المؤلفون: Renáta Sütő, Marianna Pócsi, Miklós Fagyas, Edit Kalina, Zsolt Fejes, Zoltán Szentkereszty, János Kappelmayer, Béla Nagy Jr.

المصدر: Microorganisms, Vol 12, Iss 1, p 229 (2024)

مصطلحات موضوعية: SARS-CoV-2, intravascular inflammation, COVID-19 disease, endothelial dysfunction, ACE2, platelets, Biology (General), QH301-705.5

الوصف: Severe SARS-CoV-2 elicits a hyper-inflammatory response that results in intravascular inflammation with endothelial injury, which contributes to increased mortality in COVID-19. To predict the outcome of severe SARS-CoV-2 infection, we analyzed the baseline level of different biomarkers of vascular disorders in COVID-19 subjects upon intensive care unit (ICU) admission and prior to any vaccination. A total of 70 severe COVID-19 patients (37 survivors and 33 non-survivors) were included with 16 age- and sex-matched controls. Vascular dysfunction was monitored via soluble VCAM-1, E-selectin, ACE2 and Lp-PLA2, while abnormal platelet activation was evaluated by soluble P-selectin and CD40L in parallel. These results were correlated with routine laboratory parameters and disease outcomes. Among these parameters, VCAM-1 and ACE2 showed significantly higher serum levels in COVID-19 patients with early death vs. convalescent subjects. VCAM-1 was significantly correlated with the Horowitz index (r = 0.3115) and IL-6 (r = 0.4599), while ACE2 was related to E-selectin (r = 0.4143) and CD40L (r = 0.2948). Lp-PLA2 was altered in none of these COVID-19 subcohorts and showed no relationship with the other parameters. Finally, the pre-treatment level of VCAM-1 (≥1420 ng/mL) and ACE2 activity (≥45.2 μU/mL) predicted a larger risk for mortality (Log-Rank p = 0.0031 and p = 0.0117, respectively). Vascular dysfunction with endothelial cell activation is linked to lethal COVID-19, and highly elevated soluble VCAM-1 and ACE2 at admission to ICU may predict unfavorable outcomes.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2076-2607/12/1/229Test; https://doaj.org/toc/2076-2607Test

الوصول الحر: https://doaj.org/article/8fdcb05175714121a420adf163769781Test

المؤلفون: Zsófia Pethő, Edit Kalina, Zoltán Pap, Katalin Hodosi, Rebeka Falcsik, Ádám Balogh, Zoltán Szekanecz, Harjit Pal Bhattoa

المصدر: BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-9 (2021)

مصطلحات موضوعية: Psoriatic arthritis, Areal and volumetric BMD, FRAX, Bone metabolism, Disease activity, Diseases of the musculoskeletal system, RC925-935

الوصف: Abstract Background Skeletal manifestations are predominant in psoriatic arthritis (PsA). The aim of this cross-sectional, case-control study is the complex assessment of areal and volumetric bone mineral density (BMD), fracture risk, vitamin D status and bone turnover markers, and its association with disease-related variables. Methods Lumbar spine (L1-L4) and femoral neck (FN) areal, and distal radius (DR) volumetric BMD, 10-year probability of major and hip osteoporotic fracture as assessed by the fracture risk assessment (FRAX) tool, markers of bone metabolism and disease activity were assessed. Results Upon comparison of the disease and age- and sex-matched control groups, there was a statistically significant difference in FN areal (0.952 (0.607–1.292) g/cm2 vs. 1.016 (0.760–1.550) g/cm2; p = 0.001) and DR total volumetric (284.3 (138.9–470.3) mg/cm3 vs. 367.0 (287.0–412.0) mg/cm3; p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2474Test

الوصول الحر: https://doaj.org/article/ac978ee6fa554007a5f2f610182a0a6aTest

المؤلفون: Gergő L. Beke, Emese Bányai, Edit Kalina, Attila Enyedi, Attila Tóth, Csongor Váradi, István Takács, Miklós Fagyas, János Kappelmayer, Dorina R. Kiss, Alexandra Csongrádi, Zoltán Papp, István Altorjay, Enikő E. Enyedi

المصدر: Clinica Chimica Acta. 500:155-162

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Sarcoidosis, Clinical Biochemistry, Peptidyl-Dipeptidase A, Biochemistry, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Positive predicative value, Internal medicine, Biopsy, medicine, Humans, Biomarker Analysis, medicine.diagnostic_test, biology, business.industry, Biochemistry (medical), Angiotensin-converting enzyme, General Medicine, Middle Aged, medicine.disease, Hexosaminidases, 030104 developmental biology, Cardiothoracic surgery, 030220 oncology & carcinogenesis, biology.protein, Biomarker (medicine), Female, Histopathology, business, Blood Chemical Analysis

الوصف: Establishing the diagnosis of sarcoidosis most often requires biopsy and histopathologic evaluation, since there is no single marker with sufficient specificity and sensitivity for the disease. Our aims were to determine and compare the diagnostic accuracies of several potential biomarkers and to develop a combined biomarker analysis tool for the diagnosis of sarcoidosis. 133 healthy individuals and 104 patients with suspected sarcoidosis and diagnostic thoracic surgery were enrolled into this study. Histopathologic results were contrasted to biomarker levels of chitotriosidase (CTO), serum amyloid-A (SAA), soluble interleukin-2 receptor (sIL-2R), lysozyme (LZM) or angiotensin converting enzyme (ACE). Sarcoidosis was confirmed by histopathology in 69 patients. CTO activity, sIL-2R concentration and ACE activity could discriminate between sarcoidosis and control patients, while SAA and LZM concentrations could not. A new combined parameter, which was derived from the multiplication of ACE by CTO activities (double product) showed the best diagnostic accuracy in this clinical study: (AUC = 0.898, sensitivity: 90.5%, specificity: 79.3%, positive and negative predictive values: 90.5% and 79.3%, respectively). Sarcoidosis can be diagnosed with the combined analysis of ACE and CTO activities more accurately than with single serum biomarkers in the absence of invasive biopsy in the majority of cases with pulmonary manifestation of sarcoidosis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a95de4423dff2aa1aeada347fc61f3Test
https://doi.org/10.1016/j.cca.2019.10.010Test

المؤلفون: Zsofia Petho, Edit Kalina, Zoltan Pap, Katalin Hodosi, Rebeka Falcsik, Adam Balogh, Zoltan Szekanecz, Harjit Pal Bhattoa

المصدر: BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-9 (2021)

مصطلحات موضوعية: musculoskeletal diseases, lcsh:Diseases of the musculoskeletal system, Bone metabolism, Psoriatic arthritis, Areal and volumetric BMD, Disease activity, lcsh:RC925-935, FRAX

الوصف: Background: Skeletal manifestations are predominant in psoriatic arthritis (PsA). The aim of this cross-sectional, case-controlled study is the complex assessment of areal and volumetric bone mineral density (BMD), fracture risk, vitamin D status and bone turnover markers, and its association with disease-related variables.Methods: Lumbar spine (L1-L4) and femur neck (FN) areal, and distal radius (DR) volumetric BMD, 10-year probability of major and hip osteoporotic fracture as assessed by the fracture risk assessment (FRAX) tool, markers of bone metabolism and disease activity were assessed.Results: Upon comparison of the disease and age- and sex-matched control groups, there was a statistically significant difference in FN areal (0.955±0.145 g/cm2 vs. 1.034±0.148 g/cm2; p=0.001) and DR total volumetric (285.7±61.8 mg/cm3 vs. 369.6±23.6 mg/cm3; p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f904f2f074729429b1c3b2da332ae54dTest
https://doi.org/10.21203/rs.3.rs-73065/v1Test

المؤلفون: Zsófia, Pethő, Edit, Kalina, Zoltán, Pap, Katalin, Hodosi, Rebeka, Falcsik, Ádám, Balogh, Zoltán, Szekanecz, Harjit Pal, Bhattoa

المصدر: BMC Musculoskeletal Disorders

مصطلحات موضوعية: musculoskeletal diseases, Hungary, Bone metabolism, Areal and volumetric BMD, Arthritis, Psoriatic, Risk Assessment, Absorptiometry, Photon, Cross-Sectional Studies, Bone Density, Case-Control Studies, Psoriatic arthritis, Humans, Disease activity, Osteoporotic Fractures, Research Article, FRAX

الوصف: Background Skeletal manifestations are predominant in psoriatic arthritis (PsA). The aim of this cross-sectional, case-control study is the complex assessment of areal and volumetric bone mineral density (BMD), fracture risk, vitamin D status and bone turnover markers, and its association with disease-related variables. Methods Lumbar spine (L1-L4) and femoral neck (FN) areal, and distal radius (DR) volumetric BMD, 10-year probability of major and hip osteoporotic fracture as assessed by the fracture risk assessment (FRAX) tool, markers of bone metabolism and disease activity were assessed. Results Upon comparison of the disease and age- and sex-matched control groups, there was a statistically significant difference in FN areal (0.952 (0.607–1.292) g/cm2 vs. 1.016 (0.760–1.550) g/cm2; p = 0.001) and DR total volumetric (284.3 (138.9–470.3) mg/cm3 vs. 367.0 (287.0–412.0) mg/cm3; p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::d7bd08459b65062378ec8bedaeee54a9Test
https://pubmed.ncbi.nlm.nih.gov/33435899Test

المؤلفون: B.J. Varga, Miklós Fagyas, K. Király, János Kappelmayer, Attila Enyedi, Edit Kalina, Attila Tóth, István Takács, István Altorjay, Zoltán Papp

المصدر: Clinica Chimica Acta. 493:S452-S453

مصطلحات موضوعية: Oncology, medicine.medical_specialty, business.industry, Internal medicine, Biochemistry (medical), Clinical Biochemistry, Medicine, General Medicine, Sarcoidosis, Biomarker Analysis, business, medicine.disease, Biochemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::459edb29f2766888e5449ae477d883f0Test
https://doi.org/10.1016/j.cca.2019.03.959Test

المؤلفون: E. Kulcsar-Jakab, Adam Balogh, Z. Pethö, K. Gulyás, A. Pusztai, Edit Kalina, Zoltán Szekanecz, Ágnes Horváth, Harjit Pal Bhattoa

المصدر: Osteoporosis International. 26:1965-1970

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Bone remodeling, Psoriatic arthritis, Bone Density, Internal medicine, Prevalence, medicine, Vitamin D and neurology, Humans, Elméleti orvostudományok, Vitamin D, Aged, Femoral neck, Aged, 80 and over, Bone mineral, Hungary, biology, business.industry, Arthritis, Psoriatic, Case-control study, Orvostudományok, Middle Aged, Vitamin D Deficiency, medicine.disease, Rheumatology, Cross-Sectional Studies, medicine.anatomical_structure, Endocrinology, Case-Control Studies, Osteocalcin, biology.protein, business

الوصف: We determined hypovitaminosis D prevalence in men with psoriatic arthritis. This is a cross-sectional, analyst blinded, age- and sex-matched, case-control study. Men with psoriatic arthritis have significantly lower 25-hydroxyvitamin D levels. Men with psoriatic arthritis are at increased odds of suffering from hypovitaminosis D. Skeletal manifestations as a result of abrupted bone metabolism may be predominant in psoriatic arthritis (PsA). Vitamin D plays a vital role in maintenance of skeletal health and is known to modulate the immune system in various autoimmune diseases including PsA. The aim of the present study was to determine the prevalence of hypovitaminosis D in a treatment naive, de novo psoriatic arthritis male cohort in a cross-sectional, analyst blinded, age- and sex-matched, case-control study. 25 hydroxyvitamin D (25OHD), parathyroid (PTH), osteocalcin (OC) and C-terminal telopeptides of type-I collagen (CTx) levels, and lumbar spine and femoral neck bone mineral density were compared between 53 PsA and controls. The prevalence of hypovitaminosis D (25 hydroxyvitamin D (25OHD) levels

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2efbfd11897088b4de05961390209d7aTest
https://doi.org/10.1007/s00198-015-3069-2Test

المؤلفون: Orsolya Karola Csenteri, Sándor Gődény, János Sándor, Edit Kalina, Harjit Pal Bhattoa

مصطلحات موضوعية: Adult, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Klinikai orvostudományok, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Risk Factors, Hyperinsulinism, Internal medicine, Hyperinsulinemia, Humans, Medicine, Obesity, 030219 obstetrics & reproductive medicine, business.industry, Insulin, nutritional and metabolic diseases, Obstetrics and Gynecology, Orvostudományok, medicine.disease, Polycystic ovary, Cardiovascular Diseases, Homeostatic model assessment, Female, lipids (amino acids, peptides, and proteins), Insulin Resistance, business, Body mass index, Dyslipidemia, Polycystic Ovary Syndrome

الوصف: The aim of this study was to utilize various insulin resistance measuring methods to determine whether insulin resistance and other parameters impact the serum lipid levels of polycystic ovary syndrome (PCOS) patients and how the serum lipid levels in these patients are affected by the body mass index (BMI). Our dataset included patients between the ages of 16 and 42 (N = 228) from the outpatient endocrinology clinic of the Department of Obstetrics and Gynecology, who demonstrated increased hair growth and bleeding disorders and came for a routine oral glucose tolerance test (OGTT). Differences in the serum lipid levels were evaluated by t-test and linear regression analysis after adjusting for BMI. A stepwise regression model was constructed to evaluate the influence of each variable on the lipid levels. In PCOS patients, we found that dyslipidemia is more prevalent among hyperinsulinemic women compared with normoinsulinemic women, even after normalizing for BMI. PCOS patients with insulin resistance, determined by the insulin sensitivity index (ISI) method, showed more significant lipid abnormalities such as low high-density lipoprotein (HDL) and apo-A levels and high total cholesterol, low-density lipoprotein (LDL) and apo-B levels than if insulin resistance (IR) determination was based on insulin level or homeostatic model assessment (HOMA).

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96de02679e4bb825d4c343369f523a2eTest

المؤلفون: Edit Kalina, Harjit Pal Bhattoa, E. Jakab, William B. Grant, Zoltan Pap, Adam Balogh, Z. Pethö

مصطلحات موضوعية: 0301 basic medicine, Quality Assurance, Health Care, Standardization, Chemiluminescence immunoassay, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Klinikai orvostudományok, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Hypovitaminosis, Reference Values, External quality assessment, Linear regression, Statistics, Humans, Medicine, Diagnostic laboratory, Vitamin D, Chromatography, High Pressure Liquid, 030109 nutrition & dietetics, business.industry, Orvostudományok, Vitamin D Deficiency, Luminescent Measurements, Cohort, NIST, business

الوصف: Standardization of 25-hydroxyvitamin D (25OHD) values is still a challenge. We propose standardization by correction of the measured 25OHD values using the linear regression bias from the National Institute of Standards and Technology (NIST) ‘total’ target values reported by Vitamin D External Quality Assessment Scheme (DEQAS). Our approach could perhaps be a practical solution to the anomaly surrounding non-standardized 25OHD values. Standardization of 25OHD values is still a challenge. We propose standardization by correction of the measured 25OHD values using the linear regression equation derived from the analysis of relationship between total 25OHD values measured by the methodology used by the laboratory and the NIST total target values (TV) reported by the DEQAS for all 5 of the DEQAS samples in a given survey. We applied our approach to standardize total 25OHD values of the HunMen cohort. All 206 samples for the HunMen cohort were evaluated using the automated Liaison DiaSorin total 25OHD chemiluminescence immunoassay (CLIA). The timing of these measurements coincided with that of the October 2015 DEQAS survey using samples 481 to 485. Following standardization, the mean total 25OHD changed from 53 to 62 nmol/L and the prevalence of hypovitaminosis D (

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2c3e0cec99a6904c6ce89726c182e3Test

المؤلفون: Harjit Pal Bhattoa, John Wamwaki, Roza Foldesi, Edit Kalina, Péter Antal-Szalmás, Adam Balogh

المصدر: Journal of Bone and Mineral Metabolism. 31:579-584

مصطلحات موضوعية: Genetic Markers, Male, Aging, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Osteocalcin, Renal function, Parathyroid hormone, Bone remodeling, chemistry.chemical_compound, Endocrinology, Bone Density, Internal medicine, medicine, Humans, Orthopedics and Sports Medicine, Vitamin D, Adaptor Proteins, Signal Transducing, Aged, Aged, 80 and over, Bone mineral, biology, business.industry, General Medicine, Middle Aged, Cystatin C, chemistry, Parathyroid Hormone, Bone Morphogenetic Proteins, biology.protein, Population study, Sclerostin, business

الوصف: The aim of this study is to evaluate the relationship of serum sclerostin levels with age, cystatin C, bone mineral density (BMD) and biochemical markers of bone turnover in healthy Hungarian men >50 years of age. We determined serum levels of sclerostin and examined its relationship to age, cystatin C, osteocalcin, C-terminal telopeptides of type-I collagen, procollagen type 1 amino-terminal propeptide, 25-hydroxyvitamin D, parathyroid hormone, and L1–L4 (LS) and femur neck (FN) BMD data available from 194 randomly selected ambulatory men belonging to the HunMen cohort. In the study population as a whole [n = 194; age (median, range) 59 (51–81) years], statistically significant correlation was found between sclerostin and age (r = 0.211; p = 0.003), cystatin C (r = 0.246; p = 0.001), FN BMD (r = 0.147; p = 0.041) and LS BMD (r = 0.169; p = 0.019). Compared to middle-aged men (age ≤59 years, n = 98), elderly men (age >59 years, n = 96) had significantly higher serum sclerostin levels (67.8 ± 15.9 vs 63.5 ± 14 pmol/L; p = 0.047). Among men with normal (T score >−1.0) FN BMD, the elderly had significantly higher serum sclerostin levels compared to the middle-aged men (70.4 ± 17 vs 63.9 ± 11.5 pmol/L; p = 0.019). Furthermore, among the elderly men cystatin C was the only significant predictor of serum sclerostin levels (standardized regression coefficient (β) = 0.487; p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a551b2d0dd074a579812e075f92aeb4Test
https://doi.org/10.1007/s00774-013-0451-zTest