المؤلفون: Terranova-Barberio, Manuela, Pawlowska, Nela, Dhawan, Mallika, Moasser, Mark, Chien, Amy J, Melisko, Michelle E, Rugo, Hope, Rahimi, Roshun, Deal, Travis, Daud, Adil, Rosenblum, Michael D, Thomas, Scott, Munster, Pamela N

المصدر: Nature communications. 11(1)

مصطلحات موضوعية: T-Lymphocytes, Lymphocytes, Tumor-Infiltrating, Humans, Breast Neoplasms, Tamoxifen, Receptors, Estrogen, Immunologic Factors, Treatment Outcome, Immunotherapy, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Antibodies, Monoclonal, Humanized, B7-H1 Antigen, Vorinostat

الوصف: Responses to immunotherapy are uncommon in estrogen receptor (ER)-positive breast cancer and to date, lack predictive markers. This randomized phase II study defines safety and response rate of epigenetic priming in ER-positive breast cancer patients treated with checkpoint inhibitors as primary endpoints. Secondary and exploratory endpoints included PD-L1 modulation and T-cell immune-signatures. 34 patients received vorinostat, tamoxifen and pembrolizumab with no excessive toxicity after progression on a median of five prior metastatic regimens. Objective response was 4% and clinical benefit rate (CR + PR + SD > 6 m) was 19%. T-cell exhaustion (CD8+ PD-1+/CTLA-4+) and treatment-induced depletion of regulatory T-cells (CD4+ Foxp3+/CTLA-4+) was seen in tumor or blood in 5/5 patients with clinical benefit, but only in one non-responder. Tumor lymphocyte infiltration was 0.17%. Only two non-responders had PD-L1 expression >1%. This data defines a novel immune signature in PD-L1-negative ER-positive breast cancer patients who are more likely to benefit from immune-checkpoint and histone deacetylase inhibition (NCT02395627).

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/63k294kqTest

مستخلص: An apparatus is provided that includes an elongate member having a distal end portion, a proximal end portion, and a medial portion that is disposed between the distal end portion and the proximal end portion. The medial portion is configured to be disposed in a ureter of a patient. The apparatus further includes an expandable member that is coupled to the elongate member. The expandable member has an expanded configuration and a collapsed configuration. The expandable member is further configured to be inserted into the ureter of the patient and configured to contact the ureter to help retain the elongate member in place within the patient.

مستخلص: A medical device including an elongate member having a distal end portion, a proximal end portion, and a medial portion disposed between the distal end portion an the proximal end portion. The proximal end portion is configured to be disposed within a bladder of a patient. A portion of the proximal end portion is configured to contact an inner wall of the bladder to help retain the bladder in an expanded configuration.

مستخلص: A ureteral stent includes a first material and a second material. The second material is formulated to have a hardness that is greater than a hardness of the first material. The second material is formulated to be soluble in a bodily fluid. The second material is combined with the first material to form a substantially homogeneous combination of the first material and the second material.

مستخلص: A medical device includes an elongate member and an expandable member. The elongate member has an inner surface and an outer surface. The inner surface defines a lumen. The elongate member has a collapsed configuration and an expanded configuration and is biased to its collapsed configuration. The expandable member is coupled to the outer surface of the elongate member. The expandable member is configured to move the elongate member from its collapsed configuration to its expanded configuration.

مستخلص: A stent according to an embodiment of the invention includes an elongate body having a proximal end portion and a distal end portion. The elongate body defines a lumen and an opening in communication with the lumen between the proximal end portion and the distal end portion configured to enable the flow of fluid therethrough. The lumen is configured to have a diameter wherein the opening has a width greater than half the size of the diameter and less than the diameter of the lumen. The opening has a length at least twice the width of opening. In some embodiments, the opening is configured to laterally receive a guidewire therethrough. The elongate body can be configured to releasably couple the guidewire within the lumen of the elongate body such that the elongate body can be slidably moved along the guidewire.

مستخلص: The invention is directed towards a medical device including an elongate member having a side wall defining a lumen configured to convey a fluid within a body of a patient. The medical device includes a reinforcement member configured to be selectively coupled to the side wall of the elongate member at a first axial location and a second axial location, the second axial location being axially offset from the first axial location. In some embodiments, the reinforcement member includes a side wall defining a lumen and the elongate member is configured to extend through the lumen defined by the side wall of the reinforcement member.

مستخلص: An apparatus is provided that includes an elongate member having a distal end portion, a proximal end portion, and a medial portion that is disposed between the distal end portion and the proximal end portion. The medial portion is configured to be disposed in a ureter of a patient. The apparatus further includes an expandable member that is coupled to the elongate member. The expandable member has an expanded configuration and a collapsed configuration. The expandable member is further configured to be inserted into the ureter of the patient and configured to contact the ureter to help retain the elongate member in place within the patient.

مستخلص: A medical device includes an elongate member and an expandable member. The elongate member has an inner surface and an outer surface. The inner surface defines a lumen. The elongate member has a collapsed configuration and an expanded configuration and is biased to its collapsed configuration. The expandable member is coupled to the outer surface of the elongate member. The expandable member is configured to move the elongate member from its collapsed configuration to its expanded configuration.

مستخلص: A medical device including an elongate member having a distal end portion, a proximal end portion, and a medial portion disposed between the distal end portion an the proximal end portion. The proximal end portion is configured to be disposed within a bladder of a patient. A portion of the proximal end portion is configured to contact an inner wall of the bladder to help retain the bladder in an expanded configuration.