المؤلفون: Daniel Santana de Carvalho, Rafael Wesley Bastos, Luana Rossato, Nalu Teixeira de Aguiar Peres, Daniel Assis Santos

المصدر: ACS Omega, Vol 9, Iss 28, Pp 30559-30570 (2024)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2470-1343Test

الوصول الحر: https://doaj.org/article/ab6342160acf4009b7f86cd7bbd3cdeeTest

المؤلفون: Víctor Joaquín Escudero-Saiz, Nathalie Melissa Romani, Pastora Rodríguez, Laura Morantes, Jimena Del Risco-Zevallos, Joaquim Casals, Marc Xipell, Elena Guillén, Gastón J. Piñeiro, Miguel Blasco, Lida M. Rodas, Luis F. Quintana, Esteban Poch, Daniel Santana, Alicia Molina Andújar

المصدر: Nefrología (English Edition), Vol 44, Iss 3, Pp 317-322 (2024)

مصطلحات موضوعية: Contraste yodado, Enfermedad renal crónica avanzada, Encefalopatía, Diseases of the genitourinary system. Urology, RC870-923

الوصف: Contrast-induced encephalopathy is a neurological complication related to contrast used in endovascular procedures or computed tomography (CT). The main risk factors are arterial hypertension, diabetes mellitus, chronic kidney disease (CKD), hyperosmolar contrasts, the amount of infused contrast and its direct infusion in the posterior cerebral territory, or pathologies with blood-brain barrier damage. Symptomatology is non-specific and may present as altered level of consciousness, neurological focality or seizures. Diagnosis is done by exclusion after ischemic or hemorrhagic stroke has been ruled out; CT or MRI are useful for differentiation. Generally, it appears shortly after exposure and the symptoms lasts 48−72h with complete recovery, although cases with persistence of symptoms or longer duration have been described. Treatment consists of monitoring, supportive measures and kidney replacement therapy (KRT) with hemodialysis (HD) in patients in chronic KRT program. It is important for the nephrologist to be aware of this entity given the susceptibility of the patient on HD as well as its potential therapeutic role in these patients. Resumen: La encefalopatía por contraste es una complicación neurológica relacionada con el contraste utilizado en procedimientos endovasculares o tomografía computarizada (TC). Los principales factores de riesgo son la hipertensión arterial, la diabetes mellitus, la enfermedad renal crónica (ERC), contrastes hiperosmolares, cantidad de contraste infundida y su infusión directa en el territorio cerebral posterior, o patologías que cursen con daño de barrera hematoencefálica. La sintomatología es inespecífica y puede presentarse como alteración del nivel de conciencia, focalidad neurológica o crisis comiciales. El diagnóstico es de exclusión tras haber descartado los accidentes cerebro-vasculares isquémicos o hemorrágicos, el TC o la resonancia magnética son de utilidad para su diferenciación. Generalmente, aparece poco tiempo tras la exposición y la sintomatología dura 48−72h con recuperación completa, aunque se han descrito casos con persistencia de los síntomas o mayor duración. El tratamiento es la monitorización con medidas de soporte y la terapia de sustitución renal con hemodiálisis (HD) en aquellos pacientes en programa crónico. Es importante que el nefrólogo conozca esta entidad dada la susceptibilidad del paciente en HD así como su potencial papel terapéutico en estos pacientes.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S201325142400107XTest; https://doaj.org/toc/2013-2514Test

الوصول الحر: https://doaj.org/article/b4f92af9a34b42c48b0554fa372034b5Test

المؤلفون: Víctor Joaquín Escudero-Saiz, Nathalie Melissa Romani, Pastora Rodríguez, Laura Morantes, Jimena Del Risco-Zevallos, Joaquim Casals, Marc Xipell, Elena Guillén, Gastón J. Piñeiro, Miguel Blasco, Lida M. Rodas, Luis F. Quintana, Esteban Poch, Daniel Santana, Alicia Molina Andújar

المصدر: Nefrología, Vol 44, Iss 3, Pp 317-322 (2024)

مصطلحات موضوعية: Iodinated contrast, Advanced chronic kidney disease, Encephalopathy, Diseases of the genitourinary system. Urology, RC870-923

الوصف: Resumen: La encefalopatía por contraste es una complicación neurológica relacionada con el contraste utilizado en procedimientos endovasculares o tomografía computarizada (TC). Los principales factores de riesgo son la hipertensión arterial, la diabetes mellitus, la enfermedad renal crónica (ERC), contrastes hiperosmolares, cantidad de contraste infundida y su infusión directa en el territorio cerebral posterior, o patologías que cursen con daño de barrera hematoencefálica. La sintomatología es inespecífica y puede presentarse como alteración del nivel de conciencia, focalidad neurológica o crisis comiciales. El diagnóstico es de exclusión tras haber descartado los accidentes cerebrovasculares (ACV) isquémicos o hemorrágicos; el TC o la resonancia magnética (RM) son de utilidad para su diferenciación. Generalmente aparece poco tiempo tras la exposición y la sintomatología dura 48-72 h con recuperación completa, aunque se han descrito casos con persistencia de los síntomas o mayor duración. El tratamiento es la monitorización con medidas de soporte y la terapia de sustitución renal con hemodiálisis (HD) en aquellos pacientes en programa crónico. Es importante que el nefrólogo conozca esta entidad, dada la susceptibilidad del paciente en HD, así como su potencial papel terapéutico en estos pacientes. Abstract: Contrast-induced encephalopathy is a neurological complication related to contrast used in endovascular procedures or computed tomography (CT). The main risk factors are arterial hypertension, diabetes mellitus, chronic kidney disease (CKD), hyperosmolar contrasts, the amount of infused contrast and its direct infusion in the posterior cerebral territory, or pathologies with blood–brain barrier damage. Symptomatology is non-specific and may present as altered level of consciousness, neurological focality or seizures. Diagnosis is done by exclusion after ischemic or hemorrhagic stroke has been ruled out; CT or MRI are useful for differentiation. Generally, it appears shortly after exposure and the symptoms lasts 48–72 h with complete recovery, although cases with persistence of symptoms or longer duration have been described. Treatment consists of monitoring, supportive measures and renal replacement therapy (RRT) with hemodialysis (HD) in patients in chronic RRT program. It is important for the nephrologist to be aware of this entity given the susceptibility of the patient on HD as well as its potential therapeutic role in these patients.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S0211699523000760Test; https://doaj.org/toc/0211-6995Test

الوصول الحر: https://doaj.org/article/b2836d469171440b8a161de1d21cdb2eTest

المؤلفون: Maria Paula de Souza Sampaio, Mateus Santana do Rosário, Lorena Cunha Martins, Luiza Vieira Luedy Trindade, Marcos Vinicius Lima de Oliveira Francisco, Bernardo Gratival Gouvea Costa, Gessica Almeida Vasconcelos, Italo Andrade Barbosa Lima, Yasmin Santos Freitas Macêdo, Fernanda Maria Lessa Carvalho, Marina Borges Rabelo de Santana, Ricardo Khouri, Hegger Fritsch, Joilson Xavier, Vagner Fonseca, Marta Giovanetti, Arabela Leal e Silva de Mello, Felicidade Mota Pereira, Gubio Soares Campos, Pedro Antonio Pereira de Jesus, Daniel Santana Farias, Murilo Santos de Souza, Adilson Junior Pinto Galvão, Felipe Oliveira Costa, Marcia Carvalho Bessa, Janeusa Rita Leite Primo Chagas, Celia Silvany, Jose Mário Meira Teles, Maricelia Maia de Lima, Tarsis Leonardo Almeida Farias, Tiago Gräf, Isadora Cristina de Siqueira

المصدر: International Journal of Infectious Diseases, Vol 145, Iss , Pp 107090- (2024)

مصطلحات موضوعية: Encephalitis, Arbovirus, Chikungunya, Brazil, Infectious and parasitic diseases, RC109-216

الوصف: Objectives: Encephalitis is a severe neurological syndrome for which herpesvirus and enteroviruses are the most common etiological agents. Arboviruses, a wildly diverse group of pathogens, are also critical epidemiological agents associated with encephalitis. In Brazil, little is known about the causative agents of encephalitis. Methods: We conducted a hospital surveillance for encephalitis between 2020 and 2022. Molecular (RT-PCR and qPCR) and serological (virus-specific IgM and viral antigens) techniques were performed in cerebrospinal fluid and serum samples obtained from study participants. Results: In the 43 participants evaluated, the etiologic agent or the presence of IgM was detected in 16 (37.2%). Nine (20.9%) cases were positive for chikungunya virus (CHIKV), three (7.0%) for dengue virus, two (4.7%) for human adenovirus, one (2.3%) for varicella-zoster virus, and one (2.3%) for enterovirus. Whole-genome sequencing revealed that the CHIKV identified belongs to the East/Central/South African lineage. Conclusion: Herein, CHIKV is a common pathogen identified in encephalitis cases. Our results reinforce previous evidence that chikungunya represents a significant cause of encephalitis during CHIKV outbreaks and epidemics and add to existing information on the epidemiology of encephalitis in Brazil.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1201971224001619Test; https://doaj.org/toc/1201-9712Test

الوصول الحر: https://doaj.org/article/11014e0213d343e9aed76d65603728c8Test

المؤلفون: Paloma Diego-Salazar, Diego Abendaño-Rivera, Daniel Santana-Vargas, Viridiana López-Ladrón-de-Guevara, José Luis Perez-Hernández, Fátima Higuera-de-la-Tijera

المصدر: Annals of Hepatology, Vol 29, Iss , Pp 101394- (2024)

مصطلحات موضوعية: Specialties of internal medicine, RC581-951

الوصف: Introduction and Objectives: Hepatic Encephalopathy (HE) is a common complication in patients with Chronic Liver Disease (CLD), and the development of this decompensation is multifactorial, including ammonia levels, inflammatory status, and sepsis, among others. A poorly studied factor in our population is the serum levels of 25-hydroxyvitamin D (25-OHD), which could act as a co-factor in HE. To assess if serum 25-hydroxyvitamin D (25-OHD) deficiency acts as a cofactor in the development of HE. Materials and Patients: Observational, retrospective, analytical, case-control study; included subjects of both sexes, 18 years old and over, diagnosed with Chronic Liver Disease of different etiologies. Complete blood count, liver and kidney function, serum electrolytes, coagulation profile, and serum levels of 25-hydroxyvitamin D were recorded. They were evaluated using the West-Haven Criteria (WH). Results: Independent samples T-test was used to compare differences between 25-hydroxyvitamin D levels in patients with and without HE. The association between 25-OHD deficiency and HE was assessed using a chi-square test, with a significance level set at alpha=0.05. Out of a total of 96 patients, 36.5% had HE. The mean 25-OHD level in the HE group was 18.78 ± 8.56, compared to 22.77 ± 9.94 in the group without HE. The T-test was significant: T (1=2.072), p =0.041. Among patients with deficiency, 20/35 (57.1%) had EH, while 22/61 (36.1%) did not have HE. The chi-square test for the association between deficiency and HE was positive, with a value of (1)=4.015, p =0.045. Conclusions: A causal relationship between 25-hydroxyvitamin D (25-OHD) deficiency and the development of HE cannot be attributed, as this is multifactorial. However, 25-OHD deficiency is common in patients with Chronic liver disease, and our study demonstrates that this deficiency acts as a cofactor, as there is a significant difference between the groups. It is necessary to validate these findings in the future through multivariate analysis to confirm our results.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1665268124001881Test; https://doaj.org/toc/1665-2681Test

الوصول الحر: https://doaj.org/article/e60b618ec0cc4f59b1ccf4734480eb29Test

المؤلفون: Carlos S. Tinitana-Jumbo, Karen A. Hernández-Bautista, María F. Higuera-de la Tijera, Víctor M. Paéz-Zayas, Daniel Santana-Vargas, Camila Montes-Castellanos, José L. Pérez-Hernández

المصدر: Annals of Hepatology, Vol 29, Iss , Pp 101419- (2024)

مصطلحات موضوعية: Specialties of internal medicine, RC581-951

الوصف: Introduction and Objectives: Prevalence of patients with decompensated cirrhosis with requirement of liver transplantation (LT) has increased in our country. A significant percentage of patients with this condition belongs to a geriatric population, which could contraindicate LT, although trends in other countries indicate that the results of LT in geriatric patients are excellent.To assess one-year survival of LT patients over 60 years Materials and Patients: Retrospective, observational, and analytical study of patients over 60 years who underwent LT, evaluating survival, cold ischemia time (CIT), hot ischemia time (HIT), and donor age (DA), compared with a group of patients under 60 years who underwent LT.We evaluated survival over time in months with a follow-up at one year of recipients under 60 years and older than 60 using the Kaplan-Meier curve and the log-rank test, with a significant alpha level

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1665268124002138Test; https://doaj.org/toc/1665-2681Test

الوصول الحر: https://doaj.org/article/00e00ed0b73d4e41b44e2bbae35a5398Test

المؤلفون: Marisela Hernandez-Santillan, Abigail Hernandez-Barragan, Moises Martínez-Castillo, Zaira Medina-Ávila, Harumi Reséndiz-García, Erik Robledo-Ramírez, Yadira Guizar-Alcántara, Amanda Álvarez-Rodea, Danna Mercado-Herrera, María F. Higuera-De La Tijera, José L. Pérez-Hernández, Daniel Santana-Vargas, Gabriela Gutiérrez-Reyes

المصدر: Annals of Hepatology, Vol 29, Iss , Pp 101425- (2024)

مصطلحات موضوعية: Specialties of internal medicine, RC581-951

الوصف: Introduction and Objectives: Chronic liver disease (CLD) is considered an important health problem worldwide. The production of IL-10 regulated the hepatic inflammation. Whereas TGF-β plays a crucial role during the progression of CLD, promoting the dysregulated production of extracellular matrix in the liver. However, the role of TGF-β1, 2, and 3 and IL-10 in CLD is not completely understood. To evaluate the circulatory values of TGF-β1, 2, and 3 and IL-10 in hepatitis C virus (HCV), Non-alcoholic fatty liver disease (NAFLD) and alcoholic cirrhosis (OHCi) and control subjects (CT). Materials and Patients: A prospective, cross sectional, observational and multicentric study. HCV (n=33), NAFLD (n=33) and OHCi patients (n=22) and CT (n=26) were enrolled. The anthropometric variables, detailed clinical history and biochemical parameters were considered. TGF-β1, 2, and 3 and IL-10 (pg/mL) were evaluated using multiple suspension arrays. Kruskal-Wallis and Mann-Whitney U test were used for the statistical analysis. The study has the approval of the Research and Ethics Commissions with code FM/DI/135/2017 and the Research Ethics Committee of the Hospital General de México Dr. Eduardo Liceaga with code DI/16/107/03/031 as well the consent informed of the patients. Results: The age of CT group was estimated at 33 yrs., while the average of the different hepatopathies was 47 yrs. Male predominance was marked in OHCi and CT, but in NAFLD the distribution of women was similar. Multiple comparison analysis revealed that serum levels of TGF-β1, 2, and 3 did not present statistical differences in each CLD group. Nevertheless, TGF-β2 isoform showed significant difference in NAFLD and OHCi vs. CT (pNAFLD>HCV showing correlation with the increment of the ratio of 4.4, 2.7, and 2.3 folds compared to CT, respectively. Conclusions: Our data showed no differential changes of TGF-β1, 2, and 3 in accordance with CLD. The up regulation of TGF-β2 isoform could be related to different inflammatory responses in NAFLD and OHCi. On the other hand, IL-10 was upregulated in all the chronic conditions reflecting its role as pro-inflammatory mediator.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1665268124002199Test; https://doaj.org/toc/1665-2681Test

الوصول الحر: https://doaj.org/article/034829b8a62b407d854f131cb628c564Test

المؤلفون: Abigail Hernandez-Barragan, Moises Martinez-Castillo, Marisela Hernandez-Santillan, Zaira Medina-Avila, Harumi Reséndiz-García, Jeovane Robledo-Ramírez, Isabel Villagomes-Lopez, Edson Hernandez-Cruz, Yadira Guízar-Alcántara, María F. Higuera-De La Tijera, José L. Pérez-Hernández, Daniel Santana-Vargas, Gabriela Gutiérrez-Reyes

المصدر: Annals of Hepatology, Vol 29, Iss , Pp 101426- (2024)

مصطلحات موضوعية: Specialties of internal medicine, RC581-951

الوصف: Introduction and Objectives: Alcoholic liver and non-alcoholic liver disease causes liver disease. Dual damage has been gaining great relevance. Insulin growth factor binding proteins (IGFBPs) regulate the signaling pathways of IGF; IGFBP-3 have emerged as promising biomarkers in HGNA; however, in alcohol intake and dual damage has not been previously reported the levels of IGFBPs. To demonstrate the changes in the serum levels of IGFBP-1, 3 and 7 in alcohol consumption, NAFLD and dual insult Materials and Patients: Prospective, cross-sectional and multicenter study; approved by the research and ethics commission of the UNAM and the General Hospital of Mexico. A clinical history was taken and an informed consent was requested. IGFBP-1, 3 and 7 were evaluated in alcoholism (OH), alcoholic liver disease (cirrhosis (CiOH)), alcoholic hepatitis (AH), NAFLD, dual patients and control group (CT) using multiple suspension arrays. Kruskal-Wallis, Mann-Whitney U test were used for the statistical analysis. Results: The data showed that alcohol dependence increased the serum levels of IGFBP-1, 3 and 7 (ng/mL) vs. CT, and vs. the other hepatopathies as follows OH>AH>CiOH>HGNA>Dual. Whereas in CiOH the levels of IGFBP-1, 3 and 7 were reduced vs. CT, but a slight increment was observed in AH; however, it never reached similar values to CT. On the other hand, in NAFLD the serum concentrations of all the IGFBPs evaluated were downregulated vs. CT. Conclusions: The serum levels of IGFBPs were regulated in a differential manner in accordance with the negative liver stimuli, these changes were more evident in alcoholism The dual stimulus showed the clear synergistic effects of alcohol consumption and diet in IGFBP regulation. IGFBPs could be used as biomarkers or targets in the control of different hepatopathies.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1665268124002205Test; https://doaj.org/toc/1665-2681Test

الوصول الحر: https://doaj.org/article/811be01074f24a3d95c07be5abfb1627Test

المؤلفون: Karina Cazarin-Chávez, María F. Higuera-De La Tijera, Daniel Santana-Vargas, Diego F. Abendaño-Rivera, Cristian Y. Sánchez-Sánchez, José L. Pérez-Hernández

المصدر: Annals of Hepatology, Vol 29, Iss , Pp 101435- (2024)

مصطلحات موضوعية: Specialties of internal medicine, RC581-951

الوصف: Introduction and Objectives: Chronic liver disease is increasingly prevalent, the causes range from MAFLD, alcohol consumption, HCV, autoimmune disease, and others. They develop complications such as: portal hypertension with esophageal and gastric varices, hepatic encephalopathy, ascites, renal injury, among others, conditioning the final stage of the disease and death; therefore, knowing the factor that has the greatest impact on mortality is relevant. To evaluate which decompensations are associated with higher mortality in patients with cirrhosis of different etiologies. Materials and Patients: Retrospective, analytical, observational study of patients with cirrhosis. To determine the factors associated with 28- and 90-day mortality, proportional hazard curves were performed for COX with encephalopathy, gastrointestinal bleeding, ascites, renal injury, ACLF and infection, with absence of the factor as reference. Considering significant α ≤0.05, SPSS-V 25.0 was used Results: 200 patients, men 53%, women 47%. Etiology: alcohol 86, MAFLD 58, autoimmune 27, dual 16 and HCV 13; 37 died at 28 days and 49 at 90 days. Cumulative mortality rate 28 days 18.4%, 90 days 24.4%, with CHI square test for the model was significant, 109.34 (10), p

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1665268124002291Test; https://doaj.org/toc/1665-2681Test

الوصول الحر: https://doaj.org/article/e0900ccdc6084695b4e88bbd36716206Test

المؤلفون: Sandra Teutli-Carrión, Claudia L. Dorantes-Nava, Miguel Y. Carmona-Castillo, Ernesto J Ávalos-Medina, Daniel Santana-Vargas, María F. Higuera-de la Tijera, José L. Pérez-Hernández

المصدر: Annals of Hepatology, Vol 29, Iss , Pp 101436- (2024)

مصطلحات موضوعية: Specialties of internal medicine, RC581-951

الوصف: Introduction and Objectives: Spontaneous bacterial peritonitis (SBP) is a severe complication that can occur in patients with cirrhosis and is associated with high mortality rates. Evaluating SBP as a risk factor in the outcome of patients with cirrhosis is important because it helps understand the impact of this complication on the overall prognosis of these patients. Therefore, the objective of this study is to identify risk factors, treatment outcomes, and mortality rates associated with SBP in this population. Materials and Patients: A retrospective and analytical study was conducted on patients with cirrhosis who developed SBP. The cause of cirrhosis and Child-Pugh score were evaluated. They were classified into early responders (ER) (more than 25% decrease in polymorphonuclear cells on the second day of effective antibiotic treatment), development of renal injury, acute-on-chronic liver failure (ACLF), and 28-day mortality. Statistical analysis included evaluating the mortality rate using the Kaplan-Meier curve, log-rank test, considering significance at p ≤ 0.05. Renal injury, ACLF, and non-early responders were independently compared. Results: A total of 79 patients were included in the study, 40 males (50.63%) and 39 females (49.36%). Alcohol-related in 49.36% of cases. Child-Pugh C was found in 67 cases (84.81%). Antibiotics were cephalosporins in 66 cases (84.81%) and carbapenems in 13 cases (16.45%). There were 6 deaths among early responders and 29 among non-early responders, with a mean survival of 25.76 days for early responders versus 9.78 days for non-early responders, p < 0.001 (Figure 1). Regarding Acute-on-Chronic Liver Failure (ACLF), there were 2 deaths in patients without ACLF and 33 deaths in patients with ACLF. The mean survival for patients without ACLF was 26.93 days, compared to 14.6 days for those with ACLF, p < 0.001. Patients without renal injury had 3 deaths, while those with renal injury had 32 deaths. The mean survival for patients without renal injury was 25.65 days, compared to 16.17 days for those with renal injury, p < 0.001 (Figure 2) Conclusions: SBP in patients with cirrhosis is associated with a high mortality rate. However, several factors such as treatment response, the presence of ACLF, and renal injury have a significant impact on patient survival.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1665268124002308Test; https://doaj.org/toc/1665-2681Test

الوصول الحر: https://doaj.org/article/cc3d834c78ef4378a7697ece1846a578Test