المؤلفون: Slagboom, Tessa N. A., van Bunderen, Christa C., van der Lely, Aart Jan, Drent, Madeleine L.

المصدر: Slagboom , T N A , van Bunderen , C C , van der Lely , A J & Drent , M L 2023 , ' Sex Differences in Long-Term Safety and Tolerability of GH Replacement Therapy in GH Deficient Adults ' , The Journal of clinical endocrinology and metabolism , vol. 108 , no. 7 , pp. e415-e424 . https://doi.org/10.1210/clinem/dgad013Test

الوصف: CONTEXT: Previous studies report that outcomes of growth hormone (GH) replacement therapy (GHRT) might be less beneficial in growth hormone deficient (GHD) women compared with men. OBJECTIVE: This study investigated possible contributing factors regarding this previously found sex difference. METHODS: This retrospective cohort study, conducted at a nationwide outpatient clinic (the Dutch National Registry of GH Treatment in Adults), included Dutch adult GHD men (n = 1335) and women (n = 1251) treated with GHRT. The patients' baseline characteristics, details of GHRT, and the tolerability and long-term safety of GHRT were measured. RESULTS: During treatment, sensitivity analysis showed that insulin-like growth factor-1 (IGF-1) SD scores remained subnormal more often in women (P < 0.001), while scores above normal were more frequent in men (P < 0.001). Women reported more adverse events (P < 0.001), especially symptoms related to fluid retention, and more often needed a dose reduction or temporary stop of GHRT (P = 0.001). In percentages, both sexes equally discontinued GHRT, as was also true for the risk in developing type 2 diabetes mellitus, benign neoplasms, and tumor recurrence. The risk of developing malignant neoplasms was higher in men (P = 0.012). CONCLUSION: Data obtained from the Dutch National Registry of GH Treatment in Adults indicate that GHD women might be treated suboptimally, reflected as lower IGF-1 status and lower GHRT tolerability, leading to more frequent changes in treatment regimen but not discontinuation of GHRT. Regarding long-term safety, we found a higher risk for development of malignancies in GHD men.

العلاقة: https://research.vumc.nl/en/publications/3b75d5fa-5b2c-4806-89d9-3ae18f3c8261Test

الإتاحة: https://doi.org/10.1210/clinem/dgad013Test
https://research.vumc.nl/en/publications/3b75d5fa-5b2c-4806-89d9-3ae18f3c8261Test
http://www.scopus.com/inward/record.url?scp=85163914053&partnerID=8YFLogxKTest

المؤلفون: Slagboom, Tessa N. A., Stenvers, Dirk Jan, van de Giessen, Elsmarieke, Roosendaal, Stefan D., de Win, Maartje M. L., Bot, Joseph C. J., Aronica, Eleonora, Post, René, Hoogmoed, Jantien, Drent, Madeleine L., Pereira, Alberto M.

المصدر: Slagboom , T N A , Stenvers , D J , van de Giessen , E , Roosendaal , S D , de Win , M M L , Bot , J C J , Aronica , E , Post , R , Hoogmoed , J , Drent , M L & Pereira , A M 2023 , ' Continuing Challenges in the Definitive Diagnosis of Cushing’s Disease : A Structured Review Focusing on Molecular Imaging and a Proposal for Diagnostic Work-Up ' , Clinical Chemistry , vol. 12 , no. 8 , 2919 . https://doi.org/10.3390/jcm12082919Test

الوصف: The definitive diagnosis of Cushing’s disease (CD) in the presence of pituitary microadenoma remains a continuous challenge. Novel available pituitary imaging techniques are emerging. This study aimed to provide a structured analysis of the diagnostic accuracy as well as the clinical use of molecular imaging in patients with ACTH-dependent Cushing’s syndrome (CS). We also discuss the role of multidisciplinary counseling in decision making. Additionally, we propose a complementary diagnostic algorithm for both de novo and recurrent or persistent CD. A structured literature search was conducted and two illustrative CD cases discussed at our Pituitary Center are presented. A total of 14 CD (n = 201) and 30 ectopic CS (n = 301) articles were included. MRI was negative or inconclusive in a quarter of CD patients. 11C-Met showed higher pituitary adenoma detection than 18F-FDG PET–CT (87% versus 49%). Up to 100% detection rates were found for 18F-FET, 68Ga-DOTA-TATE, and 68Ga-DOTA-CRH, but were based on single studies. The use of molecular imaging modalities in the detection of pituitary microadenoma in ACTH-dependent CS is of added and complementary value, serving as one of the available tools in the diagnostic work-up. In selected CD cases, it seems justified to even refrain from IPSS.

العلاقة: https://research.vumc.nl/en/publications/98d88637-5255-400f-a6a2-6bc2d0ce17beTest

الإتاحة: https://doi.org/10.3390/jcm12082919Test
https://research.vumc.nl/en/publications/98d88637-5255-400f-a6a2-6bc2d0ce17beTest
http://www.scopus.com/inward/record.url?scp=85154574322&partnerID=8YFLogxKTest

المؤلفون: Galle, Sara A., Deijen, Jan Berend, Milders, Maarten V., de Greef, Mathieu H. G., Scherder, Erik J. A., van Duijn, Cornelia M., Drent, Madeleine L.

المصدر: Galle , S A , Deijen , J B , Milders , M V , de Greef , M H G , Scherder , E J A , van Duijn , C M & Drent , M L 2023 , ' The effects of a moderate physical activity intervention on physical fitness and cognition in healthy elderly with low levels of physical activity : a randomized controlled trial ' , Alzheimer's Research and Therapy , vol. 15 , no. 1 , 12 . https://doi.org/10.1186/s13195-022-01123-3Test

الوصف: Background: Increasing physical activity is one of the most promising and challenging interventions to delay or prevent cognitive decline and dementia. Methods: We conducted a randomized controlled trial to assess the effects of a physical activity intervention, aimed at increasing step count, in elderly with low levels of physical activity on measures of strength, balance, aerobic capacity, and cognition. Participants were assigned to 9 months of exercise counseling or active control. Results: The intention-to-treat analyses show that the intervention, compared to control, increases the level of physical activity, but has no significant effect on physical fitness and cognition. Those who increased their physical activity with 35% or more show significant improvements in aerobic capacity, gait speed, verbal memory, executive functioning, and global cognition, compared to those who did not achieve a 35% increase. Limitations: The number of participants that achieved the intended improvement was lower than expected. Conclusion: Responder analyses suggest an improvement of physical fitness and cognition in those who achieved an increase in physical activity of at least 35%. Trial registration: The trial protocol is registered at the Dutch Trial Register NL5675, August 1, 2016.

العلاقة: https://research.vumc.nl/en/publications/cfc29c01-7dcd-49d6-840b-a4112247d9ecTest

الإتاحة: https://doi.org/10.1186/s13195-022-01123-3Test
https://research.vumc.nl/en/publications/cfc29c01-7dcd-49d6-840b-a4112247d9ecTest
http://www.scopus.com/inward/record.url?scp=85146140720&partnerID=8YFLogxKTest

المؤلفون: Galle, Sara A., Liu, Jun, Bonnechere, Bruno, Amin, Najaf, Milders, Maarten M., Deijen, Jan Berend, Scherder, Erik J. A., Drent, Madeleine L., Voortman, Trudy, Ikram, M. Arfan, van Duijn, Cornelia M.

المصدر: Galle , S A , Liu , J , Bonnechere , B , Amin , N , Milders , M M , Deijen , J B , Scherder , E J A , Drent , M L , Voortman , T , Ikram , M A & van Duijn , C M 2023 , ' The long-term relation between physical activity and executive function in the Rotterdam Study ' , European Journal of Epidemiology , vol. 38 , no. 1 , pp. 71-81 . https://doi.org/10.1007/s10654-022-00902-4Test

الوصف: Background: Research on the association between physical inactivity and cognitive decline and dementia is dominated by studies with short-term follow-up, that might be biased by reverse causality. Objective: Investigate the long-term association between physical activity, cognition, and the rate of age-associated cognitive decline. Methods: We investigated the association between late-life physical activity and executive functioning and rate of decline of executive abilities during follow-up of up to 16 years, in 3553 participants of the prospective Rotterdam Study cohort. Measurement took place in 1997–1999, 2002–2004, 2009–2011, and 2014–2015. Results: At baseline (age ± 72 years), higher levels of physical activity were associated with higher levels of executive functioning (adjusted mean difference = 0.03, 95% CI: 0.00 ; 0.06, p = 0.03). This difference remained intact up to 16 years of follow-up. The level of physical activity at baseline was unrelated to the rate of decline of executive abilities over time, in the whole group (adjusted mean difference in change time*physical activity = 0.00, 95% CI: -0.00 ; 0.01, p = 0.31). However, stratification by APOE genotype showed that the accelerated decline of executive abilities observed in those with the ApoE-ε4 allele might be attenuated by higher levels of physical activity in late adulthood (ApoE-ε4 carriers: B time*physical activity = 0.01, 95% CI: 0.00 ; 0.01, p = 0.03). Conclusion: Higher levels of physical activity in late adulthood are related to higher levels of executive functioning, up to 16 years of follow-up. Accelerated decline of executive abilities observed in those with the ApoE-ε4 allele might be mitigated by higher levels of physical activity.

العلاقة: https://pure.eur.nl/en/publications/4a8b9ee4-9cd9-4e80-81d9-99fed0e0775dTest

الإتاحة: https://doi.org/10.1007/s10654-022-00902-4Test
https://pure.eur.nl/en/publications/4a8b9ee4-9cd9-4e80-81d9-99fed0e0775dTest
http://www.scopus.com/inward/record.url?scp=85138855301&partnerID=8YFLogxKTest
https://researchinformation.amsterdamumc.org/en/publications/the-long-term-relation-between-physical-activity-and-executive-fu-2Test

المؤلفون: Slagboom, Tessa N. A., van Bunderen, Christa C., De Vries, Ralph, Bisschop, Peter H., Drent, Madeleine L.

المساهمون: Pfizer Pharmaceuticals

المصدر: Pituitary ; volume 26, issue 4, page 319-332 ; ISSN 1386-341X 1573-7403

مصطلحات موضوعية: Endocrinology, Endocrinology, Diabetes and Metabolism

الوصف: Objective Diagnostic delay is high in acromegaly and leads to increased morbidity and mortality. The aim of this study is to systematically assess the most prevalent clinical signs, symptoms and comorbidities of acromegaly at time of diagnosis. Design A literature search (in PubMed, Embase and Web of Science) was performed on November 18, 2021, in collaboration with a medical information specialist. Methods Prevalence data on (presenting) clinical signs, symptoms and comorbidities at time of diagnosis were extracted and synthesized as weighted mean prevalence. The risk of bias was assessed for each included study using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data. Results Risk of bias and heterogeneity was high in the 124 included articles. Clinical signs and symptoms with the highest weighted mean prevalence were: acral enlargement (90%), facial features (65%), oral changes (62%), headache (59%), fatigue/tiredness (53%; including daytime sleepiness: 48%), hyperhidrosis (47%), snoring (46%), skin changes (including oily skin: 37% and thicker skin: 35%), weight gain (36%) and arthralgia (34%). Concerning comorbidities, acromegaly patients more frequently had hypertension, left ventricle hypertrophy, dia/systolic dysfunction, cardiac arrhythmias, (pre)diabetes, dyslipidemia and intestinal polyps- and malignancy than age- and sex matched controls. Noteworthy, cardiovascular comorbidity was lower in more recent studies. Features that most often led to diagnosis of acromegaly were typical physical changes (acral enlargement, facial changes and prognatism), local tumor effects (headache and visual defect), diabetes, thyroid cancer and menstrual disorders. Conclusion Acromegaly manifests itself with typical physical changes but also leads to a wide variety of common comorbidities, emphasizing that recognition of a combination of these features is key to establishing the diagnosis.

الإتاحة: https://doi.org/10.1007/s11102-023-01322-7Test

المؤلفون: Slagboom, Tessa N A, Lely, Aart Jan van der, Drent, Madeleine L, Bunderen, Christa C van

المصدر: European Journal of Endocrinology; Jun2024, Vol. 190 Issue 6, p434-445, 12p

مصطلحات موضوعية: SOMATOTROPIN, HORMONE therapy, CARDIOVASCULAR diseases risk factors, ADULTS, WAIST-hip ratio, CEREBROVASCULAR disease, PITUITARY dwarfism

مستخلص: Objective Given the previously identified sex differences in cardiovascular (CV) morbidity and mortality in patients with growth hormone deficiency (GHD) receiving GH replacement therapy (GHRT), our aim is to investigate sex-specific differences in the efficacy of (long-term) GHRT on CV risk profile and disease in subjects with GHD. Our hypothesis is that women will experience less beneficial effects than men. Design Retrospective nationwide cohort study. Methods We compared all men (n = 1335) and women (n = 1251) with severe GHD registered in the Dutch National Registry of GH Treatment in Adults database with respect to CV risk profile and morbidity at baseline and during follow-up. Results Men had a more unfavourable CV risk profile at baseline. During the first years of GHRT, the reduction in waist circumference, waist-to-hip ratio, total cholesterol, and triglyceride levels was greater in men than in women (all P <.05). Between-sex differences in effects during later follow-up were less clear. No sex differences were found in the risk of developing non-fatal cardiovascular or cerebrovascular diseases during GHRT. Conclusions Our results suggest that men with GHD did indeed experience more beneficial effects of GHRT on body composition and lipoprotein metabolism than women, at least in the early years of treatment. Also, the more unfavourable CV risk profile at baseline in men did not translate into a sex difference in the risk of developing CV and cerebrovascular morbidity during GHRT. [ABSTRACT FROM AUTHOR]

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المؤلفون: Slagboom, Tessa N.A., Van Der Lely, Aart Jan, Drent, Madeleine L., Van Bunderen, Christa C.

المصدر: Slagboom , T N A , Van Der Lely , A J , Drent , M L & Van Bunderen , C C 2024 , ' Exploring the sex difference in cardiovascular risk during growth hormone therapy in adults ' , European Journal of Endocrinology , vol. 190 , no. 6 , pp. 434-445 . https://doi.org/10.1093/ejendo/lvae060Test

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الوصف: Objective: Given the previously identified sex differences in cardiovascular (CV) morbidity and mortality in patients with growth hormone deficiency (GHD) receiving GH replacement therapy (GHRT), our aim is to investigate sex-specific differences in the efficacy of (long-term) GHRT on CV risk profile and disease in subjects with GHD. Our hypothesis is that women will experience less beneficial effects than men. Design: Retrospective nationwide cohort study. Methods: We compared all men (n = 1335) and women (n = 1251) with severe GHD registered in the Dutch National Registry of GH Treatment in Adults database with respect to CV risk profile and morbidity at baseline and during follow-up. Results: Men had a more unfavourable CV risk profile at baseline. During the first years of GHRT, the reduction in waist circumference, waist-to-hip ratio, total cholesterol, and triglyceride levels was greater in men than in women (all P <. 05). Between-sex differences in effects during later follow-up were less clear. No sex differences were found in the risk of developing non-fatal cardiovascular or cerebrovascular diseases during GHRT. Conclusions: Our results suggest that men with GHD did indeed experience more beneficial effects of GHRT on body composition and lipoprotein metabolism than women, at least in the early years of treatment. Also, the more unfavourable CV risk profile at baseline in men did not translate into a sex difference in the risk of developing CV and cerebrovascular morbidity during GHRT.

العلاقة: https://pure.eur.nl/en/publications/59251e92-653c-43da-8d69-aabe1770210fTest

الإتاحة: https://doi.org/10.1093/ejendo/lvae060Test
https://pure.eur.nl/en/publications/59251e92-653c-43da-8d69-aabe1770210fTest
http://www.scopus.com/inward/record.url?scp=85195329419&partnerID=8YFLogxKTest

المؤلفون: van Beek, Dirk-Jan, Pieterman, Carolina R. C., Wessels, Frank J., van de Ven, Annenienke C., de Herder, Wouter W., Dekkers, Olaf M., Zandee, Wouter T., Drent, Madeleine L., Bisschop, Peter H., Havekes, Bas, Borel Rinkes, Inne H. M., Vriens, Menno R., Valk, Gerlof D.

المصدر: van Beek , D-J , Pieterman , C R C , Wessels , F J , van de Ven , A C , de Herder , W W , Dekkers , O M , Zandee , W T , Drent , M L , Bisschop , P H , Havekes , B , Borel Rinkes , I H M , Vriens , M R & Valk , G D 2022 , ' Diagnosing pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 in daily practice ' , Frontiers in Endocrinology , vol. 13 , 926491 . https://doi.org/10.3389/fendo.2022.926491Test

الوصف: Background: In multiple endocrine neoplasia type 1 (MEN1), pancreatic neuroendocrine tumors (PanNETs) have a high prevalence and represent the main cause of death. This study aimed to assess the diagnostic accuracy of the currently used conventional pancreatic imaging techniques and the added value of fine needle aspirations (FNAs). Methods: Patients who had at least one imaging study were included from the population-based MEN1 database of the DutchMEN Study Group from 1990 to 2017. Magnetic resonance imaging (MRI), computed tomography (CT), endoscopic ultrasonography (EUS), FNA, and surgical resection specimens were obtained. The first MRI, CT, or EUS was considered as the index test. For a comparison of the diagnostic accuracy of MRI versus CT, patients with their index test taken between 2010 and 2017 were included. The reference standard consisted of surgical histopathology or radiological follow-up. Results: A total of 413 patients (92.8% of the database) underwent 3,477 imaging studies. The number of imaging studies per patient increased, and a preference for MRI was observed in the last decade. Overall diagnostic accuracy was good with a positive (PPV) and negative predictive value (NPV) of 88.9% (95% confidence interval, 76.0–95.6) and 92.8% (89.4–95.1), respectively, for PanNET in the pancreatic head and 92.0% (85.3–96.0) and 85.3% (80.5–89.1), respectively, in the body/tail. For MRI, PPV and NPV for pancreatic head tumors were 100% (76.1–100) and 87.1% (76.3–93.6) and for CT, 60.0% (22.9–88.4) and 70.4% (51.3–84.3), respectively. For body/tail tumors, PPV and NPV were 91.3% (72.0–98.8) and 87.0% (75.3–93.9), respectively, for MRI and 100% (74.9–100) and 77.8% (54.3–91.5), respectively, for CT. Pathology confirmed a PanNET in 106 out of 110 (96.4%) resection specimens. FNA was performed on 34 lesions in 33 patients and was considered PanNET in 24 [all confirmed PanNET by histology (10) or follow-up (14)], normal/cyst/unrepresentative in 6 (all confirmed PanNET by follow-up), and adenocarcinoma in 4 (2 ...

العلاقة: https://research.vumc.nl/en/publications/0481e5ac-4d6e-41e7-b12d-5734fae247eaTest

الإتاحة: https://doi.org/10.3389/fendo.2022.926491Test
https://research.vumc.nl/en/publications/0481e5ac-4d6e-41e7-b12d-5734fae247eaTest
http://www.scopus.com/inward/record.url?scp=85140310846&partnerID=8YFLogxKTest

المؤلفون: van Andel, Merel, van Schoor, Natasja M., Korten, Nicole C., Heijboer, Annemieke C., Drent, Madeleine L.

المصدر: van Andel , M , van Schoor , N M , Korten , N C , Heijboer , A C & Drent , M L 2022 , ' Ghrelin, leptin and high-molecular-weight adiponectin in relation to depressive symptoms in older adults : Results from the Longitudinal Aging Study Amsterdam ' , Journal of Affective Disorders , vol. 296 , pp. 103-110 . https://doi.org/10.1016/j.jad.2021.09.069Test

الوصف: Background: Ghrelin, leptin and high-molecular-weight (HMW) adiponectin have been linked to depression in middle-aged adults. Pathophysiological mechanisms of depression change as age progresses and it is unclear whether the same associations exist in older adults. Methods: We analyzed the associations between ghrelin, leptin and HMW adiponectin and depressive symptoms (Center for Epidemiologic Studies Depression (CES-D) score ≥ 16) in a community-dwelling cohort of 898 participants in a multivariable logistic regression analysis at baseline and after three years of follow-up, were applicable stratified by sex, age and waist-hip-ratio (WHR). Results: At baseline no significant associations were found. After three years of follow-up ghrelin was associated with higher odds for depressive symptoms (fully adjusted continuous analysis OR 2.27, 95% CI 1.42 – 3.61). There was effect modification for age and WHR, with significant associations in participants younger than 69.7 years (median) and with a WHR below 0.9554 (mean). In the sex-stratified analysis for leptin we found significant associations in men (fully adjusted continuous analysis OR 1.07, 95% CI 1.02 – 1.12). For HMW adiponectin there were no significant associations in the multivariable analysis. Limitations: As our cohort consisted of relatively healthy participants with intact cognitive function, selection bias may have contributed to lack of significant baseline associations. Conclusions: Our results show significant associations between ghrelin and – for men only - leptin and depressive symptoms after three years of follow up. This may provide a new therapeutic window for treatment of depressive symptoms in older adults, as both ghrelin and leptin are positively influenced by weight loss.

العلاقة: https://research.vumc.nl/en/publications/ae4d93d5-b916-4605-896f-6a4a7707008dTest

الإتاحة: https://doi.org/10.1016/j.jad.2021.09.069Test
https://research.vumc.nl/en/publications/ae4d93d5-b916-4605-896f-6a4a7707008dTest
http://www.scopus.com/inward/record.url?scp=85115955728&partnerID=8YFLogxKTest

المؤلفون: Boertien, Tessel M., Van Someren, Eus J.W., Coumou, Adriaan D., van den Broek, Annemieke K., Klunder, Jet H., Wong, Wing Yi, van der Hoeven, Adrienne E., Drent, Madeleine L., Romijn, Johannes A., Fliers, Eric, Bisschop, Peter H.

المصدر: Boertien , T M , Van Someren , E J W , Coumou , A D , van den Broek , A K , Klunder , J H , Wong , W Y , van der Hoeven , A E , Drent , M L , Romijn , J A , Fliers , E & Bisschop , P H 2022 , ' Compression of the optic chiasm is associated with reduced photoentrainment of the central biological clock ' , European Journal of Endocrinology , vol. 187 , no. 6 , pp. 809-821 . https://doi.org/10.1530/EJE-22-0527Test

الوصف: Objective: Pituitary tumours that compress the optic chiasm are associated with long-term alterations in sleep-wake rhythm. This may result from damage to intrinsically photosensitive retinal ganglion cells (ipRGCs) projecting from the retina to the hypothalamic suprachiasmatic nucleus via the optic chiasm to ensure photoentrainment (i.e. synchronisation to the 24-h solar cycle through light). To test this hypothesis, we compared the post-illumination pupil response (PIPR), a direct indicator of ipRGC function, between hypopituitarism patients with and without a history of optic chiasm compression. Design: Observational study, comparing two predefined groups. Methods: We studied 49 patients with adequately substituted hypopituitarism: 25 patients with previous optic chiasm compression causing visual disturbances (CC+ group) and 24 patients without (CC- group). The PIPR was assessed by chromatic pupillometry and expressed as the relative change between baseline and post-blue-light stimulus pupil diameter. Objective and subjective sleep parameters were obtained using polysomnography, actigraphy, and questionnaires. Results: Post-blue-light stimulus pupillary constriction was less sustained in CC+ patients compared with CC- patients, resulting in a significantly smaller extended PIPR (mean difference: 8.1%, 95% CI: 2.2-13.9%, P = 0.008, Cohen's d = 0.78). Sleep-wake timing was consistently later in CC+ patients, without differences in sleep duration, efficiency, or other rest-activity rhythm features. Subjective sleep did not differ between groups. Conclusion: Previous optic chiasm compression due to a pituitary tumour in patients with hypopituitarism is associated with an attenuated PIPR and delayed sleep timing. Together, these data suggest that ipRGC function and consequently photoentrainment of the central biological clock is impaired in patients with a history of optic chiasm compression.

وصف الملف: application/pdf

العلاقة: https://research.vu.nl/en/publications/84642ca9-cd2b-4159-8243-02e02abcb6daTest

الإتاحة: https://doi.org/10.1530/EJE-22-0527Test
https://research.vu.nl/en/publications/84642ca9-cd2b-4159-8243-02e02abcb6daTest
https://hdl.handle.net/1871.1/84642ca9-cd2b-4159-8243-02e02abcb6daTest
https://research.vu.nl/ws/files/213755203/Compression_of_the_optic_chiasm_is_associated_with_reduced_photoentrainment_of_the_central_biological_clock.pdfTest
http://www.scopus.com/inward/record.url?scp=85141890662&partnerID=8YFLogxKTest
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