المؤلفون: Francesca Palandri, Elena M. Elli, Giuseppe Auteri, Massimiliano Bonifacio, Giulia Benevolo, Florian H. Heidel, Simona Paglia, Malgorzata M. Trawinska, Costanza Bosi, Elena Rossi, Mario Tiribelli, Alessia Tieghi, Alessandra Iurlo, Nicola Polverelli, Giovanni Caocci, Gianni Binotto, Francesco Cavazzini, Eloise Beggiato, Daniela Cilloni, Caterina Tatarelli, Francesco Mendicino, Maurizio Miglino, Monica Bocchia, Monica Crugnola, Camilla Mazzoni, Andrea D. Romagnoli, Giovanni Rindone, Sara Ceglie, Alessandra D’Addio, Eleonora Santoni, Daniele Cattaneo, Daniela Bartoletti, Roberto M. Lemoli, Mauro Krampera, Antonio Cuneo, Gianpietro C. Semenzato, Roberto Latagliata, Elisabetta Abruzzese, Nicola Vianelli, Michele Cavo, Alessandro Andriani, Valerio De Stefano, Giuseppe A. Palumbo, Massimo Breccia

المصدر: Blood Cancer Journal, Vol 13, Iss 1, Pp 1-5 (2023)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2044-5385Test

الوصول الحر: https://doaj.org/article/142637191ad84c61a603c3e424c76be2Test

المؤلفون: Giuseppe Auteri, Simona Paglia, Camilla Mazzoni, Mattia Biondo, Marta Venturi, Andre Davide Romagnoli, Daniela Bartoletti, Michele Cavo, Nicola Vianelli, Francesca Palandri

المصدر: Mediterranean Journal of Hematology and Infectious Diseases, Vol 15, Iss 1 (2023)

مصطلحات موضوعية: Immune Thrombocytopenia, COVID19, vaccine, SARS-CoV-2, Diseases of the blood and blood-forming organs, RC633-647.5

الوصف: BACKGROUND AND OBJECTIVES Several infections and vaccinations can provoke immune thrombocytopenia (ITP) onset or relapse. Information on ITP epidemiology and management during the Covid19 pandemic is scarce. In a large monocenter ITP cohort, we assessed incidence of and risk factors for: 1) ITP onset/relapse after Covid19 vaccination/ infection; 2) Covid19 infection. METHODS Information on date/type of anti-Covid19 vaccine, platelet count before and within 30 days from vaccine and date/grade of Covid19, was collected via phone call or during hematological visits. ITP relapse was defined as a drop in PLT count within 30 days from vaccination, compared to PLT count before vaccination that required a rescue therapy OR a dose increase of an ongoing therapy OR a PLT count

وصف الملف: electronic resource

العلاقة: http://www.mjhid.org/index.php/mjhid/article/view/5275Test; https://doaj.org/toc/2035-3006Test

الوصول الحر: https://doaj.org/article/2196f5e9c0794694aabd650d640a1cd0Test

المؤلفون: Francesca Palandri, Giuseppe Alberto Palumbo, Elena Maria Elli, Nicola Polverelli, Giulia Benevolo, Bruno Martino, Elisabetta Abruzzese, Mario Tiribelli, Alessia Tieghi, Roberto Latagliata, Francesco Cavazzini, Micaela Bergamaschi, Gianni Binotto, Monica Crugnola, Alessandro Isidori, Giovanni Caocci, Florian Heidel, Novella Pugliese, Costanza Bosi, Daniela Bartoletti, Giuseppe Auteri, Daniele Cattaneo, Luigi Scaffidi, Malgorzata Monica Trawinska, Rossella Stella, Fiorella Ciantia, Fabrizio Pane, Antonio Cuneo, Mauro Krampera, Gianpietro Semenzato, Roberto Massimo Lemoli, Alessandra Iurlo, Nicola Vianelli, Michele Cavo, Massimo Breccia, Massimiliano Bonifacio

المصدر: Blood Cancer Journal, Vol 11, Iss 1, Pp 1-4 (2021)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2044-5385Test

الوصول الحر: https://doaj.org/article/1a0e0feee4a847eb9105d5df87c25b48Test

المؤلفون: Francesca Palandri, Christian Di Pietro, Francesca Ricci, Pier Luigi Tazzari, Vanda Randi, Daniela Bartoletti, Michele Cavo, Nicola Vianelli, Giuseppe Auteri

المصدر: Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 8, Pp n/a-n/a (2021)

مصطلحات موضوعية: ADAMTS‐13, caplacizumab, COVID‐19, rituximab, thrombotic thrombocytopenic purpura, TTP, Diseases of the blood and blood-forming organs, RC633-647.5

الوصف: Abstract Recently, treatment of immune‐mediated thrombotic thrombocytopenic purpura (ITTP) has changed with the advent of caplacizumab in clinical practice. The International Working Group (IWG) has recently integrated the ADAMTS‐13 activity/autoantibody monitoring in consensus outcome definitions. We report three ITTP cases during the coronavirus disease 2019 pandemic, that received a systematic evaluation of ADAMTS‐13 activity and autoantibodies. We describe how the introduction of caplacizumab and ADAMTS‐13 monitoring could change the management of ITTP patients and discuss whether therapeutic choices should be based on the clinical response alone. ADAMTS‐13 activity/antibodies were assessed every 5 days. Responses were evaluated according to updated IWG outcome definitions. These kinetics, rather than clinical remission, guided the therapy, allowing early and safe caplacizumab discontinuation and sensible administration of rituximab. Caplacizumab was cautiously discontinued after achieving ADAMTS‐13 complete remission. These cases illustrate that prospective ADAMTS‐13 evaluation and use of updated IWG definitions may improve real‐life patients’ management in the caplacizumab era.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2475-0379Test

الوصول الحر: https://doaj.org/article/b0c87e16f0054fb59bc0527a706c92a2Test

المؤلفون: Gianluigi Colalucci, Daniela Bartoletti

المصدر: Conservation Science in Cultural Heritage, Vol 19, Iss 1, Pp 99-115 (2019)

مصطلحات موضوعية: frieze, primer, frame, thermoplastic resin, Arts in general, NX1-820

الوصف: In 1897, the architect Ernesto Basile was commissioned to design the new Chamber in the Italian Parliament. Basile visualised a long painted frieze crowning the Chamber. The assignment was given to the painter Aristide Sartorio who executed it between 1908 and 1911. The frieze is 105 meters long, 3.75 high, and consists of 50 panels painted on canvas. In 1998 the frieze was examined closely and several problems regarding its state of conservation became evident, such as the loss of elasticity of the canvas and the widespread tendency of the paint film to become detached. In order to study the problem and plan the restoration for the entire frieze, it was decided to do a pilot restoration on only one of the 50 panels. The restoration was carried out in an equipped environment inside the Parliament, during the period 2003- 2004. Based on the studies carried out over the two years, it was possible to plan the restoration of the entire frieze, which was completed in one year: from 2006 to 2007. The panels were taken to a Roman studio exclusively dedicated to this restoration. It was not possible to do the restoration in situ as it would have created a disturbance in the working of the Parliament. The panels painted by Sartorio with a particular technique based on oil and wax, were treated with BEVA 371, reactivated with heat using a flat, low pressure table, and with a heated curved low pressure table specially designed by us. Using the same system and cloth bands, the edges of the panels were reinforced and then placed on their original frames. Finally, the veil of greasy particulate matter that had deposited over a century was removed. The restoration, directed by the Architectural Superintendency of Rome, was preceded and accompanied by numerous scientific research studies on the colors, canvas, color medium, wood and microclimate of the frieze. An extensive detailed color photographic documentation recorded all the phases of the restoration.

وصف الملف: electronic resource

العلاقة: https://conservation-science.unibo.it/article/view/10346Test; https://doaj.org/toc/1974-4951Test; https://doaj.org/toc/1973-9494Test

الوصول الحر: https://doaj.org/article/eca9b2feaba94526a819ba0862a4a2eeTest

المؤلفون: Giuseppe Auteri, Daniela Bartoletti, Clara Bertuzzi, Francesco Bacci, Valeria Tonini, Lucia Catani, Nicola Vianelli, Michele Cavo, Francesca Palandri

المصدر: Hematology Reports, Vol 13, Iss 2 (2021)

مصطلحات موضوعية: Splenomegaly, Next Generation Sequencing, Myeloproliferative Neoplasms, Diseases of the blood and blood-forming organs, RC633-647.5

الوصف: Many diseases can induce splenomegaly, however, about 5% of splenomegalies are idiopathic. When there is no underlying treatable cause, and the splenomegaly significantly affects the quality of life, splenectomy is the best therapeutic choice. A 67-year-old woman had idiopathic and asymptomatic splenomegaly. The increase in splenomegaly resulted in hypersplenism with cytopenia and symptoms related to abdominal discomfort. The patient underwent splenectomy which led to clinical improvement. A histological examination showed the presence of hematopoietic tissue. Peripheral blood Next Generation Sequencing with the myeloid panel SOPHiA Genetics showed the following mutations: ASXL1, SRSF2, KRAS and TET2. Three out of these four mutations were also found in the splenic tissue. Next Generation Sequencing could be useful in the diagnosis of splenomegalies associated with myeloproliferative neoplasms otherwise defined as idiopathic, in order to address a therapeutic strategy.

وصف الملف: electronic resource

العلاقة: https://www.pagepress.org/journals/index.php/hr/article/view/8814Test; https://doaj.org/toc/2038-8322Test; https://doaj.org/toc/2038-8330Test

الوصول الحر: https://doaj.org/article/6dc866c8a1e043e783adc7d456a891a2Test

المؤلفون: Martina Barone, Lucia Catani, Francesca Ricci, Marco Romano, Dorian Forte, Giuseppe Auteri, Daniela Bartoletti, Emanuela Ottaviani, Pier Luigi Tazzari, Nicola Vianelli, Michele Cavo, Francesca Palandri

المصدر: OncoImmunology, Vol 9, Iss 1 (2020)

مصطلحات موضوعية: myelofibrosis, monocyte, ruxolitinib, extracellular vesicles, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Myelofibrosis (MF) is characterized by chronic inflammation and hyper-activation of the JAK-STAT pathway. Infections are one of the main causes of morbidity/mortality. Therapy with Ruxolitinib (RUX), a JAK1/2 inhibitor, may further increase the infectious risk. Monocytes are critical players in inflammation/immunity through cytokine production and release of bioactive extracellular vesicles. However, the functional behavior of MF monocytes, particularly during RUX therapy, is still unclear. In this study, we found that monocytes from JAK2V617F-mutated MF patients show an altered expression of chemokine (CCR2, CXCR3, CCR5) and cytokine (TNF-α-R, IL10-R, IL1β-R, IL6-R) receptors. Furthermore, their ability to produce and secrete free and extracellular vesicles-linked cytokines (IL1β, TNF-α, IL6, IL10) under lipopolysaccharides (LPS) stimulation is severely impaired. Interestingly, monocytes from RUX-treated patients show normal level of chemokine, IL10, IL1β, and IL6 receptors together with a restored ability to produce intracellular and to secrete extracellular vesicles-linked cytokines after LPS stimulation. Conversely, RUX therapy does not normalize TNF-R1/2 receptors expression and the LPS-driven secretion of free pro/anti-inflammatory cytokines. Accordingly, upon LPS stimulation, in vitro RUX treatment of monocytes from MF patients increases their secretion of extracellular vesicles-linked cytokines but inhibits the secretion of free pro/anti-inflammatory cytokines. In conclusion, we demonstrated that in MF the infection-driven response of circulating monocytes is defective. Importantly, RUX promotes their infection-driven cytokine production suggesting that infections following RUX therapy may not be due to monocyte failure. These findings contribute to better interpreting the immune vulnerability of MF and to envisaging strategies to improve the infection-driven immune response.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2162-402XTest

الوصول الحر: https://doaj.org/article/6dcbe6ddbddd40ca95f38f7cec8aa42bTest

المؤلفون: Dorian Forte, Flaminia Fanelli, Marco Mezzullo, Martina Barone, Giulia Corradi, Giuseppe Auteri, Daniela Bartoletti, Marina Martello, Emanuela Ottaviani, Carolina Terragna, Antonio Curti, Uberto Pagotto, Francesca Palandri, Michele Cavo, Lucia Catani

المصدر: International Journal of Molecular Sciences, Vol 21, Iss 9, p 3399 (2020)

مصطلحات موضوعية: endocannabinoids, N-acylethanolamines, myeloproliferative neoplasms, myelofibrosis, polycythemia vera, essential thrombocythemia, Biology (General), QH301-705.5, Chemistry, QD1-999

الوصف: Growing evidence highlights the endocannabinoid (EC) system involvement in cancer progression. Lipid mediators of this system are secreted by hematopoietic cells, including the ECs 2-arachidonoyl-glycerol (2AG) and arachidonoyl-ethanolamide (AEA), the 2AG metabolite 1AG, and members of N-acylethanolamine (NAE) family—palmitoyl-ethanolamide (PEA) and oleoyl-ethanolamide (OEA). However, the relevance of the EC system in myeloproliferative neoplasms (MPN) was never investigated. We explored the EC plasma profile in 55 MPN patients, including myelofibrosis (MF; n = 41), polycythemia vera (PV; n = 9), and essential thrombocythemia (ET; n = 5) subclasses and in 10 healthy controls (HC). AEA, PEA, OEA, 2AG, and 1AG plasma levels were measured by LC–MS/MS. Overall considered, MPN patients displayed similar EC and NAE levels compared to HC. Nonetheless, AEA levels in MPN were directly associated with the platelet count. MF patients showed higher levels of the sum of 2AG and 1AG compared to ET and PV patients, higher OEA/AEA ratios compared to HC and ET patients, and higher OEA/PEA ratios compared to HC. Furthermore, the sum of 2AG and 1AG positively correlated with JAK2V617F variant allele frequency and splenomegaly in MF and was elevated in high-risk PV patients compared to in low-risk PV patients. In conclusion, our work revealed specific alterations of ECs and NAE plasma profile in MPN subclasses and potentially relevant associations with disease severity.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/21/9/3399Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/cecee641bf8f4d528e386b89a0351b3bTest

المؤلفون: Francesca Palandri, Massimo Breccia, Camilla Mazzoni, Giuseppe Auteri, Elena Maria Elli, Malgorzata M. Trawinska, Nicola Polverelli, Mario Tiribelli, Giulia Benevolo, Alessandra Iurlo, Alessia Tieghi, Florian H. Heidel, Giovanni Caocci, Eloise Beggiato, Gianni Binotto, Francesco Cavazzini, Maurizio Miglino, Costanza Bosi, Monica Crugnola, Monica Bocchia, Bruno Martino, Novella Pugliese, Mattia Biondo, Marta Venturi, Luigi Scaffidi, Alessandro Isidori, Daniele Cattaneo, Mauro Krampera, Fabrizio Pane, Daniela Cilloni, Gianpietro Semenzato, Roberto M. Lemoli, Antonio Cuneo, Elisabetta Abruzzese, Daniela Bartoletti, Simona Paglia, Nicola Vianelli, Michele Cavo, Massimiliano Bonifacio, Giuseppe A. Palumbo

المصدر: Cancer. 129:1704-1713

مصطلحات موضوعية: Cancer Research, Oncology, ruxolitinib, cytopenia, myelofibrosis, myelodepletive phenotype, myeloproliferative neoplasms

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75234af541a1ffd87d4f63defcaf092aTest
https://doi.org/10.1002/cncr.34722Test

المؤلفون: Giuseppe Auteri, Camilla Mazzoni, Mattia Biondo, Simona Paglia, Marta Venturi, Andrea Davide Romagnoli, Daniela Bartoletti, Michele Cavo, Nicola Vianelli, Francesca Palandri

المصدر: Blood. 140:8396-8398

مصطلحات موضوعية: Immunology, Cell Biology, Hematology, Biochemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3fc6e88a99af39d65c31148882dcbe58Test
https://doi.org/10.1182/blood-2022-162557Test