-
1دورية أكاديمية
المؤلفون: E. T. Koh, K. P. Leong, I. Y. Y. Tsou, V. H. Lim, L. Y. Pong, S. Y. Chong, A. Seow, Tan Tock, Seng Hospital Rheumatoid
المساهمون: The Pennsylvania State University CiteSeerX Archives
الوصف: with rheumatoid arthritis
وصف الملف: application/pdf
-
2
المؤلفون: Bernard P. Leung, Hwee Siew Howe, K S S Tay, W G Law, K O Kong, Bernard Yu-Hor Thong, T Y Lian, E T Koh, Tang Ching Lau, F L Chia, H H Chng
المصدر: Clinical and experimental immunology. 189(3)
مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Immunology, Enzyme-Linked Immunosorbent Assay, Disease, G Antibody, Disease activity, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Asian People, immune system diseases, Limit of Detection, B-Cell Activating Factor, Immunology and Allergy, Medicine, Humans, Lupus Erythematosus, Systemic, B-cell activating factor, skin and connective tissue diseases, Autoantibodies, 030203 arthritis & rheumatology, Singapore, biology, business.industry, Autoantibody, Original Articles, Middle Aged, Pathophysiology, stomatognathic diseases, 030104 developmental biology, Immunoglobulin G, Cohort, biology.protein, Female, Antibody, business
الوصف: Summary To measure the levels of B cell-activating factor (BAFF) and endogenous anti-BAFF autoantibodies in a cohort of multi-ethnic Asian systemic lupus erythematosus (SLE) patients in Singapore, to determine their correlation with disease activity. Serum samples from 121 SLE patients and 24 age- and sex-matched healthy controls were assayed for BAFF and anti-BAFF immunoglobulin (Ig)G antibody levels by enzyme-linked immunosorbent assay (ELISA). The lowest reliable detection limit for anti-BAFF-IgG antibody levels was defined as 2 standard deviations (s.d.) from blank. Correlation of serum BAFF and anti-BAFF IgG levels with disease activity [scored by SLE Activity Measure revised (SLAM-R)], and disease manifestations were determined in these 121 patients. SLE patients had elevated BAFF levels compared to controls; mean 820 ± 40 pg/ml and 152 pg ± 45/ml, respectively [mean ± standard error of the mean (s.e.m.), P < 0·01], which were correlated positively with anti-dsDNA antibody levels (r = 0·253, P < 0·03), and SLAM-R scores (r = 0·627, P < 0·01). In addition, SLE patients had significantly higher levels of anti-BAFF IgG, which were correlated negatively with disease activity (r = –0·436, P < 0·01), levels of anti-dsDNA antibody (r = –0·347, P
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0281cc6c99a585ebfe1767d1a00548eTest
https://pubmed.ncbi.nlm.nih.gov/28388832Test -
3
المؤلفون: S. Vasoo, E. T. Koh, B. Y. H. Thong
المصدر: APLAR Journal of Rheumatology. 9:157-160
مصطلحات موضوعية: musculoskeletal diseases, medicine.medical_specialty, Systemic lupus erythematosus, business.industry, medicine.disease, Malignancy, Infliximab, Surgery, Etanercept, Rheumatoid arthritis, Heart failure, Internal medicine, medicine, Demyelinating disease, Adalimumab, skin and connective tissue diseases, business, medicine.drug
الوصف: Anti-tumour necrosis factor-α (anti-TNF-α) agents are biologic disease-modifying antirheumatic drugs (DMARDs) used in the treatment of moderate to severe rheumatoid arthritis (RA). We describe the demographic and therapeutic profiles of 22 patients who received anti-TNF-α therapy for RA in two hospitals in Singapore. The majority of patients were female, middle-aged, full-time working adults with limitation in their social or vocational activities. The mean RA disease duration was 101.4 ± 101.6 months (3.4–401.3). All received conventional DMARDs for a mean of almost 7 years before starting anti-TNF-α, with the majority having failed two or more DMARDs. The most commonly used anti-TNF-α therapies were infliximab (90.9%), etanercept (18.2%) and adalimumab (4.5%). Only one patient developed a major infection, while three developed minor infections requiring temporary cessation of anti-TNF-α therapy. There were no cases of malignancy, drug-induced lupus, demyelinating disease or congestive heart failure during an average of 36.9 ± 21.9 months (3.9–63.0) from initiation of therapy.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4bcfb59e97e6cd90b58075285d9e17aeTest
https://doi.org/10.1111/j.1479-8077.2006.00191.xTest -
4
المؤلفون: L. C. Chew, Siew Pang Chan, Hiok Hee Chng, T. Y. Lian, W. G. Law, Khai Pang Leong, Bernard Yu-Hor Thong, N. Sangeetha, E T Koh, Tang Ching Lau, K. O. Kong, Y. K. Cheng, H. J. Ho, Hwee Siew Howe, L. Y. Pong, L. S. Hoi, C. L. Teh, Humeira Badsha
المصدر: Rheumatology. 44:1267-1276
مصطلحات موضوعية: Adult, medicine.medical_specialty, Activities of daily living, Psychometrics, SF-36, Severity of Illness Index, Rheumatology, Cronbach's alpha, Quality of life, Surveys and Questionnaires, Activities of Daily Living, medicine, Content validity, Health Status Indicators, Humans, Lupus Erythematosus, Systemic, Pharmacology (medical), skin and connective tissue diseases, Lupus erythematosus, Rasch model, business.industry, Reproducibility of Results, Middle Aged, medicine.disease, humanities, Quality of Life, Physical therapy, Factor Analysis, Statistical, business, Clinical psychology
الوصف: Objectives. Systemic lupus erythematosus (SLE), a chronic illness with an unpredictable and variable course, profoundly affects the quality of life (QOL). General health questionnaires are used to assess QOL in SLE, but a disease-specific instrument could offer enhanced responsiveness and content validity. We detail the steps we took to develop and validate a new SLE-specific QOL instrument, SLEQOL. Methods. Rheumatology professionals nominated items that they felt were important determinants of QOL of SLE patients. One hundred SLE patients were asked to assess the importance and frequency of occurrence of these items and to suggest those that had not been listed. Item reduction was performed using Rasch model and factor analyses to create a new questionnaire in English. This final questionnaire was administered to a cohort of 275 patients to study its psychometric properties. Results. Fifty-one items covering a wide range of QOL concerns were identified. The patients’ responses led to the elimination of 11. The new questionnaire of 40 items was found to have Cronbach’s alpha of 0.95 and to consist of eight domains covering physical, mental and social QOL issues. It has good test–retest reliability, poor to fair cross-sectional correlation with the SF-36, with poor correlation with lupus activity or damage indices. The SLEQOL was more responsive to change than the SF-36. Conclusions. We have developed a new 40-item SLEQOL in English and showed that it is valid for use in SLE patients in Singapore. It offers better content validity and responsiveness to change than the SF-36.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1ef9cf4c13c15963b340c77b44c1c5Test
https://doi.org/10.1093/rheumatology/keh605Test -
5
المؤلفون: Dafna D. Gladman, P. Lee, E. T. Koh, Mahmoud Abu-Shakra
المصدر: ResearcherID
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Systemic disease, Hypertension, Pulmonary, Anti-Inflammatory Agents, Systemic scleroderma, Gastroenterology, Cohort Studies, Pulmonary heart disease, Pulmonary Heart Disease, Rheumatology, Prednisone, Internal medicine, Humans, Medicine, Pharmacology (medical), Restrictive lung disease, Demography, Retrospective Studies, Scleroderma, Systemic, business.industry, Histocompatibility Testing, Penicillamine, Respiratory disease, Middle Aged, medicine.disease, Connective tissue disease, Pulmonary hypertension, Surgery, Dyspnea, Antirheumatic Agents, Pulmonary Diffusing Capacity, Female, business, medicine.drug
الوصف: A retrospective chart review was carried out on 344 patients with systemic sclerosis (SSc) followed prospectively for the occurrence of pulmonary hypertension (PHT). Seventeen patients (4.9%) were found to have PHT. Eight patients had isolated PHT, while in nine PHT was associated with restrictive lung disease (RLD). The subset with RLD developed PHT earlier, but had longer survival than patients with isolated PHT. Patients with limited scleroderma tend to develop isolated PHT, while in those with diffuse disease PHT is associated with RLD. Irrespective of disease type, PHT in SSc has an extremely poor prognosis with a median survival of 12 months following diagnosis.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ff6434eb61f168962720b4aa40e723Test
https://doi.org/10.1093/rheumatology/35.10.989Test -
6
المؤلفون: C Y Tang, Khai Pang Leong, Julian Thumboo, Bernard Yu-Hor Thong, E T Koh
المصدر: Lupus. 11:127-129
مصطلحات موضوعية: Hypersensitivity, Immediate, China, medicine.medical_specialty, Adolescent, Cyclophosphamide, 030204 cardiovascular system & hematology, Drug Hypersensitivity, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, immune system diseases, Internal medicine, medicine, Humans, Lupus Erythematosus, Systemic, skin and connective tissue diseases, 030203 arthritis & rheumatology, Lupus erythematosus, Angioedema, business.industry, medicine.disease, Hypersensitivity reaction, Immunology, Urticaria pigmentosa, Female, medicine.symptom, business, Anaphylaxis, medicine.drug, Type I hypersensitivity
الوصف: Cyclophosphamide is an important immunosuppressive agent in the treatment of many rheumatic diseases. Urticaria and anaphylaxis to intravenous cyclophosphamide (i.v. CYC) have been reported in patients with haematological and solid organ malignancies. This is the first report in the rheumatology literature of a type I hypersensitivity reaction following monthly i.v. CYC. An 18-year-old girl with systemic lupus erythematosus (SLE) developed generalized urticaria (without concomitant angioedema or anaphylaxis) following i.v. CYC. She had previously developed life threatening angioedema following a respiratory tract infection. She successfully completed regular pulse i.v. CYC with pre-medication with anti-histamine. In the absence of a severe type I hypersensitivity reaction and other suitable immunosuppressive agents, i.v. CYC may be safely continued with pre-medication and careful monitoring during each infusion.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56aed939f3bda3464c9962b74080d6aTest
https://doi.org/10.1191/0961203302lu140crTest -
7
المؤلفون: K P, Leong, E Y Y, Chong, K O, Kong, S P, Chan, B Y H, Thong, T Y, Lian, H H, Chng, E T, Koh, C L, Teh, T C, Lau, W G, Law, Y K, Cheng, H, Badsha, L C, Chew, W H, Yong, H S, Howe, Justina, Tan
المصدر: Lupus. 19(1)
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Cyclophosphamide, Azathioprine, Severity of Illness Index, Rheumatology, Quality of life, immune system diseases, Internal medicine, Severity of illness, Medicine, Humans, Lupus Erythematosus, Systemic, skin and connective tissue diseases, Physician-Patient Relations, Singapore, Proteinuria, Lupus erythematosus, Systemic lupus erythematosus, business.industry, Middle Aged, medicine.disease, Physical therapy, Linear Models, Quality of Life, Female, medicine.symptom, business, medicine.drug
الوصف: Patients with systemic lupus erythematosus often assess their disease activity differently from their physicians. We studied the factors associated with this discordance. The data provided by 534 systemic lupus erythematosus patients were analyzed. We compared the physician and patient assessments of lupus activity on a visual-assessment scale from the same visit. We collected clinical data and scores from MOS 36-Item Short-Form Health Survey, Systemic Lupus Erythematosus Quality-of-Life Questionnaire, Rheumatology Attitudes Index, Systemic Lupus Erythematosus Disease Activity Index, and revised Systemic Lupus Activity Measure. Patients tended to score their disease activity higher than do their physicians, when these factors were present: poorer general health assessment, presence of thrombocytopenia, hypertension and urinary sediments, and difficulty in carrying groceries. Physicians tended to score the disease activity higher than do the patients in these circumstances proteinuria, hemolysis, use of azathioprine or cyclophosphamide, tiredness, photosensitivity, higher revised Systemic Lupus Activity Measure score, casturia, and patient report of being more easily ill than are other patients. There was only moderate correlation between the discordance in the baseline and the subsequent visits. The physician assessment of disease activity at baseline correlated better with an objective measure of disease activity (revised Systemic Lupus Activity Measure) in the subsequent visit than the patient assessment. In conclusion, discordance in the perception of disease activity between patients and physicians may be amenable to intervention.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe533352626e7f620a49214a4fc44dfTest
https://pubmed.ncbi.nlm.nih.gov/19880553Test -
8
المؤلفون: C L Teh, Bernard P. Leung, T Y Lian, Hwee Siew Howe, Tang Ching Lau, K O Kong, A W Tan, E T Koh, Y K Cheng, Bernard Yu-Hor Thong, W G Law, Khai Pang Leong, H H Chng
المصدر: Clinical and experimental immunology. 156(1)
مصطلحات موضوعية: Adult, Male, Systemic disease, medicine.medical_specialty, Immunology, Peripheral blood mononuclear cell, Sensitivity and Specificity, Severity of Illness Index, Serology, Young Adult, immune system diseases, Immunopathology, Internal medicine, Medicine, Immunology and Allergy, Humans, Lupus Erythematosus, Systemic, skin and connective tissue diseases, Cells, Cultured, Autoimmune disease, Lupus erythematosus, biology, business.industry, Middle Aged, medicine.disease, Connective tissue disease, Chemokine CXCL10, Endocrinology, Translation Studies, biology.protein, Female, Antibody, business, Biomarkers, Follow-Up Studies
الوصف: SummaryOur objective was to investigate the serum levels of interferon-inducible protein-10 (IP-10) in systemic lupus erythematosus (SLE) and their correlation with disease activity and organ manifestations. Serum IP-10 levels were assessed in 464 SLE patients and 50 healthy donors. Disease activity was assessed by the revised SLE Activity Measure, and the concomitant active organ manifestations, anti-ds DNA antibody titres, complement levels and erythrocyte sedimentation rates recorded. Peripheral blood mononuclear cell (PBMC) synthesis of IP-10 in SLE patients and controls was determined by in vitro cultures stimulated with mitogen or lipopolysaccharide. Elevated serum IP-10 levels were observed in SLE patients, which were significantly higher in the presence of active haematological and mucocutaneous manifestations. SLE PBMCs exhibited enhanced spontaneous IP-10 production in vitro. Serial IP-10 levels correlated with longitudinal change in SLE activity, even at low levels where anti-dsDNA antibody and complement levels remain unchanged. These data demonstrate that IP-10 levels are increased in SLE and serum IP-10 may represent a more sensitive marker for monitoring disease activity than standard serological tests.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e24e84177ff8570850b6f2094ee15ffTest
https://pubmed.ncbi.nlm.nih.gov/19175619Test -
9
المؤلفون: A Seow, E T Koh, Khai Pang Leong, V H Lim, L Y Pong, I Y Y Tsou, S Y Chong
المصدر: Rheumatology (Oxford, England). 45(8)
مصطلحات موضوعية: Adult, Cross-Cultural Comparison, Male, medicine.medical_specialty, Psychometrics, SF-36, Severity of Illness Index, Arthritis, Rheumatoid, Rheumatology, Quality of life, Cronbach's alpha, Asian People, Floor effect, Criterion validity, Medicine, Humans, Pharmacology (medical), Aged, Aged, 80 and over, Singapore, business.industry, Construct validity, Middle Aged, Physical therapy, Quality of Life, Ceiling effect, Female, business, Epidemiologic Methods
الوصف: Objective To assess the reliability, validity and sensitivity to change of a Chinese version of the 36-item Short-Form Health Survey (SF-36) in Chinese-speaking patients with rheumatoid arthritis (RA) in Singapore. Methods The psychometric properties of the Chinese Hong Kong standard version of the SF-36 were assessed in 401 RA patients. The construct validity of the Chinese SF-36 was assessed by comparison with the American College of Rheumatology (ACR) functional status, a validated Chinese Health Assessment Questionnaire (C-HAQ) and markers of RA activity and severity. Results The overall Cronbach's coefficient alpha was 0.921, reflecting excellent internal consistency. The instrument showed reasonable test-retest reliability except in the social functioning (SF) subscale. There was a significant ceiling effect in the role physical (RP), SF and role emotional (RE) subscales and a floor effect in the RP and RE subscales. Physical function (PF) and SF were strongly correlated with C-HAQ and patient's assessment of RA activity [Pearson's correlation coefficient (r) ranging from -0.41 to -0.53] and moderately correlated with ACR functional status (r = -0.35 and -0.3, respectively). Weak correlations were also found between the Chinese SF-36 and markers of RA activity, deformed joint count and radiographic damage. PF and SF were the subscales most responsive to change in quality of life (QOL). Conclusion The Chinese SF-36 showed reasonable reliability, criterion validity and responsiveness with limitations in certain subscales. Overall, the physical domains and PF in particular may be the most ideal psychometric measures of QOL in RA.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59d947a330b72f123c1144b39605786Test
https://pubmed.ncbi.nlm.nih.gov/16495318Test -
10
المؤلفون: Y K, Cheng, S W, Leo, C J, Edwards, E T, Koh
المصدر: Annals of the Academy of Medicine, Singapore. 32(5)
مصطلحات موضوعية: Arthritis, Infectious, Endophthalmitis, Middle Aged, Neisseria meningitidis, Risk Assessment, Severity of Illness Index, United Kingdom, Anti-Bacterial Agents, Meningococcal Infections, Treatment Outcome, Humans, Drug Therapy, Combination, Female, Follow-Up Studies
الوصف: Arthritis and endophthalmitis are both recognised complications of meningococcal infection. They may occur in the presence or absence of meningitis or meningococcaemia. Primary meningococcal arthritis (PMA) and endophthalmitis are important diagnoses to recognise as delayed treatment would result in permanent joint and eye damage. We report the first patient with both PMA and meningococcal endophthalmitis and present a review of the literature.An afebrile, non-toxic, 54-year-old female presented with arthritis and a painful red left eye following an episode of diarrhoea. An initial diagnosis of reactive arthritis with uveitis was made. However, subsequent microbiological investigations isolated Neisseria meningitides thus confirming the final diagnosis.Antibiotics were instituted.There was complete resolution of the arthritis but her left eye vision had deteriorated to just perception of light.The presentations of PMA and meningococcal endophthalmitis are often confusing. This should be considered in the differential diagnosis of reactive arthritis and acute dermatitis-arthritis syndrome.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::678f0e8339eecc4a38da64396a7b1361Test
https://pubmed.ncbi.nlm.nih.gov/14626806Test
