المؤلفون: Simon S. Smith, Kalina R. Rossa, Shamsi Shekari Soleimanloo, Cassandra L. Pattinson, Dwayne L. Mann, Shannon L. Edmed, Paul M. Salmon, Karen A. Sullivan

المصدر: Heliyon, Vol 10, Iss 5, Pp e27066- (2024)

مصطلحات موضوعية: Risky driving, Sleepy driver, Young driver, Road crash risk, Sleep banking, Sleep extension, Science (General), Q1-390, Social sciences (General), H1-99

الوصف: Background: Road trauma is a leading cause of death and disability for young Australians (15–24 years). Young adults are overrepresented in crashes due to sleepiness, with two-thirds of their fatal crashes attributed to sleepy driving. This trial aims to examine the effectiveness of a sleep extension and education program for improved road safety in young adults. Methods: Young adults aged 18–24 years (n = 210) will be recruited for a pragmatic randomised controlled trial employing a placebo-controlled, parallel-groups design. The intervention group will undergo sleep extension and receive education on sleep, whereas the placebo control group will be provided with information about diet and nutrition. The primary outcomes of habitual sleep and on-road driving performance will be assessed via actigraphy and in-vehicle accelerometery. A range of secondary outcomes including driving behaviours (driving simulator), sleep (diaries and questionnaire) and socio-emotional measures will be assessed. Discussion: Sleep is a modifiable factor that may reduce the risk of sleepiness-related crashes. Modifying sleep behaviour could potentially help to reduce the risk of young driver sleepiness-related crashes. This randomised control trial will objectively assess the efficacy of implementing sleep behaviour manipulation and education on reducing crash risk in young adult drivers.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2405844024030974Test; https://doaj.org/toc/2405-8440Test

الوصول الحر: https://doaj.org/article/f2e39be5a11d46caaa6f92ef1245e2a1Test

المؤلفون: Luke D. J. Thomson, Shane A. Landry, Simon A. Joosten, Dwayne L. Mann, Ai‐Ming Wong, Tim Cheung, Mulki Adam, Caroline J. Beatty, Garun S. Hamilton, Bradley A. Edwards

المصدر: Physiological Reports, Vol 10, Iss 16, Pp n/a-n/a (2022)

مصطلحات موضوعية: combination therapy, muscarinic antagonists, noradrenergic, obstructive sleep apnoea., pharmacotherapy, serotonergic, Physiology, QP1-981

الوصف: Abstract Previous trials have demonstrated that the combination of noradrenergic reuptake inhibitors with an antimuscarinic can substantially reduce the apnoea‐hypopnoea index (AHI) and improve airway collapsibility in patients with obstructive sleep apnoea (OSA). However, some studies have shown that when administered individually, neither noradrenergic or serotonergic agents have been effective at alleviating OSA. This raises the possibility that serotonergic agents (like noradrenergic agents) may also need to be delivered in combination to be efficacious. Therefore, we investigated the effect of an antimuscarinic (oxybutynin) on OSA severity when administered with either duloxetine or milnacipran, two dual noradrenergic/serotonergic reuptake inhibiters. A randomized, double‐blind, 4 way cross‐over, placebo‐controlled trial in ten OSA patients was performed. Patients received each drug condition separately across four overnight in‐lab polysomnography (PSG) studies ~1‐week apart. The primary outcome measure was the AHI. In addition, the four key OSA endotypes (collapsibility, muscle compensation, arousal threshold, loop gain) were measured non‐invasively from the PSGs using validated techniques. There was no significant effect of either drug combinations on reducing the total AHI or improving any of the key OSA endotypes. However, duloxetine+oxybutynin did significantly increase the fraction of hypopnoeas to apnoeas (FHypopnoea) compared to placebo (p = 0.02; d = 0.54). In addition, duloxetine+oxybutynin reduced time in REM sleep (p = 0.009; d = 1.03) which was positively associated with a reduction in the total AHI (R2 = 0.62; p = 0.02). Neither drug combination significantly improved OSA severity or modified the key OSA endotypes when administered as a single dose to unselected OSA patients.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2051-817XTest

الوصول الحر: https://doaj.org/article/e869c14f7d4443539a449890b85b2de8Test

المؤلفون: Brandon Nokes, Christopher N. Schmickl, Rebbecca Brena, Nana Naa‐Oye Bosompra, Dillon Gilbertson, Scott A. Sands, Rakesh Bhattacharjee, Dwayne L. Mann, Robert L. Owens, Atul Malhotra, Jeremy E. Orr

المصدر: Physiological Reports, Vol 10, Iss 12, Pp n/a-n/a (2022)

مصطلحات موضوعية: Physiology, QP1-981

الوصف: Abstract There is a need for alternatives to positive airway pressure for the treatment of obstructive sleep apnea and snoring. Improving upper airway dilator function might alleviate upper airway obstruction. We hypothesized that transoral neuromuscular stimulation would reduce upper airway collapse in concert with improvement in genioglossal muscle function. Subjects with simple snoring and mild OSA (AHI

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2051-817XTest

الوصول الحر: https://doaj.org/article/1d5ded184fde435895d4d022a4b0346eTest

المؤلفون: Daniel M. Mammel, John L. Carroll, Barbara B. Warner, Bradley A. Edwards, Dwayne L. Mann, Michael J. Wallendorf, Julie A. Hoffmann, Cameron M. Conklin, Harley Pyles, James S. Kemp

المصدر: American Journal of Respiratory and Critical Care Medicine. 207:594-601

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Critical Care and Intensive Care Medicine

الوصف: Preterm infants are at risk for ventilatory control instability that may be due to aberrant peripheral chemoreceptor activity. While term infants have increasing peripheral chemoreceptor contribution to overall ventilatory drive with increasing postnatal age, how peripheral chemoreceptor contribution changes in preterm infants with increasing postmenstrual age is not known.To evaluate peripheral chemoreceptor activity between 32 and 52 weeks postmenstrual age in preterm infants, using both quantitative and qualitative measures.55 infants born between 24 weeks 0 days and 28 weeks 6 days gestation underwent hyperoxic testing at 1 to 4 time points between 32 and 52 weeks postmenstrual age. Quantitative minute ventilation decreases were calculated, and qualitative responses were categorized as apnea, continued breathing with a clear reduction in minute ventilation, sigh breaths, and no response.280 hyperoxic tests were analyzed (2.2 ± 0.3 tests per infant at each time point). Mean peripheral chemoreceptor contribution to ventilatory drive was 85.2 ± 20.0% at 32 weeks and 64.1 ± 22.0% at 52 weeks. Apneic responses were more frequent at earlier postmenstrual ages.Among preterm infants, the peripheral chemoreceptor contribution to ventilatory drive was greater at earlier postmenstrual ages. Apnea was a frequent response to hyperoxic testing at earlier postmenstrual ages, suggesting high peripheral chemoreceptor activity. A clearer description of how peripheral chemoreceptor activity changes over time in preterm infants may help explain how ventilatory control instability contributes to apnea and sleep-disordered breathing later in childhood.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69569c70806c0f5b8a4d2dac89940e60Test
https://doi.org/10.1164/rccm.202206-1033ocTest

المؤلفون: Shane A. Landry, Dwayne L. Mann, Richard Beare, Richard McIntyre, Caroline Beatty, Luke D.J. Thomson, Jinny Collet, Simon A. Joosten, Garun S. Hamilton, Bradley A. Edwards

المصدر: Chest.

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d1dd5d7e2009a8c21f96a8f6879691eeTest
https://doi.org/10.1016/j.chest.2023.03.025Test