المؤلفون: Emre Kaya, Seval Yilmaz, Feyza Aksu, Ahmet Kavaklı

المصدر: Revista Científica, Vol 34, Iss 1 (2024)

مصطلحات موضوعية: Acetaminophen, antioxidant, ozone, oxidative stress, toxicity, Cattle, SF191-275, Veterinary medicine, SF600-1100

الوصف: This study aims to investigate the effects of Ozone therapy used in traditional and complementary medicine on possible toxicity caused by Acetaminophen (APAP). There was no intervention in first group (control). The second group received 150 µg·kg-1 day, i.p. for three weeks of ozone, 2 g·kg-1 orally single dose APAP to third group, and APAP+Ozone to fourth group. APAP was administered on 21st day of ozone application. Malondialdehyde (MDA) levels, reduced glutathione (GSH) levels, and antioxidant enzyme activities were all measured to assess their contribution to pathogenesis of toxicity in blood tissues. Compared to the control group, the group receiving APAP showed increased MDA levels (P=0.009) and decreased GSH levels (P

وصف الملف: electronic resource

العلاقة: https://produccioncientificaluz.org/index.php/cientifica/article/view/41862Test; https://doaj.org/toc/0798-2259Test; https://doaj.org/toc/2521-9715Test

الوصول الحر: https://doaj.org/article/3e574d4dbcae4bd6a4269d95f7f818c8Test

المؤلفون: Seval Yilmaz, Emre Kaya, Harun Yonar, Harun Uslu

المصدر: Revista Científica, Vol 34, Iss 1 (2024)

مصطلحات موضوعية: Doxorubicin, toxicity, pyruvate kinase, superoxide dismutase, molecular docking, Cattle, SF191-275, Veterinary medicine, SF600-1100

الوصف: This study aimed to investigate the effect of propolis on pyruvate kinase (PK) which is a key enzyme in glycolysis and superoxide dismutase (SOD), an antioxidant enzyme on toxicity induced by DOX in different tissues. Using molecular docking, It was looked into how propolis affected the enzymes responsible for glycolysis and the antioxidant system. There was no application in the first group (control). The second group received 100 mg·kg-1 day of propolis by gavage needle for 7 days, a single dose of 20 mg·kg-1 intraperitoneal DOX to the third group, and propolis+DOX to the fourth group. Two days prior to DOX administration, propolis application began, and it lasted for seven days. PK and SOD activities were determined in liver, heart, kidney, and testis tissues, and molecular docking was applied to ratify the activity of some propolis components (caffeic acid phenethyl ester (CAPE) and Quercetin) on PK and SOD enzymes. When the DOX group was compared with the control group, a decrease in PK and SOD activities were found, and significant difference was found in PK and SOD activities. Administration of DOX decreased PK and SOD activities of liver, heart, kidney, and testis tissues. In conclusion, our study reveals that DOX disrupts glycolysis in rat tissues. CAPE and Quercetin compounds were shown to interact similarly with the cocrystal ligands of PK and SOD. In addition, when the interaction types of these compounds especially on PK and the docking scores obtained were examined, it can be said that they show higher affinity than DOX.

وصف الملف: electronic resource

العلاقة: https://produccioncientificaluz.org/index.php/cientifica/article/view/41702Test; https://doaj.org/toc/0798-2259Test; https://doaj.org/toc/2521-9715Test

الوصول الحر: https://doaj.org/article/dff25d0728d04004a58f85fa367be051Test

المؤلفون: Emre Kaya, Seval Yılmaz, Zülal Altay, Şeyma Özer Kaya, Neriman Çolakoğlu, Emine Sarman

المصدر: Revista Científica, Vol 34, Iss 1 (2024)

مصطلحات موضوعية: Antioxidant, cyclophosphamide, malondialdehyde, oxidative stress, propolis, Cattle, SF191-275, Veterinary medicine, SF600-1100

الوصف: El objetivo de este estudio fue evaluar el posible efecto terapéutico del propóleo sobre la peroxidación lipídica testicular inducida por ciclofosfamida (CP) y sobre los cambios asociados en los parámetros espermatológicos en los espermatozoides epididimarios y la estructura histopatológica de los testículos de rata. Las ratas se separaron aleatoriamente en 4 grupos con 7 ratas en cada grupo. Se formaron grupos como; 1.er grupo: grupo control (ratas no tratadas), 2.º grupo: grupo tratado con propóleo, 3.er grupo: grupo tratado con CP y 4.º grupo: grupo tratado con CP+propóleo. Se administró propóleo a las ratas en una dosis de 200 mg·kg bw -1 mediante alimentación forzada durante 7 días (d). Se administró CP a las ratas en una dosis única de 150 mg·kg pc -1 por vía intraperitoneal. La administración de propóleo se inició 2 días antes de la administración de CP y continuó durante 7 días. Niveles de malondialdehído (MDA) y glutatión reducido (GSH), actividades de catalasa (CAT), glutatión peroxidasa (GSH-Px), glutatión S-transferasa (GST) y superóxido dismutasa (SOD), parámetros espermatológicos, peso de los órganos reproductivos. y se determinó la estructura histopatológica. En comparación con el grupo de control, los niveles de MDA y las actividades de SOD aumentaron significativamente; Si bien las actividades de CAT y GST disminuyeron, no se encontraron cambios en los niveles de GSH ni en las actividades de GSH-Px en el grupo CP. En el grupo tratado con CP, hubo una disminución en la motilidad de los espermatozoides del epidídimo, la densidad de los espermatozoides en los espermatozoides del epidídimo y el peso de los testículos, la próstata, el epidídimo y la vesícula seminal; mientras que hubo un aumento en la proporción de espermatozoides anormales en comparación con el grupo de control en los espermatozoides epididimarios. El propóleo normalizó los parámetros bioquímicos y espermatológicos en los espermatozoides epididimarios. El examen histopatológico del tejido testicular mostró que los cambios histopatológicos más significativos, como restos celulares, invaginación y degeneración, ocurrieron en el grupo CP. En la patogénesis de la toxicidad testicular inducida por la PC puede desempeñar un papel el deterioro del equilibrio oxidante-antioxidante y el propóleo puede reducir los efectos secundarios graves de las alteraciones inducidas por la PC.

وصف الملف: electronic resource

العلاقة: https://produccioncientificaluz.org/index.php/cientifica/article/view/41701Test; https://doaj.org/toc/0798-2259Test; https://doaj.org/toc/2521-9715Test

الوصول الحر: https://doaj.org/article/fe589e26d22e4e49ae02b7579b565f8aTest

المؤلفون: Tamer Coşkun, Emre Kaya

المصدر: Journal of Contemporary Medicine, Vol 12, Iss 6, Pp 930-936 (2022)

مصطلحات موضوعية: tırnak batması, heifetz, vandenbos, winograde, ingrown toenail, winograd, Medicine

الوصف: Abstract Background: In ingrown toenail, classifications and the treatment approaches according to staging has been clearly reported in the literature. However, there are not enough data about the selection of the appropriate surgical technique according to the stage. In this study, we compared two different surgical techniques in patients with Heifetz stage 2 and 3 in means of surgical results, recovery time, patient comfort and cosmetics. Methods: Between January 2019 and January 21, patients who applied with the complaint of ingrown toenails who were treated with two mentioned surgical techniques in two centers with at least 1 year follow-up were included. The patients were evaluated preoperatively in means of the Heifetz classification. In group 1 (n:54) matrix excising Winograd and in group 2 (n:51) matrix preserving Vandenbos techniques were used. Postoperative recovery time, complication rates, functional and cosmetic patient satisfaction were evaluated in tall cases. Results: 105 cases of ingrown toenails treated surgically were included in the study. 62 (59%) cases were Heifetz stage 2, 43 (41%) cases were Heifetz stage 3. No statistically significant difference was found between Heifetz stage 2 and stage 3, regardless of surgical technique, in complication, recurrence, patient functional/cosmetic satisfaction rates, and recovery time. In overall analysis regardless of Heifetz staging, recovery time was shorter with Winograd method (p:0.0001), complication and recurrence rates were lower with Vandenbos method (p:0.0001), and VAS cosmetic satisfaction was higher in Vandenbos (p:0.002). Conclusion: Winograd and Vandenbos in Heifitz stages 2 and 3 have low complication rates and high patient satisfaction. Earlier healing could be achieved with the Winograd technique, while low complication/recurrence rates and high cosmetic satisfaction could be achieved with the Vandenbos technique. Early recovery/high cosmetic expectation should be considered instead of Heifetz staging in determining the surgical technique.

وصف الملف: electronic resource

العلاقة: https://dergipark.org.tr/tr/download/article-file/2650422Test; https://doaj.org/toc/2667-7180Test

الوصول الحر: https://doaj.org/article/06b8b35a4d174af2b0522fa55fe61d58Test

المؤلفون: Eren Polat, Emre Kaya, Münir Mert Oral, Nisanur Çelikdemir

المصدر: Revista Científica, Vol 32 (2022)

مصطلحات موضوعية: Calcium oxalate, cat, dog, urolite, struvite, Cattle, SF191-275, Veterinary medicine, SF600-1100

الوصف: In this study, the presence and types of urine crystals in cats and dogs with urolithiasis/crystaluria and the effects of some demographic factors (such as type, breed, age, sex, sterilization status) on them were evaluated. In the study, physical, chemical and sediment examinations of urine samples of 67 cats and dogs were performed. It was determined that 83.58% of the animals with crystals in their urine were male. It was determined that 63.64% of the female animals and 44.64% of the male animals with crystals detected in the urinary tract were sterilized. It was determined that urinary crystals were more common in cats between 1-3 years of age (AO) and in dogs older than 3 AO. It was determined that calcium oxalate crystal (64.41%) in cats and struvite crystal (50%) in dogs were the most common crystals. It was determined that urine crystals were found mostly in cross breeds in cats and dogs. It was determined that most of the cats and dogs with urine crystals were fed with home meals and non-branded foods. It was determined that urinary tract infections had an effect on the formation of urine crystals. As a result, it was concluded that it is important in terms of Veterinary Medicine that such studies should be routinely performed, especially in the United States of North America (such as the Minnesota Urolith Center), since urine crystals cause significant lower urinary system diseases.

وصف الملف: electronic resource

العلاقة: https://produccioncientificaluz.org/index.php/cientifica/article/view/38755Test; https://doaj.org/toc/0798-2259Test; https://doaj.org/toc/2521-9715Test

الوصول الحر: https://doaj.org/article/542ec28dce3c4236becd6d8e5d747351Test

المؤلفون: Murat Gurger, Erhan Yilmaz, Seval Yilmaz, Gokhan Once, Mustafa Konuk, Emre Kaya, Yakup Say, Gokhan Artas, Hakan Artas

المصدر: Journal of Orthopaedic Surgery and Research, Vol 14, Iss 1, Pp 1-10 (2019)

مصطلحات موضوعية: Grape seed, Proanthocyanidin, Antioxidant, Fracture healing, Biomechanics, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

الوصف: Abstract Background The positive effects of grape seed proanthocyanidin extract (GSPE) on bone health, which is a potent antioxidant, are known but its effects on fracture healing are not sufficiently covered in the literature. This study aims to investigate the effects of GSPE on fracture healing and biomechanics of healing bone. Materials and methods Sixty-four adult Wistar-Albino male rats were divided into 8 groups of 8 animals in each group. Osteotomy was performed to the right femurs of all groups except the negative control (G1) and positive control (G2) groups, and intramedullary Kirchner wire was used for fixation. GSPE was given to half of the rats (G2-G4-G6-G8) 100 mg/kg/day by oral gavage. The rats were sacrificed on the tenth (G3–G4), twentieth (G5–G6), and thirtieth (G1–G2–G7–G8) days, respectively, and histopathological, radiological, and biomechanical examinations were performed. Results Histopathological examination of the specimens from the callus tissues revealed that bone healing was more prominent in the groups supplemented with GSPE (G4, G6, G8). There was a statistically significant improvement in radiological recovery scores and callus volumes in groups with GSPE. When biomechanical strengths were evaluated, it was found that GSPE increased bone strength not only in fracture groups but also in the positive control group (G2). Conclusions As a result, this study showed that GSPE, a potent anti-oxidant, had a positive effect on bone healing and improved mechanical strength of the healing bone.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s13018-019-1251-5Test; https://doaj.org/toc/1749-799XTest

الوصول الحر: https://doaj.org/article/f544a2c625ef42fcb361117b818afef9Test

المؤلفون: Fuat Emre Kaya, Antonello Monsù Scolaro

المصدر: Sustainability; Volume 15; Issue 9; Pages: 7554

مصطلحات موضوعية: building sector, circular economy, climate change, stakeholders

جغرافية الموضوع: agris

الوصف: There is an evident relationship between climate change and the building sector through reciprocal environmental impacts. The circular economy is fitted into this relationship as a mitigation strategy in the building sector, thanks to its nature of life cycle perspective consideration, support for stakeholder collaboration, and the ideology of waste minimization, reduction of natural resource consumption, and greenhouse gas emissions. This article aims to conduct two subsequential systematic literature reviews to evaluate the status in the scientific literature about the circular economy as a climate change mitigation strategy in the building sector and to find the place taken in the scientific literature about the stakeholder’s involvement toward circularity transition in the abovementioned link. As a result of the methodological approach, publicly available and reliable publications have been identified and analyzed based on the publication year and territory. The results indicate an increasing scientific literature contribution about the context, but the stakeholder concept is considerably taken less place; thus, it is a gap in the scientific literature. The stakeholder focal point, which the innovativeness of this article lays down, needs more attention in academic research, thus in the sector with the strengthening collaboration and mutual awareness among stakeholders.

وصف الملف: application/pdf

العلاقة: Environmental Sustainability and Applications; https://dx.doi.org/10.3390/su15097554Test

الإتاحة: https://doi.org/10.3390/su15097554Test

المؤلفون: Zakir AVŞAR, Ayşe Elif EMRE KAYA, Songül OMUR

المصدر: Türk Kültürü ve Hacı Bektaş Velî Araştırma Dergisi, Iss 96, Pp 201-228 (2020)

مصطلحات موضوعية: alevilik, ansiklopedi, sözlük, çerçevele kuramı, History of scholarship and learning. The humanities, AZ20-999, Social sciences (General), H1-99

الوصف: Hemen bütün dinlerde değişik anlayış ve yaşayış biçimleri olarak mezhepler ortaya çıkmıştır. Mezheplere mensup bireylerin aynı dine inanmalarına rağmen, mezhepler, mensupları arasında çok acı sonuçlar doğuran çatışmalara kaynaklık etmiştir. Dünya tarihinde farklı mezheplerin mensuplarının birbirleri ile çatışmalarının çok kanlı ve acılı hatıraları vardır ve bu hatıralar yine o dinlerin ve mezheplerin mensuplarınca diri tutulmak istenmektedir. Bazı durumlarda da siyasal erkler bu çatışmaları diri tutmayı kendi varlıklarının devamı için teşvik etmektedirler. İslam dininde de mezhepler vardır. Farklı mezheplerin mensupları arasında ise zamanla ön yargılar ve bunlara dayalı çatışmalar, anlaşmazlıklar ortaya çıkmıştır. Bu ön yargılar tarihsel süreç içinde bazen daha öne çıkmış, bazı dönemlerde ise önemini yitirmiştir. İslam dininde Sünni ve Şii mezhepler arası ilişkiler günümüzde de ayrılıkların ve çatışmaların olduğu bir iklimde devam etmektedir. Ne yazık ki bu durum Müslümanlar arasında ön yargıları beslemekte, kavga ve çatışmaları canlı tutmaktadır. Nüfusun mezhepsel yoğunluğuna göre azınlıkta kalan ötekileştirilmekte, ötekine ait ön yargılar sözlü ve yazılı kültür üzerinden beslenmektedir. Ülkemizde de Müslümanlar arasında mezhepsel farklılıklar söz konusu olmakla beraber, toplumda yerleşik ayrımcılık ve buna bağlı çatışmalar oldukça sınırlıdır. Geçmişte bazı dönemlerde meydana gelen olayların kökeninde ise ön yargılar, yanlış bilgilendirmeler, gerçeklerle bağı olmayan söylentiler yer almaktadır. Toplumsal bellekte üzüntü ile hatırlanan bu tür hadiselerin bir daha tekrarlanmaması için oluşan ön yargıların, yanlış bilgilerin kaynağını veya kaynaklarını tespit etmek oldukça önemli hale gelmektedir. Bu çalışmada, dijital kültürün yaygınlaşmasına karşın ansiklopedi ve sözlüklerin geçtiğimiz yüzyılın önemli yazılı kültür ürünleri olmaya devam ettikleri düşüncesinden hareketle, Cumhuriyet tarihimiz boyunca çıkan ansiklopedi ve sözlüklerde Alevilik ve bağlantılı kavramlara bakılmış, bu tanımlar üzerinden bir ön yargı inşa edilip edilmediği, toplumsal kutuplaşmaların, ayrışmaların önünün açılıp açılmadığı gibi hususlar üzerinde bir kanaat sahibi olunmaya çalışılmıştır. Çalışmada incelenen ansiklopedilerde bulunan “Alevilik”, “Bektaşilik”, “Şiilik”, “Kızılbaşlık” ve “Hz. Ali” maddelerinin dili, üslubu, mesajı incelenmiştir. Yine ansiklopedilerde, az olmakla birlikte, İslam tarihi ve mezhepler tarihi bakımından önemli olan “Sıffin Savaşı”nı anlatan maddeler de inceleme konusu yapılmıştır. Benzer bir çalışma da sözlükler üzerinde yürütülmüştür. İncelenen sözlüklerde konuyla ilgili olarak, Alevi, Bektaşi, Kızılbaş ve Şii kavramları genel olarak yer bulurken, Ali ve Sıffin Savaşı maddelerine yalnızca bir sözlükte rastlanmıştır. İncelemeler çerçeveleme kuramı üzerinden gerçekleştirilmiş, ansiklopedi ve sözlüklerde çizilen Alevilik ve bağlantılı kavramların çerçevesinin var olan mezhepsel çatışma ve ayrışmanın, ön yargıların kaynağı olup olmadığı araştırılmıştır. İnsanların birbirlerinin inanç ve mezheplerine ilişkin olarak buralarda yer alan yaklaşımlar üzerinden bir bakış açısı inşasına girip girmedikleri veya insanlarda mezhepsel ayrılıklara yönelik olarak var olan olumsuzluklarda ansiklopedi ve sözlüklerdeki tanımların bir etkisi olup olmadığı maddelerin bu bağlamda incelenmesiyle ortaya konulmak istenmiştir.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1306-8253Test; https://doaj.org/toc/2147-9895Test

الوصول الحر: https://doaj.org/article/30df0b09a7304214a0eee3ea3549b925Test

المؤلفون: Tacettin Ayanoğlu, Emre Arıkan, Onur Yılmaz, Halil Gökkuş, Yasin Emre Kaya, Kutay Engin Özturan

المصدر: Acta Orthopaedica et Traumatologica Turcica, Vol 56, Iss 5, Pp 311-315 (2022)

مصطلحات موضوعية: Orthopedic surgery, RD701-811

العلاقة: https://www.aott.org.tr/en/investigating-the-magnetic-resonance-imaging-cross-section-area-that-best-correlates-with-intraoperative-hamstring-autograft-size-137273Test; https://doaj.org/toc/1017-995XTest; https://doaj.org/article/2a8fd210aaf2412eb7efa9e0b97ded86Test

الإتاحة: https://doi.org/10.5152/j.aott.2022.21183Test
https://doaj.org/article/2a8fd210aaf2412eb7efa9e0b97ded86Test

المؤلفون: Recai Özkılıç, Tolgahan Kuru, Serdar İpek, Ekrem Keski̇n, Cengiz Işık, Yasin Emre Kaya

المصدر: Acta Medica Alanya, Vol 2, Iss 3, Pp 149-158 (2018)

مصطلحات موضوعية: osteoartrit, tenoksikam, hyalüronik asit, osteoarthritis, tenoxicam, hyaluronic acid, Medicine

الوصف: Aim: The objective of this study is comparing the effects of intra-articular hyaluronic acid (HA) and tenoxicam aplications on joint range of motion (ROM) and pain in patients with gonarthrosis.Patients and Method: This study was designed as prospective, non-randomized controlled, and single-blinded trial. 60 patients diagnosed with Grade II and Grade III osteoarthritis (OA) according to the American College of Rheumatology (ACR) criteria were consecutively enrolled. Patients were divided into two groups whereby the first group received intra-articular HA three times a week and the other group received a single dose intra-articular tenoxicam. Pre-treatment and after-treatment VAS and ROM values of the groups were compared.Results: In the HA Group, 20 patients (66.6%) were female, 10 patients (33.3%) were male and the mean age of them was 59.6 years (range 45-75 years). In the Tenoxicam Group, 24 patients (80%) were female, 6 (20%) patients were male, and the average age of this group was 61.5 years (range 45-75 years). VAS scores knee flexion and extension ROM values on the 1st day, the 15th day, the 1st month,the2nd month, and the 3rd month after the treatment, significantly improved in both groups (p 0.05). Conclusion: It was seen that intra-articular HA and tenoxicam administration seem to be effective and reliable methods in Grade 2-3 knee OA patients; but tenoxicam was more effective in reducing pain and relieving joint movements compared to HA injection in the early periods.

وصف الملف: electronic resource

العلاقة: https://dergipark.org.tr/en/pub/medalanya/issue/39772/419286?publisher=alkuTest; https://doaj.org/toc/2587-0319Test

الوصول الحر: https://doaj.org/article/1e57fc2ac58a49c69cff22c4365a05a8Test