelle spectrograph with precision radial velocity (PRV) capability that will be a first light instrument for the Giant Magellan Telescope (GMT). G-CLEF has a PRV precision goal of 40 cm/sec (10 cm/s for multiple measurements) to enable detection of Earth-like exoplanets in the habitable zones of sun-like stars'. This precision is a primary driver of G-CLEF's structural design. Extreme stability is necessary to minimize image motions at the CCD detectors. Minute changes in temperature, pressure, and acceleration environments cause structural deformations, inducing image motions which degrade PRV precision. The instrument's structural design will ensure that the PRV goal is achieved under the environments G-CLEF will be subjected to as installed on the GMT azimuth platform, including: Millikelvin (0.001 K) thermal soaks and gradients 10 millibar changes in ambient pressure Changes in acceleration due to instrument tip/tilt and telescope slewing Carbon fiber/cyanate composite was selected for the optical bench structure in order to meet performance goals. Low coefficient of thermal expansion (C 1E) and high stiffness-to-weight are key features of the composite optical bench design. Manufacturability and serviceability of the instrument are also drivers of the design. In this paper, we discuss analyses leading to technical choices made to minimize G-CLEF's sensitivity to changing environments. Finite element analysis (FEA) and image motion sensitivity studies were conducted to determine PRV performance under operational environments. We discuss the design of the optical bench structure to optimize stiffness to -weight and minimize deformations due to inertial and pressure effects. We also discuss quasi-kinematic mounting of optical elements and assemblies, and optimization of these to ensure minimal image motion under thermal, pressure, and inertial loads expected during PRV observations.

الإتاحة: http://hdl.handle.net/10150/622418Test
http://arizona.openrepository.com/arizona/handle/10150/622418Test

المؤلفون: Evans, Ian

المصدر: Herald on Sunday (Auckland, N.Z.), 8 Jun 2014; n.504:p.6

المؤلفون: Sharpley, Christopher F, School of Science and Technology, orcid:0000-0001-7922-4848, Bitsika, Vicki, orcid:0000-0003-2518-6684, Arnold, Wayne M, orcid:0000-0002-5993-4081, Evans, Ian D, School of Education, orcid:0000-0002-2231-3134, Jesulola, Emmanuel, Agnew, Linda, orcid:0000-0002-2803-0995

مصطلحات موضوعية: Neurosciences

الوصف: Melancholia represents a particular subtype of depressive symptomatology. Unlike Major Depressive Disorder (MDD), Melancholia has not been conclusively associated with peripheral inflammation, although there may be some methodological reasons confounding that finding. To overcome some of those methodological limitations, the correlation between one index of peripheral inflammation (C-Reactive Protein: CRP) and Melancholia was investigated in a community sample of 40 male and 51 female participants (aged 18–75 years) who provided a blood sample and self-report data on an established measure of Melancholia (MEL). Results indicated that females had significantly higher concentrations of CRP than males, and that there were different patterns of association between the MEL items and CRP for males and females. Although the predominant differences were for the MEL symptoms of cognitive confusion (females only) and feelings of low self-worth (males only), each sex had distinct networks of associations between CRP and the eight MEL items used here. These findings may provide some explanation of the lack of clear results regarding the CRP-Melancholia link in the previous literature, and also argue for development of clinical assessment and treatment approaches that differ for males and females.

العلاقة: https://hdl.handle.net/1959.11/60359Test; https://rune.une.edu.au/web/retrieve/4aa5125a-631f-4a77-a8ba-179b885d3891Test; une:1959.11/60359

الإتاحة: https://hdl.handle.net/1959.11/60359Test
https://rune.une.edu.au/web/retrieve/4aa5125a-631f-4a77-a8ba-179b885d3891Test

المؤلفون: Abhishek, Abhishek, Stevenson, Matthew D, Nakafero, Georgina, Grainge, Matthew J, Evans, Ian, Alabas, Oras, Card, Tim, Taal, Maarten W, Aithal, Guruprasad P, Fox, Christopher P, Mallen, Christian D, van der Windt, Danielle A, Riley, Richard D, Warren, Richard B, Williams, Hywel C

المصدر: Abhishek , A , Stevenson , M D , Nakafero , G , Grainge , M J , Evans , I , Alabas , O , Card , T , Taal , M W , Aithal , G P , Fox , C P , Mallen , C D , van der Windt , D A , Riley , R D , Warren , R B & Williams , H C 2024 , ' Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies ' , The British journal of ....

مصطلحات موضوعية: Adult, Cost-Benefit Analysis, Female, Hematologic Tests, Humans, Male, Necrosis, Quality-Adjusted Life Years, Retrospective Studies, Tumor Necrosis Factor-alpha

الوصف: BACKGROUND: There is no evidence base supporting the use of six-monthly monitoring blood tests for the early detection of liver, blood, and renal toxicity during established anti-TNF-alpha treatment. OBJECTIVES: To evaluate the incidence and risk factors of anti-TNF-alpha treatment cessation due to liver, blood, and renal side-effects and, to estimate the cost-effectiveness of alternate intervals between monitoring blood tests. METHODS: A secondary-care based retrospective cohort study was performed. Data from the British Association of Dermatologists Biologic and Immunomodulators Register were used. Patients with at-least moderate psoriasis prescribed their first anti-TNF-alpha treatment were included. Treatment discontinuation due to monitoring blood test abnormality was the primary-outcome.Patients were followed-up from treatment start to the earliest of outcome, drug-discontinuation, death, five years, or 31/07/2021. The incidence rate and 95% confidence intervals (CIs) of anti-TNF-alpha discontinuation with monitoring blood test abnormality was calculated. Multivariate Cox regression was used to examine the association between risk-factors and outcome. A mathematical model evaluated costs and quality-adjusted life years (QALYs) associated with lengthening the time between monitoring blood tests during anti-TNF-alpha treatment. RESULTS: The cohort included 8,819 participants (3,710 (42.1%) female, mean age (standard deviation) 44.76 (13.20) years) that contributed 25,058 person-years of follow-up and experienced 125 treatment discontinuations due to monitoring blood test abnormality at an incidence rate (95%CI) of 5.85 (4.91-6.97)/1,000 person-years. Of these, 64, and 61 discontinuations occurred within the first year, and after the first-year of treatment start at an incidence rate (95% CI) of 8.62 (6.74-11.01) and 3.44 (2.67-4.42)/1000 person-years respectively. Increasing age in years, diabetes, and liver disease associated with anti-TNF-alpha discontinuation with monitoring blood test abnormality with ...

العلاقة: https://research.manchester.ac.uk/en/publications/02e38be4-d09b-41a3-904c-cf44e36d49b7Test

الإتاحة: https://doi.org/10.1093/bjd/ljad430Test
https://research.manchester.ac.uk/en/publications/02e38be4-d09b-41a3-904c-cf44e36d49b7Test
https://www.mendeley.com/catalogue/f6fd9503-ae7d-34e7-a8dd-8019d9cb76e3Test/
http://www.scopus.com/inward/record.url?scp=85187962446&partnerID=8YFLogxKTest

المؤلفون: Barrett, Christa E., Evans, Ian, Morgan, Timothy, Olivier, Alicia K.

المساهمون: National Fish and Wildlife Foundation, Global Center for Aquatic Health and Food Security

المصدر: Journal of Histotechnology ; page 1-8 ; ISSN 0147-8885 2046-0236

الإتاحة: https://doi.org/10.1080/01478885.2024.2327155Test

المؤلفون: Sharpley, Christopher F., Bitsika, Vicki, Arnold, Wayne M., Evans, Ian D., Jesulola, Emmanuel, Agnew, Linda L.

المصدر: Psychiatry Research Communications ; volume 4, issue 2, page 100163 ; ISSN 2772-5987

الإتاحة: https://doi.org/10.1016/j.psycom.2024.100163Test
https://api.elsevier.com/content/article/PII:S2772598724000096?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2772598724000096?httpAccept=text/plainTest

المؤلفون: Minár, Jozef, Drăguţ, Lucian, Evans, Ian S., Feciskanin, Richard, Gallay, Michal, Jenčo, Marián, Popov, Anton

المساهمون: Agentúra na podporu výskumu a vývoja Slovenskej republiky

المصدر: Earth-Science Reviews ; volume 248, page 104631 ; ISSN 0012-8252

مصطلحات موضوعية: General Earth and Planetary Sciences

الإتاحة: https://doi.org/10.1016/j.earscirev.2023.104631Test
https://api.elsevier.com/content/article/PII:S0012825223003203?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0012825223003203?httpAccept=text/plainTest

المؤلفون: Bitsika, Vicki, School of Science and Technology, orcid:0000-0003-2518-6684, Sharpley, Christopher F, orcid:0000-0001-7922-4848, Vessey, Kirstan A, orcid:0000-0003-1031-1964, Evans, Ian D, School of Education, orcid:0000-0002-2231-3134

مصطلحات موضوعية: Neurosciences

الوصف: The presence of sex-based asymmetry in the behaviours of youths with Autism Spectrum Disorder (ASD) is currently under research scrutiny. ASD is characterised by challenging behaviour (CB) and is often accompanied by anxiety, both of which often exacerbate social interaction difficulties. The present study examined the presence of sex-based asymmetry in the prevalence of CB and anxiety and in the association between CB and anxiety in a sample including 32 male autistic youths (M age = 10.09, SD = 3.83, range = 6–18 yr) and 32 female autistic youths (M age = 10.31, SD = 2.57, range = 6–15 yr) matched for age, IQ, and ASD severity (p > .101). While the prevalence and severity of behavioural characteristics across males and females with ASD were similar ( .101). While the prevalence and severity of behavioural characteristics across males and females with ASD were similar (p = .767), representing symmetry, there was asymmetry in the ways that CBs and anxiety were associated with each other across the two sexes. Specifically, there were 3 instances of symmetry (r > .3, .3, p r p > .05) in the association between five aspects of CB and five anxiety disorders. These findings emphasise the underlying sex-based .05) in the association between five aspects of CB and five anxiety disorders. These findings emphasise the underlying sex-based symmetry in the prevalence of ASD-related behaviours, also highlighting unique sex-based asymmetry in the association between CBs and anxiety in autistic youths.

العلاقة: https://hdl.handle.net/1959.11/60755Test; https://rune.une.edu.au/web/retrieve/f9c82f72-9b17-4a23-9a71-93fea6588569Test; une:1959.11/60755

الإتاحة: https://hdl.handle.net/1959.11/60755Test
https://rune.une.edu.au/web/retrieve/f9c82f72-9b17-4a23-9a71-93fea6588569Test

المؤلفون: Evans, Ian

المصدر: New Zealand herald, 3 Nov 2012; p.A15