المؤلفون: Cirovic, Aleksandar, Schmidt, Felix N, Vujacic, Marko, Sihota, Praveer, Petrovic, Bojan, Zivkovic, Vladimir, Bascarevic, Zoran, Nikolic, Slobodan, Djonic, Danijela, Djuric, Marija, Busse, Björn, Milovanovic, Petar

المساهمون: Science Fund of the Republic of Serbia, BoFraM, DiaBoNet, Ministry of Science of the Republic of Serbia, Alexander von Humboldt Foundation, German Research Foundation, DFG

المصدر: JBMR Plus ; volume 8, issue 3 ; ISSN 2473-4039

الوصف: There is still limited understanding of the microstructural reasons for the higher susceptibility to fractures in individuals with type 2 diabetes mellitus (T2DM). In this study, we examined bone mineralization, osteocyte lacunar parameters, and microhardness of the femoral neck trabeculae in 18 individuals with T2DM who sustained low-energy fracture (T2DMFx: 78 ± 7 years, 15 women and 3 men) and 20 controls (74 ± 7 years, 16 women and 4 men). Femoral necks of the T2DMFx subjects were obtained at a tertiary orthopedic hospital, while those of the controls were collected at autopsy. T2DMFx individuals had lower trabecular microhardness (P = .023) and mineralization heterogeneity (P = .001), and a tendency to a lower bone area with mineralization above 95th percentile (P = .058) than the controls. There were no significant intergroup differences in the numbers of osteocyte lacunae per bone area, mineralized lacunae per bone area, and total lacunae per bone area (each P > .05). After dividing the T2DMFx group based on the presence of vascular complications (VD) to T2DMFxVD (VD present) and T2DMFxNVD (VD absent), we observed that microhardness was particularly reduced in the T2DMFxVD group (vs. control group, P = .02), while mineralization heterogeneity was significantly reduced in both T2DMFx subgroups (T2DMFxNVD vs. control, P = .002; T2DMFxVD vs. control, P = .038). The observed changes in mineralization and microhardness may contribute to the increased hip fracture susceptibility in individuals with T2DM.

الإتاحة: https://doi.org/10.1093/jbmrpl/ziae005Test
https://academic.oup.com/jbmrplus/article-pdf/8/3/ziae005/57408557/ziae005.pdfTest

المؤلفون: Cirovic, Aleksandar V, Cirovic, Ana V, Vujacic, Marko D, Djonic, Danijela D, Djuric, Marija P, Milovanovic, Petar D

المصدر: Arch Orthop Trauma Surg ; ISSN:1434-3916 ; Volume:144 ; Issue:6

مصطلحات موضوعية: Cortical porosity, Cortical thickness, Distal clavicle, Placement, Screws

الوصف: Cortical thickness and porosity are two main determinants of cortical bone strength. Thus, mapping variations in these parameters across the full width of the distal end of the clavicle may be helpful for better understanding the basis of distal clavicle fractures and for selecting optimal surgical treatment.

العلاقة: https://doi.org/10.1007/s00402-024-05345-yTest; https://pubmed.ncbi.nlm.nih.gov/38691146Test

الإتاحة: https://doi.org/10.1007/s00402-024-05345-yTest
https://pubmed.ncbi.nlm.nih.gov/38691146Test

المؤلفون: Cirovic, Aleksandar, Cirovic, Ana, Djukic, Danica, Djonic, Danijela, Zivkovic, Vladimir, Nikolic, Slobodan, Djuric, Marija, Milovanovic, Petar

المساهمون: Science Fund of the Republic of Serbia

المصدر: Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الوصف: Although several studies have analyzed inter-individual differences in the femoral neck cortical microstructure, intra-individual variations have not been comprehensively evaluated. By using microCT, we mapped cortical pore volume fraction (Ct.Po) and thickness (Ct.Th) along the superolateral femoral neck in 14 older women (age: 77.1 ± 9.8 years) to identify subregions and segments with high porosity and/or low thickness—potential “critical” spots where a fracture could start. We showed that Ct.Po and Ct.Th significantly differed between basicervical, midcervical, and subcapital subregions of the femoral neck ( p < 0.001), where the subcapital subregion showed the lowest mean Ct.Th and the highest mean Ct.Po. These cortical parameters also varied substantially with age and with the location of the analyzed microsegments along the individual’s neck ( p < 0.001), showing multiple microsegments with high porosity and/or low thickness. Although the highest ratio of these microsegments was found in the subcapital subregion, they were also present at other examined subregions, which may provide an anatomical basis for explaining the fracture initiation at various sites of the superolateral neck. Given that fractures likely start at structurally and mechanically weaker spots, intra-individual variability in Ct.Po and Ct.Th should be considered and the average values for the entire femoral neck should be interpreted with caution.

الإتاحة: https://doi.org/10.1038/s41598-022-19866-2Test
https://www.nature.com/articles/s41598-022-19866-2.pdfTest
https://www.nature.com/articles/s41598-022-19866-2Test

المؤلفون: Djurić, Marija, Levstek, Lucija, Oprčkal, Primož, Mladenovič, Ana, Pranjić, Alenka Mauko, Ščančar, Janez, Milačič, Radmila

المساهمون: Javna Agencija za Raziskovalno Dejavnost RS

المصدر: Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الوصف: Anion-exchange high performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) was used for simultaneous speciation of chromate, molybdate and arsenate. The repeatability of measurement tested for multielemental standard solution of chromate, molybdate and arsenate (50 ng mL −1 of Cr, Mo and As, pH 12) was ± 0.9%, ± 4.9% and ± 4.1%, respectively. Limits of quantification (LOQs) were low (0.53 ng mL −1 for chromate and arsenate and 1.03 ng mL −1 for molybdate, expressed as elemental concentrations). A wide linear concentration range (from LOQs to 500 ng mL −1 ) was obtained. The performances of this method enabled simultaneous speciation analysis in samples of water from lysimeters, in which three geotechnical composites, made of recycled waste, were installed in parallel in compacted and uncompacted, 20 times less dense form. The release of toxic chemical species of elements into lysimetric waters from each composite was studied. The results revealed that the degree of compaction and the composition of composites both have a significant influence on leaching of chromate, molybdate and arsenate. The study proved that multielemental speciation analysis is fast and cost-effective method for investigations of environmental impacts of materials, made from recycled waste, and can be used in other similar applications.

الإتاحة: https://doi.org/10.1038/s41598-022-19600-yTest
https://www.nature.com/articles/s41598-022-19600-y.pdfTest
https://www.nature.com/articles/s41598-022-19600-yTest

المؤلفون: Janovic, Natasa, Janovic, Aleksa, Milicic, Biljana, Djuric, Marija

المساهمون: Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

المصدر: Brazilian Journal of Otorhinolaryngology ; volume 88, issue 5, page 663-668 ; ISSN 1808-8694

مصطلحات موضوعية: Otorhinolaryngology

الإتاحة: https://doi.org/10.1016/j.bjorl.2020.09.004Test
https://api.elsevier.com/content/article/PII:S1808869420301579?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1808869420301579?httpAccept=text/plainTest

المؤلفون: Jadzic, Jelena, Tomanovic, Nada, Djukic, Danica, Zivkovic, Vladimir, Nikolic, Slobodan, Djuric, Marija, Milovanovic, Petar, Djonic, Danijela

المصدر: Bone Reports ; volume 16, page 101303 ; ISSN 2352-1872

مصطلحات موضوعية: Orthopedics and Sports Medicine, Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.1016/j.bonr.2022.101303Test
https://api.elsevier.com/content/article/PII:S2352187222001383?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352187222001383?httpAccept=text/plainTest

المؤلفون: Jadzic, Jelena, Milovanovic, Petar, Djukic, Danica, Zivkovic, Vladimir, Nikolic, Slobodan, Tomanovic, Nada, Djuric, Marija, Djonic, Danijela

المصدر: Bone Reports ; volume 16, page 101407 ; ISSN 2352-1872

مصطلحات موضوعية: Orthopedics and Sports Medicine, Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.1016/j.bonr.2022.101407Test
https://api.elsevier.com/content/article/PII:S235218722200242X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S235218722200242X?httpAccept=text/plainTest

المؤلفون: Cirovic, Aleksandar, Djukic, Danica, Cirovic, Ana, Zivkovic, Vladimir, Djonic, Danijela, Nikolic, Slobodan, Djuric, Marija, Milovanovic, Petar

المصدر: Bone Reports ; volume 16, page 101341 ; ISSN 2352-1872

مصطلحات موضوعية: Orthopedics and Sports Medicine, Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.1016/j.bonr.2022.101341Test
https://api.elsevier.com/content/article/PII:S2352187222001760?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352187222001760?httpAccept=text/plainTest

المؤلفون: Cirovic, Aleksandar, Vujacic, Marko, Petrovic, Bojan, Cirovic, Ana, Zivkovic, Vladimir, Nikolic, Slobodan, Djonic, Danijela, Bascarevic, Zoran, Djuric, Marija, Milovanovic, Petar

المساهمون: Science Fund of the Republic of Serbia

المصدر: Calcified Tissue International ; volume 110, issue 1, page 65-73 ; ISSN 0171-967X 1432-0827

مصطلحات موضوعية: Endocrinology, Orthopedics and Sports Medicine, Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.1007/s00223-021-00894-5Test

المؤلفون: Liu, Yaming, Antonijević, Djorde, Li, Ruining, Fan, Yuxuan, Dukić, Ksenija, Mićić, Milutin, Yu, Genyu, Li, Zhiyu, Djurić, Marija, Fan, Yifang

المساهمون: National Natural Science Foundation of China, Natural Science Foundation of Fujian Province, Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

المصدر: Frontiers in Endocrinology ; volume 12 ; ISSN 1664-2392

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism

الوصف: The aim of the present paper is to determine the sex of the individual using three-dimensional geometric and inertial analyses of metatarsal bones. Metatarsals of 60 adult Chinese subjects of both sexes were scanned using Aquilion One 320 Slice CT Scanner. The three-dimensional models of the metatarsals were reconstructed, and thereafter, a novel software using the center of mass set as the origin and the three principal axes of inertia was employed for model alignment. Eight geometric and inertial variables were assessed: the bone length, bone width, bone height, surface-area-to-volume ratio, bone density, and principal moments of inertia around the x , y , and z axes. Furthermore, the discriminant functions were established using stepwise discriminant function analysis. A cross-validation procedure was performed to evaluate the discriminant accuracy of functions. The results indicated that inertial variables exhibit significant sexual dimorphism, especially principal moments of inertia around the z axis. The highest dimorphic values were found in the surface-area-to-volume ratio, principal moments of inertia around the z axis, and bone height. The accuracy rate of the discriminant functions for sex determination ranged from 88.3% to 98.3% (88.3%–98.3% cross-validated). The highest accuracy of function was established based on the third metatarsal bone. This study showed for the first time that the principal moment of inertia of the human bone may be successfully implemented for sex estimation. In conclusion, the sex of the individual can be accurately estimated using a combination of geometric and inertial variables of the metatarsal bones. The accuracy should be further confirmed in a larger sample size and be tested or independently developed for distinct population/age groups before the functions are widely applied in unidentified skeletons in forensic and bioarcheological contexts.

الإتاحة: https://doi.org/10.3389/fendo.2021.734362Test