المؤلفون: Ashley F.P. Sanders, Graham L. Baum, Michael P. Harms, Sridhar Kandala, Susan Y. Bookheimer, Mirella Dapretto, Leah H. Somerville, Kathleen M. Thomas, David C. Van Essen, Essa Yacoub, Deanna M. Barch

المصدر: Developmental Cognitive Neuroscience, Vol 57, Iss , Pp 101145- (2022)

مصطلحات موضوعية: Brain development, Cortical thickness, Socioeconomic status, HCP, Puberty, Brain networks, Neurophysiology and neuropsychology, QP351-495

الوصف: The human cerebral cortex undergoes considerable changes during development, with cortical maturation patterns reflecting regional heterogeneity that generally progresses in a posterior-to-anterior fashion. However, the organizing principles that govern cortical development remain unclear. In the current study, we characterized age-related differences in cortical thickness (CT) as a function of sex, pubertal timing, and two dissociable indices of socioeconomic status (i.e., income-to-needs and maternal education) in the context of functional brain network organization, using a cross-sectional sample (n = 789) diverse in race, ethnicity, and socioeconomic status from the Lifespan Human Connectome Project in Development (HCP-D). We found that CT generally followed a linear decline from 5 to 21 years of age, except for three functional networks that displayed nonlinear trajectories. We found no main effect of sex or age by sex interaction for any network. Earlier pubertal timing was associated with reduced mean CT and CT in seven networks. We also found a significant age by maternal education interaction for mean CT across cortex and CT in the dorsal attention network, where higher levels of maternal education were associated with steeper age-related decreases in CT. Taken together, our results suggest that these biological and environmental variations may impact the emerging functional connectome.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1878929322000883Test; https://doaj.org/toc/1878-9293Test

الوصول الحر: https://doaj.org/article/0abb0f4903764e26b1a1266c0754394fTest

المؤلفون: Matthew F. Glasser, Timothy S. Coalson, Michael P. Harms, Junqian Xu, Graham L. Baum, Joonas A. Autio, Edward J. Auerbach, Douglas N. Greve, Essa Yacoub, David C. Van Essen, Nicholas A. Bock, Takuya Hayashi

المصدر: NeuroImage, Vol 258, Iss , Pp 119360- (2022)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: T1-weighted divided by T2-weighted (T1w/T2w) myelin maps were initially developed for neuroanatomical analyses such as identifying cortical areas, but they are increasingly used in statistical comparisons across individuals and groups with other variables of interest. Existing T1w/T2w myelin maps contain radiofrequency transmit field (B1+) biases, which may be correlated with these variables of interest, leading to potentially spurious results. Here we propose two empirical methods for correcting these transmit field biases using either explicit measures of the transmit field or alternatively a ‘pseudo-transmit’ approach that is highly correlated with the transmit field at 3T. We find that the resulting corrected T1w/T2w myelin maps are both better neuroanatomical measures (e.g., for use in cross-species comparisons), and more appropriate for statistical comparisons of relative T1w/T2w differences across individuals and groups (e.g., sex, age, or body-mass-index) within a consistently acquired study at 3T. We recommend that investigators who use the T1w/T2w approach for mapping cortical myelin use these B1+ transmit field corrected myelin maps going forward.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1053811922004797Test; https://doaj.org/toc/1095-9572Test

الوصول الحر: https://doaj.org/article/1881e790dd474fb8b7f72d77012d133fTest

المؤلفون: Takayuki Ose, Joonas A. Autio, Masahiro Ohno, Stephen Frey, Akiko Uematsu, Akihiro Kawasaki, Chiho Takeda, Yuki Hori, Kantaro Nishigori, Tomokazu Nakako, Chihiro Yokoyama, Hidetaka Nagata, Tetsuo Yamamori, David C. Van Essen, Matthew F. Glasser, Hiroshi Watabe, Takuya Hayashi

المصدر: NeuroImage, Vol 250, Iss , Pp 118965- (2022)

مصطلحات موضوعية: Marmoset, brain, cranium, subject variability, coordinates, neurosurgery, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Localising accurate brain regions needs careful evaluation in each experimental species due to their individual variability. However, the function and connectivity of brain areas is commonly studied using a single-subject cranial landmark-based stereotactic atlas in animal neuroscience. Here, we address this issue in a small primate, the common marmoset, which is increasingly widely used in systems neuroscience. We developed a non-invasive multi-modal neuroimaging-based targeting pipeline, which accounts for intersubject anatomical variability in cranial and cortical landmarks in marmosets. This methodology allowed creation of multi-modal templates (MarmosetRIKEN20) including head CT and brain MR images, embedded in coordinate systems of anterior and posterior commissures (AC-PC) and CIFTI grayordinates. We found that the horizontal plane of the stereotactic coordinate was significantly rotated in pitch relative to the AC-PC coordinate system (10 degrees, frontal downwards), and had a significant bias and uncertainty due to positioning procedures. We also found that many common cranial and brain landmarks (e.g., bregma, intraparietal sulcus) vary in location across subjects and are substantial relative to average marmoset cortical area dimensions. Combining the neuroimaging-based targeting pipeline with robot-guided surgery enabled proof-of-concept targeting of deep brain structures with an accuracy of 0.2 mm. Altogether, our findings demonstrate substantial intersubject variability in marmoset brain and cranial landmarks, implying that subject-specific neuroimaging-based localization is needed for precision targeting in marmosets. The population-based templates and atlases in grayordinates, created for the first time in marmoset monkeys, should help bridging between macroscale and microscale analyses.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1053811922000945Test; https://doaj.org/toc/1095-9572Test

الوصول الحر: https://doaj.org/article/c217f83763704e8ea0a71112cb51198dTest

المؤلفون: Jennifer Stine Elam, Matthew F. Glasser, Michael P. Harms, Stamatios N. Sotiropoulos, Jesper L.R. Andersson, Gregory C. Burgess, Sandra W. Curtiss, Robert Oostenveld, Linda J. Larson-Prior, Jan-Mathijs Schoffelen, Michael R. Hodge, Eileen A. Cler, Daniel M. Marcus, Deanna M. Barch, Essa Yacoub, Stephen M. Smith, Kamil Ugurbil, David C. Van Essen

المصدر: NeuroImage, Vol 244, Iss , Pp 118543- (2021)

مصطلحات موضوعية: Diffusion imaging, Functional MRI, Parcellation, Magnetoencephalography, Connectivity, Behavior, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: The Human Connectome Project (HCP) was launched in 2010 as an ambitious effort to accelerate advances in human neuroimaging, particularly for measures of brain connectivity; apply these advances to study a large number of healthy young adults; and freely share the data and tools with the scientific community. NIH awarded grants to two consortia; this retrospective focuses on the “WU-Minn-Ox” HCP consortium centered at Washington University, the University of Minnesota, and University of Oxford. In just over 6 years, the WU-Minn-Ox consortium succeeded in its core objectives by: 1) improving MR scanner hardware, pulse sequence design, and image reconstruction methods, 2) acquiring and analyzing multimodal MRI and MEG data of unprecedented quality together with behavioral measures from more than 1100 HCP participants, and 3) freely sharing the data (via the ConnectomeDB database) and associated analysis and visualization tools. To date, more than 27 Petabytes of data have been shared, and 1538 papers acknowledging HCP data use have been published. The “HCP-style” neuroimaging paradigm has emerged as a set of best-practice strategies for optimizing data acquisition and analysis. This article reviews the history of the HCP, including comments on key events and decisions associated with major project components. We discuss several scientific advances using HCP data, including improved cortical parcellations, analyses of connectivity based on functional and diffusion MRI, and analyses of brain-behavior relationships. We also touch upon our efforts to develop and share a variety of associated data processing and analysis tools along with detailed documentation, tutorials, and an educational course to train the next generation of neuroimagers. We conclude with a look forward at opportunities and challenges facing the human neuroimaging field from the perspective of the HCP consortium.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1053811921008168Test; https://doaj.org/toc/1095-9572Test

الوصول الحر: https://doaj.org/article/fe93c1d02763446c88062ba1a386abf5Test

المؤلفون: Chihiro Yokoyama, Joonas A. Autio, Takuro Ikeda, Jérôme Sallet, Rogier B. Mars, David C. Van Essen, Matthew F. Glasser, Norihiro Sadato, Takuya Hayashi

المصدر: NeuroImage, Vol 245, Iss , Pp 118693- (2021)

مصطلحات موضوعية: Primate, Social behavior, Comparative connectomics, Neuroimaging, Cross-species, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Social interaction is thought to provide a selection pressure for human intelligence, yet little is known about its neurobiological basis and evolution throughout the primate lineage. Recent advances in neuroimaging have enabled whole brain investigation of brain structure, function, and connectivity in humans and non-human primates (NHPs), leading to a nascent field of comparative connectomics. However, linking social behavior to brain organization across the primates remains challenging. Here, we review the current understanding of the macroscale neural mechanisms of social behaviors from the viewpoint of system neuroscience. We first demonstrate an association between the number of cortical neurons and the size of social groups across primates, suggesting a link between neural information-processing capacity and social capabilities. Moreover, by capitalizing on recent advances in species-harmonized functional MRI, we demonstrate that portions of the mirror neuron system and default-mode networks, which are thought to be important for representation of the other's actions and sense of self, respectively, exhibit similarities in functional organization in macaque monkeys and humans, suggesting possible homologies. With respect to these two networks, we describe recent developments in the neurobiology of social perception, joint attention, personality and social complexity. Together, the Human Connectome Project (HCP)-style comparative neuroimaging, hyperscanning, behavioral, and other multi-modal investigations are expected to yield important insights into the evolutionary foundations of human social behavior.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1053811921009666Test; https://doaj.org/toc/1095-9572Test

الوصول الحر: https://doaj.org/article/5740c6cef8074caaa164c0f43695bb5dTest

المؤلفون: Joonas A. Autio, Qi Zhu, Xiaolian Li, Matthew F. Glasser, Caspar M. Schwiedrzik, Damien A. Fair, Jan Zimmermann, Essa Yacoub, Ravi S. Menon, David C. Van Essen, Takuya Hayashi, Brian Russ, Wim Vanduffel

المصدر: NeuroImage, Vol 236, Iss , Pp 118082- (2021)

مصطلحات موضوعية: MRI, Standardization, Non-human primate, Multi-site, PRIME-DE, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Recent methodological advances in MRI have enabled substantial growth in neuroimaging studies of non-human primates (NHPs), while open data-sharing through the PRIME-DE initiative has increased the availability of NHP MRI data and the need for robust multi-subject multi-center analyses. Streamlined acquisition and analysis protocols would accelerate and improve these efforts. However, consensus on minimal standards for data acquisition protocols and analysis pipelines for NHP imaging remains to be established, particularly for multi-center studies. Here, we draw parallels between NHP and human neuroimaging and provide minimal guidelines for harmonizing and standardizing data acquisition. We advocate robust translation of widely used open-access toolkits that are well established for analyzing human data. We also encourage the use of validated, automated pre-processing tools for analyzing NHP data sets. These guidelines aim to refine methodological and analytical strategies for small and large-scale NHP neuroimaging data. This will improve reproducibility of results, and accelerate the convergence between NHP and human neuroimaging strategies which will ultimately benefit fundamental and translational brain science.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1053811921003591Test; https://doaj.org/toc/1095-9572Test

الوصول الحر: https://doaj.org/article/06a803cfc02541d0ae80018629cc38ccTest

المؤلفون: Michiel Cottaar, Matteo Bastiani, Nikhil Boddu, Matthew F. Glasser, Suzanne Haber, David C. van Essen, Stamatios N. Sotiropoulos, Saad Jbabdi

المصدر: NeuroImage, Vol 227, Iss , Pp 117693- (2021)

مصطلحات موضوعية: tractography, diffusion MRI, connectome, gyral bias, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Many brain imaging studies aim to measure structural connectivity with diffusion tractography. However, biases in tractography data, particularly near the boundary between white matter and cortical grey matter can limit the accuracy of such studies. When seeding from the white matter, streamlines tend to travel parallel to the convoluted cortical surface, largely avoiding sulcal fundi and terminating preferentially on gyral crowns. When seeding from the cortical grey matter, streamlines generally run near the cortical surface until reaching deep white matter. These so-called “gyral biases” limit the accuracy and effective resolution of cortical structural connectivity profiles estimated by tractography algorithms, and they do not reflect the expected distributions of axonal densities seen in invasive tracer studies or stains of myelinated fibres. We propose an algorithm that concurrently models fibre density and orientation using a divergence-free vector field within gyral blades to encourage an anatomically-justified streamline density distribution along the cortical white/grey-matter boundary while maintaining alignment with the diffusion MRI estimated fibre orientations. Using in vivo data from the Human Connectome Project, we show that this algorithm reduces tractography biases. We compare the structural connectomes to functional connectomes from resting-state fMRI, showing that our model improves cross-modal agreement. Finally, we find that after parcellation the changes in the structural connectome are very minor with slightly improved interhemispheric connections (i.e, more homotopic connectivity) and slightly worse intrahemispheric connections when compared to tracers.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1053811920311782Test; https://doaj.org/toc/1095-9572Test

الوصول الحر: https://doaj.org/article/77c83873839342c792e81e819a9e22aaTest

المؤلفون: Shinsuke Koike, Saori C. Tanaka, Tomohisa Okada, Toshihiko Aso, Ayumu Yamashita, Okito Yamashita, Michiko Asano, Norihide Maikusa, Kentaro Morita, Naohiro Okada, Masaki Fukunaga, Akiko Uematsu, Hiroki Togo, Atsushi Miyazaki, Katsutoshi Murata, Yuta Urushibata, Joonas Autio, Takayuki Ose, Junichiro Yoshimoto, Toshiyuki Araki, Matthew F. Glasser, David C. Van Essen, Megumi Maruyama, Norihiro Sadato, Mitsuo Kawato, Kiyoto Kasai, Yasumasa Okamoto, Takashi Hanakawa, Takuya Hayashi

المصدر: NeuroImage: Clinical, Vol 30, Iss , Pp 102600- (2021)

مصطلحات موضوعية: Multi-site study, HCP-style brain imaging, Psychiatric disorders, Neurological disorders, Harmonization protocol, Traveling subjects, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

الوصف: Psychiatric and neurological disorders are afflictions of the brain that can affect individuals throughout their lifespan. Many brain magnetic resonance imaging (MRI) studies have been conducted; however, imaging-based biomarkers are not yet well established for diagnostic and therapeutic use. This article describes an outline of the planned study, the Brain/MINDS Beyond human brain MRI project (BMB-HBM, FY2018 ~ FY2023), which aims to establish clinically-relevant imaging biomarkers with multi-site harmonization by collecting data from healthy traveling subjects (TS) at 13 research sites. Collection of data in psychiatric and neurological disorders across the lifespan is also scheduled at 13 sites, whereas designing measurement procedures, developing and analyzing neuroimaging protocols, and databasing are done at three research sites. A high-quality scanning protocol, Harmonization Protocol (HARP), was established for five high-quality 3 T scanners to obtain multimodal brain images including T1 and T2-weighted, resting-state and task functional and diffusion-weighted MRI. Data are preprocessed and analyzed using approaches developed by the Human Connectome Project. Preliminary results in 30 TS demonstrated cortical thickness, myelin, functional connectivity measures are comparable across 5 scanners, suggesting sensitivity to subject-specific connectome. A total of 75 TS and more than two thousand patients with various psychiatric and neurological disorders are scheduled to participate in the project, allowing a mixed model statistical harmonization. The HARP protocols are publicly available online, and all the imaging, demographic and clinical information, harmonizing database will also be made available by 2024. To the best of our knowledge, this is the first project to implement a prospective, multi-level harmonization protocol with multi-site TS data. It explores intractable brain disorders across the lifespan and may help to identify the disease-specific pathophysiology and imaging biomarkers for clinical practice.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2213158221000449Test; https://doaj.org/toc/2213-1582Test

الوصول الحر: https://doaj.org/article/28aa337fce2c445e8cea870bd036167dTest

المؤلفون: Joonas A. Autio, Matthew F. Glasser, Takayuki Ose, Chad J. Donahue, Matteo Bastiani, Masahiro Ohno, Yoshihiko Kawabata, Yuta Urushibata, Katsutoshi Murata, Kantaro Nishigori, Masataka Yamaguchi, Yuki Hori, Atsushi Yoshida, Yasuhiro Go, Timothy S. Coalson, Saad Jbabdi, Stamatios N. Sotiropoulos, Henry Kennedy, Stephen Smith, David C. Van Essen, Takuya Hayashi

المصدر: NeuroImage, Vol 215, Iss , Pp 116800- (2020)

مصطلحات موضوعية: Macaque, Primate, Human connectome project, Parallel imaging, Cortex, Resting-state, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Macaque monkeys are an important animal model where invasive investigations can lead to a better understanding of the cortical organization of primates including humans. However, the tools and methods for noninvasive image acquisition (e.g. MRI RF coils and pulse sequence protocols) and image data preprocessing have lagged behind those developed for humans. To resolve the structural and functional characteristics of the smaller macaque brain, high spatial, temporal, and angular resolutions combined with high signal-to-noise ratio are required to ensure good image quality. To address these challenges, we developed a macaque 24-channel receive coil for 3-T MRI with parallel imaging capabilities. This coil enables adaptation of the Human Connectome Project (HCP) image acquisition protocols to the in-vivo macaque brain. In addition, we adapted HCP preprocessing methods to the macaque brain, including spatial minimal preprocessing of structural, functional MRI (fMRI), and diffusion MRI (dMRI). The coil provides the necessary high signal-to-noise ratio and high efficiency in data acquisition, allowing four- and five-fold accelerations for dMRI and fMRI. Automated FreeSurfer segmentation of cortex, reconstruction of cortical surface, removal of artefacts and nuisance signals in fMRI, and distortion correction of dMRI all performed well, and the overall quality of basic neurobiological measures was comparable with those for the HCP. Analyses of functional connectivity in fMRI revealed high sensitivity as compared with those from publicly shared datasets. Tractography-based connectivity estimates correlated with tracer connectivity similarly to that achieved using ex-vivo dMRI. The resulting HCP-style in vivo macaque MRI data show considerable promise for analyzing cortical architecture and functional and structural connectivity using advanced methods that have previously only been available in studies of the human brain.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1053811920302871Test; https://doaj.org/toc/1095-9572Test

الوصول الحر: https://doaj.org/article/40adf4d18e3e4e36a2d21e50fbe81699Test

المؤلفون: Takuya Hayashi, Yujie Hou, Matthew F Glasser, Joonas A Autio, Kenneth Knoblauch, Miho Inoue-Murayama, Tim Coalson, Essa Yacoub, Stephen Smith, Henry Kennedy, David C Van Essen

المصدر: NeuroImage, Vol 229, Iss , Pp 117726- (2021)

مصطلحات موضوعية: Functional MRI, Diffusion MRI, Retrograde tracer, Connectivity, Connectome, Hierarchy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Multi-modal neuroimaging projects such as the Human Connectome Project (HCP) and UK Biobank are advancing our understanding of human brain architecture, function, connectivity, and their variability across individuals using high-quality non-invasive data from many subjects. Such efforts depend upon the accuracy of non-invasive brain imaging measures. However, ‘ground truth’ validation of connectivity using invasive tracers is not feasible in humans. Studies using nonhuman primates (NHPs) enable comparisons between invasive and non-invasive measures, including exploration of how “functional connectivity” from fMRI and “tractographic connectivity” from diffusion MRI compare with long-distance connections measured using tract tracing. Our NonHuman Primate Neuroimaging & Neuroanatomy Project (NHP_NNP) is an international effort (6 laboratories in 5 countries) to: (i) acquire and analyze high-quality multi-modal brain imaging data of macaque and marmoset monkeys using protocols and methods adapted from the HCP; (ii) acquire quantitative invasive tract-tracing data for cortical and subcortical projections to cortical areas; and (iii) map the distributions of different brain cell types with immunocytochemical stains to better define brain areal boundaries. We are acquiring high-resolution structural, functional, and diffusion MRI data together with behavioral measures from over 100 individual macaques and marmosets in order to generate non-invasive measures of brain architecture such as myelin and cortical thickness maps, as well as functional and diffusion tractography-based connectomes. We are using classical and next-generation anatomical tracers to generate quantitative connectivity maps based on brain-wide counting of labeled cortical and subcortical neurons, providing ground truth measures of connectivity. Advanced statistical modeling techniques address the consistency of both kinds of data across individuals, allowing comparison of tracer-based and non-invasive MRI-based connectivity measures. We aim to ...

العلاقة: http://www.sciencedirect.com/science/article/pii/S1053811921000033Test; https://doaj.org/toc/1095-9572Test; https://doaj.org/article/52f6375711d14fe188b60de01d124a74Test

الإتاحة: https://doi.org/10.1016/j.neuroimage.2021.117726Test
https://doaj.org/article/52f6375711d14fe188b60de01d124a74Test