المؤلفون: Ahangari, Najmeh, Sahebkar, Amirhossein, Azimi-Nezhad, Mohsen, Ghazizadeh, Hamideh, Moohebati, Mohsen, Ebrahim, Mahmoud, Esmaeili, Habibollah, Ferns, Gordon A, Pasdar, Alireza, Ghayour Mobarhan, Majid

الوصف: Background: familial hypercholesterolemia (FH), a hereditary disorder, is caused by pathogenic variants in the LDLR, APOB, and PCSK9 genes. This study has assessed genetic variants in a family, clinically diagnosed with FH. Methods: A family was recruited from MASHAD study in Iran with possible FH based on the Simon Broom criteria. The DNA sample of an affected individual (proband) was analyzed using whole exome sequencing, followed by bioinformatics and segregation analyses. Results: A novel splice site variant (c.345-2A>G) was detected in the LDLRAP1 gene, which was segregated in all affected family members. Moreover, HMGCR rs3846662 g.23092A>G was found to be homozygous (G/G) in the proband, probably leading to reduced response to simvastatin and pravastatin. Conclusion: LDLRAP1 c.345-2A>G could alter the phosphotyrosine-binding domain, which acts as an important part of biological pathways related to lipid metabolism.

وصف الملف: application/pdf

العلاقة: http://sro.sussex.ac.uk/id/eprint/105572/1/Article-v25n5p374-en.pdfTest; Ahangari, Najmeh, Sahebkar, Amirhossein, Azimi-Nezhad, Mohsen, Ghazizadeh, Hamideh, Moohebati, Mohsen, Ebrahim, Mahmoud, Esmaeili, Habibollah, Ferns, Gordon A, Pasdar, Alireza and Ghayour Mobarhan, Majid (2021) A novel splice site variant in the LDLRAP1 gene causes familial hypercholesterolemia. Iranian Biomedical Journal, 25 (5). pp. 374-379. ISSN 1028-852X

الإتاحة: https://doi.org/10.52547/ibj.25.5.374Test
http://sro.sussex.ac.uk/id/eprint/105572Test/
http://sro.sussex.ac.uk/id/eprint/105572/1/Article-v25n5p374-en.pdfTest

المؤلفون: Khadivzadeh, Talat, Rezamahaleh, FatemeAhmadi, Asgharinekah, SeyedMohsen, Esmaeili, Habibollah

المصدر: Journal of Education and Health Promotion ; volume 9, issue 1, page 337 ; ISSN 2277-9531

الإتاحة: https://doi.org/10.4103/jehp.jehp_588_20Test

المؤلفون: Khadivzade, Talat, Rajati, Reihane, Esmaeili, Habibollah, Danesh, Fereshte

المصدر: Iranian Journal of Nursing and Midwifery Research ; volume 28, issue 2, page 144 ; ISSN 1735-9066

الإتاحة: https://doi.org/10.4103/ijnmr.ijnmr_189_21Test

المؤلفون: Abbaspour, Hadi, Kareshki, Hossein, Esmaeili, Habibollah, Karimi Moonaghi, Hossein

المصدر: Journal of Qualitative Research in Health Sciences ; volume 12, issue 2, page 100-106 ; ISSN 2645-6109

مصطلحات موضوعية: Health (social science), Medicine (miscellaneous), General Nursing

الوصف: Background: The journey to nursing professionalism is a constantly progressing process. The present study aimed to explain the experiences of nursing students and faculty members regarding the unseen consequences of the hidden curriculum for nursing professionalism. Methods: In this qualitative study, 25 nursing students and faculty members at Mashhad University of Medical Sciences were selected and interviewed based on purposive sampling. After data collection, all the recorded interviews were transcribed and reviewed, and their subcategories, categories, and themes were extracted using the qualitative content analysis approach proposed by Graneheim and Lundman. Results: A total of 1382 initial codes and two main themes were extracted from the interviews. The obtained categories were non-constructive and destructive clinical environment, unfavorable educational environment, the gap between theory and practice, inappropriate role model, neglect of scientific nursing knowledge, loss of professional values, undervaluing nursing professionalism, favorable clinical environment, favorable faculty environment, and faculty member as an effective role model. Conclusion: Professional behaviors have significant impacts on professionalism in nursing. There is a significant gap between the current nursing practice and professional nursing in some aspects. Therefore, it is important to consider all consequences of the hidden curriculum to achieve professionalism.

الإتاحة: https://doi.org/10.34172/jqr.2023.15Test
https://jqr1.kmu.ac.ir/article_92236_fdd927dfc45f3892d96958b3fe293f96.pdfTest

المؤلفون: Alirezaei, Somayeh, Yazdanpanah, Mohammad Javad, Esmaeili, Habibollah, Khadem, Nayereh, Zabolinejad, Naghmeh, Sadeghi, Fatemeh, Roudsari, Robab Latifnejad

المساهمون: Mashhad University of Medical Sciences, Mashhad, Iran

المصدر: Current Women s Health Reviews ; volume 19, issue 2 ; ISSN 1573-4048

الوصف: Background: Striae gravidarum, which occurs in most pregnancies, is unpleasant for women, and its treatment is costly. A preventive measure for this condition is applying herbal oils to maintain the skin's elasticity. The current study investigated the effect of a topical combined herbal cream on the occurrence and severity of striae gravidarum in primiparous women. Methods: In this triple-blind randomized clinical trial, 90 primiparous women in their first trimester of pregnancy, attending healthcare centres in Mashhad, Iran, were randomly allocated into two groups of herbal cream and placebo, from which 54 completed the study. The intervention group received 0.3 g of the cream, topically, composed of Calendula (Pot marigold), Anthemis nobilis (Chamomile), Pelargonium Graveolens (Rose Geranium), Theobroma oil (Cocoa Butter) and Soybean, twice a day for three days a week from 14-16 to 27-30 weeks of gestation and the placebo group received a moisturizing cream. At the gestational age of 38-40 weeks, the incidence and severity of striae on the abdominal skin were evaluated using the Atwal numerical scoring system and digital photography. Results: There was a significant difference between the prevalence of striae in the intervention and placebo group (43.3% vs 87.5%) (P<0.0001). Also, a significant difference was seen between the two groups in terms of the severity of the striae (P < 0.001). In the intervention group, the severity of striae in 86.7%, 13.3%, and 0% of the cases was mild, moderate, and severe, respectively, whereas, in the placebo group, it was occurred as mild, moderate, and severe in 37.5%, 58.3%, and 4.2% of the cases. Conclusion: Considering the effect of topically applied herbal cream, it is recommended that health care providers suggest pregnant women to use such herbal creams to avoid striae gravidarum development. Clinical Trial Registration Number: IRCT20190305042927

الإتاحة: https://doi.org/10.2174/1573404818666220518163029Test
https://www.eurekaselect.com/205000/articleTest

المؤلفون: Zomorrodian, Davoud, Khajavi-Rad, Abolfazl, Avan, Amir, Ebrahimi, Mahmoud, Nematy, Mohsen, Azarpazhooh, Mahmoud Reza, Emamian, Marzieh, Sadeghzade, Mahsa, Mirhafez, Seyed Reza, Mohammadi, Maryam, Mousavi, Mina, Esmaeili, Habibollah, Moohebati, Mohsen, Parizadeh, Mohammad Reza, Ferns, Gordon A, Ghayour-Mobarhan, Majid

المصدر: Journal of Epidemiology and Community Health (1979-), 2015 Jun 01. 69(6), 594-598.

الوصول الحر: http://www.jstor.org/stable/44018468Test

المؤلفون: Arasteh, Siavash, Moohebati, Mohsen, Avan, Amir, Esmaeili, Habibollah, Ghazizadeh, Hamideh, Mahdizadeh, Adeleh, Rahmani, Farzad, Mohamamdazade, Elham, Ferns, Gordon A., Parizadeh, Mohammad Reza, Ghayour-Mobarhan, Majid

المساهمون: Mashhad University of Medical Science (MUMS), Iran

المصدر: Indian Heart Journal ; volume 70, issue 6, page 788-792 ; ISSN 0019-4832

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.ihj.2017.11.017Test
https://api.elsevier.com/content/article/PII:S0019483217305114?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0019483217305114?httpAccept=text/plainTest

المؤلفون: Rajati, Reihane, Khadivzade, Talat, Esmaeili, Habibollah, Danesh, Fereshte

المصدر: Iranian Journal of Nursing & Midwifery Research; Mar/Apr2023, Vol. 28 Issue 2, p144-149, 6p

مصطلحات موضوعية: FERTILITY, HUMAN fertility, MOTIVATION (Psychology), EMPLOYEE motivation, WOMEN employees

مصطلحات جغرافية: IRAN

مستخلص: Background: In the last three decades, childbearing in Iran has decreased more than many countries in the world. The aim of this study was to explore the fertility motivation of Working women and their husbands and discover which one determines the number of children. Materials and Methods: This correlational study was conducted on 540 employed, married women and their husbands (270 couples) living in Mashhad, Iran, during 2017-2018. The participants were selected through multistage cluster sampling. Then, a random number table was used. Subsequently, questionnaires were distributed and completed at home, and collected after 24 h. Data were collected using a demographic characteristics form and the Childbearing Questionnaire (CBQ). Results: The mean(SD) positive motivation scores of men and women differed significantly [92.77 (13.04) Vs. 92.22 (13.51) df = 4; p = 0.001;]. The mean (SD) negative motivation scores of men and women also differed significantly 55.42 (10.94) Vs. 56.78 (10.57) df = 4; p = 0.001;]. Conclusions: According to the scores obtained for the positive and negative fertility motivations of working women and their husbands, women were more in favor of having children and had an ambivalent motivation to bear children. Moreover, the working women's spouses were more indifferent to fertility. The results of this study can help reproductive health policymakers in childbearing. [ABSTRACT FROM AUTHOR]

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المؤلفون: Kargar, Mehrdad, Tavassoli, Samira, Avan, Amir, Ebrahim, Mahmoud, Azarpazhooh, Mahmoud Reza, Asoodeh, Rasool, Nematy, Mohsen, Hassanian, Seyed Mahdi, Rahmani, Farzad, Mohammadzade, Elham, Esmaeili, Habibollah, Moohebat, Mohsen, Ferns, Gordon A, Ghayour-Mobarhan, Majid, Parizadeh, Seyed Mohammed Reza

الوصف: Background Heat shock protein 27 (HSP27) is an intracellular molecular chaperone that is expressed at high levels following the exposure of cells to environmental stressors such as heat, toxins, and free radicals. High levels of HSP antigens and antibody titers have been reported in several conditions including cardiovascular disease and cancers. We measured serum anti-HSP27 antibody levels in 993 subjects and assessed the associations between serum anti-HSP27 antibody levels and demographic characteristics including coronary risk factors. Methods A total of 993 subjects were recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study. Demographic, clinical, and biochemical parameters and serum anti-HSP27 antibody titers were determined in all the subjects. Results Serum anti-HSP27 antibody levels increased with increasing age in men. No significant differences in levels were detected between men and women. Serum anti-HSP27 antibody levels were significantly higher in obese subjects than in nonobese subjects (P = 0.046); however, no significant influence of smoking status was observed. Moreover, serum anti-HSP27 antibody titers were positively associated with age, body mass index, waist/hip ratio, the presence of diabetes mellitus, nonsmoking habit, serum triglycerides, cholesterol, and high-sensitivity c-reactive protein. Conclusion We have found that serum anti-HSP27 antibody titers are related to several cardiovascular risk factors, necessitating further studies on the value of this emerging marker for risk stratification.

وصف الملف: application/pdf

العلاقة: http://sro.sussex.ac.uk/id/eprint/67463/1/AS_479695687950336%401491379772278_content_1.pdfTest; Kargar, Mehrdad, Tavassoli, Samira, Avan, Amir, Ebrahim, Mahmoud, Azarpazhooh, Mahmoud Reza, Asoodeh, Rasool, Nematy, Mohsen, Hassanian, Seyed Mahdi, Rahmani, Farzad, Mohammadzade, Elham, Esmaeili, Habibollah, Moohebat, Mohsen, Ferns, Gordon A, Ghayour-Mobarhan, Majid and Parizadeh, Seyed Mohammed Reza (2017) Relationship between serum anti-heat shock protein 27 antibody levels and obesity. Clinical Biochemistry, 50 (12). pp. 690-695. ISSN 0009-9120

الإتاحة: https://doi.org/10.1016/j.clinbiochem.2017.02.015Test
http://sro.sussex.ac.uk/id/eprint/67463Test/
http://sro.sussex.ac.uk/id/eprint/67463/1/AS_479695687950336%401491379772278_content_1.pdfTest

المؤلفون: Kazemi-Bajestani, Seyyed MR, Tayefi, Maryam, Ebrahimi, Mahmoud, Heidari-Bakavoli, Ali R, Moohebati, Mohsen, Parizadeh, Seyyed MR, Esmaeili, Habibollah, Ferns, Gordon AA, Ghayour-Mobarhan, Majid

المصدر: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine ; volume 54, issue 6, page 644-648 ; ISSN 0004-5632 1758-1001

الوصف: Background Metabolic syndrome is defined by a clustering of cardiovascular risk factors and is associated with a heightened inflammatory state. A raised serum high-sensitivity C-reactive protein, a marker of inflammation, is also known to associate with cardiovascular risk. We have investigated the relationship between the presence of metabolic syndrome and serum high-sensitivity C-reactive protein concentration in a large representative Persian population cohort without a history of cardiovascular disease. Methods The MASHAD study population cohort comprised 9778 subjects, who were recruited from the city of Mashhad, Iran, between 2007 and 2008. Several cardiovascular risk factors were measured in this population without cardiovascular disease. Individuals were categorized into quartiles of serum high-sensitivity C-reactive protein concentration: first quartile – 0.72 (0.59–0.85) (median [range]) mg/L, second quartile – 1.30 (1.14–1.4) mg/L, third quartile – 2.29 (1.92–2.81) mg/L and fourth quartile – 6.63 (4.61–11.95) mg/L, respectively. The prevalence of metabolic syndrome in each quartile was determined using either International Diabetes Federation or Adult Treatment Panel III criteria. Results The prevalence of metabolic syndrome was highest in the fourth quartile for serum high-sensitivity C-reactive protein (1220 subjects [50.0%]), and significantly higher than that in the first quartile (reference group) (634 subjects [25.9%]) ( P < 0.001). A positive smoking habit (OR, 1.47 [1.26–1.70], P < 0.001) and the presence of either metabolic syndrome-International Diabetes Federation (OR, 1.35 [1.18–1.55], P < 0.001) or metabolic syndrome-ATPIII (OR, 1.40 [1.18–1.50], P < 0.001) were strong predictors of a fourth quartile for serum high-sensitivity C-reactive protein concentration. Conclusions There was a significant association between high concentrations of serum high-sensitivity C-reactive protein and the presence of metabolic syndrome among individuals without a history of cardiovascular ...

الإتاحة: https://doi.org/10.1177/0004563216676842Test