المؤلفون: Nassar, Amin H., El-Am, Edward, Denu, Ryan, Alaiwi, Sarah Abou, El Zarif, Talal, Macaron, Walid, Abdel-Wahab, Noha, Desai, Aakash, Smith, Caleb, Parikh, Kaushal, Abbasi, Muhannad, Farhat, Elias Bou, Williams, James M., Collins, Jeremy D., Al-Hader, Ahmad, McKay, Rana R., Malvar, Carmel, Sabra, Mohamad, Zhong, Caiwei, El Alam, Raquelle, Chehab, Omar, Lima, Joao, Phan, Minh, Pria, Hanna Ferreira Dalla, Trevino, Alexandra, Neilan, Tomas G., Kwan, Jennifer M., Ravi, Vinod, Deshpande, Hari, Demetri, George, Choueiri, Toni K., Naqash, Abdul Rafeh

المساهمون: Medicine, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Cardiac sarcomas, Cardiac tumors, Immune checkpoint inhibitors, Treatment-related adverse events

الوصف: Background: Primary cardiac soft tissue sarcomas (CSTS) affect young adults, with dismal outcomes. Objectives: The aim of this study was to investigate the clinical outcomes of patients with CSTS receiving immune checkpoint inhibitors (ICIs). Methods: A retrospective, multi-institutional cohort study was conducted among patients with CSTS between 2015 and 2022. The patients were treated with ICI-based regimens. The Kaplan-Meier method was used to estimate overall survival (OS) and progression-free survival (PFS). Objective response rates were determined according to Response Evaluation Criteria in Solid Tumors version 1.1. Treatment-related adverse events were graded per the Common Terminology Criteria for Adverse Events version 5.0. Results: Among 24 patients with CSTS, 17 (70.8%) were White, and 13 (54.2%) were male. Eight patients (33.3%) had angiosarcoma. At the time of ICI treatment, 18 patients (75.0%) had metastatic CSTS, and 4 (16.7%) had locally advanced disease. ICIs were administered as the first-line therapy in 6 patients (25.0%) and as the second-line therapy or beyond in 18 patients (75.0%). For the 18 patients with available response data, objective response rate was 11.1% (n = 2 of 18). The median PFS and median OS in advanced and metastatic CSTS (n = 22) were 5.7 months (95% CI: 2.8-13.3 months) and 14.9 months (95% CI: 5.7-23.7 months), respectively. The median PFS and OS were significantly shorter in patients with cardiac angiosarcomas than in those with nonangiosarcoma CSTS: median PFS was 1.7 vs 11 months, respectively (P < 0.0001), and median OS was 3.0 vs 24.0 months, respectively (P = 0.008). Any grade treatment-related adverse events occurred exclusively in the 15 patients with nonangiosarcoma CSTS (n = 7 [46.7%]), of which 6 (40.0%) were grade ≥3. Conclusions: Although ICIs demonstrate modest activity in CSTS, durable benefit was observed in a subset of patients with nonangiosarcoma, albeit with higher toxicity.

وصف الملف: application/pdf

العلاقة: JACC: CardioOncology; Nassar AH, El-Am E, Denu R, et al. Clinical Outcomes Among Immunotherapy-Treated Patients With Primary Cardiac Soft Tissue Sarcomas: A Multicenter Retrospective Study. JACC CardioOncol. 2024;6(1):71-79. Published 2024 Jan 16. doi:10.1016/j.jaccao.2023.11.007; https://hdl.handle.net/1805/41903Test

الإتاحة: https://doi.org/10.1016/j.jaccao.2023.11.007Test
https://hdl.handle.net/1805/41903Test

المؤلفون: Nassar, Amin H, El Zarif, Talal, Khalid, Ahmed Bilal, Rahme, Serena, Zhong, Caiwei, Kwak, Lucia, Salame, Marita, Farhat, Elias Bou, Freeman, Dory, El-Am, Edward, Ravishankar, Arjun, Ahmad, Bachar, Aboubakar Nana, Frank, Kaldas, David, Naqash, Abdul Rafeh, Sharon, Elad, LeBoeuf, Nicole R, Cortellini, Alessio, Malgeri, Andrea, Gupta, Shruti, Al-Hader, Ahmad, Sparks, Jeffrey A, Linnoila, Jenny, Hamnvik, Ole-Petter R, Mouhieddine, Tarek H, Marron, Thomas, Parikh, Kaushal, McKay, Rana R, Dilling, Thomas, Choueiri, Toni K, Adib, Elio, Najem, Elie, Kim, So Yeon, Sonpavde, Guru

المساهمون: UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de pneumologie

المصدر: Journal for immunotherapy of cancer, Vol. 12, no.3, p. e008724 (2024)

مصطلحات موضوعية: Humans, Middle Aged, Aged, Immune Checkpoint Inhibitors, Carcinoma, Non-Small-Cell Lung, Retrospective Studies, Lung Neoplasms, Paraneoplastic Syndromes, Non-Small Cell Lung Cancer, PARANEOPLASTIC SYNDROME

الوصف: Patients with paraneoplastic syndromes (PNS) are excluded from clinical trials involving immune checkpoint inhibitors (ICIs) due to safety concerns. Moreover, real-world data on efficacy and safety is scarce. In this retrospective study, data were collected on patients with PNS and solid tumors receiving ICI between 2015 and 2022 at nine institutions. Patients were classified into: Cohort 1 (pre-existing PNS before ICI initiation), cohort 2 (PNS during ICI treatment), and cohort 3 (PNS after ICI discontinuation). Patients with metastatic non-small cell lung cancer (NSCLC) (mNSCLC) from cohort 1 were matched to patients who were PNS-free at each institution up to a 1:3 ratio for age, sex, type of ICI, use of concurrent chemotherapy, and number of lines of systemic therapy prior to ICI initiation. Kaplan-Meier method was used to assess overall survival (OS) and time-to-next treatment (TTNT). Among 109 patients with PNS treated with ICIs, median age at ICI initiation was 67 years (IQR: 58-74). The most represented cancer type was NSCLC (n=39, 36%). In cohort 1 (n=55), PNS exacerbations occurred in 16 (29%) patients with median time to exacerbation after ICI of 1.1 months (IQR: 0.7-3.3). Exacerbation or de novo PNS prompted temporary/permanent interruption of ICIs in 14 (13%) patients. For cohort 2 (n=16), median time between ICI initiation and de novo PNS was 1.2 months (IQR: 0.4-3.5). Treatment-related adverse events (trAEs) occurred in 43 (39%) patients. Grade ≥3 trAEs occurred in 18 (17%) patients. PNS-directed immunosuppressive therapy was required in 55 (50%) patients. We matched 18 patients with mNSCLC and PNS (cohort 1) to 40 without PNS, treated with ICIs. There was no significant difference in OS or TTNT between patients with mNSCLC with and without PNS, although a trend was seen towards worse outcomes in patients with PNS. TrAEs occurred in 6/18 (33%) and 14/40 (35%), respectively. Grade ≥3 trAEs occurred in 4 (22%) patients with PNS and 7 (18%) patients without PNS. Exacerbations of pre-existing PNS ...

العلاقة: boreal:285807; http://hdl.handle.net/2078.1/285807Test; info:pmid/38448038; urn:EISSN:2051-1426

الإتاحة: https://doi.org/10.1136/jitc-2023-008724Test
http://hdl.handle.net/2078.1/285807Test

المؤلفون: Akiki, Elias, Arghami, Arman, Abbasi, Muhannad A., El-Am, Edward A., Ahmad, Ali, Foley, Thomas A., Daly, Richard C., Maleszewski, Joseph J., Kurmann, Reto, Klarich, Kyle W.

المصدر: Frontiers in Cardiovascular Medicine ; volume 11 ; ISSN 2297-055X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: A 73-year-old woman presented to the emergency department with a syncopal episode and a history of dizzy spells. A transthoracic echocardiogram demonstrated a large left atrial mass extending into the right upper pulmonary veins. Subsequently, cardiac magnetic resonance imaging and coronary computed tomography angiography with three-dimensional reconstruction and printing of the heart and mass were performed, which demonstrated a high index of suspicion for an atypical left atrial myxoma. The mass was excised robotically, and the pathology report confirmed a diagnosis of myxoma.

الإتاحة: https://doi.org/10.3389/fcvm.2024.1340406Test

المؤلفون: Ahmad, Ali, El-Am, Edward A., Mazur, Piotr, Akiki, Elias, Sorour, Ahmed A., Kurmann, Reto D., Klarich, Kyle W., Arghami, Arman, Rowse, Phillip G., Daly, Richard C., Dearani, Joseph A.

المساهمون: Mayo Foundation for Medical Education and Research

المصدر: Mayo Clinic Proceedings: Innovations, Quality & Outcomes ; volume 8, issue 2, page 143-150 ; ISSN 2542-4548

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.mayocpiqo.2024.01.001Test
https://api.elsevier.com/content/article/PII:S2542454824000018?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2542454824000018?httpAccept=text/plainTest

المؤلفون: Abbasi, Muhannad Aboud, El-Am, Edward, Deshmukh, Abhishek, Dispenzieri, Angela, Grogan, Martha, Ezzeddine, Omar Abou, Lin, Grace

المساهمون: Pfizer Inc

المصدر: JACC: CardioOncology ; volume 6, issue 2, page 313-314 ; ISSN 2666-0873

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Oncology

الإتاحة: https://doi.org/10.1016/j.jaccao.2024.01.005Test
https://api.elsevier.com/content/article/PII:S2666087324000450?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666087324000450?httpAccept=text/plainTest

المؤلفون: Nassar, Amin H., El-Am, Edward, Denu, Ryan, Abou Alaiwi, Sarah, El Zarif, Talal, Macaron, Walid, Abdel-Wahab, Noha, Desai, Aakash, Smith, Caleb, Parikh, Kaushal, Abbasi, Muhannad, Bou Farhat, Elias, Williams, James M., Collins, Jeremy D., Al-Hader, Ahmad, McKay, Rana R., Malvar, Carmel, Sabra, Mohamad, Zhong, Caiwei, El Alam, Raquelle, Chehab, Omar, Lima, Joao, Phan, Minh, Dalla Pria, Hanna Ferreira, Trevino, Alexandra, Neilan, Tomas G., Kwan, Jennifer M., Ravi, Vinod, Deshpande, Hari, Demetri, George, Choueiri, Toni K., Naqash, Abdul Rafeh

المصدر: JACC: CardioOncology ; volume 6, issue 1, page 71-79 ; ISSN 2666-0873

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Oncology

الإتاحة: https://doi.org/10.1016/j.jaccao.2023.11.007Test
https://api.elsevier.com/content/article/PII:S2666087323003563?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666087323003563?httpAccept=text/plainTest

المؤلفون: Akiki, Elias, Ahmad, Ali, El-Am, Edward A., Casanegra, Ana I., Klarich, Kyle W., Kurmann, Reto

المصدر: Frontiers in Cardiovascular Medicine ; volume 10 ; ISSN 2297-055X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: An elderly female with metastatic adenocarcinoma of the lung and atrial fibrillation presented with multiple embolic strokes while on anticoagulation with Apixaban. After further investigation, a TEE showed lesions of non-bacterial thrombotic endocarditis on the mitral valve. A decision to switch the patient to LMWH for anticoagulation was then made and a follow-up TEE showed resolution of the NBTE. In this abstract, we show that heparin should remain as the anticoagulation agent of choice in the setting of NBTE associated with malignancy.

الإتاحة: https://doi.org/10.3389/fcvm.2023.1208190Test

المؤلفون: Oguz, Didem, Huntley, Geoffrey D., El-Am, Edward A., Scott, Christopher G., Thaden, Jeremy J., Pislaru, Sorin V., Fabre, Katarina L., Singh, Mandeep, Greason, Kevin L., Crestanello, Juan A., Pellikka, Patricia A., Oh, Jae K., Nkomo, Vuyisile T.

المصدر: Frontiers in Cardiovascular Medicine ; volume 10 ; ISSN 2297-055X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background Atrial fibrillation (AF) portends poor prognosis in patients with aortic stenosis (AS). Objectives This study aimed to study the association of AF vs. sinus rhythm (SR) with outcomes in asymptomatic severe AS during routine clinical practice. Methods We identified 909 asymptomatic patients from 3,208 consecutive patients with aortic valve area ≤1.0 cm 2 and left ventricular ejection fraction ≥50% at a tertiary academic center. Patients were grouped by rhythm at the time of transthoracic echocardiogram [SR: 820/909 (90%) and AF: 89/909 (10%)]. Propensity-matched analyses (2 SR:1 AF) matching 174 SR to 89 AF patients by age, sex, and clinical comorbidities were used to compare outcomes. Results In the propensity-matched cohort, median age (82 ± 8 vs. 81 ± 9 years, p = 0.31), sex distribution (male 58% vs. 52%, p = 0.30), and Charlson comorbidity index (4.0 vs. 3.0, p = 0.26) were not different in AF vs. SR. Median follow-up duration was 2.6 (IQR: 1.0–4.4) years. The 1-year rate of aortic valve replacement (AVR) was not different (AF: 32% vs. SR: 37%, p = 0.31). All-cause mortality was higher in AF [hazard ratio (HR): 1.68 (1.13–2.50), p = 0.009]. Independent predictors of mortality were age [HR: 1.92 (1.40–2.62), p < 0.001], Charlson comorbidity index [1.09 (1.03–1.15), p = 0.002], aortic valve peak velocity [HR: 1.87 (1.20–2.94), p = 0.006], stroke volume index [HR: 0.75 (0.60–0.93), p = 0.01], moderate or more mitral regurgitation [HR: 2.97 (1.43–6.19), p = 0.004], right ventricular systolic dysfunction [HR: 2.39 (1.29–4.43), p = 0.006], and time-dependent AVR [HR: 0.36 (0.19–0.65), p = 0.0008]. There was no significant interaction of AVR and rhythm ( p = 0.57). Conclusions Lower forward flow, right ventricular systolic dysfunction, and mitral regurgitation identified increased risk of subsequent mortality in asymptomatic patients with AF and AS. Additional studies of risk stratification of asymptomatic AS in AF vs. SR are needed.

الإتاحة: https://doi.org/10.3389/fcvm.2023.1195123Test

المؤلفون: Akiki, Elias, Ahmad, Ali, El-Am, Edward, Abbasi, Muhannad, Klarich, Kyle W., Kurmann, Reto

المصدر: Journal of the American College of Cardiology ; volume 81, issue 8, page 3037 ; ISSN 0735-1097

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/s0735-1097Test(23)03481-2
https://api.elsevier.com/content/article/PII:S0735109723034812?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0735109723034812?httpAccept=text/plainTest

المؤلفون: Al-abcha, Abdullah, Al-Asad, Khalid Saeed, Saleh, Yehia, Abbasi, Muhannad, El-Am, Edward, Alkhouli, Mohamad Adnan

المصدر: Journal of the American College of Cardiology ; volume 81, issue 8, page 1046 ; ISSN 0735-1097

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/s0735-1097Test(23)01490-0
https://api.elsevier.com/content/article/PII:S0735109723014900?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0735109723014900?httpAccept=text/plainTest