المؤلفون: Volpe, Nicola, Sen, Cihat, Turan, Sifa, Sepulveda, Waldo, Khalil, Asma, Rolnik, Daniel, De Robertis, Valentina, Volpe, Paolo, Gil, Mar M, Chaveeva, Petya, Dagklis, Themistoklis, Pooh, Ritsuko, Kosinski, Przemyslaw, Cruz, Jader, Huertas, Erasmo, D' Antonio, Francesco, Rodrigues Calvo, Jesus, Daneva Markova, Ana

المصدر: Journal of perinatal medicine ; Germany

مصطلحات موضوعية: fetal anatomy, first trimester, guideline

الوصف: This recommendation document follows the mission of the World Association of Perinatal Medicine in collaboration with the Perinatal Medicine Foundation. We aim to bring together groups and individuals throughout the world for precise standardization to implement the ultrasound evaluation of the fetus in the first trimester of pregnancy and improve the early detection of anomalies and the clinical management of the pregnancy. The aim is to present a document that includes statements and recommendations on the standard evaluation of the fetal anatomy in the first trimester, based on quality evidence in the peer-reviewed literature as well as the experience of perinatal experts around the world. © 2022 Walter de Gruyter GmbH, Berlin/Boston 2022. ; https://doi.org/10.1515/jpm-2022-0125Test

العلاقة: Journal of Perinatal Medicine; http://hdl.handle.net/10713/18830Test

الإتاحة: https://doi.org/10.1515/jpm-2022-0125Test
http://hdl.handle.net/10713/18830Test

المؤلفون: Georgievska, Jadranka, Tofoski, Gligor, Dimitrov, Goran, Daneva-Markova, Ana, Jovanovska, Viktorija, Dabeski, Dragi, Jovcevski, Sashe, Dzikova, Elena, Atanasova, Aleksandra

المصدر: Archives of Public Health; Vol. 14 No. 2 (2022): Arch Pub Health; 58-71 ; Архиви на јавното здравје; Том. 14 Бр. 2 (2022): Архиви на јавно здравје; 58-71 ; 1857-7148

مصطلحات موضوعية: endometriosis, inflammation, cytokines, interleukin, serum tumor markers, ендометриоза, воспаление, цитокини, интерлеукин, серумски тумор маркери

الوصف: Endometriosis is a multifactorial disease which etiopathogenesis has not been elucidated. One of the theories of etiopathogenesis is the inflammatory theory. Aims of the study: To develop a practical non-invasive test for the diagnosis of endometriosis by examining some inflammatory markers and cytokines; to compare the highly sensitive C-reactive protein (hsCRP), cytokines (interleukin-6-IL-6 and tumor necrotizing factor alpha) and the tumor marker cancer antigen 125 (CA-125) among healthy patients and patients with endometriosis; to determine the sensitivity and specificity of each biomarker separately in the diagnosis of endometriosis and to determine their role in the diagnosis of endometriosis. Materials and methods: In a prospective study conducted at the University Clinic for Gynecology and Obstetrics, Ss. Cyril and Methodius University in Skopje, North Macedonia 138 patients were included of a reproductive age between 18-50 years (83 with diagnosis endometriosis operated laparoscopically or with laparotomy) and a control group of 55 healthy women, in a period between 01.09.2018 to 01.05.2021. Serum levels of IL-6, TNF-α, hs-CRP and tumor marker CA-125 were evaluated in both groups. Results: Serum levels of CA-125, IL-6 and TNF-α and hs-CRP were significantly higher in patients with endometriosis compared to the control group. The surface under the ROC curve (AUC) for IL-6, CA-125, hs-CRP, and TNF-α has shown that as individual markers they all have a discriminatory capacity to diagnose patients with endometriosis. Conclusions: Results obtained in our study showed statistically significantly higher serum concentrations of CA-125, IL-6 and TNF-α and hs-CRP in patients with endometriosis compared to the control group of patients. However, none of these biomarkers showed a high sensitivity for diagnosis of endometriosis. It is necessary to find a panel combination of biomarkers with a high sensitivity of about 100% that will enable early diagnosis of endometriosis. ; Ендометриозата е мултифакторно ...

وصف الملف: application/pdf

العلاقة: https://www.id-press.eu/aph/article/view/6060/5579Test; https://www.id-press.eu/aph/article/view/6060/5598Test; https://www.id-press.eu/aph/article/view/6060Test

الإتاحة: https://doi.org/10.3889/aph.2022.6060Test
https://www.id-press.eu/aph/article/view/6060Test

المؤلفون: Avramovska, Maja, Karanfilski, Borislav, Dimitrov, Goran, Dzikova, Elena, Daneva Markova, Ana, Hadzi Lega, Marija, Tofoski, Gligor, Sikole, Aleksandar

المصدر: Acta clinica Croatica ; ISSN 0353-9466 (Print) ; ISSN 1333-9451 (Online) ; Volume 60. ; Issue 2.

مصطلحات موضوعية: Isolated hypothyroxinemia, Perinatal outcome, Low birth weight, Preterm birth, Obesity, Izolirana hipotiroksinemija, Perinatalni ishod, Mala porođajna težina, Prijevremeni porođaj, Pretilost

الوصف: Isolated maternal hypothyroxinemia (IMH) is defined as the presence of low maternal total thyroxine (TT4) level in conjunction with normal maternal thyroid-stimulating hormone (TSH) level. The aim was to investigate whether IMH is associated with adverse pregnancy outcome in North Macedonia. Dried blood spot samples were obtained from 359 pregnant women meeting the inclusion criteria and analyzed for TT4 and TSH. Postpartum data were entered from their medical histories. Out of 359 women, 131 (37.42%) belonged to IMH group. There were statistically significant differences in birth weight (p=0.043), intrauterine growth restriction (IUGR) (p=0.028), Apgar score at 1 min <7 (p=0.018) and cesarean section for dystocia/disproportion (p=0.024) between the IMH and normal thyroid function (NTF) groups. In regression analysis, TSH was a significant variable predicting Apgar score (βst=0.05597, p=0.047), body mass index predicting birth weight (βst=0.02338, p=0.045) and TT4 predicting small for gestational age/IUGR (βst=-0.089834, p=0.029) in IMH group. TT4 was a strong predictor of birth weight (βst=-0.004778, p=0.003) and premature delivery (βst=0.028112, p=0.004) in NTF group. The impact of IMH in pregnancy remains controversial. IMH was associated with an increased maternal BMI and higher birth weight of neonates. Overweight could be a potential risk factor for thyroid dysfunction in pregnant women, and specifically IMH. The worst fetal outcome was seen in IMH mothers examined in second trimester. We found TSH, TT4 and BMI to be strong predictors of perinatal outcomes. ; Izolirana hipotiroksinemija majke (IMH) je prisutnost niske koncentracije ukupnog tiroksina (TT4) u majke u kombinaciji s normalnim majčinim hormonom za stimulaciju štitnjače (TSH). Cilj naše studije bio je istražiti je li IMH povezan sa štetnim ishodom trudnoće u Sjevernoj Makedoniji. U 359 trudnica koje su zadovoljile kriterije uzeti su uzorci osušene kapi krvi koji su analizirani na TT4 i TSH. Podaci nakon porođaja uneseni su za svaku majku iz ...

وصف الملف: application/pdf

العلاقة: https://hrcak.srce.hr/263490Test

الإتاحة: https://doi.org/10.20471/acc.2021.60.02.10Test
https://hrcak.srce.hr/263490Test
https://hrcak.srce.hr/file/382918Test

المؤلفون: Avramovska, Maja, Milevska Kostova, Neda, Karanfilski, Borislav, Hunziker, Sandra, Vaskova, Olivija, Dimitrov, Goran, Dzikova, Elena, Daneva Markova, Ana, Hadzi Lega, Marija, Tofoski, Gligor, Sikole, Aleksandar

المصدر: Revista Brasileira de Ginecologia e Obstetricia, 43 (10)

مصطلحات موضوعية: thyroid stimulating hormone, total thyroxine, thyroglobulin, perinatal outcomes, low birth weight

الوصف: Objective Thyroid diseases are the second most common endocrine disorders in the reproductive period of women. They can be associated with intrauterine growth restriction (IUGR), preterm delivery, low Apgar score, low birthweight (LBW) or fetal death. The aim of the present study is to explore thyroid dysfunction and its relationship with some poor perinatal outcomes (Apgar Score, low birthweight, and preterm delivery). Methods Dried blood spot samples from 358 healthy pregnant women were analyzed for thyroid stimulating hormone (TSH), total thyroxine (TT4), and thyroglobulin (Tg). Neonatal data were collected upon delivery. Four groups were formed based on thyroid function tests (TFTs). Results Of the 358 tested women, 218 (60.72%) were euthyroid. Isolated hypothyroxinemia was present in 132 women (36.76%), subclinical hyperthyroidism in 7 women (1.94%), and overt hypothyroidism in 1 (0.28%). The perinatal outcomes IUGR (p = 0.028) and Apgar score 1 minute (p = 0.015) were significantly different between thyroid function test [TFT]-distinct groups. In the multiple regression analysis, TT4 showed a statistically significant inverse predictive impact on LBW (p < 0.0001), but a positive impact of Tg on LBW (p = 0.0351). Conclusion Thyroid hormones alone do not have a direct impact on neonatal outcomes, but the percentage of their participation in the total process cannot be neglected. Based on the regression analysis, we can conclude that TT4 and Tg can be used as predictors of neonatal outcome, expressed through birthweight and Apgar score. The present study aims to contribute to determine whether a test for thyroid status should become routine screening during pregnancy.

وصف الملف: application/application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/wos/000719059600003; http://hdl.handle.net/20.500.11850/517634Test

الإتاحة: https://doi.org/20.500.11850/517634Test
https://doi.org/10.3929/ethz-b-000517634Test
https://doi.org/10.1055/s-0041-1736172Test
https://hdl.handle.net/20.500.11850/517634Test

المؤلفون: AVRAMOVSKA, MAJA, KARANFILSKI, BORISLAV, DIMITROV, GORAN, TOFOSKI, GLIGOR, DZIKOVA, ELENA, DANEVA MARKOVA, ANA, HADZI-LEGA, MARIJA, SOTIROSKI, KOSTA, VASKOVA, OLIVIJA, SIKOLE, ALEKSANDAR

المصدر: Acta medica Croatica ; ISSN 1330-0164 (Print) ; ISSN 1848-8897 (Online) ; Volume 74 ; Issue 3

مصطلحات موضوعية: pregnancy, urinary iodine concentratio, iodine nutritional status, birth weight, gestational age at birth, thyroid metabolism, trudnoća, koncentracija joda u mokraći, prehrambeni status joda, težina rođenja, gestacijska dob pri rođenju, metabolizam štitnjače

الوصف: Introduction: This study determined urine iodine concentration (UIC) during gestation, assessed the maternal iodine nutrition status and correlated it with gestational age at birth (GAB) and birth weight (BW).The measurement of UIC provides the best single measurement of the iodine nutritional status in population. Objective: Determination of UIC in pregnant women in North Macedonia. Methods: This prospective study assessed the iodine nutrition status during the course of pregnancy with reference of median UIC among 364 healthy pregnant women in different gestational age (in trimester and 5-week intervals). Results: The overall and the 1st to the 3rd trimester median UIC were: 183.7, 207, 189.75 and 169.28 [μg/L], respectively. The median UIC (μg/L) results according to 5-week interval in advancing gestation were: 232.34, 200.13, 152.81, 194.39, 181.28, 160.28, 169.41 and 175.24, respectively. We detected 5.22% (19/364) and 74.72% (272/364) with the median UIC < 50 μg/L and UIC ≥ 100 μg/L, respectively. In multiple regression, the median UIC (β = 0.0000767, P = 0.929) had no statistically signifi cant prediction to the GAB. Disease prevalence results for mean UIC in detecting BW had no statistical signifi cance: area under curve (AUC) = 0.521, z-statistic (0.340), sensitivity (45.83%), specifi city (66.27%), predictive (6.59%) and P value (0.734). Conclusion: Iodine status of pregnant women in our study is generally suffi cient by World Health Organization recommendations. The median UIC in each trimester and 5-week interval has statistically insignifi cant decrease in accordance to the advancing gestation. The median UIC has no signifi cance in predicting GAB and BW. ; Uvod: Ova je studija utvrdila koncentraciju joda u mokraći (UIC) tijekom trudnoće, procijenila prehrambeni status joda kod majke i povezala ga s gestacijskom dobi pri rođenju (GAB) i porođajnom težinom (BW). Mjerenje UIC-a omogućava najbolje pojedinačno mjerenje prehrambenog statusa joda u populaciji. Cilj: Određivanje UIC-a trudnicama u ...

وصف الملف: application/pdf

العلاقة: https://hrcak.srce.hr/245735Test

الإتاحة: https://hrcak.srce.hr/245735Test
https://hrcak.srce.hr/file/356986Test

المؤلفون: Daneva Markova, Ana, Hadzi-Lega, Marija, Dimitrov, Goran, Tofovski, Gligor, Georgievska, Jadranka, Dzikova, Elena, Kjaev, Ivo

المصدر: https://www.intechopen.com/books/6243Test.

مصطلحات موضوعية: Autoantibodies and Cytokines

الوصف: Aim: the purpose of the actual study was to evaluate, in the third trimester of pregnancy, the relationship between the formation of anti-inflammatory IL-10 cytokine and several indicators of moderate and severe preeclampsia. Materials and methods: in the third trimester of gestation, examination of the biochemical markers of preeclampsia (PE) and maternal IL-10 levels was conducted in 100 women with pregnancies complicated by varying degrees of preeclampsia and in 100 normotensive patients, hospitalized at the University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia. Patients with preeclampsia were categorized into moderate and severe preeclampsia groups according to the degree of preeclampsia. Logistic regression of the different parameters for the occurrence of severe preeclampsia analysis was used to determine the predictive value. Results: the regression analysis detected systolic blood pressure of 160 mmHg or higher, diastolic blood pressure of 100 mmHg or higher, persistent proteinuria in pregnancy, serum LDH concentration of 450 U/L or higher, and reduced serum concentrations of IL-10 as significant predictors of severe preeclampsia. Conclusion: significantly, lower IL-10 concentrations in maternal serum in patients with severe preeclampsia in comparison with respective concentrations in patients with moderate preeclampsia can be considered as major pathognomonic laboratory sign of severe form of preeclampsia.

العلاقة: https://mts.intechopen.com/articles/show/title/indicators-of-preeclampsia-in-correlation-with-maternal-cytokines-in-pregnancyTest

الإتاحة: https://doi.org/10.5772/intechopen.76344Test
https://mts.intechopen.com/articles/show/title/indicators-of-preeclampsia-in-correlation-with-maternal-cytokines-in-pregnancyTest

المؤلفون: Aleksioska Papestiev, Irena, Antovska, Vesna, Dabeski, Drage, Ilieva, Natasha, Kjaev, Ivo, Daneva Markova, Ana, Dzikova, Elena, Asani, Pajtim

العلاقة: Journal of Morphological Sciences; 157; 164

الإتاحة: https://doi.org/10.55302/jms2362157apTest

المؤلفون: Tofiloska, Valentina, Krstevska, Maria, Daneva-Markova, Ana, Jovanovska, Viktorija

المصدر: Open Access Macedonian Journal of Medical Sciences; Vol. 7 No. 1 (2019): Jan 15 (OAMJMS); 88-91 ; 1857-9655

مصطلحات موضوعية: Postmenopausis, bleeding, Postmenopausal patients, Serum estradiol, BMI, Endometrial malignancy

الوصف: BACKGROUND: Postmenopausis is a period that begins one year after the last menstrual period. Abnormal uterine bleeding could be of different origins. AIM: This study aimed to determine the association of serum estrogen hormone levels and obesity with the occurrence of endometrial bleeding in post-menopausal women. MATERIAL AND METHODS: Prospective clinical study involving 120 postmenopausal patients treated at the University Clinic for Gynecology and Obstetrics-Skopje, divided into two groups: control and study. The control group consisted of 40 postmenopausal patients without endometrial bleeding, hospitalised and operated due to urogenital pathology. The study group consisted of 80 patients with endometrial bleeding who were divided into three subgroups according to the thickness of the endometrium: from 5-8 mm, 8-11 mm and above 11 mm. In all subjects, estradiol and BMI was determined. RESULTS: Estradiol levels were statistically higher in the study group compared to control while statistically significant difference among the three subgroups according to the thickness of the endometrium about the levels of estradiol in blood is not found. About BMI, the results showed that there was no statistical significance between the two examined groups. CONCLUSION: Patients with endometrial bleeding have increased levels of estradiol and are at increased risk of endometrial cancer about controls, the likelihood of endometrial cancer significantly increases by 1,108 times.

وصف الملف: application/pdf

العلاقة: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.079/2783Test; https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.079/2754Test; https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.079Test

الإتاحة: https://doi.org/10.3889/oamjms.2019.079Test
https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.079Test

المؤلفون: Hadzi-Lega Marija, Daneva Markova Ana, Stefanovic Milan

المصدر: Sanamed, Vol 9, Iss 2, Pp 143-150 (2014)

مصطلحات موضوعية: Preterm labor, transvaginal ultrasound, predictive value, sensitivity, specifies, Medicine (General), R5-920

الوصف: Objective: To assess the combined use of cervical length and cervical phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) in the prediction of preterm delivery in symptomatic women in next 14 days. Methods: Cervical length was prospectively measured in 58 consecutive singleton pregnancies with intact membranes and regular contractions at 24–36 weeks, and phIGFBP-1 was assessed. Demographic data was evaluated (history of previous preterm delivery, history of spontaneous abortion, parity, BMI, maternal age, Orthodox or Muslims). Results: Values of all variables were evaluated (demographic data, cervical length and values of phIGFBP-1) alone and in combination with cervical length of ≤15 mm and more than 15 mm. In women with cervical length less than 15 mm/phIGFPB-1 was positive in 30 patients (22 of them delivered in 14 days). In women with cervical length less than 15 mm/phIGFBP-1 was positive in 9 of delivered pregnant women in 14 days. In women with cervical length less than 25 mm/phIGFBP-1was positive in 26 patients (2 of them delivered in 14 days). In patients with cervical length more than 25 mm/ph IGFBP-1 was positive in 4 patients (2 of them delivered in 14 days). With logistic regression we confirmed that with OR 0.117 and CI 95% (0.046–0.295) and p < 0.01 odds for preterm birth among patients with negative phIGFBP-1 is 0.117 lower than the odds for preterm birth among patients with positive test results. With same test for p = 0.009 (p < 0.01) we confirmed with OR and CI 95% (0.06 to 0.671) that cervical length less than 25 mm is good predictor of preterm delivery with symptomatic patients. Probability for delivery in the following 14 days with patients with positive phIGFBP-1and cervical length ≤ 15 mm is 0.88 or probability for not delivering in those patients is 0.12. In 88% patients with positive phIGFBP-1 and cervical length ≤ 15 mm will deliver in the following 14 days. Conclusions: In symptomatic women phIGFBP-1 may significantly improve the risk assessment for preterm delivery with cervical length and help to plan subsequent pregnancy management.

وصف الملف: electronic resource

العلاقة: http://www.sanamed.rs/sanamed_pdf/sanamed_9_2/Hadzi_Lega_Marija.pdfTest; https://doaj.org/toc/1452-662XTest; https://doaj.org/toc/2217-8171Test

الوصول الحر: https://doaj.org/article/9ee1b216cc0a4821a2a8f8849166de5cTest

المؤلفون: Hadzi Lega, Marija, Daneva Markova, Ana, Stefanovic, Milan, Tanturovski, Mile

المصدر: Bosnian Journal of Basic Medical Sciences; Vol. 15 No. 1 (2015); 51-56 ; 1840-4812 ; 1512-8601

مصطلحات موضوعية: Preterm labor, fFN, IL-6, predictive value

الوصف: Preterm delivery is the leading cause of neonatal mortality and morbidity. The rate of preterm births has been estimated to be about 15 million, which accounts for 11.1% of all live births worldwide. The purpose of this study was to evaluate the cervico-vaginal (CVF) cytokine IL-6 and fetal fibronectin (fFN) status as predictors of preterm delivery in patients with symptoms of preterm labor. Patients with symptoms suggestive of preterm labor were recruited from September 2013 to March 2014. Vaginal swabs were taken for fetal fibronectin test (fFN) and CVF IL-6. Antibiotics, steroids and tocolytics were administered, where appropriate. The outcome was measured by the occurrence of preterm delivery within 14 days from the day of hospital admission. Cut-off value of 1305 pg/mL for the concentration of IL-6 in the CVF was the best predictor of preterm delivery, with the sensitivity of 69.4% and specificity of 68.2%. Patients with positive fFN test had the OR of 6.429 (95%CI 1.991-20.758) to deliver prematurely. The multivariate analysis of combined fFN and CVF IL-6 tests resulted in risk of 86.7% to deliver prematurely, if both tests were positive. The combination of both tests performed better than the individual tests and decreased the false positive rate, which in turn reduced the chances for inappropriate patient treatment, bringing down the costs.

وصف الملف: application/pdf; text/xml

العلاقة: https://www.bjbms.org/ojs/index.php/bjbms/article/view/93/92Test; https://www.bjbms.org/ojs/index.php/bjbms/article/view/93/2065Test; https://www.bjbms.org/ojs/index.php/bjbms/article/view/93Test

الإتاحة: https://doi.org/10.17305/bjbms.2015.1.93Test
https://www.bjbms.org/ojs/index.php/bjbms/article/view/93Test