المؤلفون: Isabelle Schuffenecker, Cécile Henquell, Audrey Mirand, Marianne Coste-Burel, Stéphanie Marque-Juillet, Delphine Desbois, Gisèle Lagathu, Laure Bornebusch, Jean-Luc Bailly, Bruno Lina

المصدر: Emerging Infectious Diseases, Vol 20, Iss 8, Pp 1343-1346 (2014)

مصطلحات موضوعية: enterovirus 71, enterovirus species A, subgenogroup C4, Picornaviridae, France, viruses, Medicine, Infectious and parasitic diseases, RC109-216

الوصف: In France during 2012, human enterovirus 71 (EV-A71) subgenogroup C4 strains were detected in 4 children hospitalized for neonatal fever or meningitis. Phylogenetic analysis showed novel and independent EV-A71 introductions, presumably from China, and suggested circulation of C4 strains throughout France. This observation emphasizes the need for monitoring EV-A71 infections in Europe.

وصف الملف: electronic resource

العلاقة: https://wwwnc.cdc.gov/eid/article/20/8/13-1858_articleTest; https://doaj.org/toc/1080-6040Test; https://doaj.org/toc/1080-6059Test

الوصول الحر: https://doaj.org/article/7626ea0bf43b47649238d69dbc49f7b3Test

المؤلفون: Elisabeth Dussaix, Delphine Desbois, Anne-marie Roque-afonso

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jcm.asm.org/content/47/5/1536.full.pdfTest.

الوصف: This article cites 25 articles, 6 of which can be accessed free at

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.630.239Test; http://jcm.asm.org/content/47/5/1536.full.pdfTest

الإتاحة: http://jcm.asm.org/content/47/5/1536.full.pdfTest

المؤلفون: Severine Haouisee, Sandrine Anne Martha, Elodie Blondel, Maxime Thouvenin, Fouad Madhi, Guilaine Barnaud, Sylvie Charachon, Jérémie Violette, Chrystèle Fabbro, Hubert Ythier, Marie Pierre Fos, Emmanuelle Varon, Danielle Roybet, Grégory Dubourg, Olivier Guilluy, Jean Marc Schneider, Stéphane Bonacorsi, Abdelmalek Belgaid, Anne Laure Roux, Alain Goudeau, Stéphane Dauger, Valérie Biran, Olivier Moquet, Anne Gougeon Jollivet, Alain Martinot, Bertrand Chevallier, Chantal Chaplain, Claude Bosi, Josette Jehan, Caroline Garandeau, Karen Milcent, Claire Plassart, Nicolas Kalach, Valérie Sivadon-Tardy, Pascal Bolot, Françoise Evreux, Ellia Mezgueldi, Mireille Cheron, Marie Françoise Prere, Nawal Nicola, Jacques Brouard, Ralph Epaud, Agnès Ferroni, Eric Moulene, Emmanuelle Dessioux, Sylvia Akitani, Aurélia Pitsch, Cyril Morisot, Danielle Landragin, Eterne Twizeyimana, François Angoulvant, Jean Sarlangue, Isabelle Glatz, Caroline Guyot, Anne Bertrou, Anne Chace, Stéphanie Honore Bouakline, Delphine Desbois, Philippe Labrune, Didier Moissenet, Sophie Boyer, Alain Barrans, Leila Lafendi, Françoise Cascarigny, Nathalie Bednarek, Albert Faye, Ahmed Sadik, Valérie Marcou, Daniele De Luca, Etienne Javouhey, Véronqiue Vernet-Garnier, Florence Doucet-Populaire, Josette Raymond, Leatitia Pantalone, Célestin M’Bamba, Jean Marc Chamouilli, Katherine Dieckmann, Mariane Marin, Philippe Lehours, Mathie Lorrot, Didier Pinquier, Hélène Garrec, Christian Herve, Martin Chalumeau, Naim Ouldali, François Gouraud, Marc Le Bideau, Laurence Eitenschenck, Emmanuel Grimprel, Hélène Biessy, Valérie Macchi, Véronique Duval, Ilhem Agha-Mir, Hakim Lahrach, H. Haas, Pierre Lureau, Farida Hamdad, Marie Hélène Pierre, Florent Girard, Valérie Asensio, Romain Basmaci, Marlène Amara, Maité Micaelo, Patricia Roussellier, Brigitte Zimmermann, Nathalie Hubert, Julie Toubiana, Mohamed Amine Yangui, Sylvie Ledru, Fréderic Tronc, Corinne Levy, Jean Gaschignard, Alain Goux, Catherine Glastre, Pierre Patoz, Francis Chomienne, Bernadette Cartier-Riviere, Stéphanie Eyssette-Gayraud, Robert M. Cohen, Rodrigue Dessein, Nicolas Soustelle, Anna Grando, Didier Jan, François Dubos, Huong Porcheret, Isabelle Savoy, Fanny Autret, Marie Noelle Adam, Marie Josée Dufour, Anne Charbonneau, Olivier Lemenand, Anne Dao-Dubremetz, Agnes Rey, Anne Cécile Hochart, Guillaume Arlet, Véronique Despert, Didier Eyer, Fabrice Lapeyre, Nevena Danekova, Olivier Sebag, Ali Khalfi, Emmanuel Jeannot, Joël Gaudelus, Marie Aliette Dommergues, Frédéric Wallet, Elodie Dorangeon, Christine Vervel, Marie Emmanuelle Juvin, Gery Courouble, Gael Guyon, Florence Richardin, Marion Decobert, Laurent Geniez, Nejib Lejri, Stéphane Béchet, Katia Barsotti, Christian Cattoen, Julien Baleine, Pierre Goumy, Laure Warin, Serge Gallet, Anthony Texier, Delphine Minette Brunel, Rachel Heyman Guenais, Grégoire Benoist, Béatrice Pellegrino, Muriel Halna, Vincent Laugel, André De Briel, Norbert Laisney, A. Vachée, Christophe De Champs, Patrick Daoud, Isabelle Haegy-Doehring, Jean-Philippe Lavigne, Simone Saumureau, Delphine Penel-Capelle, Véronique Blanc, Abdelaziz Oulepsir, Elise Launay

المساهمون: Association Clinique et Thérapeutique Infantile du Val-de-Marne, Groupe de Pathologie Infectieuse Pédiatrique [Paris] (GPIP), Société Française de Pédiatrie (SFP), Urgences pédiatriques, Hôpital Necker Enfants Malades, Université Paris Descartes, Paris, France, parent, Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)

المصدر: The Lancet Infectious Diseases
The Lancet Infectious Diseases, New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001-, 2018, 18 (9), pp. 983-991. ⟨10.1016/S1473-3099(18)30349-9⟩

مصطلحات موضوعية: Male, Serotype, Pediatrics, medicine.medical_specialty, Future studies, Adolescent, Population, Serogroup, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, medicine, Humans, 030212 general & internal medicine, Child, education, book, Prospective survey, National health, education.field_of_study, Meningitis, Pneumococcal, business.industry, Incidence, Incidence (epidemiology), Streptococcal Vaccines, Infant, Newborn, Infant, PNEUMOCOCCAL MENINGITIS, medicine.disease, Health Surveys, 3. Good health, Streptococcus pneumoniae, Infectious Diseases, Child, Preschool, Pediatric Infectious Disease, book.journal, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, business, Meningitis, Forecasting

الوصف: Successive implementation of seven-valent then 13-valent pneumococcal conjugate vaccines (PCVs) led to a marked decrease in pneumococcal disease burden, including pneumococcal meningitis. We assessed the long-term effect of implementation of PCVs on incidence of pneumococcal meningitis in children in France over a 16-year period.We did a quasi-experimental, population-based interrupted time-series analysis with a nationwide prospective survey over 16 years in France, recruiting children aged younger than 15 years from 227 paediatric wards from January, 2001, to December, 2016. The main outcome by the time-series model was the estimated incidence of pneumococcal meningitis per 100 000 children (of a population of 12·6 million children in 2017) before and after PCV7 and PCV13 implementation. The time-series model was based on segmented regression with autoregressive error.We enrolled 1778 children with pneumococcal meningitis. PCV13 implementation led to a significant reduction in monthly incidence of pneumococcal meningitis from 0·12 per 100 000 children before PCV13 to a nadir of 0·07 in December, 2014 (-38%, 95% CI -56·1 to -20·4; p0·0001). A sharp increase occurred during 2015 and 2016, (+2·3% per month, incidence of 0·13 per 100 000 children at the end of the study period, p=0·0002), mainly related to an increase of serotype 24F, which was frequently penicillin resistant.The early effect of PCV13 implementation greatly reduced the incidence of pneumococcal meningitis in children less than 15 years old. However, a sharp rebound in incidence linked to the emergence of serotype 24F compromised the long-term PCV efficacy. If confirmed in future studies and in other countries, pneumococcal meningitis incidence rebound and 24F emergence should be considered when developing next-generation PCVs.The French Pediatric Infectious Diseases Group, Association Clinique et Thérapeutique Infantile du Val de Marne, Pfizer, and for the National Reference Centre for Pneumococci, the French National Health Agency.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358a41505b8769b160536393f1209215Test
https://doi.org/10.1016/s1473-3099Test(18)30349-9

المؤلفون: Diane Descamps, Sophie Matheron, Geneviève Chêne, Florence Damond, Gilles Collin, Antoine Bénard, Delphine Desbois, Bénédicte Roquebert, Gilles Peytavin, In Vitro, Phenotypic Susceptibility Human

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://aac.asm.org/content/52/4/1545.full.pdfTest.

الوصف: This article cites 14 articles, 6 of which can be accessed free at

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.530.9166Test; http://aac.asm.org/content/52/4/1545.full.pdfTest

الإتاحة: http://aac.asm.org/content/52/4/1545.full.pdfTest

المؤلفون: Doi:j. Clin Microbiol, Vincent Mackiewicz, Elisabeth Dussaix, Bénédicte Roquebert, Delphine Desbois, Anne-marie Roque-afonso, Liliane Grangeot-keros, Diagnostic Relevance Of Immunoglobulin G

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jcm.asm.org/content/42/11/5121.full.pdfTest.

الوصف: This article cites 17 articles, 3 of which can be accessed free at

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.618.6548Test; http://jcm.asm.org/content/42/11/5121.full.pdfTest

الإتاحة: http://jcm.asm.org/content/42/11/5121.full.pdfTest

المؤلفون: Jacques Izopet, Jacqueline Cottalorda, Vincent Calvez, Charlotte Charpentier, Henia Saoudin, Georges Dos Santos, Mary-Anne Trabaud, Francis Barin, V. Calvez, Cécile Henquell, Delphine Desbois, C. Delaugerre, Slim Fourati, D. Bettinger, Thomas Bourlet, Anne Krivine, Bernard Masquelier, S. Vallet, M. Bouvier-Alias, Catherine Tamalet, B. Masquelier, S. Rogez, Coralie Pallier, J. C. Plantier, C. Charpentier, F. Barin, J. Cottalorda, A. Maillard, Alexandre Storto, G. DosSantos, Chakib Alloui, B. Montes, Marie-Laure Chaix, A. G. Marcelin, Anne Signori-Schmuck, D. Desbois, Anne-Geneviève Marcelin, Marie Laure Chaix, C. Tamalet, F. Brun-Vézinet, Françoise Brun-Vézinet, J. Izopet, Philippe Flandre, G. Anies, Anne Maillard, Diane Descamps, Patrice Andre, Jean-Claude Tardy, Dominique Costagliola, Brigitte Montes, Laurence Morand-Joubert, Annick Ruffault, Jean-Christophe Plantier, Sophie Pakianather, L. Morand-Joubert, Constance Delaugerre

المصدر: Journal of Antimicrobial Chemotherapy. 65:2620-2627

مصطلحات موضوعية: Male, Microbiology (medical), Anti-HIV Agents, HIV Infections, Drug resistance, Nucleoside Reverse Transcriptase Inhibitor, 03 medical and health sciences, 0302 clinical medicine, HIV Protease, Drug Resistance, Viral, HIV Seropositivity, Prevalence, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Pharmacology, 0303 health sciences, Reverse-transcriptase inhibitor, biology, 030306 microbiology, Proteolytic enzymes, biology.organism_classification, Virology, HIV Reverse Transcriptase, Reverse transcriptase, 3. Good health, Infectious Diseases, Chronic Disease, Mutation, Immunology, Lentivirus, HIV-1, Reverse Transcriptase Inhibitors, Female, France, Viral disease, Viral load, medicine.drug

الوصف: Objectives: To estimate the prevalence of transmitted drug resistance mutations and non-B subtype circulation in antiretroviral-naive chronically HIV-1-infected patients in France. Methods: Resistance mutations were sought in samples from 530 newly diagnosed HIV-1-infected patients from October 2006 to March 2007. Protease and reverse transcriptase mutations were identified from the 2007 Stanford Resistance Surveillance list. Results: Reverse transcriptase and protease resistance mutations were determined in 466 patients with duration of seropositivity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a0281a34a877227a1687b3f7e4d2b1Test
https://doi.org/10.1093/jac/dkq380Test

المؤلفون: Stéphan Vagner, Delphine Desbois, Vincent Mackiewicz, Elisabeth Dussaix, Anne Cammas, Anne-Marie Roque-Afonso, Eric Marchadier, Frédérik Beaulieux, Sandra Pierredon

المصدر: Journal of Virology. 84:10139-10147

مصطلحات موضوعية: Adult, Adolescent, Genotype, Five prime untranslated region, Molecular Sequence Data, Immunology, Biology, medicine.disease_cause, Microbiology, Virus, Cell Line, Young Adult, Virology, medicine, Humans, Genetic variability, Child, Phylogeny, DNA Primers, Hepatitis, Mutation, Base Sequence, Virulence, fungi, Genetic Variation, Hepatitis A, Middle Aged, medicine.disease, Genetic translation, Internal ribosome entry site, Genetic Diversity and Evolution, Protein Biosynthesis, Insect Science, Acute Disease, DNA, Viral, Mutagenesis, Site-Directed, Nucleic Acid Conformation, RNA, Viral, France, Hepatitis A virus, 5' Untranslated Regions, HeLa Cells

الوصف: Mutations in the internal ribosome entry site (IRES) of hepatitis A virus (HAV) have been associated with enhanced in vitro replication and viral attenuation in animal models. To address the possible role of IRES variability in clinical presentation, IRES sequences were obtained from HAV isolates associated with benign ( n = 8) or severe ( n = 4) hepatitis. IRES activity was assessed using a bicistronic dual-luciferase expression system in adenocarcinoma (HeLa) and hepatoma (HuH7) cell lines. Activity was higher in HuH7 than in HeLa cells, except for an infrequently isolated genotype IIA strain. Though globally low, significant variation in IRES-dependent translation efficiency was observed between field isolates, reflecting the low but significant genetic variability of this region (94.2% ± 0.5% nucleotide identity). No mutation was exclusive of benign or severe hepatitis, and variations in IRES activity were not associated with a clinical phenotype, indirectly supporting the preponderance of host factors in determining the clinical presentation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1a52ecf0153710f12be0e34f764f33Test
https://doi.org/10.1128/jvi.02598-09Test

المؤلفون: Anne Marie Roque-Afonso, Delphine Desbois, Elisabeth Dussaix

المصدر: Future Virology. 5:233-242

مصطلحات موضوعية: Molecular epidemiology, Viral Epidemiology, viruses, Biology, Molecular diagnostics, Virology, Hepatitis a virus, Serology, Immune system, Polyclonal antibodies, Immunology, biology.protein, Avidity

الوصف: The diagnosis of hepatitis A virus (HAV) infection is based on the detection of anti-HAV IgM. Shortcomings of this serological approach include the persistence of IgM after normalization of liver enzymes or its detection during polyclonal activation of the immune system due to unrelated viral infection or autoimmune diseases. Molecular diagnosis of HAV along with anti-HAV IgG avidity measurement are helpful in case of positive IgM where laboratory evidence of acute hepatitis is absent and there is no epidemiologic link to other cases. Molecular epidemiology allows us to determine whether viruses from different locations are related to each other and provides further understanding of viral epidemiology by identifying sources and transmission modes. It has been demonstrated that the rapid turnover of HAV strains in low-endemicity countries is caused by their introduction by travelers. Growing sequence databases allow for the identification of geographic origin of viral strains. Collaboration between surveillance laboratories, including database sharing, should be promoted for deeper investigation of outbreaks and improved prevention approaches.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::219571eb51683abacf9d2e715a56462dTest
https://doi.org/10.2217/fvl.10.9Test

المؤلفون: Jean-Charles Duclos-Vallée, Elina Teicher, Laurence Bonhomme-Faivre, Delphine Desbois, Didier Samuel, Teresa Antonini, Chadi Abbara, Daniel Vittecoq

المصدر: Liver Transplantation. 15:1336-1342

مصطلحات موضوعية: Hepatitis B virus, Transplantation, Enfuvirtide, Hepatology, business.industry, medicine.medical_treatment, Hepatitis C virus, virus diseases, Immunosuppression, Lopinavir, Liver transplantation, medicine.disease_cause, immune system diseases, Immunology, medicine, Surgery, Ritonavir, business, Viral load, medicine.drug

الوصف: The aim of this study was to evaluate the impact of an enfuvirtide-based antiretroviral (ARV) regimen on the management of immunosuppression and follow-up in hepatitis C virus (HCV)/hepatitis B virus (HBV)/human immunodeficiency virus (HIV)-coinfected liver transplant patients in comparison with a lopinavir/ritonavir-based ARV regimen. Tacrolimus and cyclosporine trough concentrations were determined at a steady state during 3 periods: after liver transplantation without ARV treatment (period 1), at the time of ARV reintroduction (period 2), and 2 to 3 months after liver transplantation (period 3). The findings for 22 HIV-coinfected patients were compared (18 with HCV and 4 with HBV); 11 patients were treated with enfuvirtide and were matched with 11 lopinavir/ritonavir-exposed patients. During period 1, tacrolimus and cyclosporine A doses were 8 and 600 mg/day, respectively, and the trough concentrations were within the therapeutic range in both groups. In period 2, the addition of lopinavir/ritonavir to the immunosuppressant regimen enabled a reduction in the dose of immunosuppressants required to maintain trough concentrations within the therapeutic range (to 0.3 mg/day for tacrolimus and 75 mg/day for cyclosporine). Immunosuppressant doses were not modified by the reintroduction of enfuvirtide, there being no change in the mean trough concentrations over the 3 periods. CD4 cell counts remained at about 200 cells/mm3. The HIV RNA viral load remained undetectable. Both groups displayed signs of mild cytolysis and cholestasis due to the recurrence of HCV, whereas no renal insufficiency was observed. Enfuvirtide is an attractive alternative to standard ARV therapy, facilitating the management of drug-drug interactions shortly after liver transplantation. Moreover, the lack of liver toxicity renders this drug valuable in the event of a severe HCV recurrence.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e3c652ad8963f6efe5b1378bf6d6cafcTest
https://doi.org/10.1002/lt.21818Test

المؤلفون: Elisabeth Dussaix, Jeanine Savary, Delphine Desbois, Anne-Marie Roque-Afonso, P. Vaghefi

المصدر: Journal of Clinical Virology. 41:129-133

مصطلحات موضوعية: Adult, Male, Time Factors, Hepatitis C virus, Hepacivirus, Enzyme-Linked Immunosorbent Assay, medicine.disease_cause, Sensitivity and Specificity, Virus, Flaviviridae, Virology, Genotype, medicine, Humans, Chromatography, biology, business.industry, virus diseases, Hepatitis C, Hepatitis C Antibodies, Hepatitis C, Chronic, Middle Aged, medicine.disease, biology.organism_classification, Infectious Diseases, Immunology, biology.protein, Female, Reagent Kits, Diagnostic, Viral disease, Antibody, business

الوصف: Background and objectives Enzyme-linked immunoassays (ELISA) are the most widely used anti-hepatitis C virus (HCV) screening tests but simple, instrument and electricity-free screening tests have been developed with results available in a few minutes. Methods The sensitivity of a rapid immuno-chromatographic assay for the detection of anti-HCV antibodies was evaluated on 421 HCV RNA-positive samples from chronic carriers and compared with ELISA method. Results The sensitivity of the ELISA method was 99.3% and the sensitivity of the rapid test was 95.5%. False negative results were independent of HCV genotype, but were associated with human immunodeficiency virus (HIV)-positive status. Among HIV-negative people, sensitivities of the rapid test and the EIA assay were 99.2% and 100%, respectively. Whereas among HIV-positive people, sensitivities were 77.5% and 96.3%. Conclusions The immuno-chromatographic test is rapid and simple, and could be used along with rapid anti-HIV determination, in settings with limited facilities or when rapid results are required.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa2c4ed940941e89eb37df7f724a4a5Test
https://doi.org/10.1016/j.jcv.2007.11.002Test