المؤلفون: Antiga, Emiliano, Bech, Rikke, Maglie, Roberto, Genovese, Giovanni, Borradori, Luca, Bockle, Barbara, Caproni, Marzia, Caux, Frédéric, Chandran, Nisha Suyien, Corrà, Alberto, D'Amore, Francesco, Daneshpazhooh, Maryam, De, Dipankar, Didona, Dario, Dmochowski, Marian, Drenovska, Kossara, Ehrchen, Jan, Feliciani, Claudio, Goebeler, Matthias, Groves, Richard, Günther, Claudia, Handa, Sanjeev, Hofmann, Silke C, Horvath, Barbara, Ioannidis, Dimitrios, Jedlickova, Hana, Kowalewski, Cezary, Kridin, Khalaf, Joly, Pascal, Lim, Yen Loo, Marinovic, Branka, Maverakis, Emanual, Meijer, Joost, Patsatsi, Aikaterini, Pincelli, Carlo, Prost, Catherine, Setterfield, Jane, Sprecher, Eli, Skiljevic, Dusan, Tasanen, Kaisa, Uzun, Soner, Van Beek, Nina, Vassileva, Snejina, Vorobyev, Artem, Vujic, Igor, Wang, Gang, Wang, Mingyue, Wozniak, Katarzyna, Yayli, Savas, Zambruno, Giovanna, Hashimoto, Takashi, Schmidt, Enno, Mascarò, José Manuel, Marzano, Angelo Valerio

المصدر: Journal of the European Academy of Dermatology and Venereology. 37(6)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Hematology, Autoimmune Disease, Animals, Rats, Autoimmune Diseases, Neoplasms, Paraneoplastic Syndromes, Paraneoplastic Syndromes, Nervous System, Societies, Medical, Dermatology & Venereal Diseases, Clinical sciences

الوصف: BackgroundParaneoplastic pemphigus (PNP), also called paraneoplastic autoimmune multiorgan syndrome (PAMS), is a rare autoimmune disease with mucocutaneous and multi-organ involvement. PNP/PAMS is typically associated with lymphoproliferative or haematological malignancies, and less frequently with solid malignancies. The mortality rate of PNP/PAMS is elevated owing to the increased risk of severe infections and disease-associated complications, such as bronchiolitis obliterans.ObjectivesThese guidelines summarize evidence-based and expert-based recommendations (S2k level) for the clinical characterization, diagnosis and management of PNP/PAMS. They have been initiated by the Task Force Autoimmune Blistering Diseases of the European Academy of Dermatology and Venereology with the contribution of physicians from all relevant disciplines. The degree of consent among all task force members was included.ResultsChronic severe mucositis and polymorphic skin lesions are clue clinical characteristics of PNP/PAMS. A complete assessment of the patient with suspected PNP/PAMS, requiring histopathological study and immunopathological investigations, including direct and indirect immunofluorescence, ELISA and, where available, immunoblotting/immunoprecipitation, is recommended to achieve a diagnosis of PNP/PAMS. Detection of anti-envoplakin antibodies and/or circulating antibodies binding to the rat bladder epithelium at indirect immunofluorescence is the most specific tool for the diagnosis of PNP/PAMS in a patient with compatible clinical and anamnestic features. Treatment of PNP/PAMS is highly challenging. Systemic steroids up to 1.5 mg/kg/day are recommended as first-line option. Rituximab is also recommended in patients with PNP/PAMS secondary to lymphoproliferative conditions but might also be considered in cases of PNP/PAMS associated with solid tumours. A multidisciplinary approach involving pneumologists, ophthalmologists and onco-haematologists is recommended for optimal management of the patients.ConclusionsThese are the first European guidelines for the diagnosis and management of PNP/PAMS. Diagnostic criteria and therapeutic recommendations will require further validation by prospective studies.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/724349n0Test

المؤلفون: Krishna, Khambe Vishal¹, De, Dipankar^{2, 1}, Sahoo, P. K.²

المصدر: Journal of Agricultural Engineering 50(1):9-13. 2013

المؤلفون: De, Dipankar

المصدر: Journal of Agricultural Engineering 45(4):50-59. 2008

المؤلفون: Satpathy Guddy, De Dipankar

المصدر: Power Electronics and Drives, Vol 9, Iss 1, Pp 122-141 (2024)

مصطلحات موضوعية: active filtering, d-statcom, proportional resonant controller, lcl filter, Electronics, TK7800-8360

الوصف: This work focuses on a new topology-control-based D-STATCOM solution with reduced DC bus voltage requirement and with an excellent grid side performance. The proposed solution consists of a main inverter and auxiliary inverter along with a transformer and LCL filter network to achieve the required DC bus reduction. A new controller structure with two proportional-multi resonant controller for the converters with only one of the inductors current as a controlled variable ensures the active damping of the LCL resonance. The power circuit configuration assists the controller to generate a difference in the modulation signal due to non-equal gains in two controllers and helps to achieve the resonance damping without capacitor current sensor. Hence, the corresponding capacitor current sensor can be eliminated. The converter operates for any point of common coupling (PCC) loading conditions and the performance of the controller is immune to the grid impedance variation. A detailed stability study is carried out for the proposed controller. The proposed controller can achieve a very fast dynamic response with an excellent stability margin. The proposed solution is verified through simulation studies and through a scaled-down experimental prototype.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2543-4292Test

الوصول الحر: https://doaj.org/article/96e75462d4b4481a801eec53ef7a078aTest

المؤلفون: Antiga, Emiliano, Bech, Rikke, Maglie, Roberto, Genovese, Giovanni, Borradori, Luca, Bockle, Barbara, Caproni, Marzia, Caux, Frédéric, Chandran, Nisha Suyien, Corrà, Alberto, D'Amore, Francesco, Daneshpazhooh, Maryam, De, Dipankar, Didona, Dario, Dmochowski, Marian, Drenovska, Kossara, Ehrchen, Jan, Feliciani, Claudio, Goebeler, Matthias, Groves, Richard, Günther, Claudia, Handa, Sanjeev, Hofmann, Silke C., Horvath, Barbara, Ioannidis, Dimitrios, Jedlickova, Hana, Kowalewski, Cezary, Kridin, Khalaf, Joly, Pascal, Lim, Yen Loo, Marinovic, Branka, Maverakis, Emanual, Meijer, Joost, Patsatsi, Aikaterini, Pincelli, Carlo, Prost, Catherine, Setterfield, Jane, Sprecher, Eli, Skiljevic, Dusan, Tasanen, Kaisa, Uzun, Soner, Van Beek, Nina, Vassileva, Snejina, Vorobyev, Artem, Vujic, Igor, Wang, Gang, Wang, Mingyue, Wozniak, Katarzyna, Yayli, Savas, Zambruno, Giovanna, Hashimoto, Takashi, Schmidt, Enno, Mascarò, José Manuel, Marzano, Angelo Valerio

المصدر: Antiga , E , Bech , R , Maglie , R , Genovese , G , Borradori , L , Bockle , B , Caproni , M , Caux , F , Chandran , N S , Corrà , A , D'Amore , F , Daneshpazhooh , M , De , D , Didona , D , Dmochowski , M , Drenovska , K , Ehrchen , J , Feliciani , C , Goebeler , M , Groves , R , Günther , C , Handa , S , Hofmann , S C , Horvath , B , Ioannidis ....

الوصف: In the version of this article initially published, 1 Prof. Angelo Valerio Marzano affiliation was listed as “Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy”. His correct affiliations are the 3 Dermatology Unit, Fondazione IRCCS Ca′ Granda Ospedale Maggiore Policlinico, Milan, Italy and 56 Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy. The error has been corrected in the online version of the article.

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/38e93207-6bf8-4e4c-89e2-3aedad9a73f4Test

الإتاحة: https://doi.org/10.1111/jdv.19489Test
https://hdl.handle.net/11370/38e93207-6bf8-4e4c-89e2-3aedad9a73f4Test
https://research.rug.nl/en/publications/38e93207-6bf8-4e4c-89e2-3aedad9a73f4Test
https://pure.rug.nl/ws/files/876947908/Corrigendum-_S2k_guidelines_on_the_management_of_paraneoplastic_pemphigus_paraneoplastic_autoimmune_multiorgan_syndrome_initiated_by_the_European_Academy_of_Dermatology_and_Venereology_EADV_.pdfTest
http://www.scopus.com/inward/record.url?scp=85170668846&partnerID=8YFLogxKTest

المؤلفون: Thakur, Neha, Chatterjee, Debajyoti, Dev, Anubha, Shilpa, Mahajan, Rahul, Handa, Sanjeev, De, Dipankar

المساهمون: Special Research Grant for MD Thesis by PGIMER, Chandigarh

المصدر: Scientific Reports ; volume 13, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الوصف: Bullous pemphigoid (BP) and mucous membrane pemphigoid (MMP) sometimes have overlapping clinical, histopathological, and direct immunofluorescence (DIF) features in the early stages. Complement deposition is an intrinsic component of the patho-mechanism of BP in contrast to MMP. Hence immunohistochemistry (IHC) for C3d and C4d may be helpful in differentiating the two disorders. Seventy-four patients of BP and 18 patients of MMP along with 10 negative controls were enrolled in this study. C3d and C4d IHC was performed in formalin-fixed skin biopsy specimens. C3d IHC staining in BP/MMP had a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 59.2%/41.2%, 100%/100%, 100%/100%, 25.6%/50.0%, respectively. C4d IHC staining in BP/MMP had a sensitivity, specificity, PPV and NPV of 26.8%/17.6%, 100%/100%, 100%/100% and 16.1%/41.7%, respectively. Receiver operator analysis showed utility of C3d in diagnosing both BP [Area under curve (AUC) = 0.8, p = 0.0001] and MMP (AUC = 0.71; p = 0.001). C4d was useful in diagnosis of BP (AUC = 0.5; p = 0.0001), but not MMP (AUC = 0.6; p = 0.064). Hence, C3d is a better diagnostic modality for BP as compared to C4d, whereas C3d and C4d have lower diagnostic importance in MMP. C3d IHC can be employed in diagnosing BP when a second biopsy for direct immunofluorescence (DIF) is not possible or where a facility for IF microscopy does not exist.

الإتاحة: https://doi.org/10.1038/s41598-023-38193-8Test
https://www.nature.com/articles/s41598-023-38193-8.pdfTest
https://www.nature.com/articles/s41598-023-38193-8Test

المؤلفون: Mahajan, Rahul, Bakshi, Shirin, Kumar, Anoop, De, Dipankar, Handa, Sanjeev

المصدر: Frontiers in Pediatrics ; volume 11 ; ISSN 2296-2360

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الوصف: Netherton syndrome (NS) is rare and multisystemic congenital skin disorder classically distinguied as a triad of congenital ichthyosiform erythroderma, trichorrhexis invaginata (TI), and an atopic diathesis. Recent advances in pathogenesis have explored the role of IL-23/Th17 pathway in NS. Herein, we present a 17 years old girl harbouring homozygous four base pair deletion in exon 26 of the SPINK5 gene, presented with pruritus, scaling, dry skin and generalized eczematous lesions. She was administered anti IL17A (subcutaneous secukinumab) therapy. The treatment was well tolerated and resulted in a favourable clinical response, reduction of the IL17A gene expression and CD4 + Th17 cell population after 6 months which revealed an abrogation of Th17-skewing during therapy.

الإتاحة: https://doi.org/10.3389/fped.2023.1297658Test

المؤلفون: Ganie, Mohd Ashraf, Chowdhury, Subhankar, Suri, Vanita, Joshi, Beena, Bhattacharya, Prasanta Kumar, Agrawal, Sarita, Malhotra, Neena, Sahay, Rakesh, Jabbar, Puthiyaveettil Khadar, Nair, Abilash, Rozati, Roya, Shukla, Amlin, Rashid, Rabiya, Shah, Idrees A., Rashid, Haroon, Wani, Imtiyaz Ahmad, Arora, Taruna, Kulkarni, Bharati, Kulkarni, Bharti, Sreenivas, V., Srivastava, Mukesh, Koul, Parvaiz, Shah, Zafar Amin, Masoodi, Shariq, Parvez, Tabassum, Yatoo, Ghulam Nabi, Ahmed, Naseer, Gojwari, Tariq, Wani, Muzafar, Qayoom, Seema, Khan, Wahid, Walia, Rama, De, Dipankar, Arora, Aashima, Singh, Tulika, Khanna, Neena

المساهمون: Department of Health Research, India, Indian Council of Medical Research

المصدر: The Lancet Regional Health - Southeast Asia ; volume 15, page 100226 ; ISSN 2772-3682

مصطلحات موضوعية: Infectious Diseases, Psychiatry and Mental health, Public Health, Environmental and Occupational Health

الإتاحة: https://doi.org/10.1016/j.lansea.2023.100226Test
https://api.elsevier.com/content/article/PII:S2772368223000860?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2772368223000860?httpAccept=text/plainTest

المؤلفون: De, Dipankar¹ dr_dipankar_de@yahoo.in, Jain, Sejal¹, Dev, Anubha¹, Chatterjee, Debajyoti²

المصدر: International Journal of Dermatology. Jun2024, p1. 6p. 5 Illustrations, 1 Chart.

مصطلحات موضوعية: *ERYTHEMA multiforme, *HUMAN skin color, *ORAL lichen planus, *ORAL submucous fibrosis, *DRUG eruptions, *ORAL mucosa, *PLASMA cells

مستخلص: In dermatology, lichenoid describes lesions with a violaceous hue that is a clinical reflection of basal cell damage in the epithelium and dense mononuclear infiltrate in the sub‐epithelium. The violaceous color results from pigment incontinence due to basal cell damage and the Tyndall effect. Although classically described in lichen planus, a lichenoid hue is noted in the oral mucosa in several other disorders that often lead to diagnostic dilemmas. Early and accurate diagnosis is important for the appropriate management of the underlying condition and prognostication. Dermatologists play a central role in managing such patients since, apart from the oral mucosa findings, the cutaneous features also help to significantly differentiate various conditions. Mimickers of oral lichen planus include nicotine stomatitis, oral submucous fibrosis, oral lichenoid lesions, mucosal discoid lupus erythematosus, pemphigus vulgaris, paraneoplastic pemphigus, mucous membrane pemphigoid, fixed drug eruption, plasma cell cheilitis/gingivitis, and erythema multiforme. While a detailed history and clinical examination can help reach a diagnosis in most cases, histopathology, immunofluorescence, and other relevant investigations help establish the diagnosis. [ABSTRACT FROM AUTHOR]

المؤلفون: Malhi, Kittu, Mustari, Akash, Singh, Sukhdeep, Kumar, Anoop, Vignesh, Pandiarajan, De, Dipankar, Handa, Sanjeev, Mahajan, Rahul

المصدر: Australasian Journal of Dermatology; Jun2024, Vol. 65 Issue 4, p402-405, 4p

مصطلحات موضوعية: CONGENITAL disorders, SIBLINGS, DERMATOMYOSITIS, EXOCRINE pancreatic insufficiency, NUCLEOTIDE sequencing, GENETIC variation, FANCONI'S anemia

مستخلص: This article discusses a rare genetic disorder called hereditary fibrosing poikiloderma (HFP) that affects two siblings. HFP is characterized by childhood poikiloderma, muscle contractures, and pulmonary fibrotic defects. The siblings presented with pigmented cheek rash, eczematous lesions, and recurrent skin and ear infections. Genetic testing revealed a novel variation in the FAM111B gene, confirming a diagnosis of HFP. Treatment includes prophylactic antibiotics, photoprotection, and vitamin D supplementation. The article also explores the differential diagnoses and management approaches for HFP. [Extracted from the article]

: Copyright of Australasian Journal of Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)