المؤلفون: Anne Devin, MD, Edith Renoult, MD, Michel Roger, MD, Marie-Josée Hébert, MD

المصدر: Transplantation Direct, Vol 4, Iss 6, p e351 (2018)

مصطلحات موضوعية: Surgery, RD1-811

وصف الملف: electronic resource

العلاقة: http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000000784Test; https://doaj.org/toc/2373-8731Test

الوصول الحر: https://doaj.org/article/b101d56d6e234d11af15a96898f7ae50Test

المؤلفون: Edith Renoult, Jacques Hubert, Nicolas Billaut, Eric Mourey

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://ndt.oxfordjournals.org/content/21/2/472.full.pdfTest.

مصطلحات موضوعية: kidney graft function

الوصف: a comparison of donor morbidity and early renal allograft outcomes

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.574.745Test; http://ndt.oxfordjournals.org/content/21/2/472.full.pdfTest

الإتاحة: http://ndt.oxfordjournals.org/content/21/2/472.full.pdfTest

المؤلفون: Michele Kessler, Marie C. Bene, Chantal Kohler, Patricia Aguilar, Edith Renoult, Loraine Jarrosson

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://cvi.asm.org/content/10/6/1117.full.pdfTest.

الوصف: This article cites 21 articles, 4 of which can be accessed free at

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.627.1296Test; http://cvi.asm.org/content/10/6/1117.full.pdfTest

الإتاحة: http://cvi.asm.org/content/10/6/1117.full.pdfTest

المؤلفون: Lynne Senécal, Jean-Sébastien Delisle, Marie-Josée Hébert, Edith Renoult, Caroline Lamarche, Lee Anne Tibbles, Suzon Collette, Julie Orio

المصدر: Transplantation

مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, viruses, Reviews, 030230 surgery, Biology, medicine.disease_cause, Virus, Nephropathy, Viral Proteins, 03 medical and health sciences, 0302 clinical medicine, Immune system, Risk Factors, Immunopathology, Virus latency, medicine, Humans, Kidney transplantation, Polyomavirus Infections, Transplantation, Dendritic Cells, medicine.disease, Kidney Transplantation, Immunity, Innate, Virus Latency, BK virus, Tumor Virus Infections, 030104 developmental biology, BK Virus, Immunology, Kidney Diseases, Virus Activation

الوصف: BK polyomavirus is ubiquitous, with a seropositivity rate of over 75% in the adult population. Primary infection is thought to occur in the respiratory tract, but asymptomatic BK virus latency is established in the urothelium. In immunocompromised host, the virus can reactivate but rarely compromises kidney function except in renal grafts, where it causes a tubulointerstitial inflammatory response similar to acute rejection. Restoring host immunity against the virus is the cornerstone of treatment. This review covers the virus-intrinsic features, the posttransplant microenvironment as well as the host immune factors that underlie the pathophysiology of polyomavirus-associated nephropathy. Current and promising therapeutic approaches to treat or prevent this complication are discussed in relation to the complex immunopathology of this condition.
Lamarche et al review the virus-intrinsic features, the posttransplant micro-environmentand the host immunological factors that underlie the pathophysiology of BK virus nephropathy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162b2107e87b83da3c94dff25327860bTest
https://doi.org/10.1097/tp.0000000000001333Test

المؤلفون: Michel Roger, Anne Devin, Edith Renoult, Marie-Josée Hébert

المصدر: Transplantation Direct, Vol 4, Iss 6, p e351 (2018)
Transplantation Direct

مصطلحات موضوعية: Transplantation, Letter, business.industry, 030232 urology & nephrology, MEDLINE, lcsh:Surgery, lcsh:RD1-811, 030230 surgery, Kidney transplant, Prodromal phase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Text mining, chemistry, Immunology, Medicine, business, DNA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ecb97226414ce014612ff3a27af1a4Test
http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000000784Test

المؤلفون: F. Coutlée, Marie-Josée Hébert, M. Latour, Catherine Girardin, Walter Schürch, Michel Pâquet, Azemi Barama, G. St Louis, Edith Renoult, Marie-Chantal Fortin, Héloïse Cardinal, Renée Lévesque

المصدر: Transplantation Proceedings. 42:4083-4087

مصطلحات موضوعية: Adult, Male, Pathology, medicine.medical_specialty, Basiliximab, medicine.medical_treatment, Urology, Renal function, Viremia, medicine.disease_cause, Nephropathy, medicine, Humans, Prospective Studies, Kidney transplantation, Transplantation, business.industry, Immunosuppression, Middle Aged, medicine.disease, Kidney Transplantation, BK virus, BK Virus, Female, Kidney Diseases, Surgery, business, medicine.drug

الوصف: Introduction BK polyomavirus-associated nephropathy (BKPVAN) is a major cause of renal failure early after kidney transplantation. The present study reports the preliminary results of prospective monitoring including a preemptive strategy for BKPVAN during the first year after kidney transplantation. Methods We monitored BK virus DNA in blood at months 1, 2, 3, 6, 9, and 12 among 92 subjects who received induction therapy (basiliximab or antithymocyte globulin), and maintenance immunosuppression with prednisone, mycophenolate mofetil, and tacrolimus. Patients with two or more consecutive measurements of viral load >104 copies/mL were treated with a stepwise approach including dose reduction or discontinuation of mycophenolate mofetil eventually followed by reduction of tacrolimus and introduction of leflunomide. Results Within 1 year, seven (7%) patients displayed sustained BK viremia at a median of 92 days after transplantation. Among 68 patients who underwent a renal allograft biopsy, seven were diagnosed as BKPVAN at a median of 15 weeks after transplantation. The diagnosis was achieved by a surveillance biopsy in four patients with stable renal function. BKPVAN was preceded by asymptomatic viremia except for two cases in whom BK viremia occurred at 6 or 11 months, after the histological diagnosis. At 12 months, six patients had cleared their viremia. Serum creatinine levels had stabilized in six recipients with BKPVAN estimated renal function was 43.7 ± 16.3 mL/min in patients with viremia and/or BKPVAN versus 61.3 ± 20.1 mL/min among patients who never became viremic (P = .03). None of the patients with viremia and/or BKPVAN lost the allograft. Conclusion BKPVAN may occur early after kidney transplantation, at a low or undetectable viremia or at some weeks after the first positive viremia. Intensive monitoring during the first 4 months after transplantation together with early protocol biopsies or interventions prompted by BK viremia may optimize BKPVAN diagnosis at a subclinical stage, thus avoiding renal dysfunction.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa0caa08ba7032bb9263bfd97616463Test
https://doi.org/10.1016/j.transproceed.2010.09.024Test

المؤلفون: Marie-Josée Hébert, Michel Pâquet, Rachid Hadjeres, Marie-Chantal Fortin, Héloïse Cardinal, Renée Lévesque, Edith Renoult, St-Louis G, Catherine Girardin, Judy Dorais, Claude Fortin

المصدر: Transplantation. 96:e64-e66

مصطلحات موضوعية: Transplantation, medicine.medical_specialty, Kidney, biology, business.industry, medicine.medical_treatment, Transplant recipient, Mycobacterium genavense, Pancreas transplantation, biology.organism_classification, medicine.disease, Gastroenterology, Diarrhea, medicine.anatomical_structure, Internal medicine, Medicine, Nontuberculous mycobacteria, medicine.symptom, business, Pancreas, Kidney transplantation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3c90d51dff7c312538cadc9e01fbaa8aTest
https://doi.org/10.1097/tp.0b013e3182a9026cTest

المؤلفون: Laurence Kessler, Edith Renoult, Pierre-Yves Benhamou, François Bayle, Laure Milliat-Guittard, Lionel Badet, Charles Thivolet, Jose Oberholzer, Cyrille Colin, Pascal Alain Robert Bucher, Alfred Penfornis, Philippe Morel, Jean Marcel Brun, Thierry Berney, Gérard Rifle, Catherine Atlan

المصدر: Transplantation, Vol. 77, No 8 (2004) pp. 1301-4

مصطلحات موضوعية: Adult, Male, Oncology, endocrine system, medicine.medical_specialty, Time Factors, Tissue and Organ Procurement, endocrine system diseases, Tissue and Organ Procurement/methods, medicine.medical_treatment, Islets of Langerhans Transplantation, Transportation, Hemoglobin A, Glycosylated/metabolism, Internal medicine, Immunopathology, medicine, Humans, Glycated Hemoglobin, Autoimmune disease, Transplantation, Type 1 diabetes, geography, geography.geographical_feature_category, ddc:617, C-Peptide, business.industry, Graft Survival, Islets of Langerhans Transplantation/methods/physiology, Creatinine/blood, Middle Aged, medicine.disease, Islet, Diabetes Mellitus, Type 1, Endocrinology, Diabetes Mellitus, Type 1/surgery, Creatinine, C-Peptide/blood, Female, France, business, Switzerland, Allotransplantation

الوصف: The influence of islet transportation on pancreatic islet allotransplantation in type 1 diabetic patients was evaluated within the GRAGIL network.From December 2001 to April 2003, 16 human pancreatic islet transplants were performed in 9 type 1 diabetic patients with an established kidney graft (functioning for at least 6 months) in four centers of the GRAGIL network. Islet isolation was performed in a core laboratory in Geneva, and the islet preparations were shipped by ambulance to each center for transplantation. One month after transplantation, the efficiency of the graft was assessed according to islet transportation time (ITT): ITT less than 2 hours (group 1, n=5), and ITT greater than 4.5 hours (group 2, n=4, mediant 5 hours).Primary graft dysfunction was observed in one patient in group 1 after one month. Two patients became insulin independent in groups 1 and 2. All other patients in both groups had a plasma C-peptide level greater than 0.5 ng/ml. The HbA1c level and the exogenous insulin needs decreased in both groups.ITT does not seem to influence the efficiency of pancreatic islet allotransplantation in type 1 diabetic patients. These results emphasize the scope for multicenter networks such as the GRAGIL group.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97fb742583f5e7a932d68f85f6b4418Test
https://doi.org/10.1097/01.tp.0000122223.79315.5dTest

المؤلفون: Marie-Josée Hébert, Laurent Létourneau-Guillon, Danielle Rouleau, St-Louis G, Alain Duclos, Catherine Girardin, Nicolas Jodoin, Michel Pâquet, Michel Léveillé, Marie-Chantal Fortin, Sylvain Lanthier, Lise St-Jean, Edith Renoult

المصدر: Transplantation. 100:e19-e20

مصطلحات موضوعية: Transplantation, Pathology, medicine.medical_specialty, business.industry, Treatment outcome, 030232 urology & nephrology, Varicella zoster virus, 030230 surgery, medicine.disease_cause, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Tomography x ray computed, medicine, business, Kidney transplantation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4c5b09a441cfad30b86778acd4d455b5Test
https://doi.org/10.1097/tp.0000000000001120Test

المؤلفون: Chantal Kohler, Anne Kennel De March, Gilbert C. Faure, Christine Prin Mathieu, Edith Renoult, Marie N. Kolopp-Sarda, Patricia Aguilar, Michěle Kessler, Marie C. Béné, Loraine Jarrosson

المصدر: Clinical and Vaccine Immunology. 10:1117-1122

مصطلحات موضوعية: Adult, Male, Microbiology (medical), Time Factors, medicine.medical_treatment, Lymphocyte, Clinical Biochemistry, Immunology, Biology, Lymphocyte Activation, Hepatitis B Antigens, Immune system, Experimental Clinical Investigation, medicine, Humans, Immunology and Allergy, Hepatitis B Antibodies, Cells, Cultured, Kidney transplantation, Immunodeficiency, Immunity, Cellular, Pokeweed mitogen, Immunosuppression, Middle Aged, Hepatitis B, medicine.disease, Kidney Transplantation, Transplantation, medicine.anatomical_structure, Antibody Formation, Kidney Failure, Chronic, Female

الوصف: Patients with renal failure represent a population at risk for hepatitis B, since only 50 to 60% of them develop protective humoral responses after vaccination. As this could be due to an altered regulation of cellular immune responses, the objectives of the present study were to evaluate the proliferative abilities of lymphocytes from patients with chronic renal failure after stimulation in vitro with a mitogen (pokeweed mitogen [PWM]) or HBsAg. In order to differentiate between the immunodeficiency associated with renal failure and that due to immunosuppression posttransplantation, the same subjects were tested before and 4 months after kidney transplantation. The lymphoproliferation assay used was performed by flow cytometry, which is based on sequential analysis of the cell cycle and which allows analysis of cytokine production. Serologically, the group of 36 patients tested comprised 22% nonresponders, 30% poor responders, and 48% responders. Lymphocyte growth was observed for all patients after stimulation with PWM, indicating that these cells had the capacity to proliferate in vitro. The level of lymphoproliferation in response to PWM was significantly reduced after transplantation, yet both before and after transplantation, all serologic nonresponders developed cellular responses to at least two vaccines. No correlation between humoral and cellular responses was shown. Proliferating cells were lymphocytes, which mostly secreted interleukin 4 (IL-4) and IL-10 for the three serologic groups. This study suggests that even when repeated vaccination fails to induce significant antibody levels in patients with renal failure, specific HBs cellular responses develop, and these may prove to be efficient in protecting these patients against hepatitis B.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025731ba2c03f1c824c67467413e5313Test
https://doi.org/10.1128/cdli.10.6.1117-1122.2003Test