المؤلفون: Durucan I., Guner S., Kilickiran Avci B., Unverengil G., Melikoglu M., Ugurlu S.

مصطلحات موضوعية: BNT162b2, COVID-19, myocarditis, myositis, vaccine, alanine aminotransferase, aspartate aminotransferase, bnt 162b 2, C reactive protein, creatine kinase, creatinine, lactate dehydrogenase, metoprolol, muscle relaxant agent, nonsteroid antiinflammatory agent, prednisolone, ramipril, spironolactone, steroid, tozinameran, troponin T, abnormal urine composition, adult, alanine aminotransferase blood level, Article, aspartate aminotransferase blood level, body weight loss, burning sensation, case report, clinical article

الوصف: A previously healthy 24-year-old male patient was referred to our clinic with bilateral lower extremity pain and dark urine, which were developed 2 weeks after receiving the second dose of the BNT162b2 vaccine against severe acute respiratory coronavirus 2. Laboratory tests indicated rhabdomyolysis. Lower extremity magnetic resonance imaging was compatible with myositis. Myositis-related antibodies were negative. Biopsy taken from gastrocnemius muscle revealed muscle necrosis and striking expression of major histocompatibility complex class I antigen. He was successfully treated, and his complaints were resolved. One week later at follow-up, he reported new-onset exertional dyspnoea with palpitations. ST-segment depressions were spotted on electrocardiography. Troponin T was found elevated as 0.595 ng/ml (normal <0.014 ng/ml). Echocardiography showed a hypokinetic left ventricle with an ejection fraction of 40% and pericardial effusion of 2 mm. An appropriate treatment plan was formulated for the diagnosis of myocarditis, eventually, the patient recovered within 10 days. The BNT162b2 messenger ribonucleic acid (mRNA) vaccine was felt to cause the aforementioned condition since no other aetiology could be identified. Although it is known that BNT162b2 may induce myocarditis, myositis concomitant myocarditis appears to be a very rare adverse effect of this vaccine. © 2022 Japan College of Rheumatology. Published by Oxford University Press.

العلاقة: Modern Rheumatology Case Reports; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1093/mrcr/rxac041Test; https://hdl.handle.net/20.500.12831/19693Test; 280; 282; 2-s2.0-85146735444

الإتاحة: https://doi.org/10.1093/mrcr/rxac041Test
https://doi.org/20.500.12831/19693Test
https://hdl.handle.net/20.500.12831/19693Test

المؤلفون: Baspinar, S. N., Alkan, A., Yuzbasioglu, M. B., Yenigun, S., Ayla, A. Y., Durucan, I., Ugurlu, S.

الوصف: [No Abstract Available]

العلاقة: Annals of The Rheumatic Diseases; Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı; https://doi.org/10.1136/annrheumdis-2022-eular.5167Test; https://hdl.handle.net/20.500.12831/8240Test; 81; 1767; WOS:000850279007261

الإتاحة: https://doi.org/10.1136/annrheumdis-2022-eular.5167Test
https://doi.org/20.500.12831/8240Test
https://hdl.handle.net/20.500.12831/8240Test

المؤلفون: Yenigun, S., Ayla, A. Y., Baspinar, S. N., Yuzbasioglu, M. B., Alkan, A., Durucan, I., Ugurlu, S.

الوصف: [No Abstract Available]

العلاقة: Annals of The Rheumatic Diseases; Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı; https://doi.org/10.1136/annrheumdis-2022-eular.5337Test; https://hdl.handle.net/20.500.12831/8242Test; 81; 1028; 1029; WOS:000850279004098

الإتاحة: https://doi.org/10.1136/annrheumdis-2022-eular.5337Test
https://doi.org/20.500.12831/8242Test
https://hdl.handle.net/20.500.12831/8242Test

المؤلفون: Baspinar, S. N., Durucan, I., Yuzbasioglu, M. B., Yenigun, S., Ayla, A. Y., Alkan, A., Ugurlu, S.

الوصف: EULAR European Congress of Rheumatology (EULAR) -- JUN 01-04, 2022 -- Copenhagen, DENMARK ; [No Abstract Available] ; European Alliance Assoc Rheumatol

العلاقة: Annals of The Rheumatic Diseases; Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı; https://doi.org/10.1136/annrheumdis-2022-eular.5180Test; https://hdl.handle.net/20.500.12831/8241Test; 81; 1767; 1768; WOS:000850279007262

الإتاحة: https://doi.org/10.1136/annrheumdis-2022-eular.5180Test
https://doi.org/20.500.12831/8241Test
https://hdl.handle.net/20.500.12831/8241Test

المؤلفون: Mustafayeva, L, Durucan, I, Ayla, AY, Ugurlu, S

المصدر: Thursday 06 October 2022 from 13:00 to 14:10

الإتاحة: https://doi.org/10.1136/lupus-2022-elm2022.97Test

المؤلفون: Firat Senturk, E., Ogun, H., Durucan, I., Yurttas, B., Ugurlu, S.

المصدر: Scientific Abstracts

الإتاحة: https://doi.org/10.1136/annrheumdis-2023-eular.5000Test

المؤلفون: Hiyamli, M. F., Ugurlu, S., Gazioglu, M. E., Sarac, I., Ozdogan, H., Yuzbasioglu, M. B., Ayla, A. Y., Besiroglu, I., Baspinar, S. N., Yenigun, S., Durucan, I., Alkan, A.

المساهمون: İstanbul Teknik Üniversitesi ,, 4070180

مصطلحات موضوعية: Sağlık Bilimleri, Romatoloji, Dahili Tıp Bilimleri, İç Hastalıkları, İmmünoloji ve Romatoloji, Klinik Tıp (MED), Klinik Tıp, ROMATOLOJİ, Tıp

العلاقة: ANNALS OF THE RHEUMATIC DISEASES; Yuzbasioglu M. B., Ayla A. Y., Besiroglu I., Baspinar S. N., Yenigun S., Durucan I., Alkan A., Gazioglu M. E., Hiyamli M. F., Sarac I., et al., "DIAGNOSTIC DELAY IN FAMILIAL MEDITERRANEAN FEVER: IS IT STILL A PROBLEM?", ANNALS OF THE RHEUMATIC DISEASES, cilt.81, ss.1768-1769, 2022; vv_1032021; av_42180010-7aa0-4950-93b6-dec7dbdf1798; http://hdl.handle.net/20.500.12627/188321Test; https://avesis.istanbul.edu.tr/api/publication/42180010-7aa0-4950-93b6-dec7dbdf1798/fileTest; https://doi.org/10.1136/annrheumdis-2022-eular.5322Test; 81; 1768; 1769

الإتاحة: https://doi.org/20.500.12627/188321Test
https://doi.org/10.1136/annrheumdis-2022-eular.5322Test
https://hdl.handle.net/20.500.12627/188321Test
https://avesis.istanbul.edu.tr/api/publication/42180010-7aa0-4950-93b6-dec7dbdf1798/fileTest

المؤلفون: Sahin, B., UĞURLU, SERDAL, Demirkol, F., Alizade, S., Ozdogan, H., Baspinar, S. N., Durucan, I., Yuzbasioglu, M. B., Yenigun, S., Ayla, A. Y., Alkan, A., Ayalti, T.

المساهمون: İstanbul Teknik Üniversitesi ,, 4070140

مصطلحات موضوعية: İmmünoloji ve Romatoloji, Sağlık Bilimleri, Romatoloji, Dahili Tıp Bilimleri, İç Hastalıkları, Tıp, Klinik Tıp (MED), Klinik Tıp, ROMATOLOJİ

العلاقة: Baspinar S. N., Durucan I., Yuzbasioglu M. B., Yenigun S., Ayla A. Y., Alkan A., Ayalti T., Demirkol F., Sahin B., Alizade S., et al., "THE MYSTERY OF FAMILIAL MEDITERRANEAN FEVER: IS THERE ANY FACTOR TRIGGERING THE ATTACKS?", EULAR European Congress of Rheumatology (EULAR), Copenhagen, Danimarka, 1 - 04 Haziran 2022, cilt.81, ss.1767-1768; vv_1032021; av_28e0ff0d-f0a9-45dc-bab0-12ac1eb80b53; http://hdl.handle.net/20.500.12627/187256Test; https://avesis.istanbul.edu.tr/api/publication/28e0ff0d-f0a9-45dc-bab0-12ac1eb80b53/fileTest; https://doi.org/10.1136/annrheumdis-2022-eular.5180Test; 81

الإتاحة: https://doi.org/20.500.12627/187256Test
https://doi.org/10.1136/annrheumdis-2022-eular.5180Test
https://hdl.handle.net/20.500.12627/187256Test
https://avesis.istanbul.edu.tr/api/publication/28e0ff0d-f0a9-45dc-bab0-12ac1eb80b53/fileTest

المؤلفون: Yuzbasioglu, M. B., Ayla, A. Y., Besiroglu, I., Baspinar, S. N., Yenigun, S., Durucan, I., Alkan, A., Gazioglu, M. E., Hiyamli, M. F., Sarac, I., Ozdogan, H., Ugurlu, S.

المصدر: Annals of the Rheumatic Diseases ; volume 81, issue Suppl 1, page 1768.2-1769 ; ISSN 0003-4967 1468-2060

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology, Immunology, Immunology and Allergy, Rheumatology

الوصف: Background Familial Mediterranean fever (FMF) is a rare hereditary autoinflammatory disease with disease onset in childhood in most cases. Although autoinflammatory disease awareness is increasing among physicians, delayed diagnosis is still prevalent as a cause of greater morbidity[1]. Objectives We aimed to study the characteristics of FMF patients diagnosed between 2000-2010 and 2011-2021 and to see if there was a difference in diagnostic delay. Methods We retrospectively evaluated the medical records of the FMF patients followed up in our rheumatology clinic that were diagnosed between 2000-2021 and split them into two groups according to the year they received their diagnosis. There were 1151 patients diagnosed between 2000-2010 (Group 1) and 821 patients diagnosed between 2011-2021 (Group 2). The data studied included gender, age of onset, diagnostic delay, attack characteristics, MEFV mutation, and family history. Results The median current age of patients in Group 1 is 37 years (IQR:30-46) and the median current age of the patients in Group 2 is 36 years (IQR:29-44). The female to male ratio was 1.57 in Group 1 and 1.75 in Group 2, with no significant difference between the groups. Group 2 had later disease onset (p<0.001) and later diagnosis (p<0.001) than Group 1 as shown in the Table 1. The proportion of patients with at least one M694V mutation was higher in Group 2 (p<0.001). The attack durations did not vary between the groups. There was no significant difference in the prevalence of abdominal pain, fever, arthritis, and arthralgia between Group 1 and Group 2. Chest pain (p=0.005), myalgia (p<0.001), and erysipelas-like erythema (p=0.041) were more common in Group 2 than Group 1. Patients with positive family history were more frequent in Group 2 than Group 1 (p=0.046). Table 1. Group 1 (2000-2010, n=1151) Group 2 (2011-2021, n=821) p Female/Male, n 704/447 522/299 0.275 Age at onset, median (IQR) years 13 (7-21) 18 (12-26) <0.001 Delay in diagnosis, median (IQR) years 4 (1-11) ...

الإتاحة: https://doi.org/10.1136/annrheumdis-2022-eular.5322Test

المؤلفون: Baspinar, S. N., Durucan, I., Yuzbasioglu, M. B., Yenigun, S., Ayla, A. Y., Alkan, A., Ayalti, T., Demirkol, F., Sahin, B., Alizade, S., Ozdogan, H., Ugurlu, S.

المصدر: Annals of the Rheumatic Diseases ; volume 81, issue Suppl 1, page 1767.3-1768 ; ISSN 0003-4967 1468-2060

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology, Immunology, Immunology and Allergy, Rheumatology

الوصف: Background Familial Mediterranean Fever (FMF) is an autoinflammatory disease characterized by recurrent episodes of fever and serositis. Although it is known that the attack frequency differs among patients carrying different mutant genotypes [1], whether physical and environmental factors play a role in triggering attacks or whether they have an influence on timing of attacks remains to be elucidated. Objectives We aimed to identify different conditions causing flare-ups in FMF course and to investigate if there is a significant difference between patients carrying distinct mutations, regarding the distribution of the factors mentioned. Methods Two hundred patients were randomly selected among individuals who were routinely followed-up with FMF diagnosis in our centre. Individuals carrying only a variant of unknown significance or polymorphism such as R202Q, according to Infevers database, were excluded in order to gather a cohort consisting of patients with definite FMF. An inquiry was made based upon triggering factors determined by the patients themselves. The patients were classified into subgroups by their sex and mutation genotype. Since M694V variant is responsible for pronounced FMF course [2], we sorted the patients according to their status for M694V mutant allele. Group A included patients carrying M694V homozygously. Group B included patients carrying at least one M694V mutant allele whereas Group C consisted of patients who were non-M694V carriers. Chi-square test was performed to assess distribution of the trigger factors in terms of establishing its significance. Results Detailed distribution of trigger factors is shown in Table 1. 144 out of 200 patients described a culprit condition. Patients usually stated more than one factor, however some patients reported only one. The most-reported trigger factors by the cohort are summarized as following: 76 emotional stress (38%), 60 menstruation (30%), 40 cold exposure (20%), 34 fatigue (17%), 13 seasonal changes (6.5%). The distribution of trigger ...

الإتاحة: https://doi.org/10.1136/annrheumdis-2022-eular.5180Test