المؤلفون: Zina Sherzad Qadir, Patrick Anthony Ball, Hana Morrissey

المصدر: Pharmacy, Vol 11, Iss 6, p 175 (2023)

مصطلحات موضوعية: antipsychotics, antipsychotics discontinuation rate, causes of relapse, optimisation of schizophrenia management, Pharmacy and materia medica, RS1-441

الوصف: This systematic review compared the efficacy and tolerance of oral antipsychotics (APDs) used in the treatment of schizophrenia following the PRISMA-P© statement (n = 21). The primary outcomes of interest were clinical response measured with symptoms’ improvement, tolerance to side effects and discontinuation reasons. There was better individual patients’ response to aripiprazole vs. ziprasidone and quetiapine ((CDSS p = 0.04), BPRS p = 0.02, YMRS p = 0.001) and ziprasidone vs. quetiapine (CGI p = 0.02, CDSS p = 0.02). Aripiprazole was more tolerated than risperidone, ziprasidone and quetiapine (p < 0.05). Quetiapine was more tolerated than aripiprazole, ziprasidone and risperidone (p < 0.05). Ziprasidone was more tolerated than quetiapine haloperidol and olanzapine (p < 0.05). Risperidone was more tolerated than olanzapine (p = 0.03) and haloperidol was more tolerated than olanzapine and quetiapine (p < 0.05). Olanzapine caused less discontinuation than quetiapine; quetiapine caused less discontinuation than ziprasidone, aripiprazole and haloperidol; ziprasidone caused less discontinuation than quetiapine, aripiprazole and haloperidol; aripiprazole caused less discontinuation than quetiapine, ziprasidone and olanzapine and olanzapine caused less discontinuation than ziprasidone and haloperidol (p < 0.05). It was concluded that individual patient clinical response, tolerance to side effects and life-threatening side effects remain the most reliable basis for selecting and continuing the use of APD.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2226-4787/11/6/175Test; https://doaj.org/toc/2226-4787Test

الوصول الحر: https://doaj.org/article/b299869abf884bf09c133eeb3bc88629Test

المؤلفون: Zina Sherzad Qadir, Nilamadhab Kar, Patrick Anthony Ball, Hana Morrissey

المصدر: Pharmacy, Vol 11, Iss 5, p 162 (2023)

مصطلحات موضوعية: antipsychotics, antipsychotics discontinuation rate, causes of relapse, optimisation of schizophrenia management, psychiatric disorders, Pharmacy and materia medica, RS1-441

الوصف: The aim of this survey of psychiatrists from the UK and India was to compare their opinions on antipsychotic medication choice and their experiences of such medications’ effectiveness and tolerability in patients who were newly diagnosed with acute schizophrenia. Following ethical approval, a cross-sectional online survey of psychiatrists from the UK and India was conducted. Ninety-five responses were received from each country. The most selected first-line APDs in both countries were olanzapine (47.5%), risperidone (42.8%) and aripiprazole (25.3%). A total of 60% of psychiatrists from India (60%) and 48% from the UK (48%) selected ‘medication efficacy’ as the main factor in their choice. Reassessment and consideration to switch most often took place within 4–6 weeks (53.7%) and 3–6 months (11.6%). The major reasons for switching antipsychotic medications were poor clinical efficacy (69%) and lack of tolerability (45%). Nonadherence was the most common reason for relapse (90% of UK psychiatrists and 70% of Indian psychiatrists), followed by illicit drug use (27.6%). The most commonly reported side effects that led to nonadherence were weight gain (10.8%), drowsiness (10.4%), erectile dysfunction and movement disorders (equally 8.7%). It was concluded that olanzapine, risperidone and aripiprazole are the most commonly selected as the initial treatment choice by psychiatrists from India and the UK. They are perceived as widely effective and well tolerated.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2226-4787/11/5/162Test; https://doaj.org/toc/2226-4787Test

الوصول الحر: https://doaj.org/article/435154a6ac934cddaec1850ea0a64171Test

المؤلفون: Mamecha Mesha, Akalewold Alemayehu, Deresse Daka

المصدر: BMC Women's Health, Vol 20, Iss 1, Pp 1-7 (2020)

مصطلحات موضوعية: Implanon, Discontinuation rate, Kucha, Ethiopia, Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270

الوصف: Abstract Background The promotion of contraception in countries with high birth rates has the potential to reduce poverty, hunger, maternal, and childhood deaths. Every year in sub-Saharan Africa approximately 14 million unintended pregnancies occurred and a sizeable proportion was due to poor use of short-term hormonal methods. Contraceptive hormonal implants are highly effective and suitable for almost all women at any stage of their reproductive lives. On the other hand, early discontinuation of the Implanon contraceptive method utilization is one of the foremost problems amid the family planning program. Early discontinuation of the Implanon contraceptive method and reasons for such discontinuation lingers the most significant anxiety for family planning programs. In unindustrialized countries, contraceptive discontinuation due to health concerns is generally higher; these complaints are often related to service quality. Hence, this study aimed to assess the prevalence and factors associated with early discontinuation of Implanon among women who ever used Implanon in Kucha district, Gamo Gofa Zone, Southern Ethiopia. Methods Implanon contraceptive device users were selected from the Kucha district using a cross-sectional community-based survey from January to March 2018. A total of 430 women were selected and data were collected through face-to-face interviews by using a pre-tested structured questionnaire. Data were cleaned, coded, and entered into Epi-Info version 7statistical software. Factors that showed association in a bivariate analysis that has a p value of less than 0.25 were entered into multiple logistic regression models for controlling confounding factors. The strength of statistical association was measured by adjusted odds ratio, at 95% confidence intervals, and p value

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12905-020-01096-1Test; https://doaj.org/toc/1472-6874Test

الوصول الحر: https://doaj.org/article/8aae287e721f47988c42207aca53c5cbTest

المؤلفون: Hiluf Ebuy Abraha (12003682), Kebede Embaye Gezae (8383203), Alemayehu Bayray Kahsay (4017554), Mengistu Hagazi Tequare (12003685)

مصطلحات موضوعية: Medicine, Cell Biology, Biotechnology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, removal registration books, march 2017 ), final cox model, clients whose partners, adjusted hazard ratios, 19 &# 8211, 08 &# 8211, overcoming identified barriers, modern contraception method, improve implanon continuity, implanon without switching, unplanned discontinuation using, unplanned discontinuation rate, 61 &# 8211, lower educational status, year unplanned discontinuation, women aged 20, study , unplanned discontinuation, unplanned manner, method contributes

الوصف: (DOCX)

العلاقة: https://figshare.com/articles/journal_contribution/English_version_questionnaire_and_checklist_/19072279Test

الإتاحة: https://doi.org/10.1371/journal.pone.0259234.s001Test

المؤلفون: Hiluf Ebuy Abraha (12003682), Kebede Embaye Gezae (8383203), Alemayehu Bayray Kahsay (4017554), Mengistu Hagazi Tequare (12003685)

مصطلحات موضوعية: Medicine, Cell Biology, Biotechnology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, removal registration books, march 2017 ), final cox model, clients whose partners, adjusted hazard ratios, 19 &# 8211, 08 &# 8211, overcoming identified barriers, modern contraception method, improve implanon continuity, implanon without switching, unplanned discontinuation using, unplanned discontinuation rate, 61 &# 8211, lower educational status, year unplanned discontinuation, women aged 20, study , unplanned discontinuation, unplanned manner, method contributes

الوصف: (DOCX)

العلاقة: https://figshare.com/articles/journal_contribution/Tigrigna_local_language_version_questionnaire_used_for_the_phone_survey_/19072282Test

الإتاحة: https://doi.org/10.1371/journal.pone.0259234.s002Test

المؤلفون: Hidenori KONDO, 今谷 潤也, 岩本 勇樹, 川上 幸雄, 林 正典, 楢﨑 慎二, 近藤 秀則

المصدر: 中部日本整形外科災害外科学会雑誌 / The Central Japan Journal of Orthopaedic Surgery & Traumatology. 2022, 65(3):475

المؤلفون: Mohammed A. Alghamdi, Carla P. Amaro, Richard Lee‐Ying, Hao‐Wen Sim, Haider Samwi, Kelvin K. Chan, Jennifer J. Knox, Yoo‐Joung Ko, Mina Swiha, Eugene Batuyong, Adriana Romagnino, Winson Y. Cheung, Vincent C. Tam, the Hepatocellular Carcinoma ‐ Cancer Health Outcomes Research Database (HCC ‐ CHORD) Consortium

المصدر: Cancer Medicine, Vol 9, Iss 14, Pp 4918-4928 (2020)

مصطلحات موضوعية: discontinuation rate, dose intensity, hepatocellular carcinoma, sorafenib, starting dose, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background Sorafenib has been shown to improve survival in patients with advanced hepatocellular carcinoma (HCC), however, full dose can be difficult to tolerate. The aim of this study was to determine whether sorafenib starting dose and mean dose intensity affect survival. Methods Patients treated with sorafenib for HCC from January 2008 to July 2016 in several Canadian provinces were included and retrospectively analyzed. The primary end point was overall survival (OS) of patients starting on sorafenib full dose compared to reduced dose. Secondary analysis compared OS with different mean dose‐intensity groups. Survival outcomes were assessed with Kaplan‐Meier curves and Cox proportional hazards models. A propensity score analysis was performed to account for treatment bias and confounding. Results Of 681 patients included, sorafenib was started at full dose in 289 patients (42%). Median survival for starting full and reduced dose was 9.4 months and 8.9 months (P = .15) respectively. After propensity score matching and adjusting for potential confounders there was still no difference in survival (HR 0.8, 95% CI, 0.61‐1.06, P = .12). Almost half of the patients (45%) received a dose intensity 75%, 50%‐75%, and

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-7634Test

الوصول الحر: https://doaj.org/article/f30b00a8c00b40719fb7ffe444f5c912Test

المؤلفون: M E Ayogu, K I Omonua, M C Ayogu

المصدر: Nigerian Journal of Medicine, Vol 28, Iss 2, Pp 161-167 (2019)

مصطلحات موضوعية: copper t-380aiud, acceptance rate, discontinuation rate, abujashort title: experience with copper t intrauterine contraceptive device in abuja, Medicine

الوصف: BACKGROUND: The Intrauterine contraceptive device has been shown to be an effective form of long acting reversible contraception. Despite this however, its uptake in Nigeria has not reached the optimum level. OBJECTIVE: The objective of this study was to determine the rate, pattern of uptake and reasons for discontinuation of use of the intrauterine contraceptive device at the University of Abuja Teaching hospital, Abuja. MATERIALS AND METHOD: A retrospective study of record cards of all the women who attended the family planning clinic between January 2007 and December 2016. Data on socio-demographic characteristics, acceptance rate, discontinuation rate and reasons for discontinuation of the IUD were extracted. RESULTS: Out of 3251 acceptors of various family planning methods, there were 1241 acceptors of IUD within the study period, giving an IUD acceptance rate of 38.2%. The contraceptive prevalence rate in relation to the number of deliveries (22,955) within the study period was 14.2%. Overall, IUD was the commonest form of contraceptive used (38.2%). The most frequent users of the IUD were women aged 35 years and above (43.5%), while the least users, (0.3%) were the teenagers. Acceptance rate of IUD was highest amongst women who were Para 4 (27.4%) and most of the women (99%) were married. The IUD was the most commonly used contraceptive in the first 5 years with more than 50% of women using the method by the third year. It subsequently became the second most commonly used contraceptive after the subdermal implant in the last 5 years. The average discontinuation rate was 12.1% and the commonest reason was the desire to get pregnancy 55(36.7%) women. The mean duration of use of IUDs in this study was 2.9+/- 1.6 years. A pearl index of 0.02 was recorded. CONCLUSION: The contraception prevalence rate is low in our center however, the IUD is among the most common methodsutilized by the clients. It is effective and has a low discontinuation rate.

وصف الملف: electronic resource

العلاقة: http://www.njmonline.org/article.asp?issn=1115-2613;year=2019;volume=28;issue=2;spage=161;epage=167;aulast=Ayogu;type=0Test; https://doaj.org/toc/1115-2613Test

الوصول الحر: https://doaj.org/article/ea39edf2f6fd445098744514300e9dafTest

المؤلفون: Tsirity G/Medhin, Kahsu Gebrekirstos Gebrekidan, Mekuria Kassa Nerea, Hagos Gerezgiher, Mebrahtom Haftu

المصدر: BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)

مصطلحات موضوعية: Implanon, Early discontinuation rate, Associated factors, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

الوصف: Abstract Objective Contraceptive discontinuation rate is very common in most developing countries, especially removal in the first year of use is common (18–63%), and the majority of these discontinuations are among women who are still in need of contraception. So the objective of this study was assessing early Implanon discontinuation rate and its associated factors in the study area. Institutional based cross sectional study was conducted and systematic random sampling technique was employed to interview the study participants. A binary logistic regression model was used to test association. Result In this study early Implanon discontinuation rate was 38%, 95% CI (32%, 44%). women who attend secondary [AOR: 95% CI 0.35 (0.14, 0.82)] and more than secondary school [AOR: 95% CI 0.23 (0.09, 0.59)] were less likely to remove Implanon early as compared to those illiterate. Mothers who were not counseled [AOR: 95% CI 2.45 (1.05, 5.69)] and those mothers who had a side effect of the method [AOR: 95% CI 2.66 (1.23, 5.72)] discontinue the method early. The study revealed that early Implanon discontinuation rate was high. Women’s educational level, presence of side effect and effective counseling were independent predictors of early Implanon removal.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s13104-018-3992-3Test; https://doaj.org/toc/1756-0500Test

الوصول الحر: https://doaj.org/article/279bbdc7c84b49e390afe95cb497101fTest

المؤلفون: Natan Pereira Gosmann (10788387), Marianna de Abreu Costa (10954747), Marianna de Barros Jaeger (10954750), Luis Souza Motta (10954753), Júlia Frozi (10954756), Lucas Spanemberg (739635), Gisele Gus Manfro (7570943), Pim Cuijpers (83464), Daniel Samuel Pine (10954759), Giovanni Abrahão Salum (7570940)

مصطلحات موضوعية: Medicine, Biotechnology, Science Policy, Mental Health, treatment discontinuation rate, acceptability, 3- level approach, PROSPERO, Selective serotonin reuptake inhibitors, assessment instrument, disorder, symptom domains, norepinephrine reuptake inhibitors, CRD, internalizing symptoms, 469 outcome measures, 3- level network meta-analysis, SMD, serotonin reuptake inhibitors, CI, efficacy, SNRI, bias, medication, SSRI, 3- level network meta-analysis Back., MEDLINE, participant, 11 November 2020

الوصف: (DOCX)

العلاقة: https://figshare.com/articles/journal_contribution/Search_terms_/14765938Test

الإتاحة: https://doi.org/10.1371/journal.pmed.1003664.s002Test