المؤلفون: Blandin, Alexia, Amosse, Jérémy, Froger, Josy, Hilairet, Gregory, Durcin, Maëva, Fizanne, Lionel, Ghesquière, Valentine, Prieur, Xavier, Chaigneau, Julien, Vergori, Luisa, Dray, Cédric, Pradère, Jean-Philippe, Blandin, Stéphanie, Dupont, Joëlle, Ducluzeau, Pierre-Henri, Dubois, Sèverine, Boursier, Jérôme, Cariou, Bertrand, Le Lay, Soazig

المساهمون: Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique EHESP (EHESP), SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques (ICAT), Université d'Angers (UA), ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Interactions Biotiques et Santé Végétale (IBSV), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS), Physiologie de la reproduction et des comportements Nouzilly (PRC), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR-22-CE18-0026,EVADIPO,Les vésicules extracellulaires enrichies en adiponectine : une thérapie anti-diabétique innnovante(2022)

المصدر: ISSN: 2211-1247.

مصطلحات موضوعية: CP: Metabolism, EVs, adipokines, adiponectin, adipose tissue, exosomes, extracellular vesicles, inflammtion, insulin resitance, obesity, type 2 diabetes, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Recent evidence supporting that adipose tissue (AT)-derived extracellular vesicles (EVs) carry an important part of the AT secretome led us to characterize the EV-adipokine profile. In addition to evidencing a high AT-derived EV secretion ability that is further increased by obesity, we identify enrichment of oligomeric forms of adiponectin in small EVs (sEVs). This adipokine is mainly distributed at the EV external surface as a result of nonspecific adsorption of soluble adiponectin. EVs also constitute stable conveyors of adiponectin in the blood circulation. Adiponectin-enriched sEVs display in vitro insulin-sensitizing effects by binding to regular adiponectin receptors. Adoptive transfer of adiponectin-enriched sEVs in high-fat-diet-fed mice prevents animals from gaining weight and ameliorated insulin resistance and tissue inflammation, with major effects observed in the AT and liver. Our results therefore provide information regarding adiponectin-related metabolic responses by highlighting EVs as delivery platforms of metabolically active forms of adiponectin molecules.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37605533; hal-04198014; https://hal.science/hal-04198014Test; https://hal.science/hal-04198014/documentTest; https://hal.science/hal-04198014/file/PIIS221112472300877X.pdfTest; PUBMED: 37605533; WOS: 001061777000001

الإتاحة: https://doi.org/10.1016/j.celrep.2023.112866Test
https://hal.science/hal-04198014Test
https://hal.science/hal-04198014/documentTest
https://hal.science/hal-04198014/file/PIIS221112472300877X.pdfTest

المؤلفون: Mlyczyńska, Ewa, Bongrani, Alice, Rame, Christelle, Węgiel, Małgorzata, Maślanka, Anna, Major, Piotr, Zarzycki, Piotr, Ducluzeau, Pierre-Henri, de Luca, Arnaud, Bourbao-Tournois, Celine, Froment, Pascal, Rak, Agnieszka, Dupont, Joelle

مصطلحات موضوعية: polycyclic aromatic hydrocarbons, naphthalene, adipose tissue, 3T3-L1 cells, adipokines

العلاقة: International Journal of Molecular Sciences, T. 24, nr 2; https://ruj.uj.edu.pl/xmlui/handle/item/306240Test; https://www.mdpi.com/1422-0067/24/2/1455Test

الإتاحة: https://doi.org/10.3390/ijms24021455Test
https://ruj.uj.edu.pl/xmlui/handle/item/306240Test
https://www.mdpi.com/1422-0067/24/2/1455Test

المؤلفون: Nabrdalik, Katarzyna, Bisson, Arnaud, Irlik, Krzysztof, Fauchier, Gregoire, Ducluzeau, Pierre Henri, Lip, Gregory Y. H., Fauchier, Laurent

المصدر: Nabrdalik , K , Bisson , A , Irlik , K , Fauchier , G , Ducluzeau , P H , Lip , G Y H & Fauchier , L 2023 , ' Metabolically 'extremely unhealthy' obese and non-obese patients with diabetes and the risk of cardiovascular events: a French nationwide cohort study ' , Clinical Research in Cardiology . https://doi.org/10.1007/s00392-023-02344-8Test

مصطلحات موضوعية: Cardiovascular events, Diabetes, Extremely unhealthy, Non-obese

الوصف: Background: Non-obese patients with diabetes mellitus (DM) are becoming more prevalent, but their cardiovascular risk (CV) especially when accompanied with cardio-renal-metabolic co-morbidities (hypertension, chronic kidney disease, hyperlipidemia) is not well characterised. The aim of the study was to assess the CV risk among patients with DM in relation to obesity and cardio-renal-metabolic co-morbidities. Materials and methods: This was a cohort study of all patients with DM without a history of major adverse cardiovascular event who were hospitalized for any reason in France in 2013 with at least 5 years of follow-up. They were categorized by the presence of obesity vs no obesity, as well as three cardio–renal–metabolic co-morbidities: hypertension, chronic kidney disease, hyperlipidemia. ‘Extremely unhealthy’ patients with DM were defined as those having all 3 co-morbidities. Results: There were 196,112 patients (mean age 65.7 (SD 13.7) years; 54.3% males) included into the analysis. During a mean follow-up of 4.69 ± 1.79 years, when adjusted for multiple covariates, the non-obese and ‘extremely unhealthy’ obese patients had the highest risk of CV death [aHR 1.40 (95% CI, 1.22–1.61) and 1.48 (95% CI, 1.25–1.75), respectively]. The ‘extremely unhealthy’ obese had the highest risk of MACE-HF [aHR 1.84 (95% CI, 1.72–1.97)] and new-onset AF [aHR 1.64 (95% CI, 1.47–1.83)]. Conclusion: Both non-obese and obese patients with DM with associated cardio-renal-metabolic co-morbidities are an ‘extremely unhealthy’ phenotype with the highest risk of CV death and CV events. Graphical abstract: [Figure not available: see fulltext.].

العلاقة: https://vbn.aau.dk/da/publications/c517774c-da88-4acc-9a52-3ad99cfe5336Test

الإتاحة: https://doi.org/10.1007/s00392-023-02344-8Test
https://vbn.aau.dk/da/publications/c517774c-da88-4acc-9a52-3ad99cfe5336Test
http://www.scopus.com/inward/record.url?scp=85178451632&partnerID=8YFLogxKTest

المؤلفون: Vanhoye, Xavier, Bardel, Claire, Rimbert, Antoine, Moulin, Philippe, Rollat-Farnier, Pierre-Antoine, Muntaner, Manon, Marmontel, Oriane, Dumont, Sabrina, Charrière, Sybil, Cornélis, François, Ducluzeau, Pierre Henri, Fonteille, Annie, Nobecourt, Estelle, Peretti, Noël, Schillo, Franck, Wargny, Matthieu, Cariou, Bertrand, Meirhaeghe, Aline, Di Filippo, Mathilde

المساهمون: Pfizer, Agence Nationale de la Recherche

المصدر: Translational Research ; volume 255, page 119-127 ; ISSN 1931-5244

مصطلحات موضوعية: Biochemistry (medical), Public Health, Environmental and Occupational Health, General Medicine, Physiology (medical)

الإتاحة: https://doi.org/10.1016/j.trsl.2022.12.002Test
https://api.elsevier.com/content/article/PII:S193152442200281X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S193152442200281X?httpAccept=text/plainTest

المؤلفون: Ducluzeau, Pierre Henri, Fauchier, Grégoire, Herbert, Julien, Semaan, Carl, Halimi, Jean Michel, Angoulvant, Denis, Fauchier, Laurent

المصدر: Diabetes & Metabolism ; volume 49, issue 3, page 101429 ; ISSN 1262-3636

مصطلحات موضوعية: Endocrinology, General Medicine, Endocrinology, Diabetes and Metabolism, Internal Medicine

الإتاحة: https://doi.org/10.1016/j.diabet.2023.101429Test
https://api.elsevier.com/content/article/PII:S1262363623000113?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1262363623000113?httpAccept=text/plainTest

المؤلفون: Maisons, Valentin, Halimi, Jean-Michel, Fauchier, Grégoire, de Fréminville, Jean-Baptiste, Goin, Nicolas, Gueguen, Juliette, Gatault, Philippe, Sautenet, Bénédicte, Angoulvant, Denis, Herbert, Julien, Bisson, Arnaud, Ducluzeau, Pierre-Henri, Fauchier, Laurent

المصدر: Diabetes & Metabolism ; volume 49, issue 3, page 101441 ; ISSN 1262-3636

مصطلحات موضوعية: Endocrinology, General Medicine, Endocrinology, Diabetes and Metabolism, Internal Medicine

الإتاحة: https://doi.org/10.1016/j.diabet.2023.101441Test
https://api.elsevier.com/content/article/PII:S126236362300023X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S126236362300023X?httpAccept=text/plainTest

المؤلفون: Peretti, Noel, Vimont, Alexandre, Mas, Emmanuel, Ferrières, Jean, Tounian, Patrick, Lemale, Julie, Boccara, Franck, Di Filippo, Mathilde, Charriere, Sybil, Moulin, Philippe, Poinsot, Pierre, Cottin, Yves, Ducluzeau, Pierre-Henri, Dourmap, Caroline, Cariou, Bertrand, Farnier, Michel, Paillard, François, Pradignac, Alain, Yelnik, Cécile, Gallo, Antonio, Bruckert, Eric, Beliard, Sophie

المصدر: The Journal of Pediatrics ; volume 253, page 18-24.e2 ; ISSN 0022-3476

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1016/j.jpeds.2022.08.041Test
https://api.elsevier.com/content/article/PII:S0022347622007776?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022347622007776?httpAccept=text/plainTest

المؤلفون: Bourdon, Guillaume, Estienne, Anthony, Chevaleyre, Claire, Ramé, Christelle, Guerif, Fabrice, Brun, Jean Sebastien, Vasseur, Claudine, Fromont, Gaëlle, Plotton, Ingrid, Dufour-Rainfray, Diane, Caldas-Silveira, Erika, Dupont, Joëlle, Froment, Pascal, Ducluzeau, Pierre-Henri

المساهمون: Physiologie de la reproduction et des comportements Nouzilly (PRC), Institut Français du Cheval et de l'Equitation Saumur (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Pôle Santé Léonard de Vinci Chambray-lès-Tours (PSLV / Clinique), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon

المصدر: ISSN: 1664-2392 ; Frontiers in Endocrinology ; https://hal.inrae.fr/hal-03742076Test ; Frontiers in Endocrinology, 2022, 13, pp.1-13. ⟨10.3389/fendo.2022.775650⟩.

مصطلحات موضوعية: human, spermatozoa, FGF21 (fibroblast growth factor 21), sperm moTility, metabolism diseases, fertility, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology

الوصف: International audience ; Lifestyle, environment and excess body weight are not only associated with an increased risk of metabolic disorders, such as type 2 diabetes, but also to other pathological processes, such as infertility. A hormone produced mainly by the liver called fibroblast growth factor 21 (FGF21) is closely linked to the energy status and is increased in patients suffering from obesity or insulin resistance. Recently, FGF21 has been shown to be associated with female fertility disorders, but no or few data about the role of FGF21 on human male fertility has been described. In the present study, FGF21 was measured in the seminal fluid at a lower level in comparison to the blood level. Thus, in the present in vitro study, we aimed to decipher the FGF21 system in human semen. To evaluate the putative role of FGF21 on spermatozoa function, we incubated human spermatozoa with increasing concentrations of recombinant human FGF21. The FGF21 in seminal fluid is potentially produced by male reproductive tract tissues. In spermatozoa, the FGF21 signal was transduced by the two main receptors FGFR1-c and FGFR3 and the cofactor beta-klotho, which are colocalized in the middle piece of spermatozoa and stimulated the PI3K/Akt and MAPK pathways. Finally, in vitro treatment by FGF21 significantly increased sperm motility and ATP levels. Concomitantly, exposure to FGF21 improved the oxidative stress, as a lower ROS level was observed. Overall, these results seem to indicate that the metabolic factor, FGF21, positively modifies the activity and quality of the parameters of human spermatozoa.

العلاقة: hal-03742076; https://hal.inrae.fr/hal-03742076Test; https://hal.inrae.fr/hal-03742076/documentTest; https://hal.inrae.fr/hal-03742076/file/BourdonG_FrontiersEndocrin_2022.pdfTest; WOS: 000766902400001

الإتاحة: https://doi.org/10.3389/fendo.2022.775650Test
https://hal.inrae.fr/hal-03742076Test
https://hal.inrae.fr/hal-03742076/documentTest
https://hal.inrae.fr/hal-03742076/file/BourdonG_FrontiersEndocrin_2022.pdfTest

المؤلفون: Gouet, Didier, Ducluzeau, Pierre Henri, Andriantaolo, Harivola, Cordroc'h, Claire, Duengler, Frédérique, Gaulier, Sophie, Godeau, Thierry, Olivier, Céline, Allix-Beguec, Caroline

المصدر: Diabetes Epidemiology and Management ; volume 8, page 100110 ; ISSN 2666-9706

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, Internal Medicine

الإتاحة: https://doi.org/10.1016/j.deman.2022.100110Test
https://api.elsevier.com/content/article/PII:S2666970622000609?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666970622000609?httpAccept=text/plainTest

المؤلفون: Bourdon, Guillaume, Froment, Pascal, Ducluzeau, Pierre-Henri

المساهمون: Physiologie de la reproduction et des comportements Nouzilly (PRC), Institut Français du Cheval et de l'Equitation Saumur (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)

المصدر: ISSN: 0767-0974.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

الوصف: International audience ; Obesity or insulin resistance are the major non-infectious diseases that continue to progress worldwide. They promote diabetes and cardiovascular diseases, but also lead to a decrease in fertility in both sexes. FGF21, discovered in the 2000s, is a hormone closely linked to the energy status and has the ability to decrease insulin resistance. Its action through the FGFR1c, 3c & 4 receptors modulates tissues involved in energy-related metabolism but also the brain and the gonads. Recent data favor a role of FGF21 in female and male fertility, but raise the question about the role of FGF21 on reproductive function. In this review, we have scanned the different FGF21 actions on the reproductive axis, suggesting a potential therapeutic role in case of infertility. ; L’obésité et l’insulinorésistance sont les principales maladies non infectieuses qui progressent le plus dans le monde. Elles favorisent l’hypertension, les maladies cardio-vasculaires, mais conduisent aussi à une chute de la fertilité dans les deux sexes. Le FGF21, découvert dans les années 2000, est lié au statut énergétique de l’organisme et améliore l’insulinorésistance. Via ses récepteurs (FGFR1c, 3c,et 4), il agit sur le foie et au niveau d'organes régulant le métabolisme glucido-lipidique, mais aussi sur le cerveau et les gonades. Des données récentes sont ainsi en faveur d’un rôle régulateur de FGF21 sur la fertilité, tant féminine que masculine. Mais quel rôle FGF21 peut-il jouer dans la reproduction ? Dans cette revue, nous avons examiné les différentes activités que présente cette hormone sur la reproduction, ouvrant la voie à une éventuelle utilisation thérapeutique en cas d’infertilité.

العلاقة: hal-03175325; https://hal.science/hal-03175325Test; https://hal.science/hal-03175325/documentTest; https://hal.science/hal-03175325/file/msc200237.pdfTest; WOS: 000630588200012

الإتاحة: https://doi.org/10.1051/medsci/2021012Test
https://hal.science/hal-03175325Test
https://hal.science/hal-03175325/documentTest
https://hal.science/hal-03175325/file/msc200237.pdfTest