المؤلفون: Razavi, Razieh, Amiri, Mahnaz, Divsalar, Kouros, Foroumadi, Alireza

المصدر: Scientific Reports ; volume 13, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الوصف: A practical technique was applied to fabricate CuO nanostructures for use as the electrocatalyst. The green synthesis of cupric oxide nanoparticles (CuO NPs) via co-precipitation is described in this paper using an aqueous extract of Origanum majorana as both reductant and stabilizer, accompanied by characterization via XRD, SEM, and FTIR. The XRD pattern revealed no impurities, whereas SEM revealed low agglomerated spherical particles. CuO nanoparticles and multi wall carbon nanotubes (MWCNTs) have been used to create a modified carbon paste electrode. Voltammetric methods were used to analyze Tramadol using CuONPs/MWCNT as a working electrode. The produced nanocomposite showed high selectivity for Tramadol analysis with peak potentials of ~ 230 mV and ~ 700 mV and Excellent linear calibration curves for Tramadol ranging from 0.08 to 500.0 µM with a correlation coefficient of 0.9997 and detection limits of 0.025. Also, the CuO NPs/MWCNT/CPE sensor shows an an appreciable sensitivity of 0.0773 μA/μM to tramadol. For the first time the B3LYP/LanL2DZ, quantum method was used to compute DFT to determine nanocomposites' connected energy and bandgap energy. Eventually, CuO NPs/CNT was shown to be effective in detecting Tramadol in actual samples, with a recovery rate ranging from 96 to 104.3%.

الإتاحة: https://doi.org/10.1038/s41598-023-34569-yTest
https://www.nature.com/articles/s41598-023-34569-y.pdfTest
https://www.nature.com/articles/s41598-023-34569-yTest

المؤلفون: Divsalar, Kouros¹ (AUTHOR), Khoramipour, Kayvan^1,2 (AUTHOR) k.khoramipour@gmail.com, Basereh, Aref³ (AUTHOR), Pirani, Hossein⁴ (AUTHOR), Amini, Reza⁵ (AUTHOR), Afarinesh, Mohammad Reza¹ (AUTHOR), Saidie, Payam⁶ (AUTHOR), Divsalar, Fatemeh⁷ (AUTHOR), Honarmand, Amin⁸ (AUTHOR), Knechtle, Beat⁹ (AUTHOR), López-Gajardo, Miguel A.¹⁰ (AUTHOR), Prieto-González, Pablo¹¹ (AUTHOR), Nobari, Hadi^10,12 (AUTHOR) hadi.nobari1@gmail.com

المصدر: Sport Sciences for Health. Jun2024, Vol. 20 Issue 2, p489-499. 11p.

مصطلحات موضوعية: *SWIMMING, *CREATINE kinase, *SWIMMERS, *LACTATE dehydrogenase, *URIC acid

مستخلص: Aim: To investigate the effects of a 10-day tapering on swimming performance, metabolic and hematologic factors, and a 200-m crawl swimming record. Methods: Eighteen male recreational swimmers (11–17 years) underwent an 8-week vigorous-intensity endurance training (three sessions per week, 90 min per session). Participants' swimming records were obtained at the end of the training period, and blood samples were drawn. After that, the taper group (TP, n = 12) underwent a 10-day taper program (training volume reduced by 15%, 30%, 45%, and 60% in the first four sessions and 70% in the last session), while the control group (CG, n = 12) kept their training load. At the end of the tapering period, a 200-m crawl swimming time was recorded, and a blood sample was collected to assess metabolic and hematologic factors. Results: 200-m swimming record improvement was higher in TP than in CG (p < 0.05). In addition, creatine phosphokinase, creatinine, urea, uric acid, and lactate dehydrogenase significantly decreased after tapering (p < 0.05). However, hematological factors did not show any significant difference between groups. Furthermore, no significant correlation between swimming records and measured parameters was found. Conclusion: Our results showed that 10 days of tapering could improve the 200-m swimming record and metabolic but not the hematological profile in young recreational swimmers. [ABSTRACT FROM AUTHOR]

المؤلفون: Zarei, Samaneh, Shafiei, Mohammad, Firouzi, Maryam, Firoozpour, Loghman, Divsalar, Kouros, Asadipour, Ali, Akbarzadeh, Tahmineh, Foroumadi, Alireza

المصدر: Heliyon ; volume 7, issue 4, page e06683 ; ISSN 2405-8440

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1016/j.heliyon.2021.e06683Test
https://api.elsevier.com/content/article/PII:S2405844021007866?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2405844021007866?httpAccept=text/plainTest

المؤلفون: Peytam, Fariba, Adib, Mehdi, Shourgeshty, Reihaneh, Firoozpour, Loghman, Rahmanian-Jazi, Mahmoud, Jahani, Mehdi, Moghimi, Setareh, Divsalar, Kouros, Faramarzi, Mohammad Ali, Mojtabavi, Somayeh, Safari, Fatemeh, Mahdavi, Mohammad, Foroumadi, Alireza

المساهمون: Tehran University of Medical Sciences

المصدر: Scientific Reports ; volume 10, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الوصف: In an attempt to find novel α -glucosidase inhibitors, an efficient, straightforward reaction to synthesize a library of fully substituted 6-amino-pyrazolo[1,5- a ]pyrimidines 3 has been investigated. Heating a mixture of α-azidochalcones 1 and 3-aminopyrazoles 2 under the mild condition afforded desired compounds with a large substrate scope in good to excellent yields. All obtained products were evaluated as α -glucosidase inhibitors and exhibited excellent potency with IC 50 values ranging from 15.2 ± 0.4 µM to 201.3 ± 4.2 µM. Among them, compound 3d was around 50-fold more potent than acarbose (IC 50 = 750.0 ± 1.5 µM) as standard inhibitor. Regarding product structures, kinetic study and molecular docking were carried out for two of the most potent ones.

الإتاحة: https://doi.org/10.1038/s41598-020-59079-zTest
https://www.nature.com/articles/s41598-020-59079-z.pdfTest
https://www.nature.com/articles/s41598-020-59079-zTest

المؤلفون: Divsalar, Kouros, Khoramipour, Kayvan, Basereh, Aref, Pirani, Hossein, Amini, Reza, Afarinesh, Mohammad Reza, Saidie, Payam, Divsalar, Fatemeh, Honarmand, Amin, Knechtle, Beat, López-Gajardo, Miguel A., Prieto-González, Pablo, Nobari, Hadi

المصدر: Sport Sciences for Health ; ISSN 1824-7490 1825-1234

مصطلحات موضوعية: Orthopedics and Sports Medicine

الإتاحة: https://doi.org/10.1007/s11332-023-01133-0Test

المؤلفون: Mahmoodi, Majid, Karami, Fatemeh, Abdollahi, Hamidreza, Giahi, Navidreza, Divsalar, Kouros, Honarmand, Amin, Modarressi, Mohammad Hossein

المصدر: Addiction and Health ; volume 15, issue 2, page 87-92 ; ISSN 2008-4633 2008-8469

الوصف: Background: Opiate abuse has been critically increased in the world, especially in Iran. Owing to the association of opiate use with multiple human cancers and neurological disorders, seeking for genetic and epigenetic effects of opium can pave the way for early diagnosis of major health defects in addicted users. Accordingly, the present study aimed to determine the methylation status of the promoter of two genes, which are actively involved in neurodevelopment and cancer evolution. Methods: DNA was isolated from peripheral blood of 28 opium abusers and 19 healthy controls and then subjected to sonication. Sonicated DNAs undergone methylated DNA immunoprecipitation-real time polymerase chain reaction (MeDIP-Real Time PCR) using specific primer pairs designed for HOXA9 and NISCH genes. Obtained data were analyzed using SPSS software. Findings: HOXA9 and NISCH genes were found to be significantly methylated in addicted users compared to controls (P<0.001) which was significantly associated with the mean of the age regarding HOXA9 gene (P=0.002). Neither opium amount nor duration or route of using was associated with the methylation status of HOXA9 or NISCH genes. Conclusion: Hypermethylation of HOXA9 and NISCH genes as tumor suppressor in opium-addicted individuals can be considered as confirmatory evidence for carcinogenesis of opium. Further studies are required to figure out the role of epigenetic alterations in cancer evolution among opium users.

الإتاحة: https://doi.org/10.34172/ahj.2023.1356Test
https://ahj.kmu.ac.ir/article_92216_4f3a5d2cc8fd72f41d5142ac91eb0527.pdfTest

المؤلفون: Nakhaee, Nouzar, Divsalar, Kouros, Bahreinifar, Sareh

المصدر: Asia Pacific Journal of Public Health, 2011 Mar 01. 23(2), 151-156.

الوصول الحر: https://www.jstor.org/stable/26723824Test

المؤلفون: Tajadini, Haleh, Zangiabadi, Nasser, Divsalar, Kouros, Safizadeh, Hossein, Esmaili, Zahra, Rafiei, Hossein

المصدر: Journal of Evidence-Based Complementary & Alternative Medicine ; volume 22, issue 1, page 37-40 ; ISSN 2156-5872 2156-5899

الوصف: Background and Aim. Migraine is a common form of headache that affects patients quality of life negatively. In addition to pharmacologic treatment, there are a variety of nonpharmacologic treatments for migraine headache. In present study, we examined the effect of prayer on intensity of migraine pain. Methods. In a prospective, randomized, controlled trial from October 2013 to June 2014, this study has been conducted in Kerman, Iran. We randomly assigned 92 patients in 2 groups to receive either 40 mg of propranolol twice a day for 2 month (group “A”) or 40 mg of propranolol twice a day for 2 months with prayer (group “B”). At the beginning of study and 3 months after intervention, patients’ pain was measured using the visual analogue scale. Results. At the beginning of study and before intervention, the mean score of pain in patients in groups A and B were 5.7 ± 1.6 and 6.5 ± 1.9, respectively. According to results of independent t test, mean score of pain intensity at the beginning of study were similar between patients in 2 groups ( P > .05). Three month after intervention, mean score of pain intensity decreased in patients in both groups. At this time, the mean scores of pain intensity were 5.4 ± 1.1 and 4.2 ± 2.3 in patients in groups A and B, respectively. This difference between groups was statistically significant ( P < .001). Conclusions. The present study revealed that prayer can be used as a nonpharmacologic pain coping strategy in addition to pharmacologic intervention for this group of patients.

الإتاحة: https://doi.org/10.1177/2156587215627551Test

المؤلفون: Divsalar, Parisa, Mohammadi, Mehrnoosh, Divsalar, Kouros

المصدر: Traffic Injury Prevention ; volume 22, issue 3, page 195-200 ; ISSN 1538-9588 1538-957X

الإتاحة: https://doi.org/10.1080/15389588.2021.1889528Test

المؤلفون: Gozashti, Mohammad, Mohammadzadeh, Elham, Divsalar, Kouros, Shokoohi, Mostafa

مصطلحات موضوعية: Opium, Thyroid function test, Free T4

الوصف: Background A number of abnormalities has been identified among drug addicted users especially heroin addicts. However, there are a few studies to assess the opium effects on thyroid hormones. the aim of the present study is to investigate the effect of opium on the thyroid function tests. Method In this case–control, 50 male addicts, aged 20–50 years, with history of addiction to opium lasting more than two years, and 50 male non-addicts as control group were randomly selected. 10 cc blood sample was taken for measurements of TSH, total T4 and T3, free T4 and T3, and T3 resin uptake (T3RU) and 50 cc urine sample for opium testing. Results The univariate analysis revealed that there was not a significant association between opium and serum levels of T4 and TSH, but compared with control group, a slight increase in total T3 and a decrease in T3RU were observed among addicts (P < 0.05). In multivariate analysis, opium was also found to exert a lowering effect on serum free T4 level after adjusting of age and cigarette smoking (P < 0.05). Conclusion The findings of the present study demonstrated that opium can influence on thyroid function by increasing total T3 and decreasing T3RU and free T4 levels.

العلاقة: http://www.jdmdonline.com/content/13/1/5Test

الإتاحة: http://www.jdmdonline.com/content/13/1/5Test