المؤلفون: Sebastian Kersting, Eric Sperlich, Bernd Schmidt, Markus von Nickisch-Rosenegk, George Kwesiga, Alexandra Kelling

المساهمون: Publica

المصدر: Journal of Natural Products. 83:3445-3453

مصطلحات موضوعية: Pharmacology, 2019-20 coronavirus outbreak, biology, Coronavirus disease 2019 (COVID-19), 010405 organic chemistry, Chemistry, Stereochemistry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Organic Chemistry, Pharmaceutical Science, Isoflavones, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Complementary and alternative medicine, Prenylation, Drug Discovery, Molecular Medicine, Erythrina sacleuxii, Antibacterial activity

الوصف: The prenylated isoflavones 5-deoxyprenylbiochanin A (7-hydroxy-4'-methoxy-3'-prenylisoflavone) and erysubin F (7,4'-dihydroxy-8,3'-diprenylisoflavone) were synthesized for the first time, starting from mono- or di-O-allylated chalcones, and the structure of 5-deoxy-3'-prenylbiochanin A was corroborated by single-crystal X-ray diffraction analysis. Flavanones are key intermediates in the synthesis. Their reaction with hypervalent iodine reagents affords isoflavones via a 2,3-oxidative rearrangement and the corresponding flavone isomers via 2,3-dehydrogenation. This enabled a synthesis of 7,4'-dihydroxy-8,3'-diprenylflavone, a non-natural regioisomer of erysubin F. Erysubin F (8), 7,4'-dihydroxy-8,3'-diprenylflavone (27), and 5-deoxy-3'-prenylbiochanin A (7) were tested against three bacterial strains and one fungal pathogen. All three compounds are inactive against Salmonella enterica subsp. enterica (NCTC 13349), Escherichia coli (ATCC 25922), and Candida albicans (ATCC 90028), with MIC values greater than 80.0 mM. The diprenylated natural product erysubin F (8) and its flavone isomer 7,4'-dihydroxy-8,3'-diprenylflavone (27) show in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA, ATCC 43300) at MIC values of 15.4 and 20.5 mM, respectively. In contrast, the monoprenylated 5-deoxy-3'-prenylbiochanin A (7) is inactive against this MRSA strain.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08d0dd7db85faa45eb6b0fa60a29effTest
https://doi.org/10.1021/acs.jnatprod.0c00932Test

المؤلفون: Anja Schüffler, Ishmael B. Masesane, Carina Weber, Gomotsang Bojase, Stefan Pusch, Runner R. T. Majinda, Till Opatz, Japheth O. Ombito

المصدر: Bulletin of the Chemical Society of Ethiopia. 34:135-140

مصطلحات موضوعية: Antifungal, Pyricularia, biology, medicine.drug_class, Chemistry, Absolute configuration, General Chemistry, 010402 general chemistry, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, Phytochemical, Mic values, Chemical constituents, medicine, Erythrina sacleuxii, Erythrina, Nuclear chemistry

الوصف: Phytochemical investigation on the root wood of Erythrina sacleuxii (Leguminosae) led to the isolation of nine secondary metabolites (1-9). Compound 1 was isolated from the genus Erythrina for the first time. The pure compounds were identified on the basis of comprehensive spectroscopic and spectrometric analyses, while their absolute configurations were determined based on chiroptical measurements. Compounds 5 and 6 showed weak antifungal activity against Pyricularia oryzae with MIC values of 20 µg/mL. Bull. Chem. Soc. Ethiop. 2020, 34(1), 135-140. DOI: https://dx.doi.org/10.4314/bcse.v34i1.12Test

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e912f25fd0afaff727ba2ba029602a94Test
https://doi.org/10.4314/bcse.v34i1.12Test

المؤلفون: Gomotsang Bojase, Runner R. T. Majinda, Japheth O. Ombito, Anja Schüffler, Ishmael B. Masesane, Till Opatz

المصدر: Arabian Journal of Chemistry, Vol 13, Iss 2, Pp 4019-4023 (2020)

مصطلحات موضوعية: Butin, Traditional medicine, biology, General Chemical Engineering, 02 engineering and technology, General Chemistry, Isoflavones, 010402 general chemistry, 021001 nanoscience & nanotechnology, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, lcsh:Chemistry, chemistry.chemical_compound, chemistry, lcsh:QD1-999, Cell culture, Ic50 values, Cytotoxic T cell, Erythrina sacleuxii, 0210 nano-technology, Cytotoxicity, Human cancer

الوصف: Two previously undescribed isoflavones, erysacleuxin C (1) and erysacleuxin D (2), together with seven known compounds (3–9), were isolated and identified from the EtOAc extract of the twigs of Erythrina sacleuxii Hua (Leguminosae). The structures of the isolated compounds were determined on the basis of their spectroscopic and spectrometric data. Evaluation of their cytotoxicity against the human cancer HeLa-S3 cell lines indicated IC50 values of 130.4, 54.9 and 73.9 µM for erysacleuxin C (1), erysacleuxin D (2) and butin (9), respectively. Keywords: Erythrina sacleuxii, Leguminosae, Isoflavone, Erysacleuxin C, Erysacleuxin D, Cytotoxicity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f2eee5cf8f83cd9c28437f39d20f31Test
http://www.sciencedirect.com/science/article/pii/S187853521930053XTest

المؤلفون: Ishmael B. Masesane, Anja Schüffler, Till Opatz, Japheth O. Ombito, Gomotsang Bojase, Runner R. T. Majinda

المصدر: Phytochemistry Letters. 26:110-114

مصطلحات موضوعية: Eremothecium coryli, biology, Traditional medicine, 010405 organic chemistry, Rhizomucor miehei, Pratensein, Plant Science, Isoflavones, biology.organism_classification, 01 natural sciences, Biochemistry, 0104 chemical sciences, Biochanin A, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Penicillium, Erythrina sacleuxii, Agronomy and Crop Science, Biotechnology, Botrytis cinerea

الوصف: Two new prenylated isoflavones, named erysacleuxin A (1) and B (2), along with eight known compounds, biochanin A (3), 5′-(3-methylbut-2-enyl)pratensein (4), 7-demethylrobustigenin (5), 3′-(3-methylbut-2-enyl)biochanin A (6) abyssinone V-4′-methyl ether (7), sigmoidin E (8), erythrinasinate (9), and burtinone (10) were isolated from the stem bark of Erythrina sacleuxii Hua (Leguminosae). The structures were determined based on spectroscopic and spectrometric data. All isolated compounds were evaluated for antifungal activity against Botrytis cinerea, Candida albicans, Eremothecium coryli, Penicillium notatum, Pyricularia oryzae, and Rhizomucor miehei with compounds 3, 4 and 6 showing weak to moderate activity against P. oryzae and R. miehei.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7d1b5e3f8a92fd653e4744405e8a3aa0Test
https://doi.org/10.1016/j.phytol.2018.05.026Test

المؤلفون: Francisca-Kamakama, Veronica M. Masila, Thomas Efferth, Mohamed E.M. Saeed, Victor Kuete, Gihan Elhaboob, Jacob O. Midiwo, Leonidah Kerubo Omosa, Boniface M. Gisacho, Sami Hamdoun, Renee Munayi, Kitur Phylis Chemutai

المصدر: Journal of ethnopharmacology. 179

مصطلحات موضوعية: food.ingredient, Cell Survival, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, food, Cell Line, Tumor, Drug Discovery, Humans, Medicinal plants, Cytotoxicity, Pharmacology, Leukemia, Plants, Medicinal, biology, Traditional medicine, Plant Extracts, Zanthoxylum gilletii, Solanum aculeastrum, Bridelia micrantha, biology.organism_classification, Antineoplastic Agents, Phytogenic, Kenya, Growth Inhibitors, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030220 oncology & carcinogenesis, Herb, visual_art, visual_art.visual_art_medium, Bark, Erythrina sacleuxii

الوصف: Ethnopharmacological relevance Plants from Kenyan flora are traditionally used against many ailments, including cancer and related diseases. Cancer is characterized as a condition with complex signs and symptoms. Recently there are recommendations that ethnopharmacological usages such as immune and skin disorders, inflammatory, infectious, parasitic and viral diseases should be taken into account when selecting plants that treat cancer. Aim The present study was aimed at investigating the cytotoxicity of a plethora of 145 plant parts from 91 medicinal plants, most of which are used in the management of cancer and related diseases by different communities in Kenya, against CCRF-CEM leukemia cell line. Materials and methods Extracts from different plant parts (leaves, stems, stem bark, roots, root barks, aerial parts and whole herb) were obtained by cold percolation using different solvent systems, such as (1:1 v/v) dichloromethane (CH2Cl2) and n-hexane (1), methanol (MeOH) and CH2Cl2 (2); neat MeOH (3), 5% H2O in MeOH (4) and with ethanol (EtOH, 5); their cytotoxicities were determined using the resazurin reduction assay against CCRF-CEM cells. Results At a single concentration of 10 μg/mL, 12 out of 145 extracts exhibited more than 50% cell inhibition. These include samples from the root bark of Erythrina sacleuxii (extracted with 50% n-hexane-CH2Cl2), the leaves of Albizia gummifera, and Strychnos usambarensis, the stem bark of Zanthoxylum gilletii, Bridelia micrantha, Croton sylvaticus, and Albizia schimperiana; the root bark of Erythrina burttii and E. sacleuxii (extracted with 50% CH2Cl2–MeOH), the stem bark of B. micrantha and Z. gilletii (extracted using 5% MeOH–H2O) and from the berries of Solanum aculeastrum (extracted with neat EtOH). The EtOH extract of the berries of S. aculeastrum and A. schimperiana stem bark extract displayed the highest cytotoxicity towards leukemia CCRF-CEM cells, with IC50 values of 1.36 and 2.97 µg/mL, respectively. Other extracts having good activities included the extracts of the stem barks of Z. gilletii and B. micrantha and leaves of S. usambarensis with IC50 values of 9.04, 9.43 and 11.09 µg/mL, respectively. Conclusions The results of this study provided information related to the possible use of some Kenyam medicinal plants, and mostly S. aculeastrum, A. schimperiana, C. sylvaticus, Z. gilletii, B. micrantha and S. usambarensis in the treatment of leukemia. The reported data helped to authenticate the claimed traditional use of these plants. However, most plants are used in combination as traditional herbal concoctions. Hence, the cytotoxicity of corresponding plant combinations should be tested in vitro to authenticate the traditional medical practitioners actual practices.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2f07cb5488c34a42eb18f6f51bc359Test
https://pubmed.ncbi.nlm.nih.gov/26721219Test

المؤلفون: Elnourani, Emadeldin A

مصطلحات موضوعية: Antimicrobial activity, Medicinal Plants Erythrina burtii, Erythrina sacleuxii, Ageratum conyzoides, Ximenia caffra, Phytochemical Analysis, isoflavone

الوصف: Medicinal plants play an important role in the health of millions of people. The four plants E. burtii, E. sacleuxii, Ageratum conyzoides and Ximenia caffra were selected on the basis of available ethnomedicinal information. The crude extracts from various parts of these plants tested against four bacteria species; three Gram positive (namely Bacillus subtilis, Staphylococcus aureus and a methicillin – resistant strain of Staphylococcus aureus, MRSA) and two Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa), using the Kirby-bauer disc diffusion technique recommended by the Clinical and Laboratory Standards Institute (CLSI). All the crude plant extracts showed antimicrobial activities against the Gram positive bacteria, including MRSA. The stem and root bark extracts of E. burtii and E. sacleuxii showed the highest activities with growth inhibition zones ranging from 8 mm at 0.050 mg/ml to 14 mm at 0.0250 mg/ml. Of these extracts the stem bark of E. sacleuxii was further tested. The extract fractions as well as five pure compounds isolated from this plant were further tested. Among the pure compounds tested, 2,3–dehydrokievitone showed the highest activity with growth inhibition zones ranging from 10 mm at the lowest concentration of 0.00312 mg/ml to 27 mm at the highest concentration of 0.0050 mg/ml against the Gram positive bacteria Bacillus subtilis, 8 mm at 0.00250 mg/ml to 18 mm at 0.0050 mg/ml, against Staphylococcus aureus,9 mm at 0.00312 mg/ml to 24 mm at 0.0050 mg/ml, against the methicillin – resistant strain of Staphylococcus aureus,it also showed activity against the Gram negative bacteria with growth inhibition zones ranging from 8 mm at 0.00625 mg/ml to 10 mm at 0.00250 mg/ml for E. coli and 8 mm at 0.00625 mg/ml to 14 mm at 0.0050 mg/ml against P. aeruginosa. The compound 3'–prenylbiochamin A also showed activity with growth inhibition zones of between 10 mm at 0.00625 mg/ml to 21 mm at 0.005 mg/ml against E. coli, 12 mm at 0.00625 mg/ml to 19 mm at 0.0050 mg/ml against S. ...

وصف الملف: application/pdf

العلاقة: http://hdl.handle.net/11295/97167Test

الإتاحة: http://hdl.handle.net/11295/97167Test

المؤلفون: Ogoche J. I. Jondiko, Peter M. Gitu, Julia Wangui, Jacob O. Midiwo, Pamela Liyala, Andrew W. Andayi, Matthias Heydenreich, Abiy Yenesew, Solomon Derese, Norman C. Waters, Hosea Akala, Martin G. Peter

المصدر: Planta Medica. 72:187-189

مصطلحات موضوعية: Stereochemistry, Plasmodium falciparum, Flavonoid, Drug Resistance, Pharmaceutical Science, Pharmacognosy, complex mixtures, Analytical Chemistry, Antimalarials, chemistry.chemical_compound, Drug Discovery, Animals, Phenols, Erythrina, Flavonoids, Pharmacology, chemistry.chemical_classification, biology, Traditional medicine, Plant Extracts, Organic Chemistry, Chloroquine, biology.organism_classification, Isoflavones, Chromatographic separation, Complementary and alternative medicine, chemistry, Polyphenol, visual_art, Plant Bark, visual_art.visual_art_medium, Institut für Chemie, Molecular Medicine, Erythrina sacleuxii, Bark

الوصف: The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4 -methoxy-3'- prenylisoflavone (trivial name 5-deoxy-3' - prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sucleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1509ed6c95d50ba94cdc9d2aee0234Test
https://doi.org/10.1055/s-2005-873200Test

المؤلفون: Yenesew Abiy., Midiwo Jacob O., Heydenreich Matthias., Schanzenbach Dirk., Peter Martin G.

مصطلحات موضوعية: Erythrina sacleuxii, Leguminosae, Stem bark, Isoflavanones, (R)-2,3-Dihydro-7-demethylrobustigenin, (R)-Saclenone

الوصف: From the stem bark of Erythrina sacleuxii two new isoflavanones, (R)-5,7-dihydroxy-2′,4′,5′-trimethoxyisoflavanone (trivial name, (R)-2,3-dihydro-7-demethylrobustigenin) and (R)-5-hydroxy-2′,4′,5′-trimethoxy-2″,2″-dimethylpyrano[5″,6″:6,7]isoflavanone (trivial name, (R)-saclenone) were isolated. In addition the known compounds shinpterocarpin, 2,3-dehydrokievitone, abyssinone V, abyssinone V-4′-methyl ether, erythrinasinate and 4′-O-methylsigmoidin B were isolated. The structures were determined on the basis of spectroscopic evidence.

العلاقة: Phytochemistry Volume 55, Issue 5, November 2000, Pages 457–459; http://www.sciencedirect.com/science/article/pii/S0031942200003496Test; http://hdl.handle.net/11295/35004Test; http://www.ncbi.nlm.nih.gov/pubmed/11140607Test

الإتاحة: http://hdl.handle.net/11295/35004Test
http://www.sciencedirect.com/science/article/pii/S0031942200003496Test
http://www.ncbi.nlm.nih.gov/pubmed/11140607Test

المؤلفون: Dirk Schanzenbach, Martin G. Peter, Jacob O. Midiwo, Matthias Heydenreich, Abiy Yenesew

المصدر: Phytochemistry. 55(5)

مصطلحات موضوعية: Stereochemistry, Plant composition, Ether, Plant Science, Horticulture, Biochemistry, chemistry.chemical_compound, Botany, East africa, Trivial name, Rosales, Molecular Biology, Stem bark, biology, Molecular Structure, Plant Stems, Chemistry, Spectrum Analysis, General Medicine, biology.organism_classification, Isoflavones, visual_art, visual_art.visual_art_medium, Institut für Chemie, Bark, Erythrina sacleuxii, Spectrum analysis

الوصف: From the stem bark of Erythrina sacleuxii two new isoflavanones, (R)-5,7-dihydroxy-2',4',5'- trimethoxyisoflavanone (trivial name, (R)-2,3-dihydro-7-demethylrobustigenin) and (R)-5-hydroxy- 2',4',5'-trimethoxy-2'',2''- dimethylpyrano[5'',6'':6,7]isoflavanone (trivial name, (R)-saclenone) were isolated. In addition the known compounds shinpterocarpin, 2,3-dehydrokievitone, abyssinone V, abyssinone V-4'-methyl ether, erythrinasinate and 4'-O-methylsigmoidin B were isolated. The structures were determined on the basis of spectroscopic evidence.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c00e4de1557a99b8f80df4681e5219Test
https://pubmed.ncbi.nlm.nih.gov/11140607Test

المؤلفون: Yenesew, Abiy, Midiwo, Jacob O, Heydenreich, Matthias, Peter, Martin G

مصطلحات موضوعية: Erythrina sacleuxii, Leguminosae, stem bark, isoflavones, 7-demethylrobustigenin, 3′-(3-methylbut-2-enyl)biochanin A, 5′-(3-methylbut-2-enyl)pratensein, 5′-formylpratensein

الوصف: From the stem bark of Erythrina sacleuxii four new isoflavones were isolated and characterized as 5,7-dihydroxy-2′,4′,5′-trimethoxyisoflavone (trivial name, 7-demethylrobustigenin), 5,7-dihydroxy-4′-methoxy3′-(3-methylbut-2-enyl)isoflavone [3′-(3-methylbut-2-enyl)biochanin A], 5,7,3′-trihydroxy-4′-methoxy-5′-(3-methylbut-2-enyl)isoflavone [5′-(3-methylbut-2-enyl)pratensein] and 5,7,3′-trihydroxy-4′-methoxy-5′-formylisoflavone (5′-formylpratensein). The structures were determined on the basis of spectroscopic evidence.

العلاقة: Phytochemistry Volume 49, Issue 1, 3 September 1998, Pages 247–249; http://www.sciencedirect.com/science/article/pii/S0031942297008807Test; http://hdl.handle.net/11295/35104Test

الإتاحة: http://hdl.handle.net/11295/35104Test
http://www.sciencedirect.com/science/article/pii/S0031942297008807Test