المؤلفون: Durmaz, Zeynep Hulya, Ayan, Durmuş, Demir, Aslıhan Dilara, Demir, Hatice Dörtok

المصدر: Malang Neurology Journal, Vol 6, Iss 1, Pp 28-31 (2020)

مصطلحات موضوعية: Medicine, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

العلاقة: https://mnj.ub.ac.id/index.php/mnj/article/view/420Test; https://doaj.org/toc/2407-6724Test; https://doaj.org/toc/2442-5001Test

الوصول الحر: https://doaj.org/article/08556355c9f64beabc3e95c41cab2f67Test

المؤلفون: Demir, Aslihan Dilara, Durmaz, Zeynep Hulya, Kilinc, Cetin, Guckan, Ridvan

المساهمون: Demir, Aslihan Dilara Amasya Univ, Res Hosp, Dept Internal Med, TR-05000 Amasya, Turkey -- Durmaz, Zeynep Hulya Amasya Univ, Res Hosp, Dept Biochem, Amasya, Turkey -- Kilinc, Cetin -- Guckan, Ridvan Amasya Univ, Res Hosp, Dept Microbiol, Amasya, Turkey

مصطلحات موضوعية: red blood cell distrubition width, glycated hemoglobin, diabetic patients, nondiabetic patients

الوصف: WOS: 000408494900001 ; Aim - Our aim in this study is evaluating the red blood cell distrubition width (RDW) and glycated hemoglobin (HbA1C) relation in nondiabetic and diabetic people who applied to our hospital and showing the usability in disease follow-up. Material and Methods - Main data of this research is the data of patients (diabetic and nondiabetic) who applied to internal diseases polyclinic between July 1, 2013 and November 31, 2014 and whose RDW, HbA1C, white blood cell, hemoglobin, and hematocrit were controlled. 82 diabetic and 32 nondiabetic patients were included in this study. Results - No statistically significant difference was observed between the diabetic and nondiabetic groups in age, male and female distribution and RDW. No statistically significant correlation was observed between RDW and age and HbA1C in order in the nondiabetic group. While a correlation which is statistically significant and in the same direction was determine between age and RDW among the diabetic group, a statistically significant correlation was not between HbA1C and RDW. Among all cases a correlation which is statistically meaningful and in the same direction was detected between age and RDW. But a statistically significant correlation was not found between HbA1C and RDW among all cases. Conclusion - According to the available results, no statistically significant correlation was determined between HbA1C and RDW in the nondiabetic patients, diabetic group or in total. But in order to provide more clearance, we believe that studies with more patients would be useful.

العلاقة: RUSSIAN OPEN MEDICAL JOURNAL; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.15275/rusomj.2016.0301Test; https://hdl.handle.net/20.500.12450/1236Test

الإتاحة: https://doi.org/20.500.12450/1236Test
https://doi.org/10.15275/rusomj.2016.0301Test
https://hdl.handle.net/20.500.12450/1236Test

المؤلفون: Demir, Aslıhan Dilara, Durmaz, Zeynep Hulya

المصدر: Asian Journal of Medical Sciences; Vol. 12 No. 7 (2021); 5-9 ; 2091-0576 ; 2467-9100

مصطلحات موضوعية: Covid-19, Age, Lactate dehydrogenase (LDH), D-Dimer, Lymphocyte

الوصف: Background: Covid-19 infectious disease becomes a pandemic and later affects the entire world it has various effects in different age groups. Aims and Objective: In our study, we aimed to investigate the distribution of biochemical tests along with age, and the incidence in different age groups under the age of 65 and over the age of 65. Materials and Methods: We planned a retrospective study. Our patients consist of 2 groups. The first group consists of 54 patients aged 18 to 65 years, and the second group consists of 38 patients aged 65 years andolder. Previously analyzed biochemical parameter values (such as lymphocyte, neutrophil, hemoglobin, platelet, CRP, LDH, AST, ALT, D-dimer, BUN, creatinine) of all patients followed up in our hospital were reached retrospectively through the hospital database. Results: There was a strong negative correlation between Alb and CRP, D-Dimer and albumin, neutrophil and albumin in patients under 65 years of age. A positive correlation was observed between other parameters. Negative moderate correlations were found between albumin and CRP, Potassiumand age, WBC and albumin, hemoglobin and creatinine, hemoglobin and LDH, platelets andhemoglobin, lymphocytes and age, lymphocytes and prothrombin time, lymphocytes andD-Dimer, neutrophils and albumin, fibrinogen and creatine kinase, erythrocyte sedimentationrate and AST, erythrocyte sedimentation rate and ALT, erythrocyte sedimentation rate andhemoglobin in patients over 65 years of age. Positive correlations were detected between otherparameters. Conclusion: ALT, creatinine, CRP, LDH, D-Dimer, WBC, neutrophil, erythrocyte sedimentation rate was significantly higher in patients over 65 years of age than in patients under 65 years of age. Platelet, lymphocytes were statistically significantly higher in patients under 65 than in patients over 65.

وصف الملف: application/pdf

العلاقة: https://www.nepjol.info/index.php/AJMS/article/view/37193/29227Test; https://www.nepjol.info/index.php/AJMS/article/view/37193Test

الإتاحة: https://www.nepjol.info/index.php/AJMS/article/view/37193Test

المؤلفون: Durmaz, Zeynep Hulya, Celep, Gokce, DUYAN ÇAMURDAN, AYSU

الوصف: Objective: The aim of this study was to determine the vitamin D status of children living in Amasya, a city in northern Turkey. Vitamin D is an essential hormone for the health of the musculoskeletal system and acts as a modulator for the immune system, a protector of the cardiovascular system and a regulator of metabolic homeostasis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_____10046::bbdef638521ceafcd2aff7f85ecb45b9Test
https://avesis.gazi.edu.tr/publication/details/01509d96-ff2b-4315-b9bf-bdbb00b51e56/oaiTest

المؤلفون: Demir, Aslihan Dilara, Durmaz, Zeynep Hulya, Demir, Orhan, Guckan, Ridvan, Kilinc, Cetin

المساهمون: Demir, Aslihan Dilara Amasya Univ, Dept Internal Med, Res Hosp, Amasya, Turkey -- Durmaz, Zeynep Hulya Amasya Univ, Dept Biochem, Res Hosp, Amasya, Turkey -- Demir, Orhan Amasya Univ, Dept Cardiol, Res Hosp, Amasya, Turkey -- Guckan, Ridvan -- Kilinc, Cetin Amasya Univ, Dept Microbiol, Res Hosp, Amasya, Turkey

مصطلحات موضوعية: Obesity, C-reactive protein (CRP), Neutrophil lymphocyte ratio (NLR)

الوصف: WOS: 000412656000027 ; Objective: Obesity is a growing problem of public health in developed and developing countries, and its prevalence is increasing in Turkey. Neutrophils play an important role in inflammation. C-Reactive Protein (CRP) is an important mediator in inflammation. In our study, we aimed to compare the changes in CRP levels and Neutrophil Lymphocyte Ratio (NLR) in obese individuals. Methods: Totally 298 individuals (251 female and 47 male) were included in the study. Patients were divided into three groups according to Body Mass Index (BMI) values. Serum neutrophil and lymphocyte levels and CRP levels were measured. Results: There is a positive correlation between Body Mass Index (BMI) and CRP. There is also a positive correlation between BMI and n/l. However, even it is too low, it can be considered as insignificant. The 4.5% of the high CRP level is attributed to an increase in BMI. Only 0.1% of the very low increase in neutrophil lymphocyte rate is attributed to an increase in the BMI. Conclusion: There is no statistical significance between neutrophil lymphocyte levels and BMI groups. In our study, the use of CRP as an indicator of inflammation in obese younger individuals is more useful than n/l ratio.

العلاقة: BIOMEDICAL RESEARCH-INDIA; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.12450/1108Test; 28; 17; 7486; 7490

الإتاحة: https://doi.org/20.500.12450/1108Test
https://hdl.handle.net/20.500.12450/1108Test

المؤلفون: Durmaz, Zeynep Hulya, Demir, Aslihan Dilara, Ozkan, Tuba, Kilinc, Cetin, Guckan, Ridvan, Tiryaki, Meral

المساهمون: Durmaz, Zeynep Hulya Amasya Univ, Dept Biochem, Res Hosp, Amasya, Turkey -- Demir, Aslihan Dilara Amasya Univ, Dept Internal Med, Res Hosp, Amasya, Turkey -- Ozkan, Tuba Amasya Univ, Dept Nutr & Dietet, Res Hosp, Amasya, Turkey -- Kilinc, Cetin -- Guckan, Ridvan Amasya Univ, Dept Microbiol, Res Hosp, Amasya, Turkey -- Tiryaki, Meral Diskapi Yildirim Beyazit Educ & Res Hosp, Dept Pathol, Ankara, Turkey

مصطلحات موضوعية: Obesity, Vitamin D, Insulin resistance, Diabetes

الوصف: WOS: 000412656000028 ; Aim: Obesity has become an important health problem in developed and developing countries. Nowadays, vitamin D deficiency is very common in obese individuals. Vitamin D deficiency and obesity are associated with cardiovascular disease, metabolic syndrome, type 2 diabetes, and other diseases. In our study, we aimed to investigate the effect of vitamin D deficiency on insulin resistance in obese subjects. Materials and methods: A total of 170 individuals, (146 females and 24 males) were included in the study. According to Body Mass Index (BMI), patients were divided into 3 groups. Serum vitamin D was compared with insulin resistance and HbA1c. Results: It was shown that serum vitamin D levels were statistically decreased according to BMI. There was also a statistically significant increase in Hba1c level due to increased BMI. There is also a positive correlation between BMI and insulin resistance. Positive correlation was found between HbA1C and insulin resistance. There was no statistically significant difference between the levels of insulin resistance among the groups of BMI. Conclusions: In conclusion, Vitamin D deficiency can be seen in obese individuals. Low serum vitamin D levels may accelerate the development of diabetes in obese individuals. Serum vitamin D levels should be measured in obese individuals and necessary treatment should be performed. This may be helpful in obesity treatment and prevention of diabetes development.

العلاقة: BIOMEDICAL RESEARCH-INDIA; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.12450/1109Test; 28; 17; 7491; 7497

الإتاحة: https://doi.org/20.500.12450/1109Test
https://hdl.handle.net/20.500.12450/1109Test

المؤلفون: Celep, Gokce¹ gokce4celep@yahoo.com, Durmaz, Zeynep Hulya²

المصدر: Annals of Medical of Research. Sep2020, Vol. 27 Issue 9, p2472-2477. 6p.

مصطلحات موضوعية: *ANEMIA diagnosis, *BLOOD cell count, *ETIOLOGY of diseases, *SOCIODEMOGRAPHIC factors, *FOLLOW-up studies (Medicine)

مستخلص: Aim: Anemia is defined as a reduction in the red blood cell mass or blood hemoglobin concentration. Complete blood count (CBC) analyses provide comprehensive information with regard to the classification of anemia. We aimed to determine the prevalence and remind the possible etiologies of anemia in our province using CBC analyses. Material and Methods: This retrospective study was conducted in a secondary healthcare center in northern Turkey. A total of 2578 healthy children enrolled. Their sociodemographic features, clinical history, and CBC results were retrospectively reviewed from the hospital records. According to CBC analyses, hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH) and red cell distribution width (RDW) levels were evaluated. Results: The prevalence of anemia in the whole study population was 27.6% (n=713). When stratified according to the age subgroups of the study, the prevalances varied between 21.3% and 41.2%. Among the anemic patients, 42.9% (n=306) had microcytic, 56.1% (n=400) had normocytic and 1% (n=7) had macrocytic anemia Conclusion: The prevalance of anemia was >20% in all the age groups, revealing that anemia is a significant public health problem in our province. Detailed analysis of the CBC provides comprehensive information regarding the classification of anemia. It saves time and money for well−child follow up by facilitating the direct application of etiologic tests. [ABSTRACT FROM AUTHOR]

المؤلفون: Celep, Gokce¹ gokce4celep@yahoo.com, Durmaz, Zeynep Hulya², Erdogan, Yalciner¹, Akpinar, Seviye¹, Kaya, Saban Abdullah³, Guckan, Rıdvan⁴

المصدر: Eurasian Journal of Medicine. Oct2019, Vol. 51 Issue 3, p252-256. 5p.

مصطلحات موضوعية: *ALLELES, *GENETIC disorders, *INFLAMMATION, *LONGITUDINAL method, *GENETIC mutation, *DESCRIPTIVE statistics, *GENOTYPES

مصطلحات جغرافية: TURKEY

مستخلص: Objective: Familial Mediterranean fever (FMF) is a common, inherited, autosomal recessive inflammatory disease in children. The diagnosis of FMF is based on clinical features and positive family history supported with genetic testing. This study aimed to determine the frequency and distribution of Mediterranean fever (MEFV) gene alterations of a city in Northern Anatolia. Materials and Methods: We evaluated MEFV gene mutations in 374 children preliminary diagnosed as FMF by a commercial kit based on real-time polymerase chain reaction technique in a one-year period, and screened 12 mutations. Results: At least one mutation was detected in 213 patients (57%) and 38 genotypes with 1 1 distinct mutations.A total of 137 (64. 3%) of mutation-positive children were heterozygous, 45 (21. 1%) were compound heterozygous, and 2 (0.9%) were complex heterozygous; and 14 (6.4%) patients were homozygous, 6 (2.8%) were compound homozygous, and 3 (1.4%) were complex homozygous. With a frequency of 50.1%, R202Q was the most common mutation. Also, R202Q/M694V was the most common compound heterozygous genotype. In 43 alleles, R202Q-M694V mutations were found to be in linkage disequilibrium. In our cohort, M694V E148Q, V726A, and M680I (G/C) were other common mutations; whereas F479L, A744S, K695R, P369S, M694I, and R76IH were the rare mutations. None of our patients had M680I (G/A) mutation. Conclusion: We determined the most common MEFV alteration prevalence in children of our region for the first time. The high R202Q mutation and linkage disequilibrium (LD) rates were the remarkable results of this study. [ABSTRACT FROM AUTHOR]